{"$update": {"343": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "4686": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7061": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4931": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7306": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4684": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7059": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4685": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7060": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4682": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7057": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4683": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7058": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4732": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7107": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4733": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7108": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4730": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7105": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4731": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7106": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4736": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7111": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4737": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7112": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4734": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7109": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4735": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7110": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4738": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7113": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4739": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7114": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4527": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6902": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4526": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6901": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "295": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4833": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7208": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4832": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7207": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "4523": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6898": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4522": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6897": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4655": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7030": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4654": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7029": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4657": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7032": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4656": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7031": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "274": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4650": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7025": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4653": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7028": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4652": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7027": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4520": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6895": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4659": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7034": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4658": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7033": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "104": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4813": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7188": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4812": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7187": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4811": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7186": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4810": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7185": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4817": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7192": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4816": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7191": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4815": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7190": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "2041": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4819": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7194": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4818": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7193": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "2048": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46507": {"category_aro_name": "OXA-42-like beta-lactamase", "category_aro_cvterm_id": "46507", "category_aro_accession": "3007718", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42."}}}}}, "4849": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7224": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "3519": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "3518": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3513": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46497": {"category_aro_name": "OXA-22-like beta-lactamase", "category_aro_cvterm_id": "46497", "category_aro_accession": "3007708", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22."}}}}}, "3512": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3511": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3510": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "3517": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3516": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3515": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3514": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46518": {"category_aro_name": "OXA-60-like beta-lactamase", "category_aro_cvterm_id": "46518", "category_aro_accession": "3007729", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60."}}}}}, "96": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5182": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7557": {"$update": {"dna_sequence": {"$update": {"fmin": "42"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5183": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7558": {"$update": {"dna_sequence": {"$update": {"fmin": "11"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5180": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7555": {"$update": {"dna_sequence": {"$update": {"fmin": "11"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5181": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7556": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5186": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7561": {"$update": {"dna_sequence": {"$update": {"fmin": "45"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5187": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7562": {"$update": {"dna_sequence": {"$update": {"fmin": "31"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1625": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5185": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7560": {"$update": {"dna_sequence": {"$update": {"fmin": "32"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5188": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7563": {"$update": {"dna_sequence": {"$update": {"fmin": "15"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5189": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7564": {"$update": {"dna_sequence": {"$update": {"fmin": "30"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3535": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "3534": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "555": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "554": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "3539": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "3538": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "5458": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7833": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5459": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7834": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5450": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7825": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1190": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5452": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7827": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5453": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7828": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5454": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7829": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1194": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5456": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7831": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1196": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1758": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1750": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4259": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6634": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4258": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6633": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1172": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4251": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6626": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4250": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6625": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4253": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6628": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4252": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6627": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4255": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6630": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4254": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6629": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4257": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6632": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4256": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6631": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5533": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7908": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5532": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7907": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5531": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7906": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5530": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7905": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5537": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7912": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5536": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7911": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5535": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7910": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5534": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7909": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5539": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7914": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5538": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7913": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1281": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1288": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "685": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1572": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46509": {"category_aro_name": "OXA-46-like beta-lactamase", "category_aro_cvterm_id": "46509", "category_aro_accession": "3007720", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46."}}}}}, "686": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "1576": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1575": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4189": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6564": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4521": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6896": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4389": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6764": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4388": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6763": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5629": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8004": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5628": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8003": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4383": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6758": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4382": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6757": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4381": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6756": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5624": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7999": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4387": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6762": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4386": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6761": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4385": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6760": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4384": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6759": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "407": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. 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{"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "3529": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4651": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7026": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5199": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7574": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5198": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7573": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "1618": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "5195": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7570": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5194": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7569": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5197": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7572": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "1967": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5191": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7566": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5190": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7565": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1610": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5192": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7567": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46524": {"category_aro_name": "OXA-9-like beta-lactamase", "category_aro_cvterm_id": "46524", "category_aro_accession": "3007735", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-9."}}}}}, "2877": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "2876": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "3356": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5449": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7824": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5448": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7823": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5443": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7818": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5442": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7817": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5441": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7816": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5440": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7815": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5447": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7822": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5446": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7821": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5445": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7820": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5444": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7819": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1761": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1764": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46517": {"category_aro_name": "OXA-58-like beta-lactamase", "category_aro_cvterm_id": "46517", "category_aro_accession": "3007728", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58."}}}}}, "1765": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1143": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1141": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1148": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "5508": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7883": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5509": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7884": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5506": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7881": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5507": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7882": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5504": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7879": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5505": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7880": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5502": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7877": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5503": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7878": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5500": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7875": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5501": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7876": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4982": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7357": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "693": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46497": {"category_aro_name": "OXA-22-like beta-lactamase", "category_aro_cvterm_id": "46497", "category_aro_accession": "3007708", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22."}}}}}, "690": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5618": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7993": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5619": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7994": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4631": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7006": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5612": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7987": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5613": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7988": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5610": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7985": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5611": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7986": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5616": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7991": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5617": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7992": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5614": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7989": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5615": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7990": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "414": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "416": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "412": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "18": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "1384": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1387": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "418": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3827": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46518": {"category_aro_name": "OXA-60-like beta-lactamase", "category_aro_cvterm_id": "46518", "category_aro_accession": "3007729", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60."}}}}}, "3826": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46497": {"category_aro_name": "OXA-22-like beta-lactamase", "category_aro_cvterm_id": "46497", "category_aro_accession": "3007708", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22."}}}}}, "3825": {"$update": {"ARO_category": {"$delete": ["35946", "35919", "35925"]}}}, "3824": {"$update": {"ARO_category": {"$delete": ["35946", "35919", "35925"]}}}, "4282": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6657": {"$update": {"dna_sequence": {"$update": {"fmin": "86"}}}}}}}}}}, "4283": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6658": {"$update": {"dna_sequence": {"$update": {"fmin": "99"}}}}}}}}}}, "4280": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6655": {"$update": {"dna_sequence": {"$update": {"fmin": "86"}}}}}}}}}}, "4281": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6656": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4286": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6661": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4287": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6662": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4284": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6659": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4285": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6660": {"$update": {"dna_sequence": {"$update": {"fmin": "86"}}}}}}}}}}, "4288": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6663": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4289": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6664": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "361": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "5276": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7651": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "385": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46509": {"category_aro_name": "OXA-46-like beta-lactamase", "category_aro_cvterm_id": "46509", "category_aro_accession": "3007720", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46."}}}}}, "4758": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7133": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4759": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7134": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4750": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7125": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4751": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7126": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4752": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7127": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4753": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7128": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4754": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7129": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4755": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7130": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4756": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7131": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4757": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7132": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5871": {"$update": {"model_sequences": {"$update": {"sequence": {"8751": {"dna_sequence": {"partial": "0", "sequence": 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{"fmin": "0"}}}}}}}}}}, "4633": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7008": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4632": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7007": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "258": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4630": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7005": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4637": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7012": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4636": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7011": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4635": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7010": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4634": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7009": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4639": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7014": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4638": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7013": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "254": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4665": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7040": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2047": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "160": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "163": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4839": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7214": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4838": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7213": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4529": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6904": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4528": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6903": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4831": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7206": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46511": {"category_aro_name": "OXA-493-like beta-lactamase", "category_aro_cvterm_id": "46511", "category_aro_accession": "3007722", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-493."}}}}}, "4830": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7205": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4525": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6900": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4524": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6899": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4835": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7210": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4834": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7209": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "4837": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7212": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4836": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7211": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1841": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "909": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46512": {"category_aro_name": "OXA-5-like beta-lactamase", "category_aro_cvterm_id": "46512", "category_aro_accession": "3007723", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-5."