{"$insert": {"6038": {"model_id": "6038", "model_name": "VIM-77", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8858": {"protein_sequence": {"accession": "WP_231869637.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGDEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "NG_078035.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGGACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "46601", "NCBI_taxonomy_name": "Pseudomonas shirazica", "NCBI_taxonomy_id": "1940636"}}}}, "ARO_accession": "3007814", "ARO_id": "46600", "ARO_name": "VIM-77", "CARD_short_name": "VIM-77", "ARO_description": "VIM-77 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6040": {"model_id": "6040", "model_name": "VIM-79", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8860": {"protein_sequence": {"accession": "UBL87558.1", "sequence": "MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLFGGCAVHELSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE"}, "dna_sequence": {"accession": "OK217280.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGAGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATTCGGTGGTTGTGCCGTTCATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36788", "NCBI_taxonomy_name": "Klebsiella oxytoca", "NCBI_taxonomy_id": "571"}}}}, "ARO_accession": "3007816", "ARO_id": "46603", "ARO_name": "VIM-79", "CARD_short_name": "VIM-79", "ARO_description": "VIM-79 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6042": {"model_id": "6042", "model_name": "VIM-81", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8862": {"protein_sequence": {"accession": "UNZ81762.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEHPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "ON059758.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGCATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007818", "ARO_id": "46605", "ARO_name": "VIM-81", "CARD_short_name": "VIM-81", "ARO_description": "VIM-81 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6037": {"model_id": "6037", "model_name": "VIM-76", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8857": {"protein_sequence": {"accession": "BDA82255.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAELEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSLTSAGNVADADLAEWPTSIERIQQRYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "LC648428.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGCTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACTCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACGCTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007813", "ARO_id": "46599", "ARO_name": "VIM-76", "CARD_short_name": "VIM-76", "ARO_description": "VIM-76 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6039": {"model_id": "6039", "model_name": "VIM-78", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8859": {"protein_sequence": {"accession": "UBK22127.1", "sequence": "MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE"}, "dna_sequence": {"accession": "OK180983.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCGGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGAGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36771", "NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584"}}}}, "ARO_accession": "3007815", "ARO_id": "46602", "ARO_name": "VIM-78", "CARD_short_name": "VIM-78", "ARO_description": "VIM-78 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6041": {"model_id": "6041", "model_name": "VIM-80", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8861": {"protein_sequence": {"accession": "MBC9045152.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEITHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "JACTAE010000183.1", "fmin": "98", "fmax": "896", "strand": "-", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007817", "ARO_id": "46604", "ARO_name": "VIM-80", "CARD_short_name": "VIM-80", "ARO_description": "VIM-80 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6043": {"model_id": "6043", "model_name": "VIM-82", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8863": {"protein_sequence": {"accession": "WP_238839790.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGTVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "NG_088450.1", "fmin": "100", "fmax": "901", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCGGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGACCGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007819", "ARO_id": "46606", "ARO_name": "VIM-82", "CARD_short_name": "VIM-82", "ARO_description": "VIM-82 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6044": {"model_id": "6044", "model_name": "VIM-83", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8864": {"protein_sequence": {"accession": "UWI53403.1", "sequence": "MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAKGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE"}, "dna_sequence": {"accession": "OP353772.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAAAGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCATGAGTTGTCAAGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36884", "NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550"}}}}, "ARO_accession": "3007820", "ARO_id": "46607", "ARO_name": "VIM-83", "CARD_short_name": "VIM-83", "ARO_description": "VIM-83 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6045": {"model_id": "6045", "model_name": "VIM-84", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8865": {"protein_sequence": {"accession": "UWQ12890.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSLTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "ON688661.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCGGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACTCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007821", "ARO_id": "46608", "ARO_name": "VIM-84", "CARD_short_name": "VIM-84", "ARO_description": "VIM-84 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6020": {"model_id": "6020", "model_name": "aac(6')-Ib-cr10", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "350"}}, "model_sequences": {"sequence": {"8755": {"protein_sequence": {"accession": "WP_124042715.1", "sequence": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPMGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA"}, "dna_sequence": {"accession": "NG_067968.1", "fmin": "100", "fmax": "655", "strand": "+", "sequence": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATGGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35914", "NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562"}}}}, "ARO_accession": "3007770", "ARO_id": "46553", "ARO_name": "aac(6')-Ib-cr10", "CARD_short_name": "aac(6')-Ib-cr10", "ARO_description": "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Escherichia coli. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics.", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound.", "category_aro_class_name": "AMR Gene Family"}, "43328": {"category_aro_accession": "3005113", "category_aro_cvterm_id": "43328", "category_aro_name": "AAC(6')-Ib-cr", "category_aro_description": "A subfamily of aminoglycoside 6'-N-acetyltransferases, AAC(6'), which doubly confer resistance to aminoglycoside and fluoroquinolone antibiotics through fluoroquinolone-acetylating activity.", "category_aro_class_name": "AMR Gene Family"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6021": {"model_id": "6021", "model_name": "aac(6')-Ib-cr11", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "350"}}, "model_sequences": {"sequence": {"8756": {"protein_sequence": {"accession": "WP_159241551.1", "sequence": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDSEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA"}, "dna_sequence": {"accession": "NG_067969.1", "fmin": "100", "fmax": "655", "strand": "+", "sequence": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATTCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36771", "NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584"}}}}, "ARO_accession": "3007771", "ARO_id": "46554", "ARO_name": "aac(6')-Ib-cr11", "CARD_short_name": "aac(6')-Ib-cr11", "ARO_description": "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Proteus mirabilis. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics.", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound.", "category_aro_class_name": "AMR Gene Family"}, "43328": {"category_aro_accession": "3005113", "category_aro_cvterm_id": "43328", "category_aro_name": "AAC(6')-Ib-cr", "category_aro_description": "A subfamily of aminoglycoside 6'-N-acetyltransferases, AAC(6'), which doubly confer resistance to aminoglycoside and fluoroquinolone antibiotics through fluoroquinolone-acetylating activity.", "category_aro_class_name": "AMR Gene Family"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6022": {"model_id": "6022", "model_name": "Vibrio vulnificus rpoB mutants conferring resistance to rifampin", "model_type": "protein variant model", "model_type_id": "40293", "model_description": "Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.", "model_param": {"snp": {"param_type": "single resistance variant", "param_description": "A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with with format [wild-type][position][mutation], e.g. R184Q.", "param_type_id": "36301", "param_value": {"13175": "S522L"}, "clinical": {"13175": "S522L"}}, "blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "2500"}}, "model_sequences": {"sequence": {"8757": {"protein_sequence": {"accession": "WP_011079201.1", "sequence": "MVYSYTEKKRIRKDFGTRPQVLDIPYLLSIQLDSFDKFIEQDPEGQYGLEAAFRSVFPIQSYNGNSELQYVSYRLGEPVFDVKECQIRGVTYSKPLRVKLRLVIFDKDAPAGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLYVRIDRRRKLPSTIILRALGKSTEEILDTFFEKVNFEVKDQTLMMELVPDRLRGETATFDIEANGTVYVEKGRRVTARHIRQLEKEGVDQIEVPVEYIVGKVSSKDYINEATGEIIVAANQEISLEALAKLSQAGHKQLEVLFTNDLDHGPFMSETLRIDSSVDRISALVEIYRMMRPGEPPTKEAAEALFESLFFSEERYDLSTVGRMKFNSSIGRDDAEEQGTLDETDIIEVMKKLIAIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDAVMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHVTHYGRLCPIETPEGPNIGLINSLSAFARCNEYGFLETPYRRVVDGVVTDEVDYLSAIEEGQFVIAQANAKLNEDGTFADELITARQKGESGLHPREHVDYMDVATNQVVSIAASLIPFLEHDDANRALMGANMQRQAVPTLKAEKPLVGTGIERNVAVDSGVTSVAKRGGIIQSVDASRIVVKVNEEELIPGEAGIDIYNLTKYTRSNQNTCINQRPCVMPGEPVLRGDVLADGPSTDLGELALGQNMRIAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELTCVARDTKLGSEEITADIPNVGESALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPNSVSGTIIDVQVFTRDGVEKDKRALEIEQMQLKEAKKDLTEEFQILEGGLLNRVKAVLLSGGYSEAKLDTTDRKKWLELTLEDDALQTQLEQLAEQYDELKADFDKKFETKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPVEDMPYDEKGQPVDIVLNPLGVPSRMNIGQILEVHLGLAAKGIGDKINQMVKEQQELAKFREFLQKVYDLGETRQKVDIASLSDEEVRTLIGNLRGGLPIATPVFDGASEASIKELLKLGGLPESGQLTLFDGRTGDAFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHAMEPGMPESFNVLLKEIRSLGINIELEDEQ"}, "dna_sequence": {"accession": "NC_004459.3", "fmin": "1187563", "fmax": "1191592", "strand": "+", "sequence": "ATGGTTTACTCTTATACCGAGAAAAAGCGCATCCGTAAGGACTTTGGTACTCGTCCACAAGTTTTGGACATTCCATACCTGCTATCGATCCAGCTCGATTCGTTCGATAAATTTATCGAACAGGATCCTGAAGGACAGTACGGTCTTGAGGCTGCTTTCCGTTCTGTATTCCCTATTCAGAGCTACAATGGTAATTCTGAGCTGCAATACGTTAGCTACCGTCTTGGTGAGCCAGTTTTTGATGTTAAAGAATGTCAAATCCGTGGTGTAACTTATTCAAAACCACTTCGCGTAAAGCTACGCCTAGTTATTTTTGATAAAGACGCGCCTGCAGGCACTGTAAAAGACATTAAAGAACAAGAAGTCTACATGGGTGAAATTCCACTCATGACAGACAATGGTACCTTTGTGATTAACGGTACCGAGAGGGTTATCGTATCTCAGCTACATCGAAGCCCAGGTGTGTTCTTCGACAGCGACAAAGGTAAGACTCACTCTTCTGGTAAAGTTCTGTACAACGCGCGTATCATTCCTTACCGTGGTTCATGGCTTGATTTTGAGTTTGATCCTAAGGACAACCTGTACGTACGTATCGACCGTCGTCGTAAGCTACCATCAACCATCATTCTTCGTGCACTAGGTAAGAGCACTGAAGAGATCTTGGATACTTTCTTCGAAAAAGTGAATTTCGAAGTGAAAGACCAGACGCTAATGATGGAGTTGGTACCAGATCGCCTACGTGGTGAAACGGCAACGTTTGATATCGAAGCAAACGGCACTGTCTATGTAGAGAAAGGTCGTCGTGTTACGGCACGCCACATCCGTCAACTTGAAAAAGAAGGCGTTGATCAGATCGAAGTACCGGTTGAGTACATCGTAGGCAAAGTGTCGTCAAAAGATTACATCAATGAAGCGACTGGCGAGATCATCGTTGCAGCGAACCAGGAAATCAGCCTTGAAGCATTGGCTAAGCTATCTCAAGCTGGCCACAAGCAGCTAGAAGTCCTGTTTACAAACGATCTAGACCATGGTCCATTCATGTCAGAAACACTACGCATCGACAGCTCTGTTGATCGTATTTCTGCACTGGTAGAAATCTACCGCATGATGCGCCCTGGTGAGCCACCAACGAAAGAAGCTGCTGAAGCTCTATTCGAAAGCTTGTTCTTCTCTGAAGAGCGTTATGACCTATCGACTGTTGGTCGTATGAAGTTCAACAGCTCCATTGGCCGTGATGATGCAGAAGAGCAAGGCACACTTGATGAAACTGACATCATCGAAGTGATGAAGAAGCTGATCGCTATCCGTAACGGTAAAGGCGAAGTGGACGATATCGACCACCTAGGTAACCGCCGTATCCGTTCTGTTGGTGAAATGGCTGAAAACCAATTCCGTGTTGGTCTAGTACGTGTTGAACGTGCAGTGAAAGAACGTCTGAGCCTAGGCGATCTTGACGCAGTGATGCCACAAGACTTGATCAATGCGAAGCCAATTTCTGCGGCAGTAAAAGAGTTCTTTGGCTCTTCTCAGCTGTCTCAGTTTATGGACCAAAACAACCCGCTATCAGAAGTCACGCACAAGCGTCGTATTTCTGCATTGGGTCCTGGTGGTCTTACTCGTGAGCGTGCTGGTTTCGAAGTTCGAGACGTACACGTAACTCACTACGGCCGCCTATGTCCGATCGAAACGCCTGAAGGTCCAAACATCGGTCTGATCAACTCTCTATCAGCATTTGCACGTTGTAACGAGTACGGCTTCCTAGAGACGCCATACCGTCGTGTTGTTGATGGTGTTGTGACAGACGAAGTGGATTACCTATCAGCGATCGAAGAAGGTCAATTTGTTATCGCTCAGGCGAACGCGAAGCTGAACGAAGATGGTACTTTCGCTGATGAGCTTATCACTGCTCGTCAAAAAGGCGAATCTGGTCTGCACCCACGTGAACATGTTGATTACATGGACGTTGCAACCAACCAGGTCGTATCTATCGCAGCATCGCTAATCCCGTTCCTAGAACACGACGATGCTAACCGCGCTCTAATGGGTGCGAACATGCAACGTCAGGCGGTTCCTACTCTGAAAGCAGAGAAACCACTTGTAGGTACAGGTATTGAGCGTAACGTAGCGGTTGACTCTGGTGTAACGTCGGTTGCTAAACGCGGCGGTATTATCCAGTCAGTTGACGCATCTCGTATCGTGGTGAAGGTTAATGAAGAAGAGTTGATTCCTGGCGAAGCTGGTATCGATATCTACAACCTAACCAAATACACTCGTTCTAACCAAAACACTTGTATCAACCAACGTCCATGTGTGATGCCGGGTGAACCAGTGCTACGTGGTGATGTGCTTGCTGATGGTCCTTCAACAGACCTAGGTGAACTTGCACTTGGTCAGAACATGCGTATCGCGTTCATGCCTTGGAACGGTTACAACTTCGAAGACTCGATCTTAGTATCTGAGCGCGTAGTTCAAGAAGACCGCTTCACGACTATCCACATTCAAGAACTGACTTGTGTGGCGCGTGATACCAAGCTGGGTTCGGAAGAAATCACAGCGGATATTCCAAACGTAGGTGAATCTGCTCTGTCTAAATTAGACGAGTCAGGTATTGTTTACATCGGTGCTGAAGTGAAGGGTGGCGACATCCTAGTTGGTAAAGTAACGCCAAAAGGTGAAACTCAGCTAACGCCTGAAGAGAAGCTACTACGTGCAATCTTTGGTGAAAAAGCATCTGACGTTAAAGATACGTCACTACGTGTACCAAACTCTGTTTCAGGTACCATCATCGACGTTCAAGTTTTCACTCGCGATGGCGTAGAGAAAGACAAGCGTGCGCTTGAAATTGAACAGATGCAGCTGAAAGAAGCGAAGAAAGACCTTACTGAAGAATTCCAGATTCTGGAAGGCGGTCTTCTAAACCGTGTTAAAGCGGTTCTTCTATCAGGTGGTTACTCTGAAGCGAAGCTAGATACAACTGATCGTAAGAAGTGGCTAGAACTGACTCTTGAAGACGACGCACTGCAAACTCAGCTTGAGCAACTTGCAGAGCAGTACGACGAGCTAAAAGCAGACTTCGATAAGAAGTTTGAAACCAAGCGTCGTAAGATCACTCAAGGTGATGACCTAGCGCCTGGCGTACTGAAGATCGTTAAAGTTTACCTAGCGGTGAAACGTCGTATCCAGCCTGGTGATAAGATGGCGGGTCGTCACGGTAACAAGGGTGTAATCTCTAAGATCAACCCTGTTGAAGACATGCCATACGATGAGAAAGGTCAGCCTGTAGACATCGTACTTAACCCATTGGGTGTACCTTCGCGTATGAACATCGGTCAGATCCTAGAAGTACACTTGGGTCTAGCAGCGAAAGGTATTGGTGACAAGATCAACCAGATGGTGAAAGAGCAGCAAGAACTCGCGAAATTCCGTGAATTCCTGCAAAAAGTTTATGATCTAGGCGAAACTCGCCAGAAAGTAGACATTGCTTCTCTGTCTGATGAAGAAGTTCGTACTCTGATTGGCAACCTACGTGGTGGCTTACCGATTGCGACTCCAGTATTTGACGGTGCGTCTGAAGCATCAATCAAAGAGCTACTGAAACTTGGCGGTCTGCCAGAGTCCGGTCAGCTAACTCTGTTTGATGGTCGCACAGGTGATGCGTTTGAGCGTCCTGTAACCGTAGGTTACATGTACATGCTGAAACTGAACCACCTTGTAGATGACAAGATGCACGCACGTTCTACTGGCTCGTACAGTCTGGTAACTCAGCAACCACTAGGTGGTAAAGCTCAGTTCGGTGGTCAGCGTTTCGGTGAGATGGAAGTATGGGCACTAGAAGCATACGGTGCTGCTTACACGCTACAAGAAATGCTAACGGTTAAGTCGGATGACGTTAACGGCCGTACTAAGATGTACAAAAACATCGTAGATGGTAACCACGCGATGGAACCAGGCATGCCTGAATCGTTCAACGTACTGTTGAAAGAGATCCGCTCGCTAGGTATCAACATCGAGCTAGAAGACGAACAGTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "46578", "NCBI_taxonomy_name": "Vibrio vulnificus CMCP6", "NCBI_taxonomy_id": "216895"}}}}, "ARO_accession": "3007794", "ARO_id": "46577", "ARO_name": "Vibrio vulnificus rpoB mutants conferring resistance to rifampin", "CARD_short_name": "Vvul_rpoB_RIF", "ARO_description": "Point mutations that occur within the Vibrio vulnificus rpoB gene resulting in resistance to rifampin.", "ARO_category": {"36349": {"category_aro_accession": "3000210", "category_aro_cvterm_id": "36349", "category_aro_name": "rifamycin-resistant beta-subunit of RNA polymerase (rpoB)", "category_aro_description": "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin.", "category_aro_class_name": "AMR Gene Family"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6023": {"model_id": "6023", "model_name": "OXA-410", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "550"}}, "model_sequences": {"sequence": {"8758": {"protein_sequence": {"accession": "HCT5551642.1", "sequence": "MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATATEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL"}, "dna_sequence": {"accession": "DAKAKM010000001.1", "fmin": "279004", "fmax": "279829", "strand": "+", "sequence": "ATGAACATTAAAGCACTCTTACTTATAACAAGCGCTATTTTTATTTCAGCCTGCTCACCTTATATAGTGTCTGCTAATCCAAATCACAGTGCTTCAAAATCTGATGAAAAAGCAGAGAAAATTAAAAATTTATTTAACGAAGCACACACTACGGGTGTTTTAGTTATCCAACAAGGCCAAACTCAACAAAGCTATGGTAATGATCTTGCTCGTGCTTCGACCGAGTATGTACCTGCTTCGACCTTCAAAATGCTTAATGCTTTGATCGGCCTTGAGCACCATAAGGCAACCGCTACAGAAGTATTTAAGTGGGACGGGCAAAAAAGGCTATTCCCAGAATGGGAAAAGAACATGACCCTAGGCGATGCTATGAAAGCTTCCGCTATTCCGGTTTATCAAGATTTAGCTCGTCGTATTGGACTTGAACTCATGTCTAATGAAGTGAAGCGTGTTGGTTATGGCAATGCAGATATCGGTACCCAAGTCGATAATTTTTGGTTGGTGGGTCCTTTAAAAATTACTCCTCAGCAAGAGGCACAATTTGCTTACAAGCTAGCTAATAAAACGCTTCCATTTAGCCAAAAAGTCCAAGATGAAGTGCAATCCATGCTATTCATAGAAGAAAAGAATGGAAATAAAATATACGCAAAAAGTGGTTGGGGATGGGATGTAGACCCACAAGTAGGCTGGTTAACTGGATGGGTTGTTCAGCCTCAAGGGAATATTGTAGCGTTCTCCCTTAACCTAGAAATGAAAAAAGGAATACCTAGCTCTGTTCGAAAAGAGATTACTTATAAAAGTTTAGAACAATTAGGTATTTTATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35507", "NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470"}}}}, "ARO_accession": "3001601", "ARO_id": "38001", "ARO_name": "OXA-410", "CARD_short_name": "OXA-410", "ARO_description": "OXA-410 is an OXA-51-like beta-lactamase.", "ARO_category": {"36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35973": {"category_aro_accession": "0000056", "category_aro_cvterm_id": "35973", "category_aro_name": "oxacillin", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis.", "category_aro_class_name": "Antibiotic"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6025": {"model_id": "6025", "model_name": "RATA-1", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "600"}}, "model_sequences": {"sequence": {"8762": {"protein_sequence": {"accession": "WFS34552.1", "sequence": "MNRLLQLTVLLLLLVTSCKTQSDKTDLLRNKIEQILSDKNAVVGVSIIGNNGKDTLSLHGDRRFPMQSVFKFHIALAVLSEIDKGKLSLDQKIEIRKDELLPEDFWSPLRDENPNGGIFTIERLIQYSVSHSDNTACDVLIRLIGTPKTVEEYIKKSGINDIQITFNEEDMQSKWENMFQNWTTPKAASQTLKLFYDNKNNLLSKSSYDFFWKTNKETTTGNNRIKGQLPEGTVVAHKTGSSGTNKETGITAAVNNIGIVFLPNGEHFIISVFVSESKENFDMNEKIIADIAKATYDFYTATEK"}, "dna_sequence": {"accession": "CP121209.1", "fmin": "1982452", "fmax": "1983367", "strand": "+", "sequence": "ATGAATAGACTTCTTCAATTAACAGTTTTGCTTTTATTACTCGTAACAAGTTGTAAAACACAATCCGACAAGACCGACTTGCTTAGGAATAAAATTGAGCAAATATTATCCGACAAAAATGCAGTAGTTGGAGTTTCAATAATTGGGAACAATGGGAAAGACACACTTTCGCTACACGGAGACAGGCGATTCCCTATGCAAAGTGTATTTAAGTTCCATATAGCATTAGCTGTATTGTCGGAAATTGACAAGGGGAAACTTTCATTAGACCAGAAAATTGAGATTCGAAAAGATGAACTTTTACCAGAAGATTTTTGGAGTCCACTTAGAGACGAAAATCCTAATGGCGGAATCTTTACTATTGAAAGACTAATTCAATATTCTGTCTCACACAGCGACAATACTGCTTGCGATGTATTAATACGACTAATTGGAACACCTAAAACGGTTGAAGAGTATATTAAGAAAAGTGGCATAAATGATATACAGATTACATTCAACGAAGAAGATATGCAGTCAAAGTGGGAAAATATGTTTCAGAATTGGACTACACCGAAAGCGGCAAGCCAAACGCTTAAATTATTTTATGACAATAAAAACAACTTGCTTTCAAAAAGCAGTTATGACTTTTTTTGGAAGACAAATAAAGAGACCACAACCGGTAATAACCGAATTAAGGGACAATTACCCGAAGGGACAGTTGTTGCTCATAAAACAGGTTCGTCTGGAACAAACAAAGAAACAGGAATTACTGCCGCTGTAAACAATATAGGAATTGTTTTTTTACCGAATGGCGAACACTTTATCATCAGTGTTTTTGTAAGTGAATCAAAAGAAAATTTTGACATGAATGAAAAAATTATAGCGGACATTGCAAAAGCAACCTATGACTTTTACACAGCAACGGAAAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36951", "NCBI_taxonomy_name": "Riemerella anatipestifer", "NCBI_taxonomy_id": "34085"}}}}, "ARO_accession": "3007801", "ARO_id": "46586", "ARO_name": "RATA-1", "CARD_short_name": "RATA-1", "ARO_description": "RATA-1 is a class A RATA-family carbapenemase.", "ARO_category": {"46585": {"category_aro_accession": "3007800", "category_aro_cvterm_id": "46585", "category_aro_name": "RATA beta-lactamase", "category_aro_description": "RATA is a family of class A carbapenemases identified from the chromosome of Riemerella anatipestifer.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6026": {"model_id": "6026", "model_name": "RATA-2", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "600"}}, "model_sequences": {"sequence": {"8763": {"protein_sequence": {"accession": "WFS32678.1", "sequence": "MNRLFQLTVLLLLFVTSCKTPSYKTDLLRNKIEQILSDKNAVVGVSIIGNNGKDTLSLNGDKRFPMQSVFKFHIALAVLSEIDKGKLSLDQKIEISKDELLPEDFWSPLRDENPNGGTFTIERLIQYSVSHSDNTACDVLIRLIGTPKTVEEYIKKSGINDIQITYNEEQMQAKWENMFQNWTTPKAASQTLKLFYENKSNLLSQSSYDFFWKTNKETTTGKNRIRGQLPEGTVVAHKTGWSGTNKETGITAAVNNIGIVFLPNGEYFIISVFVSESKEDFDTNEKIIADIAKATYDFYTTTEK"}, "dna_sequence": {"accession": "CP121210.1", "fmin": "1997284", "fmax": "1998199", "strand": "+", "sequence": "ATGAATAGACTTTTTCAATTGACAGTTTTACTATTATTATTCGTTACAAGTTGTAAAACTCCCTCCTACAAGACAGACTTACTGCGAAATAAAATTGAGCAAATATTATCCGACAAAAACGCAGTAGTTGGAGTTTCAATAATTGGTAACAATGGAAAAGACACACTTTCGCTAAACGGAGACAAGCGATTTCCTATGCAAAGCGTATTTAAGTTCCACATAGCATTAGCTGTATTATCGGAAATTGACAAAGGAAAACTTTCCTTAGACCAAAAAATTGAGATTAGCAAAGATGAACTTTTACCGGAAGATTTTTGGAGCCCTCTTAGAGACGAAAACCCTAATGGTGGAACTTTTACTATTGAAAGACTAATTCAATATTCCGTTTCTCATAGCGACAATACTGCTTGTGATGTTTTAATACGGCTAATAGGAACACCTAAAACGGTTGAAGAATACATTAAAAAAAGTGGCATAAATGATATACAAATCACTTATAACGAAGAACAAATGCAGGCTAAGTGGGAAAATATGTTTCAGAATTGGACTACACCAAAAGCAGCAAGCCAAACTCTTAAATTATTTTATGAGAATAAAAGCAATTTGCTTTCACAAAGTAGTTATGACTTTTTTTGGAAAACGAATAAAGAGACAACAACTGGTAAAAACCGTATAAGGGGGCAATTGCCAGAAGGAACAGTTGTTGCTCACAAGACAGGTTGGTCAGGGACAAACAAAGAAACAGGAATTACTGCCGCAGTTAACAATATTGGTATCGTTTTTTTACCTAATGGCGAATACTTTATCATAAGTGTATTTGTAAGTGAATCAAAAGAAGATTTTGACACAAATGAAAAAATTATAGCAGACATTGCAAAAGCAACTTATGACTTTTACACAACAACTGAAAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36951", "NCBI_taxonomy_name": "Riemerella anatipestifer", "NCBI_taxonomy_id": "34085"}}}}, "ARO_accession": "3007802", "ARO_id": "46587", "ARO_name": "RATA-2", "CARD_short_name": "RATA-2", "ARO_description": "RATA-2 is a class A RATA-family carbapenemase.", "ARO_category": {"46585": {"category_aro_accession": "3007800", "category_aro_cvterm_id": "46585", "category_aro_name": "RATA beta-lactamase", "category_aro_description": "RATA is a family of class A carbapenemases identified from the chromosome of Riemerella anatipestifer.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6027": {"model_id": "6027", "model_name": "CARB-56", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8847": {"protein_sequence": {"accession": "QVO43826.1", "sequence": "MKKLFLLAGLMVCSTLSYASQLNEDISLLEQQTSSRIGVSVWDTQADERWDYRGDERFPLMSTFKTLACAKMLSDMDSGKLSKNATAKVDERSIVVWSPVMDKLAGQNTRIEHACEAAMLMSDNTAANLVLNEIGGPKAVTMFLRTIGDKATRLDRIEPRLNEATPGDSRDTTTPNAILNTLRTLIEGETLSYESRVQLKIWMQDNKVSDSLMRSVLPTGWSIADRSGAGGHGSRGINAIIWKENHRPVYISIYVTETELSLQARDQLVAQISQLILQKYKDN"}, "dna_sequence": {"accession": "MZ092819.1", "fmin": "0", "fmax": "852", "strand": "+", "sequence": "ATGAAAAAGTTATTTTTGTTGGCTGGGCTAATGGTTTGCTCAACCCTAAGTTACGCGTCCCAACTGAATGAGGACATTTCTCTCCTCGAGCAACAAACCTCAAGCAGAATTGGGGTGTCAGTTTGGGATACCCAAGCAGACGAGCGTTGGGATTACCGTGGCGATGAACGCTTCCCACTCATGAGCACATTCAAAACCCTAGCTTGTGCCAAAATGCTAAGTGATATGGACAGCGGTAAGCTAAGTAAAAATGCGACCGCAAAAGTCGATGAGCGCAGTATCGTTGTATGGTCTCCAGTGATGGATAAGCTCGCAGGCCAAAACACACGCATAGAGCACGCGTGTGAAGCCGCTATGTTAATGAGTGATAATACTGCAGCCAACTTGGTATTAAATGAAATTGGCGGCCCTAAAGCCGTAACAATGTTTCTGCGAACAATTGGAGATAAAGCAACGCGCCTAGACAGAATAGAACCTCGCTTGAACGAAGCCACACCAGGCGACAGCCGCGATACAACCACACCTAACGCCATACTAAACACTCTGCGAACCTTGATCGAAGGCGAAACGTTGTCTTATGAGTCTCGTGTACAATTAAAAATCTGGATGCAAGACAACAAAGTTTCAGACTCGTTAATGCGTTCTGTATTACCAACAGGTTGGTCTATTGCAGACCGTTCTGGTGCGGGTGGTCATGGTTCGCGTGGCATTAACGCGATTATATGGAAGGAAAATCATCGACCTGTTTACATTAGTATTTATGTCACAGAAACCGAGCTCTCACTTCAAGCTAGGGACCAGCTCGTTGCGCAGATAAGTCAGTTGATTTTACAAAAGTACAAAGACAATTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "43205", "NCBI_taxonomy_name": "Vibrio alginolyticus", "NCBI_taxonomy_id": "663"}}}}, "ARO_accession": "3007803", "ARO_id": "46589", "ARO_name": "CARB-56", "CARD_short_name": "CARB-56", "ARO_description": "CARB-56 is a class A CARB-17-like beta-lactamase identified from Vibrio alginolyticus.", "ARO_category": {"36230": {"category_aro_accession": "3000091", "category_aro_cvterm_id": "36230", "category_aro_name": "CARB beta-lactamase", "category_aro_description": "CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6028": {"model_id": "6028", "model_name": "VIM-74", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8848": {"protein_sequence": {"accession": "QTG68659.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSAGVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "MW811442.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGGGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007804", "ARO_id": "46590", "ARO_name": "VIM-74", "CARD_short_name": "VIM-74", "ARO_description": "VIM-74 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6036": {"model_id": "6036", "model_name": "VIM-75", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8856": {"protein_sequence": {"accession": "QYZ89894.1", "sequence": "MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE"}, "dna_sequence": {"accession": "MZ748327.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCGGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGAGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAACGTGCTATACGGTGGTTGTGCCGTTCATGAGTTGTCAAGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36771", "NCBI_taxonomy_name": "Proteus mirabilis", "NCBI_taxonomy_id": "584"}}}}, "ARO_accession": "3007812", "ARO_id": "46598", "ARO_name": "VIM-75", "CARD_short_name": "VIM-75", "ARO_description": "VIM-75 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6046": {"model_id": "6046", "model_name": "VIM-85", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8866": {"protein_sequence": {"accession": "UWQ12891.1", "sequence": "MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHNDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSLTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "ON688662.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCGCGTCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCGGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATAACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACTCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007822", "ARO_id": "46609", "ARO_name": "VIM-85", "CARD_short_name": "VIM-85", "ARO_description": "VIM-85 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6047": {"model_id": "6047", "model_name": "VIM-86", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8867": {"protein_sequence": {"accession": "WAU52774.1", "sequence": "MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSAKVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE"}, "dna_sequence": {"accession": "OP998371.1", "fmin": "0", "fmax": "801", "strand": "+", "sequence": "ATGTTAAAAGTTATTAGTAGTTTATTGGTCTACATGACCGCGTCTGTCATGGCTGTCGCAAGTCCGTTAGCCCATTCCGGGGAGCCGAGTGGTGAGTATCCGACAGTCAACGAAATTCCGGTCGGAGAGGTCCGACTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCGGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAAAAGCAAATTGGACTTCCCGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGCAGAGGGGAACGAGATTCCCACGCATTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAGCTCTTCTATCCTGGTGCTGCGCATTCGACCGACAATCTGGTTGTATACGTCCCGTCAGCGAAAGTGCTATACGGTGGTTGTGCCGTTCATGAGTTGTCAAGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCGTTGAGCGGATTCAAAAACACTACCCGGAAGCAGAGGTCGTCATTCCCGGGCACGGTCTACCGGGCGGTCTAGACTTGCTCCAGCACACAGCGAACGTTGTCAAAGCACACAAAAATCGCTCAGTCGCCGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36946", "NCBI_taxonomy_name": "Providencia stuartii", "NCBI_taxonomy_id": "588"}}}}, "ARO_accession": "3007823", "ARO_id": "46610", "ARO_name": "VIM-86", "CARD_short_name": "VIM-86", "ARO_description": "VIM-86 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6048": {"model_id": "6048", "model_name": "VIM-87", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "500"}}, "model_sequences": {"sequence": {"8868": {"protein_sequence": {"accession": "EME7055635.1", "sequence": "MFKLLSKLLVYLTTSIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE"}, "dna_sequence": {"accession": "ABPYXB010000003.1", "fmin": "211323", "fmax": "212124", "strand": "-", "sequence": "ATGTTCAAACTTTTGAGTAAGTTATTGGTCTATTTGACCACATCTATCATGGCTATTGCGAGTCCGCTCGCTTTTTCCGTAGATTCTAGCGGTGAGTATCCGACAGTCAGCGAAATTCCGGTCGGGGAGGTCCGGCTTTACCAGATTGCCGATGGTGTTTGGTCGCATATCGCAACGCAGTCGTTTGATGGCGCAGTCTACCCGTCCAATGGTCTCATTGTCCGTGATGGTGATGAGTTGCTTTTGATTGATACAGCGTGGGGTGCGAAAAACACAGCGGCACTTCTCGCGGAGATTGAGAAGCAAATTGGACTTCCTGTAACGCGTGCAGTCTCCACGCACTTTCATGACGACCGCGTCGGCGGCGTTGATGTCCTTCGGGCGGCTGGGGTGGCAACGTACGCATCACCGTCGACACGCCGGCTAGCCGAGGTAGAGGGGAACGAGATTCCCACGCACTCTCTAGAAGGACTCTCATCGAGCGGGGACGCAGTGCGCTTCGGTCCAGTAGAACTCTTCTATCCTGGTGCTGCGCATTCGACCGACAACTTAGTTGTGTACGTCCCGTCTGCGAGTGTGCTCTATGGTGGTTGTGCGATTTATGAGTTGTCACGCACGTCTGCGGGGAACGTGGCCGATGCCGATCTGGCTGAATGGCCCACCTCCATTGAGCGGATTCAACAACACTACCCGGAAGCACAGTTCGTCATTCCGGGGCACGGCCTGCCGGGCGGTCTAGACTTGCTCAAGCACACAACGAATGTTGTAAAAGCGCACACAAATCGCTCAGTCGTTGAGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007824", "ARO_id": "46611", "ARO_name": "VIM-87", "CARD_short_name": "VIM-87", "ARO_description": "VIM-87 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase.", "ARO_category": {"36030": {"category_aro_accession": "3000021", "category_aro_cvterm_id": "36030", "category_aro_name": "VIM beta-lactamase", "category_aro_description": "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants.  VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.  There is a strong incidence of these in East Asia.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6049": {"model_id": "6049", "model_name": "GES-47", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8869": {"protein_sequence": {"accession": "BCT36862.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGYMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "LC612389.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAACGGCGCAGCGCTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCGAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGATACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "43788", "NCBI_taxonomy_name": "Klebsiella michiganensis", "NCBI_taxonomy_id": "1134687"}}}}, "ARO_accession": "3007825", "ARO_id": "46612", "ARO_name": "GES-47", "CARD_short_name": "GES-47", "ARO_description": "GES-47 is a class A carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6050": {"model_id": "6050", "model_name": "GES-48", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8870": {"protein_sequence": {"accession": "BCT36863.1", "sequence": "MRFIHALLLAGIAHSAYSSEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "LC612390.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATTCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAACGGCGCAGCGCTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCGAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36936", "NCBI_taxonomy_name": "Aeromonas caviae", "NCBI_taxonomy_id": "648"}}}}, "ARO_accession": "3007826", "ARO_id": "46613", "ARO_name": "GES-48", "CARD_short_name": "GES-48", "ARO_description": "GES-48 is a class A carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6051": {"model_id": "6051", "model_name": "GES-49", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8871": {"protein_sequence": {"accession": "BCY26593.1", "sequence": "MRFIHVLLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "LC637995.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGTACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39671", "NCBI_taxonomy_name": "Aeromonas veronii bv. veronii", "NCBI_taxonomy_id": "197701"}}}}, "ARO_accession": "3007827", "ARO_id": "46614", "ARO_name": "GES-49", "CARD_short_name": "GES-49", "ARO_description": "GES_49 is a class A  carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6052": {"model_id": "6052", "model_name": "GES-50", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8872": {"protein_sequence": {"accession": "BDB58072.1", "sequence": "MRFIHTLLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "LC654878.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACACACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAACGGCGCAGCGCTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCGAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "43788", "NCBI_taxonomy_name": "Klebsiella michiganensis", "NCBI_taxonomy_id": "1134687"}}}}, "ARO_accession": "3007828", "ARO_id": "46615", "ARO_name": "GES-50", "CARD_short_name": "GES-50", "ARO_description": "GES-50 is a class A carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6053": {"model_id": "6053", "model_name": "GES-51", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8873": {"protein_sequence": {"accession": "BDB58073.1", "sequence": "MRFIHVLLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "LC654879.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGTACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCGAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "43754", "NCBI_taxonomy_name": "Citrobacter portucalensis", "NCBI_taxonomy_id": "1639133"}}}}, "ARO_accession": "3007829", "ARO_id": "46616", "ARO_name": "GES-51", "CARD_short_name": "GES-51", "ARO_description": "GES-51 is a class A carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6054": {"model_id": "6054", "model_name": "GES-52", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8874": {"protein_sequence": {"accession": "UOM32505.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGQNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "ON166564.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGGGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCAGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007830", "ARO_id": "46617", "ARO_name": "GES-52", "CARD_short_name": "GES-52", "ARO_description": "GES-52 is a class A GES-like extended-spectrum beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6055": {"model_id": "6055", "model_name": "GES-53", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8875": {"protein_sequence": {"accession": "UQM94989.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGQNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "ON418962.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCAGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36884", "NCBI_taxonomy_name": "Enterobacter cloacae", "NCBI_taxonomy_id": "550"}}}}, "ARO_accession": "3007831", "ARO_id": "46618", "ARO_name": "GES-53", "CARD_short_name": "GES-53", "ARO_description": "GES-53 is a class A carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6056": {"model_id": "6056", "model_name": "GES-54", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8876": {"protein_sequence": {"accession": "BDI54505.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPAMERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "LC709174.