}}}}}, "5298": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7673": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5299": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7674": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5296": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7671": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5297": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7672": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5294": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7669": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5295": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7670": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5292": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7667": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5293": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7668": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5290": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7665": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5291": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7666": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "3531": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3530": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3533": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "3532": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "5058": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7433": {"$update": {"dna_sequence": {"$update": {"fmin": "29"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5059": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7434": {"$update": {"dna_sequence": {"$update": {"fmin": "14"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3537": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "3536": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "5054": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7429": {"$update": {"dna_sequence": {"$update": {"fmin": "33"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5055": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7430": {"$update": {"dna_sequence": {"$update": {"fmin": "23"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5056": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7431": {"$update": {"dna_sequence": {"$update": {"fmin": "25"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5057": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7432": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5050": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7425": {"$update": {"dna_sequence": {"$update": {"fmin": "39"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5051": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7426": {"$update": {"dna_sequence": {"$update": {"fmin": "33"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5052": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7427": {"$update": {"dna_sequence": {"$update": {"fmin": "18"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5053": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7428": {"$update": {"dna_sequence": {"$update": {"fmin": "39"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4336": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6711": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4337": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6712": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4335": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6710": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4333": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6708": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1978": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1972": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5476": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7851": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5477": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7852": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5474": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7849": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5475": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7850": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5472": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7847": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5473": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7848": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5470": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7845": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5471": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7846": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5478": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7853": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5479": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7854": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5274": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7649": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5275": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7650": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1777": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5277": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7652": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5270": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7645": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5271": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7646": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5272": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7647": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5273": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7648": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5278": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7653": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5279": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7654": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1151": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5519": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7894": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5518": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7893": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5511": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7886": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5510": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7885": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5513": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7888": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5512": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7887": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5515": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7890": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5514": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7889": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5517": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7892": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5516": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7891": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1551": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "59": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "55": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "537": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5605": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7980": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5604": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7979": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5607": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7982": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5606": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7981": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5601": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7976": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5600": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7975": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5603": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7978": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5136": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7511": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5609": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7984": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5608": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7983": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1902": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1399": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1398": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1396": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1394": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene 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{"model_sequences": {"$update": {"sequence": {"$update": {"6669": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4297": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6672": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "853": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "4291": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6666": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4290": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6665": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4293": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6668": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4292": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6667": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4695": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7070": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4749": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7124": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4748": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7123": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4743": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7118": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4741": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7116": {"$update": 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{"model_sequences": {"$update": {"sequence": {"$update": {"7071": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4608": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6983": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4609": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6984": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4606": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6981": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4607": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6982": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4604": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6979": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4605": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6980": {"$update": {"dna_sequence": 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{"7658": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5282": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7657": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5285": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7660": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5284": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7659": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5287": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7662": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5286": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7661": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5049": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7424": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5048": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7423": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5047": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7422": {"$update": {"dna_sequence": {"$update": {"fmin": "49"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5046": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7421": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5045": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7420": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5044": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7419": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5043": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7418": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5042": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7417": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5041": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7416": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5040": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7415": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46522": {"category_aro_name": "OXA-679-like beta-lactamase", "category_aro_cvterm_id": "46522", "category_aro_accession": "3007733", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679."}}}}}, "1807": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1806": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1804": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1802": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4996": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7371": {"$update": {"dna_sequence": {"$update": {"fmin": "29"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4997": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7372": {"$update": {"dna_sequence": {"$update": {"fmin": "39"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4994": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7369": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4995": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7370": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4992": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7367": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46522": {"category_aro_name": "OXA-679-like beta-lactamase", "category_aro_cvterm_id": "46522", "category_aro_accession": "3007733", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679."}}}}}, "4993": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7368": {"$update": {"dna_sequence": {"$update": {"fmin": "11"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4990": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7365": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4991": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7366": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4998": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7373": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4999": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7374": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "813": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "816": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "5461": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7836": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5460": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7835": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5463": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7838": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5462": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7837": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5465": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7840": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5464": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7839": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5467": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7842": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5466": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7841": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5469": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7844": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5468": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7843": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5267": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7642": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5266": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7641": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5265": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7640": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5264": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7639": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5263": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7638": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5262": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7637": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1706": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5260": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7635": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4572": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6947": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5269": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7644": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5268": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7643": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4573": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6948": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4574": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6949": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4575": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6950": {"$update": {"dna_sequence": {"$update": {"fmin": "72"}}}}}}}}}}, "1128": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1122": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1126": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "521": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "523": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1016": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "6006": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4198": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6573": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4199": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6574": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4196": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6571": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4197": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6572": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4194": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6569": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4195": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6570": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1238": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46517": {"category_aro_name": "OXA-58-like beta-lactamase", "category_aro_cvterm_id": "46517", "category_aro_accession": "3007728", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58."}}}}}, "4193": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6568": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4190": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6565": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4191": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6566": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5670": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8045": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5671": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8046": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5672": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8047": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5673": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8048": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4358": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6733": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5675": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8050": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5676": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8051": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5677": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8052": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5678": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8053": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4355": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6730": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4356": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6731": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4357": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6732": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4350": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6725": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4351": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6726": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4352": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6727": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4353": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6728": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "_version": "3.2.9", "4901": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7276": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46496": {"category_aro_name": "OXA-214-like beta-lactamase", "category_aro_cvterm_id": "46496", "category_aro_accession": "3007707", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214."}}}}}, "4900": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7275": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46497": {"category_aro_name": "OXA-22-like beta-lactamase", "category_aro_cvterm_id": "46497", "category_aro_accession": "3007708", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22."}}}}}, "4903": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7278": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "430": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4902": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7277": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4673": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7048": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "3800": {"$update": {"ARO_category": {"$delete": ["35939", "36981", "35951", "37084", "35930"]}}}, "4687": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7062": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4907": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7282": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4906": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7281": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "5708": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8083": {"$update": {"dna_sequence": {"$update": {"fmin": "93"}}}}}}}}}}, "5709": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8084": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5704": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8079": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5705": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8080": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5706": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8081": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5707": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8082": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5700": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8075": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5701": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8076": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5702": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8077": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5703": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8078": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4174": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6549": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4175": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6550": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4176": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6551": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4177": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6552": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4170": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6545": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4171": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6546": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4172": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6547": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4173": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6548": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4178": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6553": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4179": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6554": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5065": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7440": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4296": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6671": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5064": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7439": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4619": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6994": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4618": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6993": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "239": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4611": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6986": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "235": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4613": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6988": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4612": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6987": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "230": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "231": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4617": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6992": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4616": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6991": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4680": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7055": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "146": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "147": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "145": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "4884": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7259": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1052": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4885": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7260": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4505": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6880": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4504": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6879": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4507": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6882": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4506": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6881": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4501": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6876": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4500": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6875": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4503": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6878": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4502": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6877": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4509": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6884": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4508": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6883": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2088": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3250": {"$update": {"dna_sequence": {"$update": {"fmin": "5027947"}}}}}}}}}}, "2080": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3228": {"$update": {"dna_sequence": {"$update": {"fmin": "223770"}}}}}}}}}}, "2086": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3236": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "2084": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3254": {"$update": {"dna_sequence": {"$update": {"fmin": "1462397"}}}}}}}}}}, "2085": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3239": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "5451": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7826": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5455": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7830": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5078": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7453": {"$update": {"dna_sequence": {"$update": {"fmin": "18"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5079": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7454": {"$update": {"dna_sequence": {"$update": {"fmin": "33"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5072": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7447": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5073": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7448": {"$update": {"dna_sequence": {"$update": {"fmin": "47"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5070": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7445": {"$update": {"dna_sequence": {"$update": {"fmin": "14"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5071": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7446": {"$update": {"dna_sequence": {"$update": {"fmin": "24"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5076": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7451": {"$update": {"dna_sequence": {"$update": {"fmin": "36"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5077": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7452": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5074": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7449": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5075": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7450": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1833": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. 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"$insert": {"46502": {"category_aro_name": "OXA-274-like beta-lactamase", "category_aro_cvterm_id": "46502", "category_aro_accession": "3007713", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274."