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAACGGCGCAGCGCTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCATGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39773", "NCBI_taxonomy_name": "Enterobacter kobei", "NCBI_taxonomy_id": "208224"}}}}, "ARO_accession": "3007832", "ARO_id": "46619", "ARO_name": "GES-54", "CARD_short_name": "GES-54", "ARO_description": "GES-54 is a class A carbapenem-hydrolyzing GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6057": {"model_id": "6057", "model_name": "GES-55", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8877": {"protein_sequence": {"accession": "UUF81220.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKESEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "ON714048.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCAAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGTCGGAGATGAGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36783", "NCBI_taxonomy_name": "Serratia marcescens", "NCBI_taxonomy_id": "615"}}}}, "ARO_accession": "3007833", "ARO_id": "46620", "ARO_name": "GES-55", "CARD_short_name": "GES-55", "ARO_description": "GES is a class A GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6058": {"model_id": "6058", "model_name": "GES-56", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8878": {"protein_sequence": {"accession": "UUT09019.1", "sequence": "MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGAANLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "OP158701.1", "fmin": "0", "fmax": "864", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAAATTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCGAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTGCTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAAAGAGCCGGAGATGGGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGCCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35507", "NCBI_taxonomy_name": "Acinetobacter baumannii", "NCBI_taxonomy_id": "470"}}}}, "ARO_accession": "3007834", "ARO_id": "46621", "ARO_name": "GES-56", "CARD_short_name": "GES-56", "ARO_description": "GES-56 is a class A GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6059": {"model_id": "6059", "model_name": "GES-57", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8886": {"protein_sequence": {"accession": "UYS49421.1", "sequence": "MRFIHALLLAGIAHSAYASENLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRNEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK"}, "dna_sequence": {"accession": "OP716785.1", "fmin": "34", "fmax": "898", "strand": "+", "sequence": "ATGCGCTTCATTCACGCACTATTACTGGCAGGGATCGCTCACTCTGCATATGCGTCGGAAAACTTAACCTTCAAGACCGATCTTGAGAAGCTAGAGCGCGAAAAAGCAGCTCAGATCGGTGTTGCGATCGTCGATCCCCAAGGAGAGATCGTCGCGGGCCACCGAATGGCGCAGCGTTTTGCAATGTGCTCAACGTTCAAGTTTCCGCTAGCCGCGCTGGTCTTTGAAAGAATTGACTCAGGCACCGAGCGGGGGGATCGAAAACTTTCATATGGGCCGGACATGATCGTCGAATGGTCTCCTGCCACGGAGCGGTTTCTAGCATCGGGACACATGACGGTTCTCGAGGCAGCGCAAGCTGCGGTGCAGCTTAGCGACAATGGGGCTACTAACCTCTTACTGAGAGAAATTGGCGGACCTGCTGCAATGACGCAGTATTTTCGTAAAATTGGCGACTCTGTGAGTCGGCTAGACCGGAATGAGCCGGAGATGGGCGACAACACACCTGGCGACCTCAGAGATACAACTACGCCTATTGCTATGGCACGTACTGTGGCTAAAGTCCTCTATGGCGGCGCACTGACGTCCACCTCGACCCACACCATTGAGAGGTGGCTGATCGGAAACCAAACGGGAGACGCGACACTACGAGCGGGTTTTCCTAAAGATTGGGTTGTTGGAGAGAAAACTGGTACCTGCGCCAACGGGGGCCGGAACGACATTGGTTTTTTTAAAGCCCAGGAGAGAGATTACGCTGTAGCGGTGTATACAACGGCCCCGAAACTATCGGCCGTAGAACGTGACGAATTAGTTGCCTCTGTCGGTCAAGTTATTACACAACTCATCCTGAGCACGGACAAATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}}, "ARO_accession": "3007835", "ARO_id": "46622", "ARO_name": "GES-57", "CARD_short_name": "GES-57", "ARO_description": "GES-57 is a class A GES-like beta-lactamase.", "ARO_category": {"36205": {"category_aro_accession": "3000066", "category_aro_cvterm_id": "36205", "category_aro_name": "GES beta-lactamase", "category_aro_description": "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6060": {"model_id": "6060", "model_name": "CARB-57", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8880": {"protein_sequence": {"accession": "QVO43827.1", "sequence": "MKKLFLLAGLMVCSTLSYASQLNEDISLIEQQTSSRIGVSVWDTQTDERWDYRGDERFPLMSTFKTLACATMLSDMDSGKLSKNATAKVDERSIVVWSPVMDKLAGQNTRVEHACEAAMLMSDNTAANLVLNEIGGPKAVTMFLRTIGDKATRLDRLEPRLNEATPGDNRDTTTPNAMVNTLRTLIEGETLSYESRVQLKIWMQDNKVSDSLMRSVLPTGWSIADRSGAGGHGSRGINAIIWKENHRPVYISIYVTETELSLQARDQLIAQISQLILQKYKDN"}, "dna_sequence": {"accession": "MZ092820.1", "fmin": "0", "fmax": "852", "strand": "+", "sequence": "ATGAAAAAGTTATTTTTGTTGGCTGGGCTAATGGTTTGCTCAACCCTAAGTTACGCTTCCCAACTGAATGAAGACATTTCTCTCATCGAACAACAAACCTCAAGCAGAATTGGAGTCTCGGTTTGGGATACGCAAACCGATGAGCGCTGGGATTACCGTGGCGATGAACGCTTCCCACTCATGAGCACATTCAAAACCTTGGCTTGCGCCACAATGCTAAGTGATATGGACAGCGGTAAGCTAAGTAAAAATGCGACCGCGAAAGTCGATGAGCGCAGCATCGTTGTGTGGTCTCCAGTGATGGACAAACTCGCAGGCCAAAACACACGCGTAGAACACGCTTGTGAAGCCGCGATGTTGATGAGTGATAATACTGCTGCCAACTTAGTATTGAATGAAATCGGCGGTCCTAAGGCCGTGACAATGTTTCTGCGAACTATTGGTGATAAAGCGACGCGCCTAGATAGATTAGAACCACGTTTGAACGAAGCGACACCGGGAGACAACCGCGACACAACCACACCTAACGCCATGGTAAACACTCTGCGAACCTTGATTGAAGGAGAAACGTTGTCTTACGAGTCTCGCGTACAATTAAAAATCTGGATGCAGGACAACAAGGTTTCAGACTCGTTAATGCGTTCAGTATTACCAACAGGTTGGTCTATCGCCGACCGCTCTGGTGCGGGTGGTCACGGTTCGCGTGGTATTAACGCAATCATATGGAAGGAAAACCATCGTCCTGTTTACATTAGTATCTATGTCACAGAAACCGAGCTATCACTTCAAGCCAGAGACCAGCTCATCGCGCAAATCAGTCAGTTGATTTTACAGAAATACAAAGATAATTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "46624", "NCBI_taxonomy_name": "Vibrio diabolicus", "NCBI_taxonomy_id": "50719"}}}}, "ARO_accession": "3007836", "ARO_id": "46623", "ARO_name": "CARB-57", "CARD_short_name": "CARB-57", "ARO_description": "CARB-57 is a class A carbenicillin-hydrolyzing CARB-like beta-lactamase.", "ARO_category": {"36230": {"category_aro_accession": "3000091", "category_aro_cvterm_id": "36230", "category_aro_name": "CARB beta-lactamase", "category_aro_description": "CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6061": {"model_id": "6061", "model_name": "CARB-58", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "600"}}, "model_sequences": {"sequence": {"8881": {"protein_sequence": {"accession": "QYJ63007.1", "sequence": "MLWSSNDVTQQGSRPKTKLAILWSLMLLYKMCDNQNYGVTYMKLLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYTSQSR"}, "dna_sequence": {"accession": "MT990446.1", "fmin": "54", "fmax": "1044", "strand": "+", "sequence": "ATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGCCATATTATGGAGCCTCATGCTTTTATATAAAATGTGTGACAATCAAAATTATGGGGTTACTTACATGAAGCTTTTATTGGCATTTTCGCTTTTAATACCATCCGTGGTTTTTGCAAGTAGTTCAAAGTTTCAGCAAGTTGAACAAGACGTTAAGGCAATTGAAGTTTCTCTTTCTGCTCGTATAGGTGTTTCCGTTCTTGATACTCAAAATGGAGAATATTGGGATTACAATGGCAATCAGCGCTTCCCGTTAACAAGTACTTTTAAAACAATAGCTTGCGCTAAATTACTATATGATGCTGAGCAAGGAAAAGTTAATCCCAATAGTACAGTCGAGATTAAGAAAGCAGATCTTGTGACCTATTCCCCTGTAATAGAAAAGCAAGTAGGGCAGGCAATCACACTCGATGATGCGTGCTTCGCAACTATGACTACAAGTGATAATACTGCGGCAAATATCATCCTAAGTGCTGTAGGTGGCCCCAAAGGCGTTACTGATTTTTTAAGACAAATTGGGGACAAAGAGACTCGTCTAGACCGTATTGAGCCTGATTTAAATGAAGGTAAGCTCGGTGATTTGAGGGATACGACAACTCCTAAGGCAATAGCCAGTACTTTGAATAAATTTTTATTTGGTTCCGCGCTATCTGAAATGAACCAGAAAAAATTAGAGTCTTGGATGGTGAACAATCAAGTCACTGGTAATTTACTACGTTCAGTATTGCCGGCGGGATGGAACATTGCGGATCGCTCAGGTGCTGGCGGATTTGGTGCTCGGAGTATTACAGCAGTTGTGTGGAGTGAGCATCAAGCCCCAATTATTGTGAGCATCTATCTAGCTCAAACACAGGCTTCAATGGCAGAGCGAAATGATGCGATTGTTAAAATTGGTCATTCAATTTTTGACGTTTATACATCACAGTCGCGCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35805", "NCBI_taxonomy_name": "Salmonella enterica subsp. enterica serovar Schwarzengrund", "NCBI_taxonomy_id": "340190"}}}}, "ARO_accession": "3007837", "ARO_id": "46625", "ARO_name": "CARB-58", "CARD_short_name": "CARB-58", "ARO_description": "CARB-58 is a PSE family class A carbenicillin-hydrolyzing CARB-like beta-lactamase.", "ARO_category": {"36230": {"category_aro_accession": "3000091", "category_aro_cvterm_id": "36230", "category_aro_name": "CARB beta-lactamase", "category_aro_description": "CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}, "6062": {"model_id": "6062", "model_name": "tet(65)", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "575"}}, "model_sequences": {"sequence": {"8885": {"protein_sequence": {"accession": "WPF67354.1", "sequence": "MLTTASLDAVGLGLVLPILPALLGQVGSAASTIPMHVGLLTALYAVMQFLCAPVLGRLSDRFGRRRVLLASLAGATVDYLILALTSTLWVFYVARAVAGITGATNAVTATVIADVTPPAERAKRYGWLGACYGGGMIAGPVIGGLFGGFSPHLPFLVAALLTAVNLTLSLSMLHETRPDLPIKSQESASTSAPFRLQAIQGVVPLIAAFGLVQLIGQAPGSTWVLFTQQRLDWSPVEVGISLSLFGLVQVLVQAVLTGRVVTRLGETRTIYLGIVADASGLIGLAFVTGSWAMMPILAALGVGGITVPALQTLLSQRTPEQHQGRLQGHLASLNSLTSILGPIAFTTIFALSQIDADGTLWFCAAALYIPCAILVTRNARSSG"}, "dna_sequence": {"accession": "CP123906.1", "fmin": "34168", "fmax": "35320", "strand": "-", "sequence": "GTGCTCACTACCGCCAGCCTCGACGCCGTGGGGCTAGGCCTGGTTCTCCCGATCCTGCCCGCACTACTGGGTCAGGTCGGCTCGGCCGCAAGCACTATCCCCATGCATGTCGGATTGCTTACCGCGCTCTACGCGGTAATGCAGTTCCTTTGCGCTCCGGTACTGGGCAGACTGTCCGATCGCTTCGGCCGCCGTCGAGTACTGTTGGCTTCCTTGGCCGGCGCGACTGTCGACTATCTCATTCTGGCCTTGACTTCGACCCTCTGGGTCTTCTACGTAGCACGGGCTGTCGCGGGCATCACCGGGGCAACAAATGCCGTGACCGCCACCGTGATCGCCGACGTCACCCCACCCGCAGAGCGGGCCAAGCGATACGGATGGCTCGGGGCGTGCTACGGCGGAGGAATGATCGCCGGCCCCGTAATCGGCGGTCTCTTCGGTGGCTTCTCACCCCATTTGCCGTTCCTCGTAGCTGCTCTCCTGACGGCGGTGAATCTCACTCTCAGCTTGAGCATGCTGCACGAGACAAGACCAGATCTCCCAATCAAGTCACAGGAGTCAGCATCGACGTCTGCGCCTTTTCGACTCCAAGCTATCCAGGGGGTGGTGCCCCTCATTGCGGCTTTCGGCCTCGTACAGCTCATCGGCCAGGCCCCCGGCTCGACGTGGGTTCTGTTCACGCAACAACGTCTCGACTGGAGCCCCGTCGAAGTCGGGATTTCCTTGTCCCTCTTCGGTCTGGTGCAGGTGCTTGTTCAGGCCGTCCTCACCGGACGGGTCGTGACGCGACTCGGCGAAACTAGAACGATCTATCTCGGCATTGTCGCCGACGCGTCGGGTCTCATAGGTCTCGCATTCGTCACCGGCTCCTGGGCGATGATGCCCATCCTCGCAGCACTCGGAGTCGGAGGTATCACGGTCCCGGCCCTGCAGACACTGCTCTCCCAACGTACTCCCGAGCAGCACCAAGGCCGGCTGCAAGGCCACCTCGCTAGCCTCAACAGCCTCACATCAATCCTCGGGCCTATTGCCTTCACGACGATCTTCGCCCTGAGTCAGATAGACGCCGATGGCACTCTATGGTTCTGCGCCGCTGCGCTCTACATTCCTTGTGCGATCCTCGTCACAAGGAACGCAAGATCCTCTGGGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "46627", "NCBI_taxonomy_name": "Corynebacterium sp. 22KM0430", "NCBI_taxonomy_id": "2989735"}}}}, "ARO_accession": "3007838", "ARO_id": "46626", "ARO_name": "tet(65)", "CARD_short_name": "tet(65)", "ARO_description": "tet(65) is a tetracycline efflux gene identified from a Corynebacterium oculi plasmid.", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}}, "6063": {"model_id": "6063", "model_name": "CIM-1", "model_type": "protein homolog model", "model_type_id": "40292", "model_description": "Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.", "model_param": {"blastp_bit_score": {"param_type": "BLASTP bit-score", "param_description": "The BLASTP bit-score is a numerical value that describes the overall quality of an alignment. Higher numbers correspond to higher similarity. The bit-score (S) is determined by the following formula: S = (\u03bb \u00d7 S \u2212 lnK)/ ln2 where \u03bb is the Gumble distribution constant, S is the raw alignment score, and K is a constant associated with the scoring matrix. This parameter is used by AMR detection models that use a protein reference sequence, e.g. the protein homolog model. The BLASTP bit-score parameter is a curated value determined from BLASTP analysis of the canonical reference sequence of a specific AMR-associated protein against the database of CARD reference sequence. This value establishes a threshold for computational prediction of RGI Strict match (above bit-score cut-off) or Loose match (below bit-score cut-off).", "param_type_id": "40725", "param_value": "475"}}, "model_sequences": {"sequence": {"8883": {"protein_sequence": {"accession": "WP_123865086.1", "sequence": "MKSVSQILLLSLFLFFLNCNTKKPSHVPKVVFKTDNLTVIQLSDHVYQHISYLNTDSFGRVPCNGMVVKQGDETVILDTPSDDKSSADLISWIKNNLNAGVNAVVATHFHNDCLGGLKEFDKNKIPSYASKKTIGLAQKNNANIPQHSFDNDLTLKVGSTNVFVKYFGEGHTKDNVVAYFPDERIMFGGCLIKEIGAGKGYLGDANVKDWSATVAKIKKHYPDVKIIIPGHGDTGGIKLLDYTIALFKDES"}, "dna_sequence": {"accession": "NZ_CP033828.1", "fmin": "721258", "fmax": "722014", "strand": "+", "sequence": "ATGAAGTCCGTATCCCAAATACTATTACTTTCCCTGTTTTTATTTTTTTTGAATTGCAATACCAAGAAACCTTCACATGTGCCTAAGGTAGTCTTTAAAACCGATAACCTCACCGTTATTCAGTTGTCCGATCATGTGTACCAGCATATTTCTTACCTGAATACAGACTCTTTTGGCCGGGTACCCTGCAACGGAATGGTTGTAAAGCAGGGAGATGAAACCGTAATATTAGATACTCCTTCTGATGACAAAAGTTCAGCAGACCTTATTTCCTGGATTAAAAATAATCTGAATGCAGGTGTTAATGCTGTCGTTGCTACTCATTTTCACAATGACTGCTTGGGCGGTCTTAAAGAATTTGATAAAAATAAGATCCCTTCCTATGCCAGTAAGAAAACAATCGGTCTTGCTCAAAAGAATAATGCAAATATTCCACAGCATAGTTTTGACAATGATCTGACATTAAAAGTCGGGAGTACGAATGTTTTTGTGAAATATTTCGGTGAAGGCCATACAAAAGATAATGTAGTAGCCTACTTTCCTGATGAACGGATTATGTTTGGAGGTTGTTTGATCAAAGAAATAGGAGCAGGCAAAGGCTACTTAGGAGATGCTAATGTAAAAGACTGGTCAGCTACCGTGGCCAAGATAAAAAAACATTATCCTGATGTGAAAATTATCATCCCGGGTCATGGTGATACAGGAGGAATAAAACTACTGGATTATACGATTGCCCTTTTCAAGGATGAATCATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36916", "NCBI_taxonomy_name": "Chryseobacterium indologenes", "NCBI_taxonomy_id": "253"}}}}, "ARO_accession": "3007840", "ARO_id": "46629", "ARO_name": "CIM-1", "CARD_short_name": "CIM-1", "ARO_description": "CIM-1 is a CIM-like carbapenem-hydrolyzing metallo-beta-lactamase identified from Chryseobacterium indologenes.", "ARO_category": {"46628": {"category_aro_accession": "3007839", "category_aro_cvterm_id": "46628", "category_aro_name": "CIM beta-lactamase", "category_aro_description": "CIM (C. indologenes MBL) are a family of subclass B1 metallo-beta-lactamases originally identified from Chryseobacterium indologenes, and which exhibit carbapenem-hydrolyzing activity.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}}}, "$update": {"4": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "7": {"$update": {"ARO_description": "CTX-M-130 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "9": {"$update": {"ARO_description": "ACT-35 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "15": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"931": {"$update": {"dna_sequence": {"$update": {"fmin": "31"}}}}}}}}}}, "21": {"$update": {"ARO_description": "OXA-329 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "22": {"$update": {"ARO_description": "ACT-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "23": {"$update": {"ARO_description": "OXA-371 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "31": {"$update": {"ARO_description": "CTX-M-155 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "32": {"$update": {"ARO_description": "DHA-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "46": {"$update": {"ARO_description": "CMY-114 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "53": {"$update": {"ARO_description": "MOX-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "57": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "59": {"$update": {"ARO_description": "OXA-256 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "61": {"$update": {"ARO_description": "OXA-330 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "64": {"$update": {"ARO_description": "CMY-70 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "65": {"$update": {"ARO_description": "GES-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "66": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "67": {"$update": {"ARO_description": "OXA-391 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "70": {"$update": {"ARO_description": "NDM-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "72": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "74": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "76": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "80": {"$update": {"ARO_description": "ACT-29 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "82": {"$update": {"ARO_description": "PER-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "93": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "94": {"$update": {"ARO_description": "CMY-79 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "98": {"$update": {"ARO_description": "CMY-48 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "103": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "113": {"$update": {"ARO_description": "VEB-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "123": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "125": {"$update": {"ARO_description": "SHV-182 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "135": {"$update": {"ARO_description": "SME-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "148": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "161": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "163": {"$update": {"ARO_description": "OXA-376 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "167": {"$update": {"ARO_description": "CMY-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "177": {"$update": {"ARO_description": "IMP-51 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "180": {"$update": {"ARO_description": "DHA-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "187": {"$update": {"ARO_description": "OXA-348 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "188": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "190": {"$update": {"ARO_description": "OXA-195 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "194": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "202": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "204": {"$update": {"ARO_description": "VIM-43 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "208": {"$update": {"ARO_description": "CMY-105 