}}}}}, "4984": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7359": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46502": {"category_aro_name": "OXA-274-like beta-lactamase", "category_aro_cvterm_id": "46502", "category_aro_accession": "3007713", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274."}}}}}, "4987": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7362": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "4986": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7361": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "4989": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7364": {"$update": 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{"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. 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An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5069": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7444": {"$update": {"dna_sequence": {"$update": {"fmin": "29"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5068": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7443": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4886": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7261": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4887": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7262": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5574": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7949": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4408": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6783": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4409": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6784": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4404": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6779": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4405": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6780": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4406": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6781": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4407": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6782": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4400": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6775": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4401": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6776": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4402": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6777": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4403": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6778": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2146": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3237": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "2145": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3242": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "4978": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7353": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4979": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7354": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "2141": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3249": {"$update": {"dna_sequence": {"$update": {"fmin": "5027947"}}}}}}}}}}, "2140": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3231": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "4974": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7349": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4975": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7350": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4976": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7351": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4977": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7352": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4970": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7345": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "4971": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7346": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "4972": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7347": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "927": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5393": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7768": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5392": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7767": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5391": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7766": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5390": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7765": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5397": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7772": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5396": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7771": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5395": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7770": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5394": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7769": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5399": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7774": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5398": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7773": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1928": {"$update": {"ARO_category": {"$delete": ["35939", "35930"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "3474": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3475": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3476": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3477": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3470": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "3471": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3472": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3473": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3478": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3479": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5489": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7864": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5488": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7863": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5487": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7862": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5486": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7861": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5485": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7860": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5484": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7859": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5483": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7858": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5482": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7857": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5481": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7856": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5480": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7855": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5249": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7624": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5248": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7623": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1728": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46507": {"category_aro_name": "OXA-42-like beta-lactamase", "category_aro_cvterm_id": "46507", "category_aro_accession": "3007718", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42."}}}}}, "5245": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7620": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5244": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7619": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5247": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7622": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5246": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7621": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5241": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7616": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5240": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7615": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5243": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7618": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5242": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7617": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5627": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8002": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5626": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8001": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5625": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8000": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4380": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6755": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5623": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7998": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5622": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7997": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "61": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5621": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7996": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "67": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5620": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7995": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5635": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8010": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1587": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1032": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1030": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3280": {"$update": {"dna_sequence": {"$update": {"fmin": "10115"}}}}}}}}}}, "500": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46517": {"category_aro_name": "OXA-58-like beta-lactamase", "category_aro_cvterm_id": "46517", "category_aro_accession": "3007728", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58."}}}}}, "1212": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "633": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "1217": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "4378": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6753": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4379": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6754": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5658": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8033": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5659": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8034": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4372": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6747": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5657": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8032": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5654": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8029": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4371": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6746": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5652": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8027": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5653": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8028": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4374": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6749": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5651": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8026": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "782": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "5636": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8011": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1100": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4457": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6832": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4243": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6618": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "3862": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "3864": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5722": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8097": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5723": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8098": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5720": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8095": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5721": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8096": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5630": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8005": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5724": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8099": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4691": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7066": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4922": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7297": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "5631": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8006": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4921": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7296": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4920": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7295": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4798": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7173": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4799": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7174": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4794": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7169": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4795": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7170": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4796": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7171": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4797": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7172": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4790": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7165": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4791": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7166": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4792": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7167": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4694": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7069": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4152": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6527": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4153": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6528": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4150": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6525": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4151": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6526": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4156": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6531": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4157": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6532": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4154": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6529": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4155": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6530": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5632": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8007": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4158": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6533": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4159": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6534": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "217": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3281": {"$update": {"dna_sequence": {"$update": {"fmin": "8015"}}}}}}}}}}, "213": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "3489": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3488": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3481": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46505": {"category_aro_name": "OXA-364-like beta-lactamase", "category_aro_cvterm_id": "46505", "category_aro_accession": "3007716", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364."}}}}}, "3480": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3483": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "3482": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46506": {"category_aro_name": "OXA-372-like beta-lactamase", "category_aro_cvterm_id": "46506", "category_aro_accession": "3007717", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-372."}}}}}, "3485": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "3487": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3486": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4563": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6938": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4562": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6937": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4561": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6936": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4560": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6935": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4567": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6942": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4566": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6941": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4565": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6940": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4564": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6939": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4569": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6944": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4568": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6943": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2396": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5010": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7385": {"$update": {"dna_sequence": {"$update": {"fmin": "26"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5011": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7386": {"$update": {"dna_sequence": {"$update": {"fmin": "15"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4899": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7274": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46497": {"category_aro_name": "OXA-22-like beta-lactamase", "category_aro_cvterm_id": "46497", "category_aro_accession": "3007708", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22."}}}}}, "4898": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7273": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46497": {"category_aro_name": "OXA-22-like beta-lactamase", "category_aro_cvterm_id": "46497", "category_aro_accession": "3007708", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22."}}}}}, "5014": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7389": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5015": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7390": {"$update": {"dna_sequence": {"$update": {"fmin": "16"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5016": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7391": {"$update": {"dna_sequence": {"$update": {"fmin": "16"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5017": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7392": {"$update": {"dna_sequence": {"$update": {"fmin": "25"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4893": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7268": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4892": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7267": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4891": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7266": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4890": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7265": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4897": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7272": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4896": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7271": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4895": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7270": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4894": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7269": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1858": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4419": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6794": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4418": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6793": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4417": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6792": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4416": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6791": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4415": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6790": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1853": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4413": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6788": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4412": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6787": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4411": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6786": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4410": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6785": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4969": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7344": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "4968": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7343": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "4967": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7342": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4966": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7341": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4965": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7340": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "916": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4963": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7338": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4962": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7337": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4961": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7336": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4960": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7335": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "1937": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46509": {"category_aro_name": "OXA-46-like beta-lactamase", "category_aro_cvterm_id": "46509", "category_aro_accession": "3007720", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46."}}}}}, "5129": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7504": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5124": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7499": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5125": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7500": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5126": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7501": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5127": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7502": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5120": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7495": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5121": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7496": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5122": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7497": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5123": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7498": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3467": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3466": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3465": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "3464": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "3463": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "3462": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "3461": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "3460": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46504": {"category_aro_name": "OXA-294-like beta-lactamase", "category_aro_cvterm_id": "46504", "category_aro_accession": "3007715", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294."}}}}}, "849": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3468": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "5238": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7613": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5239": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7614": {"$update": {"dna_sequence": {"$update": {"fmin": "30"}}}}}}}}}}, "5230": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7605": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46522": {"category_aro_name": "OXA-679-like beta-lactamase", "category_aro_cvterm_id": "46522", "category_aro_accession": "3007733", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679."}}}}}, "1730": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "1733": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "5233": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7608": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46522": {"category_aro_name": "OXA-679-like beta-lactamase", "category_aro_cvterm_id": "46522", "category_aro_accession": "3007733", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679."}}}}}, "5234": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7609": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5235": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7610": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5236": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7611": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5237": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7612": {"$update": {"dna_sequence": {"$update": {"fmin": "94"}}}}}}}}}}, "758": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46492": {"category_aro_name": "OXA-198-like beta-lactamase", "category_aro_cvterm_id": "46492", "category_aro_accession": "3007703", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-198."}}}}}, "1595": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3282": {"$update": {"dna_sequence": {"$update": {"fmin": "3737"}}}}}}}}}}, "1596": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "1598": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5344": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7719": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5345": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7720": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5346": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7721": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5347": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7722": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5340": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7715": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1020": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5342": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7717": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5343": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7718": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5348": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7723": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5349": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7724": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "605": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46517": {"category_aro_name": "OXA-58-like beta-lactamase", "category_aro_cvterm_id": "46517", "category_aro_accession": "3007728", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58."}}}}}, "604": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4367": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6742": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4366": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6741": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4361": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6736": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4360": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6735": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4363": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6738": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4362": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6737": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4369": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6744": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4368": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6743": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5649": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8024": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5648": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8023": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5457": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7832": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5641": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8016": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5640": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8015": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5643": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8018": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5642": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8017": {"$update": {"dna_sequence": {"$update": {"fmin": "81"}}}}}}}}}}, "5645": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8020": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5644": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8019": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5647": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8022": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "635": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1112": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46517": {"category_aro_name": "OXA-58-like beta-lactamase", "category_aro_cvterm_id": "46517", "category_aro_accession": "3007728", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58."}}}}}, "1115": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1118": {"$update": {"model_sequences": {"$update": {"sequence": {"8744": {"dna_sequence": {"partial": "0", "sequence": "ATGGCAATCCGAATCTTCGCGATACTTTTCTCCATTTTTTCTCTTGCCACTTTCGCGCATGCGCAAGAAGGCACGCTAGAACGTTCTGACTGGAGGAAGTTTTTCAGCGAATTTCAAGCCAAAGGCACGATAGTTGTGGCAGACGAACGCCAAGCGGATCGTGCCATGTTGGTTTTTGATCCTGTGCGATCGAAGAAACGCTACTCGCCTGCATCGACATTCAAGATACCTCATACACTTTTTGCACTTGATGCAGGCGCTGTTCGTGATGAGTTCCAGATTTTTCGATGGGACGGCGTTAACAGGGGCTTTGCAGGCCACAATCAAGACCAAGATTTGCGATCAGCAATGCGGAATTCTACTGTTTGGGTGTATGAGCTATTTGCAAAGGAAATTGGTGATGACAAAGCTCGGCGCTATTTGAAGAAAATCGACTATGGCAACGCCGATCCTTCGACAAGTAATGGCGATTACTGGATAGAAGGCAGCCTTGCAATCTCGGCGCAGGAGCAAATTGCATTTCTCAGGAAGCTCTATCGTAACGAGCTGCCCTTTCGGGTAGAACATCAGCGCTTGGTCAAGGATCTCATGATTGTGGAAGCCGGTCGCAACTGGATACTGCGTGCAAAGACGGGCTGGGAAGGCCGTATGGGTTGGTGGGTAGGATGGGTTGAGTGGCCGACTGGCTCCGTATTCTTCGCACTGAATATTGATACGCCAAACAGAATGGATGATCTTTTCAAGAGGGAGGCAATCGTGCGGGCAATCCTTCGCTCTATTGAAGCGTTACCGCCCAACCCGGCAGTCAACTCGGACGCTGCGCGATAA", "fmax": "1528", "accession": "X07260.1", "fmin": "700", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Typhimurium", "NCBI_taxonomy_id": "90371", "NCBI_taxonomy_cvterm_id": "35732"}, "protein_sequence": {"accession": "CAA30246.1", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR"}}}}}, "ARO_category": {"$delete": ["35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "1449": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46507": {"category_aro_name": "OXA-42-like beta-lactamase", "category_aro_cvterm_id": "46507", "category_aro_accession": "3007718", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42."}}}}}, "4588": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6963": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4585": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6960": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4856": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7231": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4587": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6962": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4586": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6961": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4853": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7228": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46511": {"category_aro_name": "OXA-493-like beta-lactamase", "category_aro_cvterm_id": "46511", "category_aro_accession": "3007722", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-493."}}}}}, "4580": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6955": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4851": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7226": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4850": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7225": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5656": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8031": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4789": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7164": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4788": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7163": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4787": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7162": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4786": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7161": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4785": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7160": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4784": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7159": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4783": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7158": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4370": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6745": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5655": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8030": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4149": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6524": {"$update": {"dna_sequence": {"$update": {"fmin": "2"}}}}}}}}}}, "4148": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6523": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4145": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6520": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4144": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6519": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4147": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6522": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4146": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6521": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4141": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6516": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4140": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6515": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4143": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6518": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4142": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6517": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "3856": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5650": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8025": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4375": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6750": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4814": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7189": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4820": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7195": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "191": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "190": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4558": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6933": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4559": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6934": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4556": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6931": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4557": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6932": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4554": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6929": {"$update": {"dna_sequence": {"$update": {"fmin": "72"}}}}}}}}}}, "4555": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6930": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4552": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6927": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4553": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6928": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4550": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6925": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4551": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6926": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5003": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7378": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5002": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7377": {"$update": {"dna_sequence": {"$update": {"fmin": "11"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5001": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7376": {"$update": {"dna_sequence": {"$update": {"fmin": "14"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5000": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7375": {"$update": {"dna_sequence": {"$update": {"fmin": "31"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5007": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7382": {"$update": {"dna_sequence": {"$update": {"fmin": "18"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5006": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7381": {"$update": {"dna_sequence": {"$update": {"fmin": "27"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5005": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7380": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5004": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7379": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5009": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7384": {"$update": {"dna_sequence": {"$update": {"fmin": "36"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5008": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7383": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "902": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4428": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6803": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4429": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6804": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4422": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6797": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4423": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6798": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4420": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6795": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4421": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6796": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4426": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6801": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4427": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6802": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1845": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1844": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4958": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7333": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4959": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7334": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4952": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7327": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4953": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7328": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4950": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7325": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4951": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7326": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4956": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7331": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4957": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7332": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4954": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7329": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4955": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7330": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4626": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7001": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5139": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7514": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5138": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7513": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "5137": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7512": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1907": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3276": {"$update": {"dna_sequence": {"$update": {"fmin": "4648"}}}}}}}}}}, "5135": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7510": {"$update": {"dna_sequence": {"$update": {"fmin": "26"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5134": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7509": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5133": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7508": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5132": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7507": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5131": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7506": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5130": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7505": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3452": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "3453": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "3450": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "3451": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "850": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "3457": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46504": {"category_aro_name": "OXA-294-like beta-lactamase", "category_aro_cvterm_id": "46504", "category_aro_accession": "3007715", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294."}}}}}, "3454": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "3455": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "3458": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46504": {"category_aro_name": "OXA-294-like beta-lactamase", "category_aro_cvterm_id": "46504", "category_aro_accession": "3007715", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294."}}}}}, "3459": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46504": {"category_aro_name": "OXA-294-like beta-lactamase", "category_aro_cvterm_id": "46504", "category_aro_accession": "3007715", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294."}}}}}, "5425": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7800": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5229": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7604": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "5228": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7603": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like 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Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5223": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7598": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5222": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7597": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5221": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7596": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5220": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7595": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5227": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7602": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5226": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7601": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5225": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7600": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5224": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7599": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5357": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7732": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5356": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7731": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5355": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7730": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5354": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7729": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5353": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7728": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5352": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7727": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5351": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7726": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5350": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7725": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5359": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7734": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5358": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7733": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1694": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1690": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4310": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6685": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4311": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6686": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4312": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6687": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4313": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6688": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4314": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6689": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4315": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6690": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4316": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6691": {"$update": {"dna_sequence": {"$update": {"fmin": "86"}}}}}}}}}}, "4317": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6692": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4318": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6693": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4319": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6694": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "611": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "617": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1276": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "615": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "1496": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "4228": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6603": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4229": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6604": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4224": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6599": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4225": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6600": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4226": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6601": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "497": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4220": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6595": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4221": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6596": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4222": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6597": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4223": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6598": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5586": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7961": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5587": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7962": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5584": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7959": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5585": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7960": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5582": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7957": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "21": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5580": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7955": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "23": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "28": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5588": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7963": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5589": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7964": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5037": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7412": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46523": {"category_aro_name": "OXA-727-like beta-lactamase", "category_aro_cvterm_id": "46523", "category_aro_accession": "3007734", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-727."}}}}}, "5031": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7406": {"$update": {"dna_sequence": {"$update": {"fmin": "8"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. 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Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4436": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6811": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4431": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6806": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4430": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6805": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4433": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6808": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4432": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6807": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4926": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7301": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4821": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7196": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4439": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6814": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4438": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6813": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "977": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4944": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7319": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4947": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7322": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4946": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7321": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "973": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4940": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7315": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4943": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7318": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4942": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7317": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "5581": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7956": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4949": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7324": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4948": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7323": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "978": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "186": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46488": {"category_aro_name": "OXA-12-like beta-lactamase", "category_aro_cvterm_id": "46488", "category_aro_accession": "3007699", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-12."}}}}}, "187": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "185": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "2111": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3270": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2113": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3241": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "2116": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3252": {"$update": {"dna_sequence": {"$update": {"fmin": "341426"}}}}}}}}}}, "5108": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7483": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5109": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7484": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5102": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7477": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5103": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7478": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5100": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7475": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5101": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7476": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "5106": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7481": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5107": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7482": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5104": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7479": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5105": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7480": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3449": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "3448": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "3445": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "3444": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "3447": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "3446": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "3441": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46502": {"category_aro_name": "OXA-274-like beta-lactamase", "category_aro_cvterm_id": "46502", "category_aro_accession": "3007713", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274."