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "210": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "211": {"$update": {"ARO_description": "TEM-206 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "214": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "221": {"$update": {"ARO_description": "CMY-100 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "224": {"$update": {"ARO_description": "MIR-2 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "225": {"$update": {"ARO_description": "CTX-M-88 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "230": {"$update": {"ARO_description": "OXA-422 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "231": {"$update": {"ARO_description": "OXA-178 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "236": {"$update": {"ARO_description": "ACT-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "238": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "241": {"$update": {"ARO_description": "ACT-30 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "242": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "244": {"$update": {"ARO_description": "SHV-164 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "246": {"$update": {"ARO_description": "CTX-M-126 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "254": {"$update": {"ARO_description": "OXA-150 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "257": {"$update": {"ARO_description": "ACT-37 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "258": {"$update": {"ARO_description": "OXA-208 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "261": {"$update": {"ARO_description": "CMY-65 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "265": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "273": {"$update": {"ARO_description": "VEB-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "280": {"$update": {"ARO_description": "CTX-M-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "283": {"$update": {"ARO_description": "CMY-85 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "286": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "288": {"$update": {"ARO_description": "CMY-60 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "293": {"$update": {"ARO_description": "SHV-180 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "297": {"$update": {"ARO_description": "CMY-98 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "301": {"$update": {"ARO_description": "CMY-95 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "302": {"$update": {"ARO_description": "TEM-207 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "306": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "307": {"$update": {"ARO_description": "CTX-M-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "308": {"$update": {"ARO_description": "CMY-118 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "309": {"$update": {"ARO_description": "CMY-35 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "310": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "312": {"$update": {"ARO_description": "OXA-167 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "318": {"$update": {"ARO_description": "OXA-358 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "319": {"$update": {"ARO_description": "OXA-366 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "326": {"$update": {"ARO_description": "OXA-225 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "327": {"$update": {"ARO_description": "GES-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "329": {"$update": {"ARO_description": "CTX-M-159 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "333": {"$update": {"ARO_description": "CARB-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "340": {"$update": {"ARO_description": "CMY-51 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "344": {"$update": {"ARO_description": "SHV-188 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "351": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8842": {"protein_sequence": {"accession": "HBX2855210.1", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARATTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}, "dna_sequence": {"accession": "DAGOBI010000132.1", "fmin": "1383", "fmax": "2244", "strand": "+", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGCCACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGAGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATCGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35915", "NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573"}}}, "$delete": ["1875"]}}}, "ARO_category": {"$delete": ["35939"]}}}, "362": {"$update": {"ARO_description": "CTX-M-151 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "364": {"$update": {"ARO_description": "CMY-83 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "369": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "371": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "373": {"$update": {"ARO_description": "MIR-3 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "374": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "378": {"$update": {"ARO_description": "TEM-214 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "379": {"$update": {"ARO_description": "OXA-148 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "380": {"$update": {"ARO_description": "CTX-M-147 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "397": {"$update": {"ARO_description": "OXA-357 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "399": {"$update": {"ARO_description": "MIR-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "401": {"$update": {"ARO_description": "ACT-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "404": {"$update": {"ARO_description": "OXA-217 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "407": {"$update": {"ARO_description": "OXA-352 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "408": {"$update": {"ARO_description": "OXA-380 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "412": {"$update": {"ARO_description": "OXA-117 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "414": {"$update": {"ARO_description": "OXA-377 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "418": {"$update": {"ARO_description": "OXA-325 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "422": {"$update": {"ARO_description": "FOX-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "423": {"$update": {"ARO_description": "DHA-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "424": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "433": {"$update": {"ARO_description": "ACT-25 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "437": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "439": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "447": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "449": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "469": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "488": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "494": {"$update": {"ARO_description": "KPC-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "495": {"$update": {"ARO_description": "CMY-28 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "496": {"$update": {"ARO_description": "KPC-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "513": {"$update": {"ARO_description": "CARB-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "519": {"$update": {"ARO_description": "VIM-26 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "521": {"$update": {"ARO_description": "OXA-386 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "527": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "529": {"$update": {"ARO_description": "SHV-185 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "533": {"$update": {"ARO_description": "CARB-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "545": {"$update": {"ARO_description": "GES-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "550": {"$update": {"ARO_description": "CMY-71 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "553": {"$update": {"ARO_description": "VIM-35 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "557": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "565": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "576": {"$update": {"ARO_description": "MIR-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "578": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "583": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "586": {"$update": {"ARO_description": "VIM-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "591": {"$update": {"ARO_description": "CTX-M-122 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "595": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "604": {"$update": {"ARO_description": "OXA-385 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "608": {"$update": {"ARO_description": "OXA-361 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "610": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "611": {"$update": {"ARO_description": "OXA-328 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "619": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "629": {"$update": {"ARO_description": "VIM-28 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "633": {"$update": {"ARO_description": "OXA-355 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "635": {"$update": {"ARO_description": "OXA-332 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "646": {"$update": {"ARO_description": "OXA-349 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "649": {"$update": {"ARO_description": "OXA-115 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "657": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "658": {"$update": {"ARO_description": "CMY-104 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "663": {"$update": {"ARO_description": "ACT-36 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "664": {"$update": {"ARO_description": "CMY-43 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "669": {"$update": {"ARO_description": "MIR-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "673": {"$update": {"ARO_description": "IMP-48 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "677": {"$update": {"ARO_description": "OXA-171 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "679": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "683": {"$update": {"ARO_description": "CMY-75 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "684": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "685": {"$update": {"ARO_description": "OXA-239 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "695": {"$update": {"ARO_description": "CMY-66 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "698": {"$update": {"ARO_description": "TEM-205 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "700": {"$update": {"ARO_description": "ACT-31 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "701": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "705": {"$update": {"ARO_description": "CMY-116 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "709": {"$update": {"ARO_description": "TEM-213 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "711": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "723": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "728": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1158": {"$update": {"dna_sequence": {"$update": {"fmin": "1"}}}}}}}}}}, "749": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "750": {"$update": {"ARO_description": "SHV-172 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "751": {"$update": {"ARO_description": "TEM-217 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "757": {"$update": {"ARO_description": "CMY-80 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "766": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "767": {"$update": {"ARO_description": "OXA-207 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "768": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "770": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "772": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"960": {"$update": {"dna_sequence": {"$update": {"fmin": "1"}}}}}}}}}}, "775": {"$update": {"ARO_description": "CMY-113 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "779": {"$update": {"ARO_description": "OXA-350 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "788": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "791": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "795": {"$update": {"ARO_description": "OXA-324 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "806": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "813": {"$update": {"ARO_description": "OXA-216 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "817": {"$update": {"ARO_description": "CTX-M-158 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "818": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "825": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "829": {"$update": {"ARO_description": "DHA-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "830": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "832": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "844": {"$update": {"ARO_description": "CMY-117 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "846": {"$update": {"ARO_description": "DHA-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "854": {"$update": {"ARO_description": "CMY-58 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "864": {"$update": {"ARO_description": "CMY-61 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "873": {"$update": {"ARO_description": "KPC-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "877": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "878": {"$update": {"ARO_description": "CTX-M-142 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "887": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "889": {"$update": {"ARO_description": "CMY-74 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "890": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "894": {"$update": {"ARO_description": "CMY-90 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "895": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "896": {"$update": {"ARO_description": "CTX-M-131 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "897": {"$update": {"ARO_description": "OXA-383 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "898": {"$update": {"ARO_description": "VEB-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "906": {"$update": {"ARO_description": "CARB-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "908": {"$update": {"ARO_description": "CTX-M-139 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "911": {"$update": {"ARO_description": "CMY-50 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "915": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "916": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1842": {"$update": {"dna_sequence": {"$update": {"fmin": "1"}}}}}}}}, "ARO_description": "OXA-36 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "917": {"$update": {"ARO_description": "SHV-186 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "923": {"$update": {"ARO_description": "VIM-25 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "926": {"$update": {"ARO_description": "KPC-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "927": {"$update": {"ARO_description": "OXA-381 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "929": {"$update": {"ARO_description": "GES-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "947": {"$update": {"ARO_description": "OXA-100 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "951": {"$update": {"ARO_description": "ACT-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "955": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "958": {"$update": {"ARO_description": "OXA-418 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "961": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "962": {"$update": {"ARO_description": "OXA-356 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "963": {"$update": {"ARO_description": "CMY-69 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "965": {"$update": {"ARO_description": "OXA-333 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "968": {"$update": {"ARO_description": "MIR-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "969": {"$update": {"ARO_description": "VEB-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "973": {"$update": {"ARO_description": "OXA-378 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "990": {"$update": {"ARO_description": "FOX-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "992": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "994": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "996": {"$update": {"ARO_description": "CMY-77 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "998": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1010": {"$update": {"ARO_description": "TEM-209 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1014": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1026": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1028": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1029": {"$update": {"ARO_description": "CMY-102 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1032": {"$update": {"ARO_description": "OXA-365 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1043": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1052": {"$update": {"ARO_description": "OXA-206 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1053": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1057": {"$update": {"ARO_description": "CTX-M-114 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1060": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1062": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1064": {"$update": {"ARO_description": "CTX-M-141 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1065": {"$update": {"ARO_description": "OXA-384 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1071": {"$update": {"ARO_description": "DHA-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1076": {"$update": {"ARO_description": "IMP-37 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1077": {"$update": {"ARO_description": "OXA-420 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1080": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1083": {"$update": {"ARO_description": "OXA-323 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1094": {"$update": {"ARO_description": "CARB-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1095": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1103": {"$update": {"ARO_description": "CMY-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1114": {"$update": {"ARO_description": "ACT-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1115": {"$update": {"ARO_description": "OXA-435 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1120": {"$update": {"ARO_description": "IMI-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1122": {"$update": {"ARO_description": "OXA-180 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1126": {"$update": {"ARO_description": "OXA-184 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1133": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1136": {"$update": {"ARO_description": "MIR-6 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1140": {"$update": {"ARO_description": "CMY-86 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1141": {"$update": {"ARO_description": "OXA-169 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1147": {"$update": {"ARO_description": "CMY-63 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1148": {"$update": {"ARO_description": "OXA-363 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1151": {"$update": {"ARO_description": "OXA-240 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1158": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1163": {"$update": {"ARO_description": "CMY-94 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1164": {"$update": {"ARO_description": "MIR-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1169": {"$update": {"ARO_description": "OXA-360 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1170": {"$update": {"ARO_description": "CMY-46 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1172": {"$update": {"ARO_description": "OXA-194 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1177": {"$update": {"ARO_description": "KPC-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1178": {"$update": {"ARO_description": "CMY-81 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1186": {"$update": {"ARO_description": "OXA-327 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1190": {"$update": {"ARO_description": "OXA-354 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1195": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1199": {"$update": {"ARO_description": "SHV-168 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1201": {"$update": {"ARO_description": "CARB-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1205": {"$update": {"ARO_description": "VIM-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1207": {"$update": {"ARO_description": "DHA-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1208": {"$update": {"ARO_description": "SHV-173 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1216": {"$update": {"ARO_description": "SHV-119 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1217": {"$update": {"ARO_description": "OXA-139 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1218": {"$update": {"ARO_description": "TEM-219 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1228": {"$update": {"ARO_description": "CMY-30 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1234": {"$update": {"ARO_description": "MIR-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1238": {"$update": {"ARO_description": "OXA-397 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1239": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1247": {"$update": {"ARO_description": "CMY-72 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1250": {"$update": {"ARO_description": "CTX-M-96 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1251": {"$update": {"ARO_description": "CTX-M-157 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1253": {"$update": {"ARO_description": "GES-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1259": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1262": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1268": {"$update": {"ARO_description": "CMY-115 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1276": {"$update": {"ARO_description": "OXA-210 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1277": {"$update": {"ARO_description": "GES-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1286": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1287": {"$update": {"model_sequences": {"$update": {"sequence": {"$update": {"1665": {"$update": {"dna_sequence": {"$update": {"fmin": "1"}}}}}}}}}}, "1293": {"$update": {"ARO_description": "OXA-197 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1309": {"$update": {"ARO_description": "ACT-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1319": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1322": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1326": {"$update": {"ARO_description": "OXA-170 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1334": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1343": {"$update": {"ARO_description": "OXA-166 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1346": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1352": {"$update": {"ARO_description": "OXA-251 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1357": {"$update": {"ARO_description": "CTX-M-132 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1359": {"$update": {"ARO_description": "OXA-233 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1362": {"$update": {"ARO_description": "IMP-31 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1364": {"$update": {"ARO_description": "CMY-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1377": {"$update": {"ARO_description": "CTX-M-60 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1383": {"$update": {"ARO_description": "IMI-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1384": {"$update": {"ARO_description": "OXA-382 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1389": {"$update": {"ARO_description": "KPC-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1402": {"$update": {"ARO_description": "OXA-390 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1403": {"$update": {"ARO_description": "OXA-388 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1406": {"$update": {"ARO_description": "OXA-121 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1407": {"$update": {"ARO_description": "CMY-62 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1412": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1419": {"$update": {"ARO_description": "OXA-454 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1429": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1430": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1431": {"$update": {"ARO_description": "GES-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1438": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8843": {"protein_sequence": {"accession": "HBU8935839.1", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}, "dna_sequence": {"accession": "DAGGWD010000033.1", "fmin": "85", "fmax": "946", "strand": "+", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGTGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGTTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35915", "NCBI_taxonomy_name": "Klebsiella pneumoniae", "NCBI_taxonomy_id": "573"}}}, "$delete": ["1147"]}}}, "ARO_category": {"$delete": ["35939"]}}}, "1439": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1448": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1451": {"$update": {"ARO_description": "MIR-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1452": {"$update": {"ARO_description": "TEM-216 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1454": {"$update": {"ARO_description": "CMY-112 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1461": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1466": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1468": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1472": {"$update": {"ARO_description": "DHA-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1475": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1484": {"$update": {"ARO_description": "ACT-27 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1485": {"$update": {"ARO_description": "MOX-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1486": {"$update": {"ARO_description": "CARB-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1487": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1490": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1492": {"$update": {"ARO_description": "MOX-3 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1495": {"$update": {"ARO_description": "ACT-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1501": {"$update": {"ARO_description": "CMY-49 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1504": {"$update": {"ARO_description": "CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1506": {"$update": {"ARO_description": "ACT-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1511": {"$update": {"ARO_description": "OXA-423 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1517": {"$update": {"ARO_description": "OXA-33 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1520": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1521": {"$update": {"ARO_description": "VIM-32 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1522": {"$update": {"ARO_description": "IMP-38 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1527": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1530": {"$update": {"ARO_description": "OXA-67 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1533": {"$update": {"ARO_description": "SHV-143 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1536": {"$update": {"ARO_description": "OXA-421 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1538": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1541": {"$update": {"ARO_description": "ACT-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1543": {"$update": {"ARO_description": "CMY-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1555": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1557": {"$update": {"ARO_description": "SHV-187 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1565": {"$update": {"ARO_description": "ACT-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1568": {"$update": {"ARO_description": "OXA-183 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1572": {"$update": {"ARO_description": "OXA-205 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1573": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1578": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1585": {"$update": {"ARO_description": "CMY-73 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1591": {"$update": {"ARO_description": "CMY-64 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1597": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1598": {"$update": {"ARO_description": "OXA-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1599": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1603": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1611": {"$update": {"ARO_description": "SME-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1616": {"$update": {"ARO_description": "CTX-M-152 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1618": {"$update": {"ARO_description": "OXA-362 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1620": {"$update": {"ARO_description": "CTX-M-156 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1621": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1625": {"$update": {"ARO_description": "OXA-179 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1628": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1634": {"$update": {"ARO_description": "CMY-78 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1637": {"$update": {"ARO_description": "MOX-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1638": {"$update": {"ARO_description": "CMY-111 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1639": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8846": {"protein_sequence": {"accession": "HBU8836957.1", "sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR"}, "dna_sequence": {"accession": "DAGGVK010000093.1", "fmin": "2639", "fmax": "3500", "strand": "+", "sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTACTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAGGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCAGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35914", "NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562"}}}, "$delete": ["1395"]}}}, "ARO_category": {"$delete": ["35939"]}}}, "1640": {"$update": {"ARO_description": "MIR-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1644": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1649": {"$update": {"ARO_description": "DHA-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1654": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1659": {"$update": {"ARO_description": "OXA-258 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1660": {"$update": {"ARO_description": "OXA-375 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1668": {"$update": {"ARO_description": "CMY-68 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1672": {"$update": {"ARO_description": "TEM-211 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1685": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1686": {"$update": {"ARO_description": "OXA-34 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1694": {"$update": {"ARO_description": "OXA-353 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1695": {"$update": {"ARO_description": "DHA-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1700": {"$update": {"ARO_description": "ACT-28 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1705": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1716": {"$update": {"ARO_description": "OXA-398 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1722": {"$update": {"ARO_description": "TEM-184 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1727": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1732": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1733": {"$update": {"ARO_description": "OXA-415 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1736": {"$update": {"ARO_description": "GES-24 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1739": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1741": {"$update": {"ARO_description": "OXA-359 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1742": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1743": {"$update": {"ARO_description": "OXA-338 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1747": {"$update": {"ARO_description": "CMY-103 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1753": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1756": {"$update": {"ARO_description": "CMY-93 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1758": {"$update": {"ARO_description": "OXA-326 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1761": {"$update": {"ARO_description": "OXA-351 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1768": {"$update": {"ARO_description": "CTX-M-144 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1774": {"$update": {"ARO_description": "CTX-M-106 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1776": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1784": {"$update": {"ARO_description": "OXA-334 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1787": {"$update": {"ARO_description": "VIM-42 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1792": {"$update": {"ARO_description": "DHA-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1793": {"$update": {"ARO_description": "DHA-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1796": {"$update": {"ARO_description": "CMY-119 