}}}}}, "3440": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3443": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "3442": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "2026": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "2755": {"$update": {"model_sequences": {"$update": {"sequence": {"8749": {"dna_sequence": {"partial": "0", "sequence": "ATGTCCGAAACCTTGCAACTCGAACAGTTAACAGGATCTTTACAGCAGCTTTTGGGTGAATCCCTATTTGCCATTTATCTGTATGGTTCAGCTGTTGATGGCGGGCTAGGTCCAGAAAGTGATCTGGATGTTTTGGTTGTGGTGAGTCAAGCTCTGACACTCCAGCAACGACAGCAACTGGCAGAAACCTTATTAAAAATTTCGTATCCAATTGGGGCAGCACAGCGTGCACTTGAAGTCACCATCGTACTTAAAGCGCAAATTCTTTCAGGCAGTTATCCACTCAGCTACGAACTACAATTTGGAGAATGGTTACGGGAGGAGTTAAACCAAGGTGCTTTGCTCCGCACACATACAGACCCTGATCTGAGTATTTTGCTGAAGAAAGCACAAGTGCATCATCGTAGTTTGTTGGGGCCAAGTTTGACACAGTGGTCAACGGCAATTCCTGAACAGCACCTCTGGCAGGCAATGGCAGACACCTATCCCTCGATTGTGGAACATTGGGATGAGGATGCCGATGAGCGTAATCAAATTTTGGCCTTATGCCGTATTTATTTTAGTTTGGTGACGAGTGAGATTGTGCCTAAAGACCAGGCCGCACACTGGGTGATAGCTCAGTTACCGTCGCAGCATCAACCCATTTTGCAGCGCATGATCCAAGAATATAAAGGTGAGATAGGCAAGCAAAGCTGGCAACAACAGCATCAGGCTTTAGGAGCTGTTGTTGACTTCCTGAGTTCAAAAATTGATGAACAATTTAAGAAGAAGAGTAGCCTGATCAAATAA", "fmax": "124807", "accession": "AYEQ01000163.1", "fmin": "124018", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter gyllenbergii NIPH 230", "NCBI_taxonomy_id": "1217658", "NCBI_taxonomy_cvterm_id": "46540"}, "protein_sequence": {"accession": "ESK39014.1", "sequence": "MSETLQLEQLTGSLQQLLGESLFAIYLYGSAVDGGLGPESDLDVLVVVSQALTLQQRQQLAETLLKISYPIGAAQRALEVTIVLKAQILSGSYPLSYELQFGEWLREELNQGALLRTHTDPDLSILLKKAQVHHRSLLGPSLTQWSTAIPEQHLWQAMADTYPSIVEHWDEDADERNQILALCRIYFSLVTSEIVPKDQAAHWVIAQLPSQHQPILQRMIQEYKGEIGKQSWQQQHQALGAVVDFLSSKIDEQFKKKSSLIK"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "400"}}}}}}, "2752": {"$update": {"model_sequences": {"$update": {"sequence": {"8748": {"dna_sequence": {"partial": "0", "sequence": "ATGCCTGATTTCATTCAGTTAGAATATCTACAAGAAAAATTACAGCAACTTTTAGCGGAATCATTATTTGCAATCTATCTTTATGGTTCAGCTGTTGATGGTGGCTTAGGGCCAGAAAGTGACCTTGATGTTCTGGTCGTGGTTACTCAACCATTAACATCTGCTTTACGCGAGCAGCTTGCACAAGAATTACTAAAAATTTCACAGCCTGTTGGGGAATTACAAAGACCATTAGAAGTTACTATTTTATTAAAAGATGAGATTCAGGCTGGAAATTATCCTTTAAGTTATGAAATGCAGTTTGGTGAATGGCTACGTGAAGAACTTAAAGAAGGTGGAACATTAAGTTCGCAGAAAGACCCAGATATTAGTATATTGCTTAGAAAAGCGAGATTTCATCATACAGTTTTATTTGGTCCAGCTTTGGACCAATGGGCACCTGAAATTTCTGATCAAGAACTATGGCAAGCAATGTCTGATACTTATCCCGAAATTGTAGCTCATTGGGATGAGGATGCAGATGAAAGAAACCAGATTTTAGCTTTATGCCGGATCTATTTTAGTTTAGTCATGAAGGATATTGCTTCAAAAGACAATGCAGCTCGATGGGTTATGCCTCAGCTTCCTCCTGAGCAGAAATTCGTATTGCAGCGGCTTATACAGGAATATAGAGGGGAAATAGGCAAACAAAATTGGCAAGAGGAACATTATGCTTTGCAGCCTATTGTTAATTTTCTGAGTTCAAAAATTGAAGAGCAGTTTGAGCAGAAAAGAAATTTGATCACATAA", "fmax": "35369", "accession": "GG704579.1", "fmin": "34580", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841", "NCBI_taxonomy_id": "575584", "NCBI_taxonomy_cvterm_id": "35598"}, "protein_sequence": {"accession": "EEX02086.1", "sequence": "MPDFIQLEYLQEKLQQLLAESLFAIYLYGSAVDGGLGPESDLDVLVVVTQPLTSALREQLAQELLKISQPVGELQRPLEVTILLKDEIQAGNYPLSYEMQFGEWLREELKEGGTLSSQKDPDISILLRKARFHHTVLFGPALDQWAPEISDQELWQAMSDTYPEIVAHWDEDADERNQILALCRIYFSLVMKDIASKDNAARWVMPQLPPEQKFVLQRLIQEYRGEIGKQNWQEEHYALQPIVNFLSSKIEEQFEQKRNLIT"}}}}}, "model_param": {"$update": {"blastp_bit_score": {"$update": {"param_value": "400"}}}}}}, "2023": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1502": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5216": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7591": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5217": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7592": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5214": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7589": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5215": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7590": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5212": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7587": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "5213": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7588": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5210": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7585": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5211": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7586": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5218": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7593": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5219": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7594": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "779": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "73": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5362": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7737": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5363": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7738": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5360": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7735": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5361": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7736": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5366": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7741": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5367": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7742": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5364": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7739": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5365": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7740": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5368": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7743": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5369": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7744": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1686": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4303": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6678": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4302": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6677": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1269": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "4300": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6675": {"$update": {"dna_sequence": {"$update": {"fmin": "10"}}}}}}}}}}, "4307": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6682": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4306": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6681": {"$update": {"dna_sequence": {"$update": {"fmin": "86"}}}}}}}}}}, "4305": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6680": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4304": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6679": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4309": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6684": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4308": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6683": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1314": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46496": {"category_aro_name": "OXA-214-like beta-lactamase", "category_aro_cvterm_id": "46496", "category_aro_accession": "3007707", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214."}}}}}, "1312": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5752": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"13165": "D87G"}}, "clinical": {"$insert": {"13165": "D87G"}}}}}}}}, "5751": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4239": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6614": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4238": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6613": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4237": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6612": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4236": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6611": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4235": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6610": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4234": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6609": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4233": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6608": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4232": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6607": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4231": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6606": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4230": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6605": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5591": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7966": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5590": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7965": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5593": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7968": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5592": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7967": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5595": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7970": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5594": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7969": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5597": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7972": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5596": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7971": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5599": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7974": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5598": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7973": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "861": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46496": {"category_aro_name": "OXA-214-like beta-lactamase", "category_aro_cvterm_id": "46496", "category_aro_accession": "3007707", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214."}}}}}, "319": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "318": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "313": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "312": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "3944": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "867": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4129": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6504": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4128": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6503": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4123": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6498": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4122": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6497": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4127": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6502": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4126": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6501": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4125": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6500": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4124": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6499": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5689": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8064": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5688": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8063": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5685": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8060": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5684": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8059": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5687": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8062": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5686": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8061": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5681": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8056": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5680": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8055": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5683": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8058": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5682": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8057": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4192": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6567": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4057": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46518": {"category_aro_name": "OXA-60-like beta-lactamase", "category_aro_cvterm_id": "46518", "category_aro_accession": "3007729", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60."}}}}}, "4056": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46518": {"category_aro_name": "OXA-60-like beta-lactamase", "category_aro_cvterm_id": "46518", "category_aro_accession": "3007729", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60."}}}}}, "4055": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4054": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46509": {"category_aro_name": "OXA-46-like beta-lactamase", "category_aro_cvterm_id": "46509", "category_aro_accession": "3007720", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46."}}}}}, "4053": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "4052": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "4051": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "4050": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "4059": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "4058": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46518": {"category_aro_name": "OXA-60-like beta-lactamase", "category_aro_cvterm_id": "46518", "category_aro_accession": "3007729", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60."}}}}}, "5978": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5674": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8049": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5977": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4359": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6734": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4354": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6729": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5679": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8054": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5029": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7404": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5028": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7403": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5021": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7396": {"$update": {"dna_sequence": {"$update": {"fmin": "11"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "865": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5023": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7398": {"$update": {"dna_sequence": {"$update": {"fmin": "21"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5022": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7397": {"$update": {"dna_sequence": {"$update": {"fmin": "21"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5025": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7400": {"$update": {"dna_sequence": {"$update": {"fmin": "14"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5024": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7399": {"$update": {"dna_sequence": {"$update": {"fmin": "28"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5027": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7402": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5026": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7401": {"$update": {"dna_sequence": {"$update": {"fmin": "21"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4440": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6815": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1860": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4442": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6817": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1862": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4444": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6819": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4445": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6820": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4446": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6821": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4447": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6822": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4448": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6823": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4449": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6824": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4930": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7305": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "965": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "4932": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7307": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4933": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7308": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4934": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7309": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4935": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7310": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "962": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "4681": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7056": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4938": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7313": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4939": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7314": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "4688": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7063": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4689": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7064": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2100": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3272": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2105": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3255": {"$update": {"dna_sequence": {"$update": {"fmin": "1462397"}}}}}}}}}}, "5115": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7490": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5114": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7489": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5117": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7492": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5116": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7491": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5111": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7486": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5110": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7485": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5113": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7488": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5112": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7487": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5119": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7494": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5118": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7493": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "3438": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3439": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4936": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7311": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "3430": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3431": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46496": {"category_aro_name": "OXA-214-like beta-lactamase", "category_aro_cvterm_id": "46496", "category_aro_accession": "3007707", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214."}}}}}, "3432": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46496": {"category_aro_name": "OXA-214-like beta-lactamase", "category_aro_cvterm_id": "46496", "category_aro_accession": "3007707", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214."}}}}}, "3433": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46501": {"category_aro_name": "OXA-266-like beta-lactamase", "category_aro_cvterm_id": "46501", "category_aro_accession": "3007712", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-266."}}}}}, "3434": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3435": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3436": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3437": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4592": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6967": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4593": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6968": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4590": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6965": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4591": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6966": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4848": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7223": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46505": {"category_aro_name": "OXA-364-like beta-lactamase", "category_aro_cvterm_id": "46505", "category_aro_accession": "3007716", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364."}}}}}, "4597": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6972": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4594": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6969": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4595": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6970": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4844": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7219": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4845": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7220": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4598": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6973": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4599": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6974": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4840": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7215": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4841": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7216": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4842": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7217": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4843": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7218": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4937": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7312": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "897": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "899": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1530": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5201": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7576": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5200": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7575": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5203": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7578": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "5202": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7577": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5205": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7580": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5204": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7579": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46488": {"category_aro_name": "OXA-12-like beta-lactamase", "category_aro_cvterm_id": "46488", "category_aro_accession": "3007699", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-12."}}}}}, "5207": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7582": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5206": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7581": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5209": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7584": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5208": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7583": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46508": {"category_aro_name": "OXA-427-like beta-lactamase", "category_aro_cvterm_id": "46508", "category_aro_accession": "3007719", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-427."}}}}}, "3544": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "3545": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "3546": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "3547": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "3540": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "3541": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "3542": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3543": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "3548": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5196": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7571": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "2960": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1780": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1784": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "767": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "5193": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7568": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5379": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7754": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5378": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7753": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1079": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "5375": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7750": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1077": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46517": {"category_aro_name": "OXA-58-like beta-lactamase", "category_aro_cvterm_id": "46517", "category_aro_accession": "3007728", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58."}}}}}, "5377": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7752": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5376": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7751": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1072": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "5370": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7745": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5373": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7748": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5372": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7747": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1679": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4338": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6713": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4339": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6714": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "674": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "675": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "4334": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6709": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "677": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4332": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6707": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1099": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4330": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6705": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4331": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6706": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1419": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1410": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1411": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "1413": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1416": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1417": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1326": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "1325": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4208": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6583": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4209": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6584": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4202": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6577": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4203": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6578": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4200": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6575": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4201": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6576": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4206": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6581": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4207": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6582": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4204": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6579": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4205": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6580": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5568": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7943": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5569": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7944": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5564": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7939": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5565": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7940": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5566": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7941": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5567": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7942": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5560": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7935": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5561": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7936": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5562": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7937": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5563": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7938": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1255": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46509": {"category_aro_name": "OXA-46-like beta-lactamase", "category_aro_cvterm_id": "46509", "category_aro_accession": "3007720", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46."}}}}}, "1258": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46516": {"category_aro_name": "OXA-55-like beta-lactamase", "category_aro_cvterm_id": "46516", "category_aro_accession": "3007727", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapanem-hydrolyzing class D OXA beta-lactamases derived from OXA-55."}}}}}, "5184": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7559": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5012": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7387": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5013": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7388": {"$update": {"dna_sequence": {"$update": {"fmin": "17"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4062": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "4063": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "4060": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "4061": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "4067": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4064": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "4065": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46506": {"category_aro_name": "OXA-372-like beta-lactamase", "category_aro_cvterm_id": "46506", "category_aro_accession": "3007717", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-372."