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1798": {"$update": {"ARO_description": "SHV-183 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1800": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1802": {"$update": {"ARO_description": "OXA-168 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1811": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8841": {"protein_sequence": {"accession": "AAA25741.1", "sequence": "MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYTSQSR"}, "dna_sequence": {"accession": "M69058.1", "fmin": "145", "fmax": "1012", "strand": "+", "sequence": "ATGAAGTTTTTATTGGCATTTTCGCTTTTAATACCATCCGTGGTTTTTGCAAGTAGTTCAAAGTTTCAGCAAGTTGAACAAGACGTTAAGGCAATTGAAGTTTCTCTTTCTGCTCGTATAGGTGTTTCCGTTCTTGATACTCAAAATGGAGAATATTGGGATTACAATGGCAATCAGCGCTTCCCGTTAACAAGTACTTTTAAAACAATAGCTTGCGCTAAATTACTATATGATGCTGAGCAAGGAAAAGTTAATCCCAATAGTACAGTCGAGATTAAGAAAGCAGATCTTGTGACCTATTCCCCTGTAATAGAAAAGCAAGTAGGGCAGGCAATCACACTCGATGATGCGTGCTTCGCAACTATGACTACAAGTGATAATACTGCGGCAAATATCATCCTAAGTGCTGTAGGTGGCCCCAAAGGCGTTACTGATTTTTTAAGACAAATTGGGGACAAAGAGACTCGTCTAGACCGTATTGAGCCTGATTTAAATGAAGGTAAGCTCGGTGATTTGAGGGATACGACAACTCCTAAGGCAATAGCCAGTACTTTGAATAAATTTTTATTTGGTTCCGCGCTATCTGAAATGAACCAGAAAAAATTAGAGTCTTGGATGGTGAACAATCAAGTCACTGGTAATTTACTACGTTCAGTATTGCCGGCGGGATGGAACATTGCGGATCGCTCAGGTGCTGGCGGATTTGGTGCTCGGAGTATTACAGCAGTTGTGTGGAGTGAGCATCAAGCCCCAATTATTGTGAGCATCTATCTAGCTCAAACACAGGCTTCAATGGCAGAGCGAAATGATGCGATTGTTAAAATTGGTCATTCAATTTTTGACGTTTATACATCACAGTCGCGCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "36752", "NCBI_taxonomy_name": "Pseudomonas aeruginosa", "NCBI_taxonomy_id": "287"}}}, "$delete": ["1096"]}}}}}, "1815": {"$update": {"ARO_description": "CTX-M-134 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1818": {"$update": {"ARO_description": "GES-26 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1827": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1829": {"$update": {"ARO_description": "CMY-87 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1833": {"$update": {"ARO_description": "OXA-374 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1851": {"$update": {"ARO_description": "KPC-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1858": {"$update": {"ARO_description": "OXA-387 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1860": {"$update": {"ARO_description": "OXA-165 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1864": {"$update": {"ARO_description": "CMY-67 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1865": {"$update": {"ARO_description": "ACC-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1871": {"$update": {"ARO_description": "OXA-389 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1874": {"$update": {"ARO_description": "OXA-196 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1875": {"$update": {"ARO_description": "MIR-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1883": {"$update": {"ARO_description": "DHA-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1888": {"$update": {"ARO_description": "MIR-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1893": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1898": {"$update": {"ARO_description": "OXA-379 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1900": {"$update": {"ARO_description": "ACT-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1901": {"$update": {"ARO_description": "CTX-M-51 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1904": {"$update": {"ARO_description": "ACT-32 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1905": {"$update": {"ARO_description": "ACT-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1910": {"$update": {"ARO_description": "CTX-M-136 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1915": {"$update": {"ARO_description": "CMY-47 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1916": {"$update": {"ARO_description": "TEM-208 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1919": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1927": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1929": {"$update": {"ARO_description": "ACT-24 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1932": {"$update": {"ARO_description": "IMP-32 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1933": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1941": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1944": {"$update": {"ARO_description": "CTX-M-148 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1945": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1947": {"$update": {"ARO_description": "CTX-M-160 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1953": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1959": {"$update": {"ARO_description": "ACT-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1967": {"$update": {"ARO_description": "OXA-116 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1968": {"$update": {"ARO_description": "SHV-189 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "1970": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1972": {"$update": {"ARO_description": "OXA-149 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1984": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1985": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "1986": {"$update": {"ARO_description": "OXA-309 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1990": {"$update": {"ARO_description": "CMY-82 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1999": {"$update": {"ARO_description": "TEM-215 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2006": {"$update": {"ARO_description": "IMP-27 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2007": {"$update": {"ARO_description": "OXA-335 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2008": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "2010": {"$update": {"ARO_description": "CTX-M-129 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2012": {"$update": {"ARO_description": "SHV-178 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "2018": {"$update": {"ARO_description": "CMY-76 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2021": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "2027": {"$update": {"ARO_description": "CMY-84 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2036": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "2038": {"$update": {"ARO_description": "KPC-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2039": {"$update": {"ARO_description": "CARB-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2047": {"$update": {"ARO_description": "OXA-322 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2050": {"$update": {"ARO_description": "OXA-331 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2057": {"$update": {"ARO_description": "SHV-179 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "2064": {"$update": {"ARO_description": "TEM-196 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2103": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "2135": {"$update": {"ARO_description": "ACT-33 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "489": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"13201": "N51T"}, "$delete": ["3678"]}, "clinical": {"$insert": {"13201": "N51T"}, "$delete": ["3678"]}}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}, "41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8818": {"protein_sequence": {"accession": "NP_218436.2", "sequence": "MSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIARGSARMASGGTA"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4407527", "fmax": "4408202", "strand": "-", "sequence": "ATGTCTCCGATCGAGCCCGCGGCGTCTGCGATCTTCGGACCGCGGCTTGGCCTTGCTCGGCGGTACGCCGAAGCGTTGGCGGGACCCGGTGTGGAGCGGGGGCTGGTGGGACCCCGCGAAGTCGGTAGGCTATGGGACCGGCATCTACTGAACTGCGCCGTGATCGGTGAGCTCCTCGAACGCGGTGACCGGGTCGTGGATATCGGTAGCGGAGCCGGGTTGCCGGGCGTGCCATTGGCGATAGCGCGGCCGGACCTCCAGGTAGTTCTCCTAGAACCGCTACTGCGCCGCACCGAGTTTCTTCGAGAGATGGTGACAGATCTGGGCGTGGCCGTTGAGATCGTGCGGGGGCGCGCCGAGGAGTCCTGGGTGCAGGACCAATTGGGCGGCAGCGACGCTGCGGTGTCACGGGCGGTGGCCGCGTTGGACAAGTTGACGAAATGGAGCATGCCGTTGATACGGCCGAACGGGCGAATGCTCGCCATCAAAGGCGAGCGGGCTCACGACGAAGTACGGGAGCACCGGCGTGTGATGATCGCATCGGGCGCGGTTGATGTCAGGGTGGTGACATGTGGCGCGAACTATTTGCGTCCGCCCGCGACCGTGGTGTTCGCACGACGTGGAAAGCAGATCGCCCGAGGGTCGGCACGGATGGCGAGTGGAGGGACGGCGTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["8134"]}}}}}, "196": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2430", "2431"]}, "clinical": {"$delete": ["2430", "2431"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8805": {"protein_sequence": {"accession": "NP_218312.1", "sequence": "MTQCASRRKSTPNRAILGAFASARGTRWVATIAGLIGFVLSVATPLLPVVQTTAMLDWPQRGQLGSVTAPLISLTPVDFTATVPCDVVRAMPPAGGVVLGTAPKQGKDANLQALFVVVSAQRVDVTDRNVVILSVPREQVTSPQCQRIEVTSTHAGTFANFVGLKDPSGAPLRSGFPDPNLRPQIVGVFTDLTGPAPPGLAVSATIDTRFSTRPTTLKLLAIIGAIVATVVALIALWRLDQLDGRGSIAQLLLRPFRPASSPGGMRRLIPASWRTFTLTDAVVIFGFLLWHVIGANSSDDGYILGMARVADHAGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASLWMRLPDLAAGLVCWLLLSREVLPRLGPAVEASKPAYWAAAMVLLTAWMPFNNGLRPEGIIALGSLVTYVLIERSMRYSRLTPAALAVVTAAFTLGVQPTGLIAVAALVAGGRPMLRILVRRHRLVGTLPLVSPMLAAGTVILTVVFADQTLSTVLEATRVRAKIGPSQAWYTENLRYYYLILPTVDGSLSRRFGFLITALCLFTAVFIMLRRKRIPSVARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFAAVGAAMAALTTVLVSPSVLRWSRNRMAFLAALFFLLALCWATTNGWWYVSSYGVPFNSAMPKIDGITVSTIFFALFAIAAGYAAWLHFAPRGAGEGRLIRALTTAPVPIVAGFMAAVFVASMVAGIVRQYPTYSNGWSNVRAFVGGCGLADDVLVEPDTNAGFMKPLDGDSGSWGPLGPLGGVNPVGFTPNGVPEHTVAEAIVMKPNQPGTDYDWDAPTKLTSPGINGSTVPLPYGLDPARVPLAGTYTTGAQQQSTLVSAWYLLPKPDDGHPLVVVTAAGKIAGNSVLHGYTPGQTVVLEYAMPGPGALVPAGRMVPDDLYGEQPKAWRNLRFARAKMPADAVAVRVVAEDLSLTPEDWIAVTPPRVPDLRSLQEYVGSTQPVLLDWAVGLAFPCQQPMLHANGIAEIPKFRITPDYSAKKLDTDTWEDGTNGGLLGITDLLLRAHVMATYLSRDWARDWGSLRKFDTLVDAPPAQLELGTATRSGLWSPGKIRIGP"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4246513", "fmax": "4249810", "strand": "+", "sequence": "ATGACACAGTGCGCGAGCAGACGCAAAAGCACCCCAAATCGGGCGATTTTGGGGGCTTTTGCGTCTGCTCGCGGGACGCGCTGGGTGGCCACCATCGCCGGGCTGATTGGCTTTGTGTTGTCGGTGGCGACGCCGCTGCTGCCCGTCGTGCAGACCACCGCGATGCTCGACTGGCCACAGCGGGGGCAACTGGGCAGCGTGACCGCCCCGCTGATCTCGCTGACGCCGGTCGACTTTACCGCCACCGTGCCGTGCGACGTGGTGCGCGCCATGCCACCCGCGGGCGGGGTGGTGCTGGGCACCGCACCCAAGCAAGGCAAGGACGCCAATTTGCAGGCGTTGTTCGTCGTCGTCAGCGCCCAGCGCGTGGACGTCACCGACCGCAACGTGGTGATCTTGTCCGTGCCGCGCGAGCAGGTGACGTCCCCGCAGTGTCAACGCATCGAGGTCACCTCTACCCACGCCGGCACCTTCGCCAACTTCGTCGGGCTCAAGGACCCGTCGGGCGCGCCGCTGCGCAGCGGCTTCCCCGACCCCAACCTGCGCCCGCAGATTGTCGGGGTGTTCACCGACCTGACCGGGCCCGCGCCGCCCGGGCTGGCGGTCTCGGCGACCATCGACACCCGGTTCTCCACCCGGCCGACCACGCTGAAACTGCTGGCGATCATCGGGGCGATCGTGGCCACCGTCGTCGCACTGATCGCGTTGTGGCGCCTGGACCAGTTGGACGGGCGGGGCTCAATTGCCCAGCTCCTCCTCAGGCCGTTCCGGCCTGCATCGTCGCCGGGCGGCATGCGCCGGCTGATTCCGGCAAGCTGGCGCACCTTCACCCTGACCGACGCCGTGGTGATATTCGGCTTCCTGCTCTGGCATGTCATCGGCGCGAATTCGTCGGACGACGGCTACATCCTGGGCATGGCCCGAGTCGCCGACCACGCCGGCTACATGTCCAACTATTTCCGCTGGTTCGGCAGCCCGGAGGATCCCTTCGGCTGGTATTACAACCTGCTGGCGCTGATGACCCATGTCAGCGACGCCAGTCTGTGGATGCGCCTGCCAGACCTGGCCGCCGGGCTAGTGTGCTGGCTGCTGCTGTCGCGTGAGGTGCTGCCCCGCCTCGGGCCGGCGGTGGAGGCCAGCAAACCCGCCTACTGGGCGGCGGCCATGGTCTTGCTGACCGCGTGGATGCCGTTCAACAACGGCCTGCGGCCGGAGGGCATCATCGCGCTCGGCTCGCTGGTCACCTATGTGCTGATCGAGCGGTCCATGCGGTACAGCCGGCTCACACCGGCGGCGCTGGCCGTCGTTACCGCCGCATTCACACTGGGTGTGCAGCCCACCGGCCTGATCGCGGTGGCCGCGCTGGTGGCCGGCGGCCGCCCGATGCTGCGGATCTTGGTGCGCCGTCATCGCCTGGTCGGCACGTTGCCGTTGGTGTCGCCGATGCTGGCCGCCGGCACCGTCATCCTGACCGTGGTGTTCGCCGACCAGACCCTGTCAACGGTGTTGGAAGCCACCAGGGTTCGCGCCAAAATCGGGCCGAGCCAGGCGTGGTATACCGAGAACCTGCGTTACTACTACCTCATCCTGCCCACCGTCGACGGTTCGCTGTCGCGGCGCTTCGGCTTTTTGATCACCGCGCTATGCCTGTTCACCGCGGTGTTCATCATGTTGCGGCGCAAGCGAATTCCCAGCGTGGCCCGCGGACCGGCGTGGCGGCTGATGGGCGTCATCTTCGGCACCATGTTCTTCCTGATGTTCACGCCCACCAAGTGGGTGCACCACTTCGGGCTGTTCGCCGCCGTAGGGGCGGCGATGGCCGCGCTGACGACGGTGTTGGTATCCCCATCGGTGCTGCGCTGGTCGCGCAACCGGATGGCGTTCCTGGCGGCGTTATTCTTCCTGCTGGCGTTGTGTTGGGCCACCACCAACGGCTGGTGGTATGTCTCCAGCTACGGTGTGCCGTTCAACAGCGCGATGCCGAAGATCGACGGGATCACAGTCAGCACAATCTTTTTCGCCCTGTTTGCGATCGCCGCCGGCTATGCGGCCTGGCTGCACTTCGCGCCCCGCGGCGCCGGCGAAGGGCGGCTGATCCGCGCGCTGACGACAGCCCCGGTACCGATCGTGGCCGGTTTCATGGCGGCGGTGTTCGTCGCGTCCATGGTGGCCGGGATCGTGCGACAGTACCCGACCTACTCCAACGGCTGGTCCAACGTGCGGGCGTTTGTCGGCGGCTGCGGACTGGCCGACGACGTACTCGTCGAGCCTGATACCAATGCGGGTTTCATGAAGCCGCTGGACGGCGATTCGGGTTCTTGGGGCCCCTTGGGCCCGCTGGGTGGAGTCAACCCGGTCGGCTTCACGCCCAACGGCGTACCGGAACACACGGTGGCCGAGGCGATCGTGATGAAACCCAACCAGCCCGGCACCGACTACGACTGGGATGCGCCGACCAAGCTGACGAGTCCTGGCATCAATGGTTCTACGGTGCCGCTGCCCTATGGGCTCGATCCCGCCCGGGTACCGTTGGCAGGCACCTACACCACCGGCGCACAGCAACAGAGCACACTCGTCTCGGCGTGGTATCTCCTGCCTAAGCCGGACGACGGGCATCCGCTGGTCGTGGTGACCGCCGCGGGCAAGATCGCCGGCAACAGCGTGCTGCACGGGTACACCCCCGGGCAGACTGTGGTGCTCGAATACGCCATGCCGGGACCCGGAGCGCTGGTACCCGCCGGGCGGATGGTGCCCGACGACCTATACGGAGAGCAGCCCAAGGCGTGGCGCAACCTGCGCTTCGCCCGAGCAAAGATGCCCGCCGATGCCGTCGCGGTCCGGGTGGTGGCCGAGGATCTGTCGCTGACACCGGAGGACTGGATCGCGGTGACCCCGCCGCGGGTACCGGACCTGCGCTCACTGCAGGAATATGTGGGCTCGACGCAGCCGGTGCTGCTGGACTGGGCGGTCGGTTTGGCCTTCCCGTGCCAGCAGCCGATGCTGCACGCCAATGGCATCGCCGAAATCCCGAAGTTCCGCATCACACCGGACTACTCGGCTAAGAAGCTGGACACCGACACGTGGGAAGACGGCACTAACGGCGGCCTGCTCGGGATCACCGACCTGTTGCTGCGGGCCCACGTCATGGCCACCTACCTGTCCCGCGACTGGGCCCGCGATTGGGGTTCCCTGCGCAAGTTCGACACCCTGGTCGATGCCCCTCCCGCCCAGCTCGAGTTGGGCACCGCGACCCGCAGCGGCCTGTGGTCACCGGGCAAGATCCGAATTGGTCCATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2078"]}}}}}, "366": {"$update": {"model_param": {"$delete": ["41343"]}, "model_sequences": {"$update": {"sequence": {"$insert": {"8829": {"protein_sequence": {"accession": "NP_214856.1", "sequence": "MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "410837", "fmax": "412760", "strand": "+", "sequence": "ATGGTCCCCGCCGGTTTGTGCGCATACCGTGATCTGAGGCGTAAACGAGCGAGAAAGTGGGGCGACACGGTGACCCAGCCCGATGACCCACGTCGGGTCGGTGTGATCGTCGAACTGATCGATCACACTATCGCCATCGCCAAACTGAACGAGCGTGGTGATCTAGTACAGCGGTTGACGCGGGCTCGCCAGCGGATCACCGACCCGCAGGTCCGTGTGGTGATCGCCGGGCTGCTCAAACAGGGCAAGAGTCAATTGCTCAATTCGTTGCTCAACCTGCCCGCGGCGCGAGTAGGCGATGACGAGGCCACCGTGGTGATCACCGTCGTAAGCTACAGCGCCCAACCGTCGGCCCGGCTTGTGCTGGCCGCCGGGCCCGACGGGACAACCGCAGCGGTTGACATTCCCGTCGATGACATCAGCACCGATGTGCGTCGGGCTCCGCACGCCGGTGGCCGCGAGGTGTTGCGGGTCGAGGTCGGCGCGCCCAGCCCGCTGCTGCGGGGCGGGCTGGCGTTTATCGATACTCCGGGTGTGGGCGGCCTCGGACAGCCCCACCTGTCGGCGACGCTGGGGCTGCTACCCGAGGCCGATGCCGTCTTGGTGGTCAGCGACACCAGCCAGGAATTCACCGAACCCGAGATGTGGTTCGTGCGGCAGGCCCACCAGATCTGTCCGGTCGGGGCGGTCGTGGCCACCAAGACCGACCTGTATCCGCGCTGGCGGGAGATCGTCAATGCCAATGCAGCACATCTGCAGCGGGCCCGGGTTCCGATGCCGATCATCGCAGTCTCATCACTGTTGCGCAGCCACGCGGTCACGCTTAACGACAAAGAGCTCAACGAAGAGTCCAACTTTCCGGCGATCGTCAAGTTTCTCAGCGAGCAGGTGCTTTCCCGCGCGACGGAGCGAGTGCGTGCTGGGGTACTCGGCGAAATACGTTCGGCAACAGAGCAATTGGCGGTGTCTCTAGGTTCCGAACTATCGGTGGTCAACGACCCGAACCTCCGTGACCGACTTGCTTCGGATTTGGAGCGGCGCAAACGGGAAGCCCAGCAGGCGGTGCAACAGACAGCGCTGTGGCAGCAGGTGCTGGGCGACGGGTTCAACGACCTGACTGCTGACGTGGACCACGACCTACGAACCCGCTTCCGCACCGTCACCGAAGACGCCGAGCGCCAGATCGACTCCTGTGACCCGACTGCGCATTGGGCCGAGATTGGCAACGACGTCGAGAATGCGATCGCCACAGCGGTCGGCGACAACTTCGTGTGGGCATACCAGCGTTCCGAAGCGTTGGCCGACGACGTCGCTCGCTCCTTTGCCGACGCGGGGTTGGACTCGGTCCTGTCAGCAGAGCTGAGCCCCCACGTCATGGGCACCGACTTCGGCCGGCTCAAAGCGCTGGGCCGGATGGAATCGAAACCGCTGCGCCGGGGCCATAAAATGATTATCGGCATGCGGGGTTCCTATGGCGGCGTGGTCATGATTGGCATGCTGTCGTCGGTGGTCGGACTTGGGTTGTTCAACCCGCTATCGGTGGGGGCCGGGTTGATCCTCGGCCGGATGGCATATAAAGAGGACAAACAAAACCGGTTGCTGCGGGTGCGCAGCGAGGCCAAGGCCAATGTGCGGCGCTTCGTCGACGACATTTCGTTCGTCGTCAGCAAACAATCACGGGATCGGCTCAAGATGATCCAGCGTCTGCTGCGCGACCACTACCGCGAGATCGCCGAAGAGATCACCCGGTCGCTCACCGAGTCCCTGCAGGCGACCATCGCGGCGGCGCAGGTGGCGGAAACCGAGCGGGACAATCGAATTCGGGAACTTCAGCGGCAATTGGGTATCCTGAGCCAGGTCAACGACAACCTTGCCGGCTTGGAGCCAACCTTGACGCCCCGGGCGAGCTTGGGACGAGCGTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2099"]}}}, "ARO_category": {"$update": {"40040": {"$update": {"category_aro_name": "ethambutol resistant