}}}}}, "4068": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4069": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "5018": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7393": {"$update": {"dna_sequence": {"$update": {"fmin": "17"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5019": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7394": {"$update": {"dna_sequence": {"$update": {"fmin": "24"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5152": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7527": {"$update": {"dna_sequence": {"$update": {"fmin": "24"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1040": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5156": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7531": {"$update": {"dna_sequence": {"$update": {"fmin": "15"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4453": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6828": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4452": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6827": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4451": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6826": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4450": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6825": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1898": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4456": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6831": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4455": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6830": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4454": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6829": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4459": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6834": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4458": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6833": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1892": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "2136": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3232": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "4690": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7065": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4693": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7068": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4692": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7067": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2132": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3263": {"$update": {"dna_sequence": {"$update": {"fmin": "1471845"}}}}}}}}}}, "2133": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3260": {"$update": {"dna_sequence": {"$update": {"fmin": "1471845"}}}}}}}}}}, "4925": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7300": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4924": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7299": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4699": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7074": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4698": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7073": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4929": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7304": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4928": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7303": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "5160": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7535": {"$update": {"dna_sequence": {"$update": {"fmin": "14"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5161": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7536": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5162": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7537": {"$update": {"dna_sequence": {"$update": {"fmin": "42"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5163": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7538": {"$update": {"dna_sequence": {"$update": {"fmin": "30"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5164": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7539": {"$update": {"dna_sequence": {"$update": {"fmin": "47"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5165": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7540": {"$update": {"dna_sequence": {"$update": {"fmin": "23"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5166": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7541": {"$update": {"dna_sequence": {"$update": {"fmin": "34"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5167": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7542": {"$update": {"dna_sequence": {"$update": {"fmin": "34"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5168": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7543": {"$update": {"dna_sequence": {"$update": {"fmin": "34"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5169": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7544": {"$update": {"dna_sequence": {"$update": {"fmin": "34"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4941": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7316": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3429": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3428": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3423": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "3422": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3421": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3420": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3427": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3426": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3425": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "3424": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "2001": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4589": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6964": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "2007": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4859": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7234": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4858": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7233": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4857": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7232": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4584": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6959": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4855": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7230": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4854": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7229": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4581": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6956": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4852": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7227": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4583": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6958": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4582": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6957": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4414": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6789": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4301": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6676": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "2910": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "2912": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46502": {"category_aro_name": "OXA-274-like beta-lactamase", "category_aro_cvterm_id": "46502", "category_aro_accession": "3007713", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274."}}}}}, "2913": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46503": {"category_aro_name": "OXA-286-like beta-lactamase", "category_aro_cvterm_id": "46503", "category_aro_accession": "3007714", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286."}}}}}, "5308": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7683": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5309": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7684": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4964": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7339": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "5300": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7675": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5301": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7676": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5302": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7677": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5303": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7678": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1065": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5305": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7680": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5306": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7681": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5307": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7682": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1660": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1087": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "1083": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4321": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6696": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4320": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6695": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4322": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6697": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4325": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6700": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4324": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6699": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4327": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6702": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4326": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6701": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5414": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7789": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5415": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7790": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5416": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7791": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5417": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7792": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5410": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7785": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5411": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7786": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5412": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7787": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5413": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7788": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5418": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7793": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5419": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7794": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1403": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1402": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4437": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6812": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1406": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4215": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6590": {"$update": {"dna_sequence": {"$update": {"fmin": "8"}}}}}}}}}}, "4214": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6589": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4217": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6592": {"$update": {"dna_sequence": {"$update": {"fmin": "84"}}}}}}}}}}, "4216": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6591": {"$update": {"dna_sequence": {"$update": {"fmin": "65"}}}}}}}}}}, "4211": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6586": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4210": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6585": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4213": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6588": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4212": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6587": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "441": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4219": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6594": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4218": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6593": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5579": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7954": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5578": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7953": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5577": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7952": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5576": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7951": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5575": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7950": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "30": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "5573": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7948": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5572": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7947": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5571": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7946": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5570": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7945": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1536": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1532": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "646": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "649": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5128": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7503": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4075": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "4074": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "4076": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "4071": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4070": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4073": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "4072": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "5083": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7458": {"$update": {"dna_sequence": {"$update": {"fmin": "22"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5082": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7457": {"$update": {"dna_sequence": {"$update": {"fmin": "23"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1962": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "5081": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7456": {"$update": {"dna_sequence": {"$update": {"fmin": "42"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5080": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7455": {"$update": {"dna_sequence": {"$update": {"fmin": "35"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5087": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7462": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3633": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46488": {"category_aro_name": "OXA-12-like beta-lactamase", "category_aro_cvterm_id": "46488", "category_aro_accession": "3007699", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-12."}}}}}, "3505": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5085": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7460": {"$update": {"dna_sequence": {"$update": {"fmin": "15"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4610": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6985": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5084": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7459": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4615": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6990": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4614": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6989": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4468": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6843": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4469": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6844": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4466": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6841": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4467": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6842": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4464": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6839": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4465": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6840": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4462": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6837": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4463": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6838": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4460": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6835": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4461": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6836": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "2122": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3271": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4668": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7043": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4669": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7044": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4918": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7293": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4919": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7294": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4664": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7039": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2128": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3256": {"$update": {"dna_sequence": {"$update": {"fmin": "1462397"}}}}}}}}}}, "4914": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7289": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4915": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7290": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4660": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7035": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4661": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7036": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4910": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7285": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4911": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7286": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "5173": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7548": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5172": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7547": {"$update": {"dna_sequence": {"$update": {"fmin": "42"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5171": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7546": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5170": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7545": {"$update": {"dna_sequence": {"$update": {"fmin": "16"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5177": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7552": {"$update": {"dna_sequence": {"$update": {"fmin": "39"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5176": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7551": {"$update": {"dna_sequence": {"$update": {"fmin": "44"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5175": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7550": {"$update": {"dna_sequence": {"$update": {"fmin": "40"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5174": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7549": {"$update": {"dna_sequence": {"$update": {"fmin": "35"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5179": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7554": {"$update": {"dna_sequence": {"$update": {"fmin": "29"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5178": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7553": {"$update": {"dna_sequence": {"$update": {"fmin": "27"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3416": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3417": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3415": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3412": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3413": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3410": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3411": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3418": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "3419": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46520": {"category_aro_name": "OXA-62-like beta-lactamase", "category_aro_cvterm_id": "46520", "category_aro_accession": "3007731", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62."}}}}}, "4868": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7243": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4869": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7244": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "2019": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "4862": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7237": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4863": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7238": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4860": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7235": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "2016": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4866": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7241": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4867": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7242": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4864": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7239": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4865": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7240": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4377": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6752": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4484": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6859": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4485": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6860": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4486": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6861": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4487": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6862": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4480": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6855": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4481": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6856": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4482": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6857": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4483": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6858": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4488": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6863": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4489": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6864": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2909": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "89": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3278": {"$update": {"dna_sequence": {"$update": {"fmin": "9051"}}}}}}}}}}, "4793": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7168": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5319": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7694": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5318": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7693": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5313": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7688": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5312": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7687": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5311": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7686": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5310": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7685": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5317": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7692": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5316": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7691": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5315": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7690": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5314": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7689": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1659": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "413": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. 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Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4679": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7054": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4678": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7053": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4677": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7052": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4676": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7051": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4675": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7050": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4674": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7049": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4905": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7280": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4672": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7047": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4671": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7046": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4670": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7045": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5148": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7523": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5149": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7524": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5146": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7521": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5147": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7522": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5144": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7519": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46496": {"category_aro_name": "OXA-214-like beta-lactamase", "category_aro_cvterm_id": "46496", "category_aro_accession": "3007707", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214."}}}}}, "5145": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7520": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46513": {"category_aro_name": "OXA-50-like beta-lactamase", "category_aro_cvterm_id": "46513", "category_aro_accession": "3007724", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50."}}}}}, "5142": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7517": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5143": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7518": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5140": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7515": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "5141": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7516": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3405": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3407": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "3406": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "3409": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3408": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5341": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7716": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4875": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7250": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4874": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7249": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4877": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7252": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46515": {"category_aro_name": "OXA-548-like beta-lactamase", "category_aro_cvterm_id": "46515", "category_aro_accession": "3007726", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-548."}}}}}, "4876": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7251": {"$update": {"dna_sequence": {"$update": {"fmin": "18"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4871": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7246": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4870": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7245": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4873": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7248": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4872": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7247": {"$update": {"dna_sequence": {"$update": {"fmin": "23"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "4879": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7254": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46515": {"category_aro_name": "OXA-548-like beta-lactamase", "category_aro_cvterm_id": "46515", "category_aro_accession": "3007726", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-548."}}}}}, "4878": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7253": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46515": {"category_aro_name": "OXA-548-like beta-lactamase", "category_aro_cvterm_id": "46515", "category_aro_accession": "3007726", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-548."}}}}}, "2068": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3234": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "2069": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3235": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "5424": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7799": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "942": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5426": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7801": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5098": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7473": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5099": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7474": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5090": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7465": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5091": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7466": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "5092": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7467": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "5093": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7468": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46491": {"category_aro_name": "OXA-184-like beta-lactamase", "category_aro_cvterm_id": "46491", "category_aro_accession": "3007702", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184."}}}}}, "5094": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7469": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "5095": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7470": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46505": {"category_aro_name": "OXA-364-like beta-lactamase", "category_aro_cvterm_id": "46505", "category_aro_accession": "3007716", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364."}}}}}, "5096": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7471": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5097": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7472": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46505": {"category_aro_name": "OXA-364-like beta-lactamase", "category_aro_cvterm_id": "46505", "category_aro_accession": "3007716", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364."}}}}}, "4497": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6872": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4496": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6871": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4495": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6870": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4494": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6869": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4493": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6868": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4492": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6867": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4491": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6866": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4490": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6865": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4499": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6874": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4498": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6873": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5326": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7701": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5327": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7702": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5324": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7699": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5325": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7700": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5322": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7697": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5323": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7698": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5320": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7695": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5321": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7696": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5328": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7703": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5329": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7704": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1641": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4365": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6740": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4364": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6739": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "573": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "572": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46521": {"category_aro_name": "OXA-63-like beta-lactamase", "category_aro_cvterm_id": "46521", "category_aro_accession": "3007732", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63."}}}}}, "5432": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7807": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5433": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7808": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5430": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7805": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5431": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7806": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5436": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7811": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5437": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7812": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5434": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7809": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5435": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7810": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5438": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7813": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5439": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7814": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "732": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4273": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6648": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4272": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6647": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1359": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4270": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6645": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4277": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6652": {"$update": {"dna_sequence": {"$update": {"fmin": "85"}}}}}}}}}}, "4276": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6651": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4275": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6650": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4274": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6649": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1352": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "4279": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6654": {"$update": {"dna_sequence": {"$update": {"fmin": "86"}}}}}}}}}}, "4278": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6653": {"$update": {"dna_sequence": {"$update": {"fmin": "99"}}}}}}}}}}, "461": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "608": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "5555": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7930": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5554": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7929": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5557": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7932": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5556": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7931": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5551": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7926": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5550": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7925": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5553": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7928": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5552": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7927": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5559": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7934": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5558": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7933": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4861": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7236": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1517": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "1511": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "959": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "958": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "4373": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6748": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5646": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8021": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4227": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6602": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4904": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7279": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46519": {"category_aro_name": "OXA-61-like beta-lactamase", "category_aro_cvterm_id": "46519", "category_aro_accession": "3007730", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61."}}}}}, "4707": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7082": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4706": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7081": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4705": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7080": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4704": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7079": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4703": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7078": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4702": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7077": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4701": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7076": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4700": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7075": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4709": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7084": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4708": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7083": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "289": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "267": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46507": {"category_aro_name": "OXA-42-like beta-lactamase", "category_aro_cvterm_id": "46507", "category_aro_accession": "3007718", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42."}}}}}, "6011": {"$update": {"ARO_description": "MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem resistant Klebsiella pneumoniae.", "CARD_short_name": "MdtQ", "model_name": "MdtQ", "ARO_name": "MdtQ"}}, "6010": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "4648": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7023": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4649": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7024": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4642": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7017": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4643": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7018": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4640": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7015": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4641": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7016": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4646": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7021": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4647": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7022": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4644": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7019": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4645": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7020": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4424": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6799": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5159": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7534": {"$update": {"dna_sequence": {"$update": {"fmin": "28"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5158": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7533": {"$update": {"dna_sequence": {"$update": {"fmin": "31"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5151": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7526": {"$update": {"dna_sequence": {"$update": {"fmin": "13"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5150": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7525": {"$update": {"dna_sequence": {"$update": {"fmin": "28"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5153": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7528": {"$update": {"dna_sequence": {"$update": {"fmin": "18"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "981": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5155": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7530": {"$update": {"dna_sequence": {"$update": {"fmin": "30"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5154": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7529": {"$update": {"dna_sequence": {"$update": {"fmin": "27"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5157": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7532": {"$update": {"dna_sequence": {"$update": {"fmin": "12"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4425": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6800": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4800": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7175": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4801": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7176": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4802": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7177": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4803": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7178": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4804": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7179": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4805": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7180": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4806": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7181": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4807": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7182": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4808": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7183": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "4809": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7184": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46487": {"category_aro_name": "OXA-114-like beta-lactamase", "category_aro_cvterm_id": "46487", "category_aro_accession": "3007698", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114."}}}}}, "2078": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3269": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "2073": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3230": {"$update": {"dna_sequence": {"$update": {"fmin": "4166658"}}}}}}}}}}, "2070": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3261": {"$update": {"dna_sequence": {"$update": {"fmin": "1471845"}}}}}}}}}}, "2074": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3227": {"$update": {"dna_sequence": {"$update": {"fmin": "3570462"}}}}}}}}}}, "3508": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "3509": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "5089": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7464": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5088": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7463": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}, "ARO_category": {"$delete": ["35939", "35930", "35951", "37084"]}}}, "3500": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3501": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46508": {"category_aro_name": "OXA-427-like beta-lactamase", "category_aro_cvterm_id": "46508", "category_aro_accession": "3007719", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-427."}}}}}, "3502": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3503": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3504": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5086": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7461": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "3506": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "3507": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46500": {"category_aro_name": "OXA-24-like beta-lactamase", "category_aro_cvterm_id": "46500", "category_aro_accession": "3007711", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24."}}}}}, "5331": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7706": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5330": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7705": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5333": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7708": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5332": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7707": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5335": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7710": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5334": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7709": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5337": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7712": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5336": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7711": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5339": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7714": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5338": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7713": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1986": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46494": {"category_aro_name": "OXA-211-like beta-lactamase", "category_aro_cvterm_id": "46494", "category_aro_accession": "3007705", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211."}}}}}, "1980": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46510": {"category_aro_name": "OXA-48-like beta-lactamase", "category_aro_cvterm_id": "46510", "category_aro_accession": "3007721", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins."}}}}}, "1981": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3277": {"$update": {"dna_sequence": {"$update": {"fmin": "6978"}}}}}}}}}}, "_timestamp": "2024-02-13T14:14:32+00:00", "569": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "560": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "566": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46493": {"category_aro_name": "OXA-2-like beta-lactamase", "category_aro_cvterm_id": "46493", "category_aro_accession": "3007704", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2."}}}}}, "5639": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8014": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5429": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7804": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5428": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7803": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1186": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1187": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1184": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46490": {"category_aro_name": "OXA-143-like beta-lactamase", "category_aro_cvterm_id": "46490", "category_aro_accession": "3007701", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143."}}}}}, "1185": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "5421": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7796": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5420": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7795": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5423": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7798": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5422": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7797": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5634": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8009": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "722": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"3275": {"$update": {"dna_sequence": {"$update": {"fmin": "3975"}}}}}}}}}}, "721": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "1741": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1743": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "4393": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6768": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4248": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6623": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4249": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6624": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4246": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6621": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4247": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6622": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4244": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6619": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4245": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6620": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4242": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6617": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1169": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46489": {"category_aro_name": "OXA-134-like beta-lactamase", "category_aro_cvterm_id": "46489", "category_aro_accession": "3007700", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134."}}}}}, "4240": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6615": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4241": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6616": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5520": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7895": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5521": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7896": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5522": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7897": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5523": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7898": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5524": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7899": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5525": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7900": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5526": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7901": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5527": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7902": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5528": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7903": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5529": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7904": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "5633": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8008": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "48": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "47": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46518": {"category_aro_name": "OXA-60-like beta-lactamase", "category_aro_cvterm_id": "46518", "category_aro_accession": "3007729", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60."}}}}}, "1568": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46486": {"category_aro_name": "OXA-10-like beta-lactamase", "category_aro_cvterm_id": "46486", "category_aro_accession": "3007697", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10."}}}}}, "5020": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"7395": {"$update": {"dna_sequence": {"$update": {"fmin": "19"}}}}}}}}, "ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "1293": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "475": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}, "795": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46495": {"category_aro_name": "OXA-213-like beta-lactamase", "category_aro_cvterm_id": "46495", "category_aro_accession": "3007706", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect."}}}}}, "1717": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46498": {"category_aro_name": "OXA-229-like beta-lactamase", "category_aro_cvterm_id": "46498", "category_aro_accession": "3007709", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229."}}}}}, "1716": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4398": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6773": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4399": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6774": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5638": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8013": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "1715": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46499": {"category_aro_name": "OXA-23-like beta-lactamase", "category_aro_cvterm_id": "46499", "category_aro_accession": "3007710", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii."}}}}}, "4441": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6816": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4390": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6765": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4391": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6766": {"$update": {"dna_sequence": {"$update": {"fmin": "0"}}}}}}}}}}, "4392": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6767": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "5637": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"8012": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4394": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6769": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4395": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6770": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4396": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6771": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "4397": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6772": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "964": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "35951", "37084"], "$insert": {"46512": {"category_aro_name": "OXA-5-like beta-lactamase", "category_aro_cvterm_id": "46512", "category_aro_accession": "3007723", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-5."}}}}}, "470": {"$update": {"ARO_category": {"$delete": ["35939", "35930", "37084"], "$insert": {"46485": {"category_aro_name": "OXA-1-like beta-lactamase", "category_aro_cvterm_id": "46485", "category_aro_accession": "3007696", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1."}}}}}, "4443": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"6818": {"$update": {"dna_sequence": {"$update": {"fmin": "100"}}}}}}}}}}, "1361": {"$update": {"ARO_category": {"$delete": ["35930", "35951", "37084"], "$insert": {"46514": {"category_aro_name": "OXA-51-like beta-lactamase", "category_aro_cvterm_id": "46514", "category_aro_accession": "3007725", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance."}}}}}}, "$delete": ["5966"], "$insert": {"6013": {"model_id": "6013", "ARO_accession": "3007694", "model_param": {"blastp_bit_score": {"param_value": "775", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}}, "ARO_description": "Achromobacter mucicolens Y3, isolated from a goose on a farm in Wenzhou, showed resistance to multiple antibiotics, including penicillins and cephalosporins. AMZ-1 showed resistance to amoxicillin, penicillin G, ampicillin, cephalothin and cefoxitin, and the resistance activity could be inhibited by beta-lactamase inhibitors.", "model_sequences": {"sequence": {"8742": {"dna_sequence": {"partial": "0", "sequence": "ATGCATCCCCGTAGACACTTTTGCGCCGGCCTCCTTGCCGTTGGGCTTTTTGCCGCCGTGTCAGCGCCCGCCGCGGGACGCTCCGAGCTGCCCTACATCGACAGCGTCGTGAACGAGGCGGCCCGCGCGGTTATCCGCCAGCACGACATCGCGGGCATGGTGATAGCCGTGACGCACCAAGGCCGCCAGCGTTTCTACACCTATGGCGTCGAATCATTGCAGACGCGGCGCGCCGTCAATCGGGACACGATCTTTGAAGTGGGCTCGATCAGCAAGACCTTCACCGTGACGCTTGCCGCGTATGCGCAGGCGAAGGGCTTGTTGCAGTTGACCGACAGTCCGGCGCGTTTTTTGCCCGAGCTGGCCGGCACTGAATTCGCCAAACTGTCCTTGCTGAACCTGGCGACGCACACGACGGGCGGTTTTCCGTTGCAGGTGCCTGACGAGGTGCGCGACAACGCGCAATTGATGCAATACCTGAAGGCCTGGAAGCCGGAGCATGCGCCCGGCACGTATCGCTCGTATGCCAATCCCAGCATTGGCATGCTGGGCGTCGTGGCGGCTGTCAGCTTGAAGCAGCCGTTTGCCCAGGCGATGGAAAAGGACCTTTTTCCGAAGCTGGGGCTGTCCAGCACGTTCATCGACGTGCCCGCCGCCAAGGCGTCGCGCTACGCGCAGGGCTACAACAAGCAGGGCGCGCCGGTGCGCGTGAATCCAGGCGTGCTGGCAGCCGAGGCCTATGGCGTGAAAACCAGCGCGCGCGACCTGCTGCGCTTCGTCGAGGCCAGCATGGACATGGACGTGCTGGACAAGGACATCCGCCGCGCCATTGCGGACACCCACGTGGGCTATTACCAGGTGGGCGCAATGACGCAGGACATGGTGTGGGAGCAGTTCCCGTATCCCGTGCCGCTGGATTCGCTGCTGACGGCCAACGCCGGCACGCTGAACAGCCAGAGCCATCCGGCCCAGGCGCTGCAGCCGCCGCTGGCGCCGCAGGCCCAGACCTGGATCAACAAGACGGGGTCCACCAACGGCTTCGGGGCCTACGTGGCGTTTGTGCCCGCGCGCAAGCTCGGCATCGTCATTCTGGCCAACCGCAATTACCCGAACGACGCGCGCGTGCGTCTGGCGGCGGAAATTCTGGGGGCGGTGGAGAAGCAGCCTATGGCGCCCGCCGGCGCGCGTTGA", "fmax": "1191", "accession": "OQ948417.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Achromobacter mucicolens", "NCBI_taxonomy_id": "1389922", "NCBI_taxonomy_cvterm_id": "46482"}, "protein_sequence": {"accession": "WHL54874.1", "sequence": "MHPRRHFCAGLLAVGLFAAVSAPAAGRSELPYIDSVVNEAARAVIRQHDIAGMVIAVTHQGRQRFYTYGVESLQTRRAVNRDTIFEVGSISKTFTVTLAAYAQAKGLLQLTDSPARFLPELAGTEFAKLSLLNLATHTTGGFPLQVPDEVRDNAQLMQYLKAWKPEHAPGTYRSYANPSIGMLGVVAAVSLKQPFAQAMEKDLFPKLGLSSTFIDVPAAKASRYAQGYNKQGAPVRVNPGVLAAEAYGVKTSARDLLRFVEASMDMDVLDKDIRRAIADTHVGYYQVGAMTQDMVWEQFPYPVPLDSLLTANAGTLNSQSHPAQALQPPLAPQAQTWINKTGSTNGFGAYVAFVPARKLGIVILANRNYPNDARVRLAAEILGAVEKQPMAPAGAR"}}}}, "model_name": "AMZ-1", "ARO_category": {"36017": {"category_aro_name": "penam", "category_aro_cvterm_id": "36017", "category_aro_accession": "3000008", "category_aro_class_name": "Drug Class", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms."}, "36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "46480": {"category_aro_name": "AMZ beta-lactamase", "category_aro_cvterm_id": "46480", "category_aro_accession": "3007693", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "The AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam."}, "36976": {"category_aro_name": "benzylpenicillin", "category_aro_cvterm_id": "36976", "category_aro_accession": "3000632", "category_aro_class_name": "Antibiotic", "category_aro_description": "Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid."}, "35951": {"category_aro_name": "cephalosporin", "category_aro_cvterm_id": "35951", "category_aro_accession": "0000032", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms."}, "37084": {"category_aro_name": "cefalotin", "category_aro_cvterm_id": "37084", "category_aro_accession": "3000704", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}, "36981": {"category_aro_name": "ampicillin", "category_aro_cvterm_id": "36981", "category_aro_accession": "3000637", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin."}, "35981": {"category_aro_name": "amoxicillin", "category_aro_cvterm_id": "35981", "category_aro_accession": "0000064", "category_aro_class_name": "Antibiotic", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan."}, "35927": {"category_aro_name": "cefoxitin", "category_aro_cvterm_id": "35927", "category_aro_accession": "0000008", "category_aro_class_name": "Antibiotic", "category_aro_description": "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases."}}, "ARO_name": "AMZ-1", "model_type": "protein homolog model", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "CARD_short_name": "AMZ-1", "ARO_id": "46481", "model_type_id": "40292"}, "6012": {"model_id": "6012", "ARO_accession": "3007692", "model_param": {"40494": {"param_value": {"13154": "R271fs", "13153": "A14fs"}, "param_type_id": "40494", "param_type": "frameshift mutation", "param_description": "A frameshift mutation, caused by a nucleotide insertion or deletion that does not equal 3 bases, encoded as [wild-type][position]fs, for example S531fs. Termination can also be denoted as: Ter[position]fs."}, "blastp_bit_score": {"param_value": "700", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}, "snp": {"param_type": "single resistance variant", "param_value": {"13152": "L44P"}, "clinical": {"13152": "L44P"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with with format [wild-type][position][mutation], e.g. R184Q."}}, "ARO_description": "These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine.", "model_sequences": {"sequence": {"8741": {"dna_sequence": {"partial": "0", "sequence": "GTGACACATTCCCAGCGTCGAGACAAGCTGAAAGCACAAATCGCTGCCTCCGGGTTGGATGCGATGCTGATCAGCGACCTGATAAACGTGCGATATCTATCAGGCTTCAGCGGGTCCAACGGCGCATTGCTGGTGTTCGCCGATGAGCGCGATGCCGTGTTGGCCACCGACGGCCGGTACCGCACTCAGGCCGCCTCGCAAGCGCCCGACCTCGAAGTGGCTATCGAGCGCGCGGTCGGGCGCTACCTGGCCGGCCGGGCCGGCGAGGCCGGCGTGGGAAAGCTGGGCTTCGAGAGCCACGTGGTCACGGTGGACGGCCTGGACGCCTTGGCGGGCGCGCTGGAGGGCAAGAACACCGAGTTGGTGCGGGCATCCGGAACTGTGGAGTCACTGCGCGAGGTTAAAGACGCCGGCGAGCTGGCGCTGCTGCGACTAGCCTGCGAAGCAGCCGATGCCGCGCTGACCGACTTGGTGGCCCGCGGCGGCCTGCGGCCGGGCCGAACCGAACGGCAGGTGAGCCGCGAGCTGGAGGCCCTGATGCTCGATCATGGCGCTGACGCGGTGTCATTCGAGACGATCGTGGCTGCCGGGGCCAATTCGGCGATCCCGCACCACCGGCCGACCGACGCGGTGCTGCAGGTCGGCGATTTCGTGAAGATCGACTTCGGCGCCCTGGTCGCCGGGTACCACTCCGATATGACCCGCACCTTCGTGTTGGGCAAGGCCGCCGACTGGCAGCTAGAGATCTATCAGCTGGTGGCCGAGGCGCAACAGGCCGGTCGGCAGGCGTTGCTGCCGGGTGCCGAGCTGCGGGGGGTGGACGCTGCAGCGCGCCAGCTGATCGCCGACGCCGGCTACGGCGAGCACTTCGGTCACGGACTGGGACACGGTGTTGGCCTGCAGATACATGAAGCGCCGGGCATCGGGGTCACATCCGCCGGTACACTACTGGCGGGCTCCGTGGTGACCGTGGAGCCCGGTGTCTATTTACCCGGCCGCGGCGGTGTCCGCATCGAGGACACATTGGTAGTGGCTGGCGGGACGCCGAAAATGCCTGAAACCGCCGGGCAGACCCCGGAATTGTTGACCCGGTTCCCCAAAGAACTGGCCATTCTGTAG", "fmax": "2860418", "accession": "NC_000962.3", "fmin": "2859299", "strand": "-"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332", "NCBI_taxonomy_cvterm_id": "39507"}, "protein_sequence": {"accession": "NP_217051.1", "sequence": "MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADERDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLGFESHVVTVDGLDALAGALEGKNTELVRASGTVESLREVKDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALMLDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDMTRTFVLGKAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVVAGGTPKMPETAGQTPELLTRFPKELAIL"}}}}, "model_name": "Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline", "ARO_category": {"46478": {"category_aro_name": "bedaquiline resistant Rv2535c", "category_aro_cvterm_id": "46478", "category_aro_accession": "3007691", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Loss-of-function mutations in Rv2535c are a common mechanism of resistance."}, "41932": {"category_aro_name": "diarylquinoline antibiotic", "category_aro_cvterm_id": "41932", "category_aro_accession": "3004491", "category_aro_class_name": "Drug Class", "category_aro_description": "A class of antibiotics used to treat specifically Mycobacterium tuberculosis infection; therefore, referred to as an antimycobacterial. Diarylquinoline antibiotics inhibit ATP synthesis in tuberculosis cells by disruption of mycobacterial ATP synthase."}, "41933": {"category_aro_name": "bedaquiline", "category_aro_cvterm_id": "41933", "category_aro_accession": "3004492", "category_aro_class_name": "Antibiotic", "category_aro_description": "A diarylquinoline antibiotic drug sold under the brand name Sirturo, used to treat infection from Mycobacterium spp., particularly multidrug-resistant tuberculosis. Bedaquiline disrupts ATP synthase by proton pump blockage, inhibiting ATP synthesis."}, "40939": {"category_aro_name": "clofazimine", "category_aro_cvterm_id": "40939", "category_aro_accession": "3004012", "category_aro_class_name": "Antibiotic", "category_aro_description": "Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death."}, "35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}}, "ARO_name": "Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline", "model_type": "protein variant model", "model_description": "Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.", "CARD_short_name": "Mtub_Rv2535_BDQ", "ARO_id": "46479", "model_type_id": "40293"}, "6015": {"model_id": "6015", "ARO_accession": "3007749", "model_param": {"blastp_bit_score": {"param_value": "500", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}, "snp": {"param_type": "single resistance variant", "param_value": {"13158": "R171P"}, "clinical": {"13158": "R171P"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with with format [wild-type][position][mutation], e.g. R184Q."}}, "ARO_description": "Point mutations in Salmonella gallinarum dihydropteroate synthase folP altered the stability of the protein, thus conferring sulfonamide resistance.", "model_sequences": {"sequence": {"8745": {"dna_sequence": {"partial": "0", "sequence": "ATGAAACTCTTCGCTCAGGGCGCCACGCTCGATCTCACTCATCCGCATGTTATGGGTATCCTGAACGTAACGCCGGATTCGTTCTCCGACGGCGGCGCGCATAACACGCTGATTGAGGCGGTGAAACATGCGAATTTAATGGTGAATGCCGGTGCGACAATTATTGATGTGGGGGGGGAATCAACGCGACCAGGCGCGGCGGAAGTGAGCGTGGAAGAAGAGCTGGATCGCGTTATTCCGGTACTGGAAGCAATCGCGCAACGTTTTGAAGTGTGGATTTCTGTGGATACCTCTAAGCCCGAGGTGATCCGTGAAGCGACAAGGGCGGGCGCGCATATTATCAATGATGTCCGTTCGCTCTCCGAGCCCGGCGCGTTGGAAGCGGCAGCGGAAACCGGCTTGCCGGTCAGTCTTATGCACATGCAGGGCAACCCCAAAACCATGCAGGAGGCGCCGAAATATGACGATGTCTTTGCCGAGGTGAATCGCTACTTTATTGAGCAAATAGCACGTTGTGAGAAGGCCGGCATCGCAAAAGAGAAATTGTTGCTCGACCCCGGATTCGGTTTCGGTAAAAATCTCTCTCACAATTATACCTTACTGGCGCGACTGGGTGAGTTTCATCATTTTAACCTGCCGCTGCTGGTGGGCATGTCACGTAAAACGATGGTTGGTCAGTTACTTAACGTGGGACCATCAGACCGTCTGAACGGCAGCCTTGCGTGCGCGGTAATTGCCGCGATGCAGGGCGCGCAGATCATTCGCGTCCATGACGTCAAAGAAACCGTAGAGGCGATGCGGGTGGTAGAAGCCACTCTGTCTGCAAAGGGAAACAAACGCTATGAGTAA", "fmax": "614247", "accession": "CP100648.1", "fmin": "613398", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Gallinarum", "NCBI_taxonomy_id": "594", "NCBI_taxonomy_cvterm_id": "35654"}, "protein_sequence": {"accession": "WMC40549.1", "sequence": "MKLFAQGATLDLTHPHVMGILNVTPDSFSDGGAHNTLIEAVKHANLMVNAGATIIDVGGESTRPGAAEVSVEEELDRVIPVLEAIAQRFEVWISVDTSKPEVIREATRAGAHIINDVRSLSEPGALEAAAETGLPVSLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEKAGIAKEKLLLDPGFGFGKNLSHNYTLLARLGEFHHFNLPLLVGMSRKTMVGQLLNVGPSDRLNGSLACAVIAAMQGAQIIRVHDVKETVEAMRVVEATLSAKGNKRYE"}}}}, "model_name": "Salmonella gallinarum folP with mutation conferring resistance to sulfonamides", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "39999": {"category_aro_name": "sulfonamide resistant dihydropteroate synthase folP", "category_aro_cvterm_id": "39999", "category_aro_accession": "3003415", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance."}, "36468": {"category_aro_name": "sulfamethoxazole", "category_aro_cvterm_id": "36468", "category_aro_accession": "3000329", "category_aro_class_name": "Antibiotic", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides."}, "36421": {"category_aro_name": "sulfonamide antibiotic", "category_aro_cvterm_id": "36421", "category_aro_accession": "3000282", "category_aro_class_name": "Drug Class", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway."}}, "ARO_name": "Salmonella gallinarum folP with mutation conferring resistance to sulfonamides", "model_type": "protein variant model", "model_description": "Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.", "CARD_short_name": "Sgal_folP_SLF", "ARO_id": "46529", "model_type_id": "40293"}, "6014": {"model_id": "6014", "ARO_accession": "3007695", "model_param": {"blastp_bit_score": {"param_value": "700", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}}, "ARO_description": "We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance.", "model_sequences": {"sequence": {"8743": {"dna_sequence": {"partial": "0", "sequence": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGAAGGCGGCCTACCGCTGAAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACAGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTTACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "fmax": "1146", "accession": "OQ297612.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562", "NCBI_taxonomy_cvterm_id": "35914"}, "protein_sequence": {"accession": "WCB91330.1", "sequence": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTEGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHSSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPYPVRVEAAWRILEKLQ"}}}}, "model_name": "CMY-185", "ARO_category": {"36000": {"category_aro_name": "antibiotic inactivation", "category_aro_cvterm_id": "36000", "category_aro_accession": "0001004", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance."}, "36208": {"category_aro_name": "CMY beta-lactamase", "category_aro_cvterm_id": "36208", "category_aro_accession": "3000069", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins."}, "35962": {"category_aro_name": "cephamycin", "category_aro_cvterm_id": "35962", "category_aro_accession": "0000044", "category_aro_class_name": "Drug Class", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases."}}, "ARO_name": "CMY-185", "model_type": "protein homolog model", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "CARD_short_name": "CMY-185", "ARO_id": "46483", "model_type_id": "40292"}, "6017": {"model_id": "6017", "ARO_accession": "3007752", "model_param": {"blastp_bit_score": {"param_value": "1300", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}, "snp": {"param_type": "single resistance variant", "param_value": {"13162": "S464F"}, "clinical": {"13162": "S464F"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with with format [wild-type][position][mutation], e.g. R184Q."}}, "ARO_description": "Point mutation in Salmonella isangi resulting in fluoroquinolone resistance.", "model_sequences": {"sequence": {"8747": {"dna_sequence": {"partial": "0", "sequence": "ATGTCGAATTCTTATGACTCCTCCAGTATCAAAGTCCTGAAAGGGCTGGATGCGGTGCGTAAGCGCCCGGGTATGTATATCGGCGACACGGATGACGGCACCGGTCTGCACCACATGGTATTCGAGGTGGTAGATAACGCTATCGACGAAGCGCTCGCAGGTCACTGTAAAGATATCGTCGTGACTATTCACGCCGATAACTCCGTGTCCGTAACGGATGATGGCCGTGGCATTCCGACCGGGATTCACCCGGAAGAAGGCGTCTCAGCGGCGGAAGTGATCATGACCGTTCTGCACGCGGGCGGTAAATTTGACGATAACTCCTATAAAGTCTCTGGTGGTCTGCACGGCGTGGGCGTCTCGGTAGTCAACGCTCTGTCGCAAAAACTGGAACTGGTTATCCAGCGAGATGGCAAAATTCACCGTCAGATCTACGAGCACGGCGTGCCGCAGGCACCCCTGGCCGTCACTGGCGATACCGATAAAACCGGCACGATGGTACGTTTCTGGCCGAGCCACGAAACCTTCACTAACGTCACTGAATTTGAATATGAGATCCTGGCGAAACGCCTGCGTGAACTGTCATTCCTGAACTCTGGCGTTTCCATCCGTCTGCGCGACAAGCGTGACGGCAAAGAAGATCATTTCCACTACGAAGGCGGCATCAAGGCGTTTGTTGAATATCTCAACAAAAACAAAACGCCGATCCACCCGAATATCTTCTACTTCTCCACCGAAAAAGACGGTATCGGCGTGGAAGTAGCGCTGCAGTGGAACGACGGTTTCCAGGAAAACATCTACTGCTTTACCAACAACATTCCGCAGCGCGACGGCGGTACCCACCTGGCAGGCTTCCGTGCGGCGATGACCCGTACGCTGAACGCCTATATGGACAAAGAAGGTTACAGCAAAAAAGCTAAAGTCAGCGCTACCGGCGATGATGCCCGTGAAGGTCTGATTGCGGTGGTTTCCGTAAAAGTACCGGACCCGAAATTCTCCTCACAGACCAAAGATAAGCTGGTCTCTTCCGAGGTGAAATCGGCGGTGGAACAGCAGATGAACGAACTGCTGAGCGAATACCTGCTGGAAAACCCATCTGACGCGAAAATTGTCGTCGGCAAAATTATCGACGCCGCGCGTGCGCGTGAAGCGGCGCGTCGCGCCCGTGAAATGACCCGTCGTAAAGGCGCGCTGGATTTAGCCGGTCTGCCGGGCAAACTGGCGGACTGTCAGGAACGCGACCCGGCGCTGTCCGAACTGTACCTGGTGGAAGGGGACTCCGCGGGCGGCTCTGCGAAGCAGGGGCGTAACCGCAAGAACCAGGCGATTCTGCCGCTGAAAGGTAAAATCCTTAACGTTGAGAAAGCGCGCTTCGACAAGATGCTTTCCTCCCAGGAAGTGGCGACGCTGATCACCGCGCTGGGCTGCGGTATCGGTCGCGACGAGTACAACCCGGACAAGCTGCGCTATCACAGCATCATCATCATGACCGATGCGGACGTCGACGGCTCGCACATCCGTACGCTGCTGTTGACCTTCTTCTATCGTCAGATGCCGGAAATCGTCGAGCGCGGCCACGTCTACATTGCCCAGCCGCCGCTGTACAAAGTCAAGAAAGGCAAGCAGGAACAGTACATCAAAGACGACGAAGCGATGGATCAGTACCAGATTTCCATCGCGCTTGACGGTGCGACTCTGCACGCGAACGCTCATGCGCCAGCGCTATCCGGCGAAGCGTTAGAAAAACTGGTCTCTGAATATAACGCCACGCAGAAAATGATTGGTCGTATGGAGCGTCGCTTCCCGAAAGCGCTGCTCAAAGAGCTGGTGTATCAGCCAACTCTGACCGAAGCCGATCTTTCTGATGAGCAGACTGTAACGCGCTGGGTGAATGCGCTGATTACCGAGCTGAACGAGAAAGAGCAGCACGGCAGTCAGTGGAAGTTCGATGTTCATACTAATACGGAACAGAATCTGTTCGAGCCTATCGTTCGCGTGCGTACGCATGGTGTGGATACCGATTATCCGTTGGATCACGAGTTTGTGACCGGCGCGGAATATCGTCGTATCTGCACGCTGGGCGAGAAGCTGCGCGGTCTGATTGAAGAGGACGCGTTTATCGAACGCGGCGAGCGTCGCCAGCCGGTAACCAGCTTCGAGCAGGCGCTGGAGTGGCTGGTGAAAGAATCACGTCGCGGTCTGGCTATCCAGCGTTATAAAGGTCTGGGTGAAATGAACCCGGATCAGCTGTGGGAAACCACCATGGACCCGGAAAGCCGCCGTATGCTGCGCGTGACCGTCAAAGATGCGATTGCTGCCGACCAGCTGTTCACTACGCTGATGGGTGATGCCGTTGAGCCGCGTCGTGCCTTTATCGAAGAGAACGCCCTGAAAGCGGCGAATATCGATATTTAA", "fmax": "60508", "accession": "NZ_JARETA010000016.1", "fmin": "58093", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Isangi", "NCBI_taxonomy_id": "1386015", "NCBI_taxonomy_cvterm_id": "46532"}, "protein_sequence": {"accession": "WP_000072047.1", "sequence": "MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKDIVVTIHADNSVSVTDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIYEHGVPQAPLAVTGDTDKTGTMVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHANAHAPALSGEALEKLVSEYNATQKMIGRMERRFPKALLKELVYQPTLTEADLSDEQTVTRWVNALITELNEKEQHGSQWKFDVHTNTEQNLFEPIVRVRTHGVDTDYPLDHEFVTGAEYRRICTLGEKLRGLIEEDAFIERGERRQPVTSFEQALEWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI"}}}}, "model_name": "Salmonella isangi gyrB conferring resistance to fluoroquinolones", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "37005": {"category_aro_name": "nalidixic acid", "category_aro_cvterm_id": "37005", "category_aro_accession": "3000661", "category_aro_class_name": "Antibiotic", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments."}, "35954": {"category_aro_name": "ciprofloxacin", "category_aro_cvterm_id": "35954", "category_aro_accession": "0000036", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "37244": {"category_aro_name": "fluoroquinolone resistant gyrB", "category_aro_cvterm_id": "37244", "category_aro_accession": "3000864", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones."}}, "ARO_name": "Salmonella isangi gyrB conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.", "CARD_short_name": "Sisa_gyrB_FLO", "ARO_id": "46533", "model_type_id": "40293"}, "6016": {"model_id": "6016", "ARO_accession": "3007751", "model_param": {"blastp_bit_score": {"param_value": "1300", "param_type_id": "40725", "param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}, "snp": {"param_type": "single resistance variant", "param_value": {"13160": "D87N", "13161": "S83F"}, "clinical": {"13160": "D87N", "13161": "S83F"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with with format [wild-type][position][mutation], e.g. R184Q."}}, "ARO_description": "Point mutations in Salmonella gyrA that confer resistance to ciprofloxacin and nalidixic acid which are fluoroquinolone antibiotics.", "model_sequences": {"sequence": {"8746": {"dna_sequence": {"partial": "0", "sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAGGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCACGGCGATTCCGCAGTGTATGACACCATCGTTCGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGGTAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATGCGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAACTGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGACGGTACGGAAAAAATTCCGGACGTCATGCCGACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACGAATATCCCGCCGCACAACCTGACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAACATATTCCGGGGCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGTACCGGTCGTGGCAAAGTGTACATTCGCGCCCGCGCGGAAGTTGAAGCTGACGCGAAAACGGGCCGTGAAACCATCATCGTCCATGAAATTCCCTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAATCCGACAAAGACGGGATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTCTACTCCCAGACCCAGCTACAGGTTTCCTTCGGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCTGAAAGACATCATTTCAGCGTTCGTGCGCCACCGCCGTGAAGTGGTGACGCGTCGGACTATTTTTGAACTGCGTAAAGCCCGTGACCGCGCGCATATCCTTGAAGCTCTGGCGATTGCGCTGGCTAACATCGACCCGATTATCGAACTGATTCGCCGCGCGCCAACGCCGGCAGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTTGCTGCGATGCTGGAGCGCGCTGGTGATGACGCTGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTATTACCTGACTGAGCAGCAGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAGTTGCTGGAGCAGATTGCTGAACTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGAGTTAATTCGCGATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCCAACAGCGCCGATATTAATATCGAAGATCTGATTAGCCAGGAAGATGTTGTCGTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACGGATTACGAAGCGCAACGTCGTGGTGGGAAAGGTAAATCTGCCGCGCGTATTAAAGAAGAAGACTTTATCGACCGTCTGCTGGTGGCCAACACCCATGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTACTGGATGAAGGTCTATCAGTTGCCGGAAGCCAGCCGTGGCGCGCGCGGTCGTCCGATCGTTAACCTGCTGCCGCTGGAAGCCAACGAACGTATCACCGCGATTCTGCCGGTTCGTGAATACGAAGAGGGCGTCAACGTATTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTGACCGAATTCAGCCGTCCGCGTTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGTTCTGACGAAGTCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGTGTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGCGCTATTCTGACCGTAACGCAAAACGGCTACGGGAAGCGTACCGCAGCGGACGAGTACCCGACCAAGTCTCGTGCGACGCAGGGCGTTATCTCTATCAAAGTGACCGAGCGCAACGGTTCCGTTGTCGGTGCGGTACAGGTAGACGATTGCGACCAGATCATGATGATCACGGATGCCGGTACTCTGGTGCGTACCCGAGTGTCTGAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCACGGCGGAAGACGAAAACGTGGTGGGTCTGCAACGCGTTGCTGAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCAGCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGACGACGTTGCGGATGACGCTGACGAGTAA", "fmax": "136825", "accession": "NZ_JARETA010000011.1", "fmin": "134188", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Isangi", "NCBI_taxonomy_id": "1386015", "NCBI_taxonomy_cvterm_id": "46532"}, "protein_sequence": {"accession": "WP_001281271.1", "sequence": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE"}}}}, "model_name": "Salmonella isangi gyrA conferring resistance to fluoroquinolones", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "37005": {"category_aro_name": "nalidixic acid", "category_aro_cvterm_id": "37005", "category_aro_accession": "3000661", "category_aro_class_name": "Antibiotic", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments."}, "35920": {"category_aro_name": "fluoroquinolone antibiotic", "category_aro_cvterm_id": "35920", "category_aro_accession": "0000001", "category_aro_class_name": "Drug Class", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death."}, "39876": {"category_aro_name": "fluoroquinolone resistant gyrA", "category_aro_cvterm_id": "39876", "category_aro_accession": "3003292", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit."}, "35954": {"category_aro_name": "ciprofloxacin", "category_aro_cvterm_id": "35954", "category_aro_accession": "0000036", "category_aro_class_name": "Antibiotic", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome."}}, "ARO_name": "Salmonella isangi gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_description": "Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.", "CARD_short_name": "Sisa_gyrA_FLO", "ARO_id": "46531", "model_type_id": "40293"}, "6019": {"model_id": "6019", "ARO_accession": "3007759", "model_param": {"blastn_bit_score": {"param_value": "4000", "param_type_id": "41093", "param_type": "BLASTN bit-score", "param_description": "The BLASTN bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a nucleotide reference sequence, e.g. the rRNA gene variant model. The BLASTN bit-score parameter is a curated value determined from BLASTN analysis of the canonical nucleotide reference sequence of a specific AMR-associated gene against the database of CARD reference sequences. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off)."}, "snp": {"param_type": "single resistance variant", "param_value": {"13171": "A2100G", "13172": "A2101G"}, "clinical": {"13171": "A2100G", "13172": "A2101G"}, "param_type_id": "36301", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with with format [wild-type][position][mutation], e.g. R184Q."}}, "ARO_description": "Point mutations in 23S rRNA of Treponema pallidum subsp. pallidum (T. pallidum), the noncultivable agent of syphilis, shown clinically to confer resistance to erythromycin, a macrolide antibiotic.", "model_sequences": {"sequence": {"8750": {"dna_sequence": {"partial": "0", "sequence": "GCGAATAGTGGTTTACGGTGGATGTCTTGGAGTTGTCAGGCGATGAAGGTCGTGATAAGCTGCGAAAAGCCTCGGGGAGGAGCACATGTCCTGTGATCCGGGGATGACCGAATGGGGTAACCCGACAGGGTAAAGCCTTGTCATTGCCTTCCTGAATGAATAGGGAGGGTAAGGCGAAACTGGGTGAACTGAACCATCTAAGTAACTTGGGAAAAGAAATCAAGAGAGATTCCGAAAGTAGTGGCGAGCGAAATTGGAGGAGCCTAAACCTGTGTCTAACAGGGGTTGTAGGGCCGCGCGGGCTTGCGTTCGGTGGGTGAAATAATCCGGCCTATAGCAGAAAGGTTTTGGGAAAGCCTGACAGAGAGGGTGAAATCCCCGTATGCGGAATGGGGCGGACCTGCTGGTGCGGTACCTGAGTACGGCGGGACACGAGGAATCCTGTCGGAATCTGGGTCGACCACGATCTAAGGCTAAATACTCGACAACTACCGATAGTGGACAAGTACCGTGAGGGAAAGATGAAAAGAACCCCGGTGAGGGGAGTGAAATAGAACCTGAAACCGTAAACCAACAAGATGTTACAGCCTGTGAGGGTGGTAGCGTGCCTTTTGTAGAATGAGCCTGCGAGTTACGGTGTGCAGCAAGGTTAAGGGATAGGAGTCCTGGAGCCGGAGGGAAACCGAGTCTTAAAAGGGCGTGGTGAGTTGTACGTCGTAGACCCGAAGCCAGGGTGATCTAGTTATGAGCAGGTTGAAACAGGGGTGAAGCCTTGTGGAGGACCGAACTATAATCTGTTAAAAAAGGTATGGATGACTTGTGACTAGGAGTGAAAGGCTAAACAAACCTGGAGATAGCTGGTTCTCCCCGAAATGCCTTTAGGGACAGCCTTATACAAAACTGTCGGAGGTAAAGCACTGGATGGGCTAGGGGGTTTCATCGCCTACCAAACCCAATCAAACTCTGAATGCCGGCAGTCAACGTGTGGGAGTGAGACTGCGTGCGACAAGGTTCGTAGTCGAGAGGGAAACAGCCCAGACCGTCAGCTAAGGTCCCGAAATACCGCTTGAGTGTGAAATGAAGTGTGGGTACCTGGACAGCCAGGAGGTTGGCTTAGAAGCAGCCATTCCTTGAAAGAGTGCGTAATAGCTCACTGGTCGAGTACGCATGCGCAGATAATGTATCGGGGCTAAGCGGTATACCGAAGCTACGGGTCTTGCATTTTTGGTGCAAGGCGGTAGGGGAGCATTCCATGTACTGATGAAGGAATATCCGGGAGGAGTTCTGGAGGGGATGGAAGAGAGAATGCAGGTATAAGTACACGAAAAGGAGGGTGAGATTCCTTCCCGCCGAAAACCTAAGGTTTCCTGGGTGAAGGTCATCTGCTCAGGGTAAGTCGGCCCCTAAGGCGAGGACGAGGGTCGTAGTCGATGGGAATCCGGTTTATATTCCGGAACCTCTTGCAATTTCGATGGCAGGACGCGTGAGGTGAAGCCCGGCCAAAGATTGGTAGTTTTGGTCTAAGTATCCGAGCCGTTTTAAGAGCGATAGGCAAATCCGTCGTTCGAGGTAAGGTGCGAGTGCGACTGGAGCGATGAGCGAAGGGAAGCAGGTGTAGTCATGGCGACGGGAAATACTGTCTAAGGTTAGGTTGCAAGAGACCGTACCGCAAACCGACACAGGTAGGTAGGATGAGTAATCTAAGGCGCTCGAGAGAACTCGCGTCAAGGAACTCGGCAAAATACACACGTAACCTCGGGAGAAGTGTGACCCTTGCCTTTGGTGAGGGTGGCAGAAAGCAGGTCCAGGCGACTGTTTATCAAAAACATAGCCATCTGCAAATCAGTAATGAGACGTATAGGTGGTGACACCTGCCCGGTGCTGGAAGGTTAAGAGGAGAGGTTCGTGGTAACACAACGCTTTGAATTGAAGCCCCAGTAAACGGCGGCCGTAACTATAACGGTCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCCGCACGAATGGTGTAACGACTCTGGACACTGTCTCGACGCGAGACTCGGTGAAATTTATGTACCGGTAAAGAAGCCGGTTACCCATAGTTAGACGGAAAGACCCCGTGAACCTTCACCGTAGCTTACTATTGGAACTTGGTTTACCATGTGTAGTATAGGTGGGAGACAGAGAAGCTTGGCCGTCAGGTTAGGCGGAGTCAACAGTGAAATACCACCCTTGGTACGTCAGGTTTCTAACCTTTGGCCGTGGATCCGGCAAAGGGACCGTGGTAGGTGGGCGGTTTGACTGGGGCGGTCGCCTCCTAAAAGGTAACGGAGGTGCGCGAAGGTCTCCTCACACCGGTTGGAAATCGGTGCGCGAGTGTAAAGGCACAAGGAGGCTTAACTGCGAGACCGACAGGTCGAGCAGATACGAAAGTAGGTCTTAGTGATCTGGCGGTAGCGTGTGGAAGCGCCGTCACTTAACGGATAAAAGGTACTCCGGGGATAACAGGCTGATTTTCCCCAAGAGTTCACATCGACGGGAAAGTTTGGCACCTCGATGTCGGCTCATCGCATCCTGGGGCTGAAGCAGGTCCCAAGGGTTTGGCTGTTCGCCAATTAAAGCGGTACGTGAGCTGGGTTCAGAACGTCGCGAGACAGTTCGGTCCCTATCTGCTATGGGCGTTGGATATGTGAGAGGAGCTGCTTTTAGTACGAGAGGACCGAAGTGGACGAACCTCTGGTGTACCAGTTATCCTGCCAAGGGTACGTGCTGGGTAGCTATGTTCGGAAGGGATAACCGCTGAAGGCATCTAAGTGGGAAGCCCGCCTCAAGATTACATATCCCTGAAGGTTGACCTTCCTGAAGACTCCTTGCACACTACAAGGTCGATAGGCTGGAGGTCTACGTACCGTAAGGTATTAAGCCGACCAGTACTAATAAGTCGTGAGGCTTGACCAT", "fmax": "2947", "accession": "NR_076156.1", "fmin": "0", "strand": "+"}, "NCBI_taxonomy": {"NCBI_taxonomy_name": "Treponema pallidum subsp. pallidum", "NCBI_taxonomy_id": "161", "NCBI_taxonomy_cvterm_id": "46542"}, "protein_sequence": {"accession": "", "sequence": ""}}}}, "model_name": "Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin", "ARO_category": {"35997": {"category_aro_name": "antibiotic target alteration", "category_aro_cvterm_id": "35997", "category_aro_accession": "0001001", "category_aro_class_name": "Resistance Mechanism", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance."}, "41251": {"category_aro_name": "23S rRNA with mutation conferring resistance to macrolide antibiotics", "category_aro_cvterm_id": "41251", "category_aro_accession": "3004125", "category_aro_class_name": "AMR Gene Family", "category_aro_description": "Nucleotide point mutations in the 23S rRNA subunit may confer resistance to macrolide antibiotics."}, "35919": {"category_aro_name": "macrolide antibiotic", "category_aro_cvterm_id": "35919", "category_aro_accession": "0000000", "category_aro_class_name": "Drug Class", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins."}, "35925": {"category_aro_name": "erythromycin", "category_aro_cvterm_id": "35925", "category_aro_accession": "0000006", "category_aro_class_name": "Antibiotic", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited."}}, "ARO_name": "Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin", "model_type": "rRNA gene variant model", "model_description": "Ribosomal RNA (rRNA) Gene Variant Models (RVM) are similar to Protein Variant Models (PVM), i.e. detect  sequences based on their similarity to a curated reference sequence and secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles, except RVMs are designed to detect AMR acquired via mutation of genes encoding ribosomal RNAs (rRNA). RVMs include a rRNA reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTN bit-score above the curated BLASTN cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTN bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.", "CARD_short_name": "Tpal_23S_ERY", "ARO_id": "46541", "model_type_id": "40295"}}}