iniA"}}}}}}, "505": {"$update": {"model_param": {"$update": {"41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8831": {"protein_sequence": {"accession": "NP_214857.1", "sequence": "MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPLRIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANVPITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLVPADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDAMLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNRALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERSGLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFEELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHWRRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "412756", "fmax": "414238", "strand": "+", "sequence": "GTGAGCACCAGCGACCGGGTCCGCGCGATTCTGCACGCAACCATCCAGGCCTACCGGGGTGCGCCGGCCTATCGTCAGCGTGGCGACGTTTTTTGCCAGCTGGACCGCATCGGTGCGCGCCTAGCCGAACCGCTGCGCATCGCGTTGGCTGGCACACTCAAGGCCGGAAAATCCACTCTCGTCAACGCCCTTGTCGGCGACGACATCGCTCCGACCGATGCCACCGAGGCCACCCGGATTGTGACCTGGTTCCGGCACGGTCCGACACCGCGGGTCACCGCCAACCATCGCGGCGGTCGACGCGCCAACGTGCCGATCACCCGTCGGGGCGGGCTGAGTTTCGACCTGCGCAGGATCAACCCGGCCGAGCTGATCGACCTGGAAGTCGAGTGGCCAGCCGAGGAACTCATCGACGCCACCATTGTTGACACCCCGGGAACGTCGTCGTTGGCATGCGATGCCTCCGAGCGCACGTTGCGGCTGCTGGTCCCCGCCGACGGGGTGCCTCGGGTGGATGCGGTGGTGTTCCTGTTGCGCACCCTGAACGCCGCTGACGTCGCGCTGCTCAAACAGATCGGTGGGCTGGTCGGCGGGTCGGTGGGAGCCCTGGGCATCATCGGGGTGGCGTCTCGCGCGGATGAGATCGGCGCGGGCCGCATCGACGCGATGCTCTCGGCCAACGACGTGGCCAAGCGGTTCACCCGCGAACTGAACCAGATGGGCATTTGCCAGGCGGTGGTGCCGGTATCCGGACTTCTTGCGCTGACCGCGCGCACACTGCGCCAGACCGAGTTCATCGCGCTGCGCAAGCTGGCCGGTGCCGAGCGCACCGAGCTCAATAGGGCCCTGCTGAGCGTGGACCGTTTTGTGCGCCGGGACAGTCCGCTACCGGTGGACGCGGGCATCCGTGCGCAATTGCTCGAGCGGTTCGGCATGTTCGGCATCCGGATGTCGATTGCCGTGCTGGCGGCCGGCGTGACCGATTCGACCGGGCTGGCCGCCGAACTGCTGGAGCGCAGCGGGCTGGTGGCGCTGCGCAATGTGATAGACCAGCAGTTCGCGCAGCGCTCCGACATGCTTAAGGCGCATACCGCCTTGGTCTCCTTGCGCCGATTCGTGCAGACGCATCCGGTGCCGGCGACCCCGTACGTCATTGCCGACATCGACCCGTTGCTAGCCGACACCCACGCCTTCGAAGAACTCCGAATGCTAAGCCTTTTGCCTTCGCGGGCAACGACATTGAACGACGACGAAATCGCGTCGCTGCGCCGCATCATCGGCGGGTCGGGCACCAGTGCCGCCGCTCGGCTGGGCCTGGATCCCGCGAATTCTCGCGAGGCCCCGCGCGCCGCGCTGGCCGCAGCGCAACACTGGCGTCGCCGTGCGGCGCATCCACTCAACGATCCGTTCACTACCAGGGCCTGTCGCGCGGCGGTGCGCAGCGCCGAGGCGATGGTGGCGGAGTTCTCTGCTCGCCGCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2100"]}}}}}, "851": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"13178": "R140S", "13179": "D8G", "13180": "R154W", "13181": "Y64D"}, "$delete": ["3426", "4213", "4225", "4292", "4308", "9925", "9928"]}, "clinical": {"$insert": {"13178": "R140S", "13179": "D8G", "13180": "R154W", "13181": "Y64D"}, "$delete": ["3426", "4213", "4225", "4292", "4308", "9925", "9928"]}}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}, "41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8786": {"protein_sequence": {"accession": "NP_216559.1", "sequence": "MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2288680", "fmax": "2289241", "strand": "-", "sequence": "ATGCGGGCGTTGATCATCGTCGACGTGCAGAACGACTTCTGCGAGGGTGGCTCGCTGGCGGTAACCGGTGGCGCCGCGCTGGCCCGCGCCATCAGCGACTACCTGGCCGAAGCGGCGGACTACCATCACGTCGTGGCAACCAAGGACTTCCACATCGACCCGGGTGACCACTTCTCCGGCACACCGGACTATTCCTCGTCGTGGCCACCGCATTGCGTCAGCGGTACTCCCGGCGCGGACTTCCATCCCAGTCTGGACACGTCGGCAATCGAGGCGGTGTTCTACAAGGGTGCCTACACCGGAGCGTACAGCGGCTTCGAAGGAGTCGACGAGAACGGCACGCCACTGCTGAATTGGCTGCGGCAACGCGGCGTCGATGAGGTCGATGTGGTCGGTATTGCCACCGATCATTGTGTGCGCCAGACGGCCGAGGACGCGGTACGCAATGGCTTGGCCACCAGGGTGCTGGTGGACCTGACAGCGGGTGTGTCGGCCGATACCACCGTCGCCGCGCTGGAGGAGATGCGCACCGCCAGCGTCGAGTTGGTTTGCAGCTCCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4593"]}}}}}, "1176": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["3244", "3761", "3770", "3793", "3796", "13070"]}, "clinical": {"$delete": ["3244", "3761", "3770", "3793", "3796", "13070"]}}}, "41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11.", "param_value": {"$update": {"10007": "-nt1384:A"}}}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout.", "param_value": {"$delete": ["8048"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8833": {"protein_sequence": {"accession": "NP_216424.1", "sequence": "MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAVQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2153888", "fmax": "2156111", "strand": "-", "sequence": "GTGCCCGAGCAACACCCACCCATTACAGAAACCACCACCGGAGCCGCTAGCAACGGCTGTCCCGTCGTGGGTCATATGAAATACCCCGTCGAGGGCGGCGGAAACCAGGACTGGTGGCCCAACCGGCTCAATCTGAAGGTACTGCACCAAAACCCGGCCGTCGCTGACCCGATGGGTGCGGCGTTCGACTATGCCGCGGAGGTCGCGACCATCGACGTTGACGCCCTGACGCGGGACATCGAGGAAGTGATGACCACCTCGCAGCCGTGGTGGCCCGCCGACTACGGCCACTACGGGCCGCTGTTTATCCGGATGGCGTGGCACGCTGCCGGCACCTACCGCATCCACGACGGCCGCGGCGGCGCCGGGGGCGGCATGCAGCGGTTCGCGCCGCTTAACAGCTGGCCCGACAACGCCAGCTTGGACAAGGCGCGCCGGCTGCTGTGGCCGGTCAAGAAGAAGTACGGCAAGAAGCTCTCATGGGCGGACCTGATTGTTTTCGCCGGCAACTGCGCGCTGGAATCGATGGGCTTCAAGACGTTCGGGTTCGGCTTCGGCCGGGTCGACCAGTGGGAGCCCGATGAGGTCTATTGGGGCAAGGAAGCCACCTGGCTCGGCGATGAGCGTTACAGCGGTAAGCGGGATCTGGAGAACCCGCTGGCCGCGGTGCAGATGGGGCTGATCTACGTGAACCCGGAGGGGCCGAACGGCAACCCGGACCCCATGGCCGCGGCGGTCGACATTCGCGAGACGTTTCGGCGCATGGCCATGAACGACGTCGAAACAGCGGCGCTGATCGTCGGCGGTCACACTTTCGGTAAGACCCATGGCGCCGGCCCGGCCGATCTGGTCGGCCCCGAACCCGAGGCTGCTCCGCTGGAGCAGATGGGCTTGGGCTGGAAGAGCTCGTATGGCACCGGAACCGGTAAGGACGCGATCACCAGCGGCATCGAGGTCGTATGGACGAACACCCCGACGAAATGGGACAACAGTTTCCTCGAGATCCTGTACGGCTACGAGTGGGAGCTGACGAAGAGCCCTGCTGGCGCTTGGCAATACACCGCCAAGGACGGCGCCGGTGCCGGCACCATCCCGGACCCGTTCGGCGGGCCAGGGCGCTCCCCGACGATGCTGGCCACTGACCTCTCGCTGCGGGTGGATCCGATCTATGAGCGGATCACGCGTCGCTGGCTGGAACACCCCGAGGAATTGGCCGACGAGTTCGCCAAGGCCTGGTACAAGCTGATCCACCGAGACATGGGTCCCGTTGCGAGATACCTTGGGCCGCTGGTCCCCAAGCAGACCCTGCTGTGGCAGGATCCGGTCCCTGCGGTCAGCCACGACCTCGTCGGCGAAGCCGAGATTGCCAGCCTTAAGAGCCAGATCCGGGCATCGGGATTGACTGTCTCACAGCTAGTTTCGACCGCATGGGCGGCGGCGTCGTCGTTCCGTGGTAGCGACAAGCGCGGCGGCGCCAACGGTGGTCGCATCCGCCTGCAGCCACAAGTCGGGTGGGAGGTCAACGACCCCGACGGGGATCTGCGCAAGGTCATTCGCACCCTGGAAGAGATCCAGGAGTCATTCAACTCCGCGGCGCCGGGGAACATCAAAGTGTCCTTCGCCGACCTCGTCGTGCTCGGTGGCTGTGCCGCCATAGAGAAAGCAGCAAAGGCGGCTGGCCACAACATCACGGTGCCCTTCACCCCGGGCCGCACGGATGCGTCGCAGGAACAAACCGACGTGGAATCCTTTGCCGTGCTGGAGCCCAAGGCAGATGGCTTCCGAAACTACCTCGGAAAGGGCAACCCGTTGCCGGCCGAGTACATGCTGCTCGACAAGGCGAACCTGCTTACGCTCAGTGCCCCTGAGATGACGGTGCTGGTAGGTGGCCTGCGCGTCCTCGGCGCAAACTACAAGCGCTTACCGCTGGGCGTGTTCACCGAGGCCTCCGAGTCACTGACCAACGACTTCTTCGTGAACCTGCTCGACATGGGTATCACCTGGGAGCCCTCGCCAGCAGATGACGGGACCTACCAGGGCAAGGATGGCAGTGGCAAGGTGAAGTGGACCGGCAGCCGCGTGGACCTGGTCTTCGGGTCCAACTCGGAGTTGCGGGCGCTTGTCGAGGTCTATGGCGCCGATGACGCGCAGCCGAAGTTCGTGCAGGACTTCGTCGCTGCCTGGGACAAGGTGATGAACCTCGACAGGTTCGACGTGCGCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5483"]}}}}}, "1197": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8803": {"protein_sequence": {"accession": "NP_215196.1", "sequence": "MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKG"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "781559", "fmax": "781934", "strand": "+", "sequence": "ATGCCAACCATCCAGCAGCTGGTCCGCAAGGGTCGTCGGGACAAGATCAGTAAGGTCAAGACCGCGGCTCTGAAGGGCAGCCCGCAGCGTCGTGGTGTATGCACCCGCGTGTACACCACCACTCCGAAGAAGCCGAACTCGGCGCTTCGGAAGGTTGCCCGCGTGAAGTTGACGAGTCAGGTCGAGGTCACGGCGTACATTCCCGGCGAGGGCCACAACCTGCAGGAGCACTCGATGGTGCTGGTGCGCGGCGGCCGGGTGAAGGACCTGCCTGGTGTGCGCTACAAGATCATCCGCGGTTCGCTGGATACGCAGGGTGTCAAGAACCGCAAACAGGCACGCAGCCGTTACGGCGCTAAGAAGGAGAAGGGCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2087"]}}}}}, "1237": {"$update": {"model_param": {"$update": {"40330": {"$update": {"param_value": {"$insert": {"13234": "L524W,T525P,H526Q,-K527", "13235": "Q513H,-F514,-M515,-D516", "13236": "-N519,S522L,S531L", "13237": "H526D,S531L", "13238": "-M515,-D516,-Q517,-N518"}, "$delete": ["4069", "4070", "4084", "4086", "4072"]}}}, "42998": {"$update": {"param_value": {"$delete": ["9777", "9784"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8799": {"protein_sequence": {"accession": "NP_215181.1", "sequence": "MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "759806", "fmax": "763325", "strand": "+", "sequence": "TTGGCAGATTCCCGCCAGAGCAAAACAGCCGCTAGTCCTAGTCCGAGTCGCCCGCAAAGTTCCTCGAATAACTCCGTACCCGGAGCGCCAAACCGGGTCTCCTTCGCTAAGCTGCGCGAACCACTTGAGGTTCCGGGACTCCTTGACGTCCAGACCGATTCGTTCGAGTGGCTGATCGGTTCGCCGCGCTGGCGCGAATCCGCCGCCGAGCGGGGTGATGTCAACCCAGTGGGTGGCCTGGAAGAGGTGCTCTACGAGCTGTCTCCGATCGAGGACTTCTCCGGGTCGATGTCGTTGTCGTTCTCTGACCCTCGTTTCGACGATGTCAAGGCACCCGTCGACGAGTGCAAAGACAAGGACATGACGTACGCGGCTCCACTGTTCGTCACCGCCGAGTTCATCAACAACAACACCGGTGAGATCAAGAGTCAGACGGTGTTCATGGGTGACTTCCCGATGATGACCGAGAAGGGCACGTTCATCATCAACGGGACCGAGCGTGTGGTGGTCAGCCAGCTGGTGCGGTCGCCCGGGGTGTACTTCGACGAGACCATTGACAAGTCCACCGACAAGACGCTGCACAGCGTCAAGGTGATCCCGAGCCGCGGCGCGTGGCTCGAGTTTGACGTCGACAAGCGCGACACCGTCGGCGTGCGCATCGACCGCAAACGCCGGCAACCGGTCACCGTGCTGCTCAAGGCGCTGGGCTGGACCAGCGAGCAGATTGTCGAGCGGTTCGGGTTCTCCGAGATCATGCGATCGACGCTGGAGAAGGACAACACCGTCGGCACCGACGAGGCGCTGTTGGACATCTACCGCAAGCTGCGTCCGGGCGAGCCCCCGACCAAAGAGTCAGCGCAGACGCTGTTGGAAAACTTGTTCTTCAAGGAGAAGCGCTACGACCTGGCCCGCGTCGGTCGCTATAAGGTCAACAAGAAGCTCGGGCTGCATGTCGGCGAGCCCATCACGTCGTCGACGCTGACCGAAGAAGACGTCGTGGCCACCATCGAATATCTGGTCCGCTTGCACGAGGGTCAGACCACGATGACCGTTCCGGGCGGCGTCGAGGTGCCGGTGGAAACCGACGACATCGACCACTTCGGCAACCGCCGCCTGCGTACGGTCGGCGAGCTGATCCAAAACCAGATCCGGGTCGGCATGTCGCGGATGGAGCGGGTGGTCCGGGAGCGGATGACCACCCAGGACGTGGAGGCGATCACACCGCAGACGTTGATCAACATCCGGCCGGTGGTCGCCGCGATCAAGGAGTTCTTCGGCACCAGCCAGCTGAGCCAATTCATGGACCAGAACAACCCGCTGTCGGGGTTGACCCACAAGCGCCGACTGTCGGCGCTGGGGCCCGGCGGTCTGTCACGTGAGCGTGCCGGGCTGGAGGTCCGCGACGTGCACCCGTCGCACTACGGCCGGATGTGCCCGATCGAAACCCCTGAGGGGCCCAACATCGGTCTGATCGGCTCGCTGTCGGTGTACGCGCGGGTCAACCCGTTCGGGTTCATCGAAACGCCGTACCGCAAGGTGGTCGACGGCGTGGTTAGCGACGAGATCGTGTACCTGACCGCCGACGAGGAGGACCGCCACGTGGTGGCACAGGCCAATTCGCCGATCGATGCGGACGGTCGCTTCGTCGAGCCGCGCGTGCTGGTCCGCCGCAAGGCGGGCGAGGTGGAGTACGTGCCCTCGTCTGAGGTGGACTACATGGACGTCTCGCCCCGCCAGATGGTGTCGGTGGCCACCGCGATGATTCCCTTCCTGGAGCACGACGACGCCAACCGTGCCCTCATGGGGGCAAACATGCAGCGCCAGGCGGTGCCGCTGGTCCGTAGCGAGGCCCCGCTGGTGGGCACCGGGATGGAGCTGCGCGCGGCGATCGACGCCGGCGACGTCGTCGTCGCCGAAGAAAGCGGCGTCATCGAGGAGGTGTCGGCCGACTACATCACTGTGATGCACGACAACGGCACCCGGCGTACCTACCGGATGCGCAAGTTTGCCCGGTCCAACCACGGCACTTGCGCCAACCAGTGCCCCATCGTGGACGCGGGCGACCGAGTCGAGGCCGGTCAGGTGATCGCCGACGGTCCCTGTACTGACGACGGCGAGATGGCGCTGGGCAAGAACCTGCTGGTGGCCATCATGCCGTGGGAGGGCCACAACTACGAGGACGCGATCATCCTGTCCAACCGCCTGGTCGAAGAGGACGTGCTCACCTCGATCCACATCGAGGAGCATGAGATCGATGCTCGCGACACCAAGCTGGGTGCGGAGGAGATCACCCGCGACATCCCGAACATCTCCGACGAGGTGCTCGCCGACCTGGATGAGCGGGGCATCGTGCGCATCGGTGCCGAGGTTCGCGACGGGGACATCCTGGTCGGCAAGGTCACCCCGAAGGGTGAGACCGAGCTGACGCCGGAGGAGCGGCTGCTGCGTGCCATCTTCGGTGAGAAGGCCCGCGAGGTGCGCGACACTTCGCTGAAGGTGCCGCACGGCGAATCCGGCAAGGTGATCGGCATTCGGGTGTTTTCCCGCGAGGACGAGGACGAGTTGCCGGCCGGTGTCAACGAGCTGGTGCGTGTGTATGTGGCTCAGAAACGCAAGATCTCCGACGGTGACAAGCTGGCCGGCCGGCACGGCAACAAGGGCGTGATCGGCAAGATCCTGCCGGTTGAGGACATGCCGTTCCTTGCCGACGGCACCCCGGTGGACATTATTTTGAACACCCACGGCGTGCCGCGACGGATGAACATCGGCCAGATTTTGGAGACCCACCTGGGTTGGTGTGCCCACAGCGGCTGGAAGGTCGACGCCGCCAAGGGGGTTCCGGACTGGGCCGCCAGGCTGCCCGACGAACTGCTCGAGGCGCAGCCGAACGCCATTGTGTCGACGCCGGTGTTCGACGGCGCCCAGGAGGCCGAGCTGCAGGGCCTGTTGTCGTGCACGCTGCCCAACCGCGACGGTGACGTGCTGGTCGACGCCGACGGCAAGGCCATGCTCTTCGACGGGCGCAGCGGCGAGCCGTTCCCGTACCCGGTCACGGTTGGCTACATGTACATCATGAAGCTGCACCACCTGGTGGACGACAAGATCCACGCCCGCTCCACCGGGCCGTACTCGATGATCACCCAGCAGCCGCTGGGCGGTAAGGCGCAGTTCGGTGGCCAGCGGTTCGGGGAGATGGAGTGCTGGGCCATGCAGGCCTACGGTGCTGCCTACACCCTGCAGGAGCTGTTGACCATCAAGTCCGATGACACCGTCGGCCGCGTCAAGGTGTACGAGGCGATCGTCAAGGGTGAGAACATCCCGGAGCCGGGCATCCCCGAGTCGTTCAAGGTGCTGCTCAAAGAACTGCAGTCGCTGTGCCTCAACGTCGAGGTGCTATCGAGTGACGGTGCGGCGATCGAACTGCGCGAAGGTGAGGACGAGGACCTGGAGCGGGCCGCGGCCAACCTGGGAATCAATCTGTCCCGCAACGAATCCGCAAGTGTCGAGGATCTTGCGTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4199"]}}}, "ARO_name": "Mycobacterium tuberculosis rpoB mutations conferring resistance to rifampicin"}}, "1339": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8809": {"protein_sequence": {"accession": "NP_215783.1", "sequence": "MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1416180", "fmax": "1417347", "strand": "-", "sequence": "ATGGCTGGTAGCGCGACAGTGGAGAAGCGGCTCGACTTCGGCCTGCTTGGACCATTGCAGATGACTATCGACGGCACCCCGGTGCCATCGGGCACCCCCAAGCAACGGGCTGTGCTAGCCATGTTGGTCATCAACCGCAACAGGCCCGTAGGAGTCGACGCCCTAATCACCGCCCTCTGGGAGGAGTGGCCACCCTCGGGCGCACGCGCGAGTATCCACTCCTACGTGTCTAATCTGCGTAAGCTCCTCGGTGGCGCCGGGATCGACCCACGGGTGGTGTTGGCCGCAGCGCCGCCGGGTTATCGGCTCAGCATCCCCGACAACACTTGCGATCTGGGGCGGTTTGTTGCCGAAAAAACCGCGGGCGTGCACGCGGCCGCCGCCGGCCGGTTCGAACAAGCCAGCCGCCACCTGTCGGCCGCATTGAGAGAATGGCGTGGGCCGGTGCTCGATGACCTGCGCGACTTCCAGTTCGTCGAACCCTTTGCCACGGCGCTGGTAGAAGACAAGGTTCTTGCCCATACCGCCAAGGCGGAGGCCGAAATCGCGTGTGGGCGGGCCAGCGCAGTGATCGCCGAGCTCGAGGCTCTGACATTCGAACACCCCTACCGGGAGCCGCTGTGGACACAGCTGATCACCGCCTACTACCTCTCCGACCGGCAATCCGATGCGCTGGGCGCCTATCGCCGGGTGAAGACAACACTGGCCGACGACCTCGGCATCGACCCCGGTCCGACGTTGCGCGCTCTCAACGAGCGGATTCTGCGTCAGCAACCGCTGGATGCCAAGAAGTCCGCCAAAACCACCGCTGCCGGCACCGTCACGGTGCTCGATCAGCGCACCATGGCGTCGGGCCAGCAGGCGGTGGCCTACCTGCACGACATCGCCTCGGGTCGCGGCTACCCACTGCAAGCCGCGGCGACCCGGATCGGGCGTCTGCATGACAACGACATCGTCCTAGACAGCGCCAACGTCAGCCGCCACCACGCCGTCATCGTCGACACGGGCACCAACTACGTCATCAACGACCTCCGATCGTCCAACGGCGTGCATGTGCAGCACGAGCGAATCCGCTCCGCGGTCACGCTGAACGACGGCGACCACATTCGCATCTGTGACCATGAATTCACGTTCCAGATCAGCGCGGGGACGCATGGCGGCACGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4712"]}}}}}, "1354": {"$update": {"model_param": {"$delete": ["42998", "43010"]}, "model_sequences": {"$update": {"sequence": {"$insert": {"8804": {"protein_sequence": {"accession": "NP_218311.1", "sequence": "MPHDGNERSHRIARLAAVVSGIAGLLLCGIVPLLPVNQTTATIFWPQGSTADGNITQITAPLVSGAPRALDISIPCSAIATLPANGGLVLSTLPAGGVDTGKAGLFVRANQDTVVVAFRDSVAAVAARSTIAAGGCSALHIWADTGGAGADFMGIPGGAGTLPPEKKPQVGGIFTDLKVGAQPGLSARVDIDTRFITTPGALKKAVMLLGVLAVLVAMVGLAALDRLSRGRTLRDWLTRYRPRVRVGFASRLADAAVIATLLLWHVIGATSSDDGYLLTVARVAPKAGYVANYYRYFGTTEAPFDWYTSVLAQLAAVSTAGVWMRLPATLAGIACWLIVSRFVLRRLGPGPGGLASNRVAVFTAGAVFLSAWLPFNNGLRPEPLIALGVLVTWVLVERSIALGRLAPAAVAIIVATLTATLAPQGLIALAPLLTGARAIAQRIRRRRATDGLLAPLAVLAAALSLITVVVFRDQTLATVAESARIKYKVGPTIAWYQDFLRYYFLTVESNVEGSMSRRFAVLVLLFCLFGVLFVLLRRGRVAGLASGPAWRLIGTTAVGLLLLTFTPTKWAVQFGAFAGLAGVLGAVTAFTFARIGLHSRRNLTLYVTALLFVLAWATSGINGWFYVGNYGVPWYDIQPVIASHPVTSMFLTLSILTGLLAAWYHFRMDYAGHTEVKDNRRNRILASTPLLVVAVIMVAGEVGSMAKAAVFRYPLYTTAKANLTALSTGLSSCAMADDVLAEPDPNAGMLQPVPGQAFGPDGPLGGISPVGFKPEGVGEDLKSDPVVSKPGLVNSDASPNKPNAAITDSAGTAGGKGPVGINGSHAALPFGLDPARTPVMGSYGENNLAATATSAWYQLPPRSPDRPLVVVSAAGAIWSYKEDGDFIYGQSLKLQWGVTGPDGRIQPLGQVFPIDIGPQPAWRNLRFPLAWAPPEADVARIVAYDPNLSPEQWFAFTPPRVPVLESLQRLIGSATPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNLWQSSSTGGPFLFTQALLRTSTIATYLRGDWYRDWGSVEQYHRLVPADQAPDAVVEEGVITVPGWGRPGPIRALP"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4243232", "fmax": "4246517", "strand": "+", "sequence": "GTGCCCCACGACGGTAATGAGCGATCTCACCGGATCGCACGCCTAGCAGCCGTCGTCTCGGGAATCGCGGGTCTGCTGCTGTGCGGCATCGTTCCGCTGCTTCCGGTGAACCAAACCACCGCGACCATCTTCTGGCCGCAGGGCAGCACCGCCGACGGCAACATCACCCAGATCACCGCCCCTCTGGTATCCGGGGCGCCACGCGCGCTGGACATCTCGATCCCCTGCTCGGCCATCGCCACGCTGCCCGCCAACGGCGGCCTGGTGCTGTCCACACTGCCGGCCGGTGGCGTGGATACCGGTAAGGCCGGGCTGTTCGTCCGCGCCAACCAGGACACGGTCGTCGTGGCGTTCCGCGACTCGGTGGCCGCGGTGGCGGCCCGCTCCACGATCGCAGCGGGAGGCTGTAGCGCGCTGCATATCTGGGCCGATACCGGCGGCGCGGGCGCTGATTTTATGGGTATACCCGGCGGCGCCGGGACCCTGCCGCCGGAGAAGAAGCCACAGGTTGGCGGCATCTTCACCGACCTGAAGGTCGGAGCGCAGCCCGGGCTGTCGGCCCGCGTCGACATCGACACTCGGTTTATCACGACGCCCGGCGCGCTCAAGAAGGCCGTGATGCTCCTCGGCGTGCTGGCGGTCCTGGTAGCCATGGTGGGGCTGGCCGCGCTGGACCGGCTCAGCAGGGGCCGCACCCTGCGCGACTGGCTGACCCGATATCGCCCGCGGGTGCGGGTCGGATTCGCCAGCCGGCTCGCTGACGCAGCGGTGATCGCGACCTTGTTGCTCTGGCATGTCATCGGCGCCACCTCGTCCGATGACGGCTACCTTCTGACCGTCGCCCGGGTCGCCCCGAAGGCCGGCTATGTAGCCAACTACTACCGGTATTTCGGCACGACGGAGGCGCCGTTCGACTGGTATACATCGGTGCTTGCCCAGCTGGCGGCGGTGAGCACCGCCGGCGTCTGGATGCGCCTGCCCGCCACCCTGGCCGGAATCGCCTGCTGGCTGATCGTCAGCCGTTTCGTGCTGCGGCGGCTGGGACCGGGCCCGGGCGGGCTGGCGTCCAACCGGGTCGCTGTGTTCACCGCTGGTGCGGTGTTCCTGTCCGCCTGGCTGCCGTTCAACAACGGCCTGCGTCCCGAGCCGCTGATCGCGCTGGGTGTGCTGGTCACGTGGGTGTTGGTGGAACGGTCGATCGCGCTCGGACGGCTGGCCCCGGCCGCGGTAGCCATCATCGTGGCGACGCTTACCGCGACGCTGGCACCGCAGGGGTTGATCGCGCTGGCCCCGCTGCTGACTGGTGCGCGCGCCATCGCCCAGAGGATCCGGCGCCGCCGGGCGACCGATGGACTGCTGGCGCCGCTGGCGGTGCTGGCCGCGGCGTTGTCGCTGATCACCGTGGTGGTGTTTCGGGACCAGACGCTGGCCACGGTGGCCGAATCGGCACGCATCAAGTACAAGGTCGGCCCGACCATCGCCTGGTACCAGGACTTCCTGCGCTACTACTTCCTTACCGTGGAGAGCAACGTTGAGGGGTCGATGTCCCGCCGGTTCGCGGTGCTGGTGTTGCTGTTCTGCCTGTTCGGGGTGCTGTTCGTGCTGCTGCGGCGCGGCCGGGTGGCGGGGCTGGCCAGCGGCCCGGCCTGGCGACTGATCGGCACTACGGCGGTCGGCCTGCTGCTGCTCACGTTCACGCCAACCAAGTGGGCCGTGCAGTTCGGCGCATTCGCCGGGCTGGCCGGGGTGTTGGGTGCGGTCACCGCGTTCACCTTTGCCCGCATCGGTCTACATAGTCGACGCAACCTCACGCTGTACGTGACCGCGTTGCTGTTCGTGCTGGCGTGGGCAACCTCGGGCATCAACGGGTGGTTCTACGTCGGCAACTACGGGGTGCCGTGGTATGACATCCAGCCCGTCATCGCCAGCCACCCGGTGACGTCGATGTTTCTGACGCTGTCGATCCTCACCGGATTGCTGGCAGCCTGGTATCACTTCCGGATGGACTACGCCGGGCACACCGAAGTCAAAGACAACCGGCGCAACCGCATCTTGGCCTCTACGCCACTGCTGGTGGTCGCGGTGATCATGGTCGCAGGCGAAGTCGGCTCGATGGCCAAGGCCGCGGTGTTCCGTTACCCGCTTTACACCACCGCCAAGGCCAACCTGACCGCGCTCAGCACCGGGCTGTCCAGCTGTGCGATGGCCGACGACGTGCTGGCCGAGCCCGACCCCAATGCCGGCATGCTGCAACCGGTTCCGGGCCAGGCGTTCGGACCGGACGGACCGCTGGGCGGTATCAGTCCCGTCGGCTTCAAACCCGAGGGCGTGGGCGAGGACCTCAAGTCCGACCCGGTGGTCTCCAAACCCGGGCTGGTCAACTCCGATGCGTCGCCCAACAAACCCAACGCCGCCATCACCGACTCCGCGGGCACCGCCGGAGGGAAGGGCCCGGTCGGGATCAACGGGTCGCACGCGGCGCTGCCGTTCGGATTGGACCCGGCACGTACCCCGGTGATGGGCAGCTACGGGGAGAACAACCTGGCCGCCACGGCCACCTCGGCCTGGTACCAGTTACCGCCCCGCAGCCCGGACCGGCCGCTGGTGGTGGTTTCCGCGGCCGGCGCCATCTGGTCCTACAAGGAGGACGGCGATTTCATCTACGGCCAGTCCCTGAAACTGCAGTGGGGCGTCACCGGCCCGGACGGCCGCATCCAGCCACTGGGGCAGGTATTTCCGATCGACATCGGACCGCAACCCGCGTGGCGCAATCTGCGGTTTCCGCTGGCCTGGGCGCCGCCGGAGGCCGACGTGGCGCGCATTGTCGCCTATGACCCGAACCTGAGCCCTGAGCAATGGTTCGCCTTCACCCCGCCCCGGGTTCCGGTGCTGGAATCTCTGCAGCGGTTGATCGGGTCAGCGACACCGGTGTTGATGGACATCGCGACCGCAGCCAACTTCCCCTGCCAGCGACCGTTTTCCGAGCATCTCGGCATTGCCGAGCTTCCGCAGTACCGGATCCTGCCGGACCACAAGCAGACGGCGGCGTCGTCGAACCTATGGCAGTCCAGCTCGACCGGCGGTCCGTTCCTGTTCACCCAGGCGCTGCTGCGCACCTCGACGATCGCCACGTACCTGCGTGGGGACTGGTATCGCGACTGGGGATCGGTGGAGCAGTACCACCGGCTGGTGCCGGCCGATCAGGCTCCAGACGCCGTTGTCGAGGAGGGCGTGATCACTGTGCCCGGCTGGGGTCGGCCAGGACCGATCAGGGCGCTGCCATGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2081"]}}}}}, "1574": {"$update": {"model_param": {"$update": {"42998": {"$update": {"param_value": {"$delete": ["9855", "13089"]}}}}, "$delete": ["43013", "43010"]}, "model_sequences": {"$update": {"sequence": {"$insert": {"8828": {"protein_sequence": {"accession": "NP_216000.1", "sequence": "MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1674201", "fmax": "1675011", "strand": "+", "sequence": "ATGACAGGACTGCTGGACGGCAAACGGATTCTGGTTAGCGGAATCATCACCGACTCGTCGATCGCGTTTCACATCGCACGGGTAGCCCAGGAGCAGGGCGCCCAGCTGGTGCTCACCGGGTTCGACCGGCTGCGGCTGATTCAGCGCATCACCGACCGGCTGCCGGCAAAGGCCCCGCTGCTCGAACTCGACGTGCAAAACGAGGAGCACCTGGCCAGCTTGGCCGGCCGGGTGACCGAGGCGATCGGGGCGGGCAACAAGCTCGACGGGGTGGTGCATTCGATTGGGTTCATGCCGCAGACCGGGATGGGCATCAACCCGTTCTTCGACGCGCCCTACGCGGATGTGTCCAAGGGCATCCACATCTCGGCGTATTCGTATGCTTCGATGGCCAAGGCGCTGCTGCCGATCATGAACCCCGGAGGTTCCATCGTCGGCATGGACTTCGACCCGAGCCGGGCGATGCCGGCCTACAACTGGATGACGGTCGCCAAGAGCGCGTTGGAGTCGGTCAACAGGTTCGTGGCGCGCGAGGCCGGCAAGTACGGTGTGCGTTCGAATCTCGTTGCCGCAGGCCCTATCCGGACGCTGGCGATGAGTGCGATCGTCGGCGGTGCGCTCGGCGAGGAGGCCGGCGCCCAGATCCAGCTGCTCGAGGAGGGCTGGGATCAGCGCGCTCCGATCGGCTGGAACATGAAGGATGCGACGCCGGTCGCCAAGACGGTGTGCGCGCTGCTGTCTGACTGGCTGCCGGCGACCACGGGTGACATCATCTACGCCGACGGCGGCGCGCACACCCAATTGCTCTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2085"]}}}}}, "1849": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8794": {"protein_sequence": {"accession": "NP_216210.1", "sequence": "MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSERAWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1917939", "fmax": "1918746", "strand": "+", "sequence": "GTGGCACGACGTGCCCGCGTTGACGCCGAGCTAGTCCGGCGGGGCCTGGCGCGATCACGTCAACAGGCCGCGGAGTTGATCGGCGCCGGCAAGGTGCGCATCGACGGGCTGCCGGCGGTCAAGCCGGCCACCGCCGTGTCCGACACCACCGCGCTGACCGTGGTGACCGACAGTGAACGCGCCTGGGTATCGCGCGGAGCGCACAAACTAGTCGGTGCGCTGGAGGCGTTCGCGATCGCGGTGGCGGGCCGGCGCTGTCTGGACGCGGGCGCATCGACCGGTGGGTTCACCGAAGTACTGCTGGACCGTGGTGCCGCCCACGTGGTGGCCGCCGATGTCGGATACGGCCAGCTGGCGTGGTCGCTGCGCAACGATCCTCGGGTGGTGGTCCTCGAGCGGACCAACGCACGTGGCCTCACACCGGAGGCGATCGGCGGTCGCGTCGACCTGGTAGTGGCCGACCTGTCGTTCATCTCGTTGGCTACCGTGTTGCCCGCGCTGGTTGGATGCGCTTCGCGCGACGCCGATATCGTTCCACTGGTGAAGCCGCAGTTTGAGGTGGGGAAAGGTCAGGTCGGCCCCGGTGGGGTGGTCCATGACCCGCAGTTGCGTGCGCGGTCGGTGCTCGCGGTCGCGCGGCGGGCACAGGAGCTGGGCTGGCACAGCGTCGGCGTCAAGGCCAGCCCGCTGCCGGGCCCATCGGGCAATGTCGAGTACTTCCTGTGGTTGCGCACGCAGACCGACCGGGCATTGTCGGCCAAGGGATTGGAGGATGCGGTGCACCGTGCGATTAGCGAGGGCCCGTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2076"]}}}}}, "1935": {"$update": {"model_param": {"$update": {"42998": {"$update": {"param_value": {"$delete": ["9604", "9606", "9610", "9611", "9614", "9620", "9621", "9623", "9628"]}}}, "43010": {"$update": {"param_value": {"$delete": ["9613"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8820": {"protein_sequence": {"accession": "NP_214520.1", "sequence": "MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "7301", "fmax": "9818", "strand": "+", "sequence": "ATGACAGACACGACGTTGCCGCCTGACGACTCGCTCGACCGGATCGAACCGGTTGACATCGAGCAGGAGATGCAGCGCAGCTACATCGACTATGCGATGAGCGTGATCGTCGGCCGCGCGCTGCCGGAGGTGCGCGACGGGCTCAAGCCCGTGCATCGCCGGGTGCTCTATGCAATGTTCGATTCCGGCTTCCGCCCGGACCGCAGCCACGCCAAGTCGGCCCGGTCGGTTGCCGAGACCATGGGCAACTACCACCCGCACGGCGACGCGTCGATCTACGACAGCCTGGTGCGCATGGCCCAGCCCTGGTCGCTGCGCTACCCGCTGGTGGACGGCCAGGGCAACTTCGGCTCGCCAGGCAATGACCCACCGGCGGCGATGAGGTACACCGAAGCCCGGCTGACCCCGTTGGCGATGGAGATGCTGAGGGAAATCGACGAGGAGACAGTCGATTTCATCCCTAACTACGACGGCCGGGTGCAAGAGCCGACGGTGCTACCCAGCCGGTTCCCCAACCTGCTGGCCAACGGGTCAGGCGGCATCGCGGTCGGCATGGCAACCAATATCCCGCCGCACAACCTGCGTGAGCTGGCCGACGCGGTGTTCTGGGCGCTGGAGAATCACGACGCCGACGAAGAGGAGACCCTGGCCGCGGTCATGGGGCGGGTTAAAGGCCCGGACTTCCCGACCGCCGGACTGATCGTCGGATCCCAGGGCACCGCTGATGCCTACAAAACTGGCCGCGGCTCCATTCGAATGCGCGGAGTTGTTGAGGTAGAAGAGGATTCCCGCGGTCGTACCTCGCTGGTGATCACCGAGTTGCCGTATCAGGTCAACCACGACAACTTCATCACTTCGATCGCCGAACAGGTCCGAGACGGCAAGCTGGCCGGCATTTCCAACATTGAGGACCAGTCTAGCGATCGGGTCGGTTTACGCATCGTCATCGAGATCAAGCGCGATGCGGTGGCCAAGGTGGTGATCAATAACCTTTACAAGCACACCCAGCTGCAGACCAGCTTTGGCGCCAACATGCTAGCGATCGTCGACGGGGTGCCGCGCACGCTGCGGCTGGACCAGCTGATCCGCTATTACGTTGACCACCAACTCGACGTCATTGTGCGGCGCACCACCTACCGGCTGCGCAAGGCAAACGAGCGAGCCCACATTCTGCGCGGCCTGGTTAAAGCGCTCGACGCGCTGGACGAGGTCATTGCACTGATCCGGGCGTCGGAGACCGTCGATATCGCCCGGGCCGGACTGATCGAGCTGCTCGACATCGACGAGATCCAGGCCCAGGCAATCCTGGACATGCAGTTGCGGCGCCTGGCCGCACTGGAACGCCAGCGCATCATCGACGACCTGGCCAAAATCGAGGCCGAGATCGCCGATCTGGAAGACATCCTGGCAAAACCCGAGCGGCAGCGTGGGATCGTGCGCGACGAACTCGCCGAAATCGTGGACAGGCACGGCGACGACCGGCGTACCCGGATCATCGCGGCCGACGGAGACGTCAGCGACGAGGATTTGATCGCCCGCGAGGACGTCGTTGTCACTATCACCGAAACGGGATACGCCAAGCGCACCAAGACCGATCTGTATCGCAGCCAGAAACGCGGCGGCAAGGGCGTGCAGGGTGCGGGGTTGAAGCAGGACGACATCGTCGCGCACTTCTTCGTGTGCTCCACCCACGATTTGATCCTGTTCTTCACCACCCAGGGACGGGTTTATCGGGCCAAGGCCTACGACTTGCCCGAGGCCTCCCGGACGGCGCGCGGGCAGCACGTGGCCAACCTGTTAGCCTTCCAGCCCGAGGAACGCATCGCCCAGGTCATCCAGATTCGCGGCTACACCGACGCCCCGTACCTGGTGCTGGCCACTCGCAACGGGCTGGTGAAAAAGTCCAAGCTGACCGACTTCGACTCCAATCGCTCGGGCGGAATCGTGGCGGTCAACCTGCGCGACAACGACGAGCTGGTCGGTGCGGTGCTGTGTTCGGCCGGCGACGACCTGCTGCTGGTCTCGGCCAACGGGCAGTCCATCAGGTTCTCGGCGACCGACGAGGCGCTGCGGCCAATGGGTCGTGCCACCTCGGGTGTGCAGGGCATGCGGTTCAATATCGACGACCGGCTGCTGTCGCTGAACGTCGTGCGTGAAGGCACCTATCTGCTGGTGGCGACGTCAGGGGGCTATGCGAAACGTACCGCGATCGAGGAATACCCGGTACAGGGCCGCGGCGGTAAAGGTGTGCTGACGGTCATGTACGACCGCCGGCGCGGCAGGTTGGTTGGGGCGTTGATTGTCGACGACGACAGCGAGCTGTATGCCGTCACTTCCGGCGGTGGCGTGATCCGCACCGCGGCACGCCAGGTTCGCAAGGCGGGACGGCAGACCAAGGGTGTTCGGTTGATGAATCTGGGCGAGGGCGACACACTGTTGGCCATCGCGCGCAACGCCGAAGAAAGTGGCGACGATAATGCCGTGGACGCCAACGGCGCAGACCAGACGGGCAATTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2055"]}}}}}, "1943": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8832": {"protein_sequence": {"accession": "NP_216761.1", "sequence": "MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFGEAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2518114", "fmax": "2519365", "strand": "+", "sequence": "GTGAGTCAGCCTTCCACCGCTAATGGCGGTTTCCCCAGCGTTGTGGTGACCGCCGTCACAGCGACGACGTCGATCTCGCCGGACATCGAGAGCACGTGGAAGGGTCTGTTGGCCGGCGAGAGCGGCATCCACGCACTCGAAGACGAGTTCGTCACCAAGTGGGATCTAGCGGTCAAGATCGGCGGTCACCTCAAGGATCCGGTCGACAGCCACATGGGCCGACTCGACATGCGACGCATGTCGTACGTCCAGCGGATGGGCAAGTTGCTGGGCGGACAGCTATGGGAGTCCGCCGGCAGCCCGGAGGTCGATCCAGACCGGTTCGCCGTTGTTGTCGGCACCGGTCTAGGTGGAGCCGAGAGGATTGTCGAGAGCTACGACCTGATGAATGCGGGCGGCCCCCGGAAGGTGTCCCCGCTGGCCGTTCAGATGATCATGCCCAACGGTGCCGCGGCGGTGATCGGTCTGCAGCTTGGGGCCCGCGCCGGGGTGATGACCCCGGTGTCGGCCTGTTCGTCGGGCTCGGAAGCGATCGCCCACGCGTGGCGTCAGATCGTGATGGGCGACGCCGACGTCGCCGTCTGCGGCGGTGTCGAAGGACCCATCGAGGCGCTGCCCATCGCGGCGTTCTCCATGATGCGGGCCATGTCGACCCGCAACGACGAGCCTGAGCGGGCCTCCCGGCCGTTCGACAAGGACCGCGACGGCTTTGTGTTCGGCGAGGCCGGTGCGCTGATGCTCATCGAGACGGAGGAGCACGCCAAAGCCCGTGGCGCCAAGCCGTTGGCCCGATTGCTGGGTGCCGGTATCACCTCGGACGCCTTTCATATGGTGGCGCCCGCGGCCGATGGTGTTCGTGCCGGTAGGGCGATGACTCGCTCGCTGGAGCTGGCCGGGTTGTCGCCGGCGGACATCGACCACGTCAACGCGCACGGCACGGCGACGCCTATCGGCGACGCCGCGGAGGCCAACGCCATCCGCGTCGCCGGTTGTGATCAGGCCGCGGTGTACGCGCCGAAGTCTGCGCTGGGCCACTCGATCGGCGCGGTCGGTGCGCTCGAGTCGGTGCTCACGGTGCTGACGCTGCGCGACGGCGTCATCCCGCCGACCCTGAACTACGAGACACCCGATCCCGAGATCGACCTTGACGTCGTCGCCGGCGAACCGCGCTATGGCGATTACCGCTACGCAGTCAACAACTCGTTCGGGTTCGGCGGCCACAATGTGGCGCTTGCCTTCGGGCGTTACTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["2084"]}}}}}, "2068": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4842": "T1506A"}}, "clinical": {"$update": {"4842": "T1506A"}}}}}}}}, "2070": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8764": {"protein_sequence": {"accession": "", "sequence": ""}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1471845", "fmax": "1473382", "strand": "+", "sequence": "TTTTGTTTGGAGAGTTTGATCCTGGCTCAGGACGAACGCTGGCGGCGTGCTTAACACATGCAAGTCGAACGGAAAGGTCTCTTCGGAGATACTCGAGTGGCGAACGGGTGAGTAACACGTGGGTGATCTGCCCTGCACTTCGGGATAAGCCTGGGAAACTGGGTCTAATACCGGATAGGACCACGGGATGCATGTCTTGTGGTGGAAAGCGCTTTAGCGGTGTGGGATGAGCCCGCGGCCTATCAGCTTGTTGGTGGGGTGACGGCCTACCAAGGCGACGACGGGTAGCCGGCCTGAGAGGGTGTCCGGCCACACTGGGACTGAGATACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCACAATGGGCGCAAGCCTGATGCAGCGACGCCGCGTGGGGGATGACGGCCTTCGGGTTGTAAACCTCTTTCACCATCGACGAAGGTCCGGGTTCTCTCGGATTGACGGTAGGTGGAGAAGAAGCACCGGCCAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGTGCGAGCGTTGTCCGGAATTACTGGGCGTAAAGAGCTCGTAGGTGGTTTGTCGCGTTGTTCGTGAAATCTCACGGCTTAACTGTGAGCGTGCGGGCGATACGGGCAGACTAGAGTACTGCAGGGGAGACTGGAATTCCTGGTGTAGCGGTGGAATGCGCAGATATCAGGAGGAACACCGGTGGCGAAGGCGGGTCTCTGGGCAGTAACTGACGCTGAGGAGCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGGTGGGTACTAGGTGTGGGTTTCCTTCCTTGGGATCCGTGCCGTAGCTAACGCATTAAGTACCCCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGCGGAGCATGTGGATTAATTCGATGCAACGCGAAGAACCTTACCTGGGTTTGACATGCACAGGACGCGTCTAGAGATAGGCGTTCCCTTGTGGCCTGTGTGCAGGTGGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCTCATGTTGCCAGCACGTAATGGTGGGGACTCGTGAGAGACTGCCGGGGTCAACTCGGAGGAAGGTGGGGATGACGTCAAGTCATCATGCCCCTTATGTCCAGGGCTTCACACATGCTACAATGGCCGGTACAAAGGGCTGCGATGCCGCGAGGTTAAGCGAATCCTTAAAAGCCGGTCTCAGTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTCGGAGTCGCTAGTAATCGCAGATCAGCAACGCTGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACGTCATGAAAGTCGGTAACACCCGAAGCCAGTGGCCTAACCCTCGGGAGGGAGCTGTCGAAGGTGGGATCGGCGATTGGGACGAAGTCGTAACAAGGTAGCCGTACCGGAAGGTGCGGCTGGATCACCTCCTTTCT", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["3261"]}}}}}, "2076": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"12974": "C1198T"}}, "clinical": {"$update": {"12974": "C1198T"}}}}}}}}, "1005": {"$update": {"model_param": {"$delete": ["41343"]}}}, "100": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["4157"]}, "clinical": {"$delete": ["4157"]}}}, "41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}, "42998": {"$update": {"param_value": {"$delete": ["13005"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8813": {"protein_sequence": {"accession": "NP_218371.1", "sequence": "MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4326003", "fmax": "4327473", "strand": "-", "sequence": "ATGACCGAGCACCTCGACGTTGTCATCGTGGGCGCTGGAATCTCCGGTGTCAGCGCGGCCTGGCACCTGCAGGACCGTTGCCCGACCAAGAGCTACGCCATCCTGGAAAAGCGGGAATCCATGGGCGGCACCTGGGATTTGTTCCGTTATCCCGGAATTCGCTCCGACTCCGACATGTACACGCTAGGTTTCCGATTCCGTCCCTGGACCGGACGGCAGGCGATCGCCGACGGCAAGCCCATCCTCGAGTACGTCAAGAGCACCGCGGCCATGTATGGAATCGACAGGCATATCCGGTTCCACCACAAGGTGATCAGTGCCGATTGGTCGACCGCGGAAAACCGCTGGACCGTTCACATCCAAAGCCACGGCACGCTCAGCGCCCTCACCTGCGAATTCCTCTTTCTGTGCAGCGGCTACTACAACTACGACGAGGGCTACTCGCCGAGATTCGCCGGCTCGGAGGATTTCGTCGGGCCGATCATCCATCCGCAGCACTGGCCCGAGGACCTCGACTACGACGCTAAGAACATCGTCGTGATCGGCAGTGGCGCAACGGCGGTCACGCTCGTGCCGGCGCTGGCGGACTCGGGCGCCAAGCACGTCACGATGCTGCAGCGCTCACCCACCTACATCGTGTCGCAGCCAGACCGGGACGGCATCGCCGAGAAGCTCAACCGCTGGCTGCCGGAGACCATGGCCTACACCGCGGTACGGTGGAAGAACGTGCTGCGCCAGGCGGCCGTGTACAGCGCCTGCCAGAAGTGGCCACGGCGCATGCGGAAGATGTTCCTGAGCCTGATCCAGCGCCAGCTACCCGAGGGGTACGACGTGCGAAAGCACTTCGGCCCGCACTACAACCCCTGGGACCAGCGATTGTGCTTGGTGCCCAACGGCGACCTGTTCCGGGCCATTCGTCACGGGAAGGTCGAGGTGGTGACCGACACCATTGAACGGTTCACCGCGACCGGAATCCGGCTGAACTCAGGTCGCGAACTGCCGGCTGACATCATCATTACCGCAACGGGGTTGAACCTGCAGCTTTTTGGTGGGGCGACGGCGACTATCGACGGACAACAAGTGGACATCACCACGACGATGGCCTACAAGGGCATGATGCTTTCCGGCATCCCCAACATGGCCTACACGGTTGGCTACACCAATGCCTCCTGGACGCTGAAGGCCGACCTGGTGTCGGAGTTTGTCTGTCGCTTGTTGAATTACATGGACGACAACGGTTTTGACACCGTGGTCGTCGAGCGACCGGGCTCAGATGTCGAAGAGCGGCCCTTCATGGAGTTCACCCCAGGTTACGTGCTGCGCTCGCTGGACGAGCTGCCCAAGCAGGGTTCGCGTACACCGTGGCGCCTGAATCAGAACTACCTACGTGACATCCGGCTCATCCGGCGCGGCAAGATCGACGACGAGGGTCTGCGGTTCGCCAAAAGGCCTGCCCCGGTGGGGGTTTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4455"]}}}, "ARO_description": "Mycobacterium tuberculosis ethA (Rv3854c) is a mono-oxygenase enzyme which activates the antibiotic ethionamide in vivo. Mutations in ethA confer resistance to ethionamide by modulating the activation and activity of the ethionamide prodrug."}}, "953": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8887": {"protein_sequence": {"accession": "WP_002381168.1", "sequence": "MNNPWRFFIVAEALLFILALWQIVHNPGLAVLLTIGVLLVAYVSRKASKTHFNNFQFVLGVVFIVIGAMNSTAVWFMLIFGVLFIGLKGFEISGVDIAERAPWRKKQMIMVETAAKEPKNGKRFKRRWFANERIGNNIYEWDDINIDLISGDTIIDLGNTLLPKEDNIIIIRKGFGRTRILVPLGVAILLEHSTFYGTVRFEEEKYQLKNESLKIYSNDYDTNLRRLKIMTNTLVGDVEVIRV"}, "dna_sequence": {"accession": "NC_004668.1", "fmin": "2790820", "fmax": "2791552", "strand": "-", "sequence": "ATGAATAACCCTTGGCGCTTTTTTATCGTCGCAGAAGCATTACTTTTTATTCTGGCGTTATGGCAAATTGTACATAATCCTGGATTAGCTGTTTTATTAACAATTGGCGTTTTACTTGTGGCCTACGTTTCCAGGAAAGCATCTAAAACACATTTTAACAACTTTCAATTCGTCCTCGGCGTTGTTTTTATTGTCATTGGTGCAATGAATAGCACGGCTGTTTGGTTTATGTTGATTTTTGGCGTACTCTTTATCGGCTTAAAAGGCTTTGAGATTTCAGGCGTGGATATAGCTGAGCGAGCACCTTGGCGAAAAAAACAAATGATTATGGTGGAGACGGCGGCAAAAGAACCTAAAAATGGCAAACGGTTTAAACGCCGCTGGTTTGCCAACGAACGCATTGGTAACAATATCTATGAATGGGACGATATCAATATTGATTTAATCTCTGGGGACACCATTATTGATTTAGGTAATACGCTACTACCGAAAGAAGACAATATTATTATTATTCGTAAAGGTTTTGGCCGCACGCGAATTCTAGTGCCGTTAGGTGTAGCTATTTTGTTAGAACATTCAACTTTTTACGGAACGGTACGTTTTGAAGAAGAAAAATATCAATTGAAAAACGAATCATTAAAAATTTACAGCAATGATTATGATACCAATCTTCGTCGTTTGAAAATTATGACGAACACTTTAGTAGGAGATGTTGAGGTGATCCGTGTATGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "37592", "NCBI_taxonomy_name": "Enterococcus faecalis V583", "NCBI_taxonomy_id": "226185"}}}, "$delete": ["4744"]}}}}}, "2131": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4801": "C517T", "4802": "C513T", "4804": "C492T", "4805": "A514T", "7820": "C516T"}}, "clinical": {"$update": {"4801": "C517T", "4802": "C513T", "4804": "C492T", "4805": "A514T", "7820": "C516T"}}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8766": {"protein_sequence": {"accession": "", "sequence": ""}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1471845", "fmax": "1473382", "strand": "+", "sequence": "TTTTGTTTGGAGAGTTTGATCCTGGCTCAGGACGAACGCTGGCGGCGTGCTTAACACATGCAAGTCGAACGGAAAGGTCTCTTCGGAGATACTCGAGTGGCGAACGGGTGAGTAACACGTGGGTGATCTGCCCTGCACTTCGGGATAAGCCTGGGAAACTGGGTCTAATACCGGATAGGACCACGGGATGCATGTCTTGTGGTGGAAAGCGCTTTAGCGGTGTGGGATGAGCCCGCGGCCTATCAGCTTGTTGGTGGGGTGACGGCCTACCAAGGCGACGACGGGTAGCCGGCCTGAGAGGGTGTCCGGCCACACTGGGACTGAGATACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCACAATGGGCGCAAGCCTGATGCAGCGACGCCGCGTGGGGGATGACGGCCTTCGGGTTGTAAACCTCTTTCACCATCGACGAAGGTCCGGGTTCTCTCGGATTGACGGTAGGTGGAGAAGAAGCACCGGCCAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGTGCGAGCGTTGTCCGGAATTACTGGGCGTAAAGAGCTCGTAGGTGGTTTGTCGCGTTGTTCGTGAAATCTCACGGCTTAACTGTGAGCGTGCGGGCGATACGGGCAGACTAGAGTACTGCAGGGGAGACTGGAATTCCTGGTGTAGCGGTGGAATGCGCAGATATCAGGAGGAACACCGGTGGCGAAGGCGGGTCTCTGGGCAGTAACTGACGCTGAGGAGCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGGTGGGTACTAGGTGTGGGTTTCCTTCCTTGGGATCCGTGCCGTAGCTAACGCATTAAGTACCCCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGCGGAGCATGTGGATTAATTCGATGCAACGCGAAGAACCTTACCTGGGTTTGACATGCACAGGACGCGTCTAGAGATAGGCGTTCCCTTGTGGCCTGTGTGCAGGTGGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCTCATGTTGCCAGCACGTAATGGTGGGGACTCGTGAGAGACTGCCGGGGTCAACTCGGAGGAAGGTGGGGATGACGTCAAGTCATCATGCCCCTTATGTCCAGGGCTTCACACATGCTACAATGGCCGGTACAAAGGGCTGCGATGCCGCGAGGTTAAGCGAATCCTTAAAAGCCGGTCTCAGTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTCGGAGTCGCTAGTAATCGCAGATCAGCAACGCTGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACGTCATGAAAGTCGGTAACACCCGAAGCCAGTGGCCTAACCCTCGGGAGGGAGCTGTCGAAGGTGGGATCGGCGATTGGGACGAAGTCGTAACAAGGTAGCCGTACCGGAAGGTGCGGCTGGATCACCTCCTTTCT", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4123"]}}}}}, "821": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8806": {"protein_sequence": {"accession": "NP_218312.1", "sequence": "MTQCASRRKSTPNRAILGAFASARGTRWVATIAGLIGFVLSVATPLLPVVQTTAMLDWPQRGQLGSVTAPLISLTPVDFTATVPCDVVRAMPPAGGVVLGTAPKQGKDANLQALFVVVSAQRVDVTDRNVVILSVPREQVTSPQCQRIEVTSTHAGTFANFVGLKDPSGAPLRSGFPDPNLRPQIVGVFTDLTGPAPPGLAVSATIDTRFSTRPTTLKLLAIIGAIVATVVALIALWRLDQLDGRGSIAQLLLRPFRPASSPGGMRRLIPASWRTFTLTDAVVIFGFLLWHVIGANSSDDGYILGMARVADHAGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASLWMRLPDLAAGLVCWLLLSREVLPRLGPAVEASKPAYWAAAMVLLTAWMPFNNGLRPEGIIALGSLVTYVLIERSMRYSRLTPAALAVVTAAFTLGVQPTGLIAVAALVAGGRPMLRILVRRHRLVGTLPLVSPMLAAGTVILTVVFADQTLSTVLEATRVRAKIGPSQAWYTENLRYYYLILPTVDGSLSRRFGFLITALCLFTAVFIMLRRKRIPSVARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFAAVGAAMAALTTVLVSPSVLRWSRNRMAFLAALFFLLALCWATTNGWWYVSSYGVPFNSAMPKIDGITVSTIFFALFAIAAGYAAWLHFAPRGAGEGRLIRALTTAPVPIVAGFMAAVFVASMVAGIVRQYPTYSNGWSNVRAFVGGCGLADDVLVEPDTNAGFMKPLDGDSGSWGPLGPLGGVNPVGFTPNGVPEHTVAEAIVMKPNQPGTDYDWDAPTKLTSPGINGSTVPLPYGLDPARVPLAGTYTTGAQQQSTLVSAWYLLPKPDDGHPLVVVTAAGKIAGNSVLHGYTPGQTVVLEYAMPGPGALVPAGRMVPDDLYGEQPKAWRNLRFARAKMPADAVAVRVVAEDLSLTPEDWIAVTPPRVPDLRSLQEYVGSTQPVLLDWAVGLAFPCQQPMLHANGIAEIPKFRITPDYSAKKLDTDTWEDGTNGGLLGITDLLLRAHVMATYLSRDWARDWGSLRKFDTLVDAPPAQLELGTATRSGLWSPGKIRIGP"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4246513", "fmax": "4249810", "strand": "+", "sequence": "ATGACACAGTGCGCGAGCAGACGCAAAAGCACCCCAAATCGGGCGATTTTGGGGGCTTTTGCGTCTGCTCGCGGGACGCGCTGGGTGGCCACCATCGCCGGGCTGATTGGCTTTGTGTTGTCGGTGGCGACGCCGCTGCTGCCCGTCGTGCAGACCACCGCGATGCTCGACTGGCCACAGCGGGGGCAACTGGGCAGCGTGACCGCCCCGCTGATCTCGCTGACGCCGGTCGACTTTACCGCCACCGTGCCGTGCGACGTGGTGCGCGCCATGCCACCCGCGGGCGGGGTGGTGCTGGGCACCGCACCCAAGCAAGGCAAGGACGCCAATTTGCAGGCGTTGTTCGTCGTCGTCAGCGCCCAGCGCGTGGACGTCACCGACCGCAACGTGGTGATCTTGTCCGTGCCGCGCGAGCAGGTGACGTCCCCGCAGTGTCAACGCATCGAGGTCACCTCTACCCACGCCGGCACCTTCGCCAACTTCGTCGGGCTCAAGGACCCGTCGGGCGCGCCGCTGCGCAGCGGCTTCCCCGACCCCAACCTGCGCCCGCAGATTGTCGGGGTGTTCACCGACCTGACCGGGCCCGCGCCGCCCGGGCTGGCGGTCTCGGCGACCATCGACACCCGGTTCTCCACCCGGCCGACCACGCTGAAACTGCTGGCGATCATCGGGGCGATCGTGGCCACCGTCGTCGCACTGATCGCGTTGTGGCGCCTGGACCAGTTGGACGGGCGGGGCTCAATTGCCCAGCTCCTCCTCAGGCCGTTCCGGCCTGCATCGTCGCCGGGCGGCATGCGCCGGCTGATTCCGGCAAGCTGGCGCACCTTCACCCTGACCGACGCCGTGGTGATATTCGGCTTCCTGCTCTGGCATGTCATCGGCGCGAATTCGTCGGACGACGGCTACATCCTGGGCATGGCCCGAGTCGCCGACCACGCCGGCTACATGTCCAACTATTTCCGCTGGTTCGGCAGCCCGGAGGATCCCTTCGGCTGGTATTACAACCTGCTGGCGCTGATGACCCATGTCAGCGACGCCAGTCTGTGGATGCGCCTGCCAGACCTGGCCGCCGGGCTAGTGTGCTGGCTGCTGCTGTCGCGTGAGGTGCTGCCCCGCCTCGGGCCGGCGGTGGAGGCCAGCAAACCCGCCTACTGGGCGGCGGCCATGGTCTTGCTGACCGCGTGGATGCCGTTCAACAACGGCCTGCGGCCGGAGGGCATCATCGCGCTCGGCTCGCTGGTCACCTATGTGCTGATCGAGCGGTCCATGCGGTACAGCCGGCTCACACCGGCGGCGCTGGCCGTCGTTACCGCCGCATTCACACTGGGTGTGCAGCCCACCGGCCTGATCGCGGTGGCCGCGCTGGTGGCCGGCGGCCGCCCGATGCTGCGGATCTTGGTGCGCCGTCATCGCCTGGTCGGCACGTTGCCGTTGGTGTCGCCGATGCTGGCCGCCGGCACCGTCATCCTGACCGTGGTGTTCGCCGACCAGACCCTGTCAACGGTGTTGGAAGCCACCAGGGTTCGCGCCAAAATCGGGCCGAGCCAGGCGTGGTATACCGAGAACCTGCGTTACTACTACCTCATCCTGCCCACCGTCGACGGTTCGCTGTCGCGGCGCTTCGGCTTTTTGATCACCGCGCTATGCCTGTTCACCGCGGTGTTCATCATGTTGCGGCGCAAGCGAATTCCCAGCGTGGCCCGCGGACCGGCGTGGCGGCTGATGGGCGTCATCTTCGGCACCATGTTCTTCCTGATGTTCACGCCCACCAAGTGGGTGCACCACTTCGGGCTGTTCGCCGCCGTAGGGGCGGCGATGGCCGCGCTGACGACGGTGTTGGTATCCCCATCGGTGCTGCGCTGGTCGCGCAACCGGATGGCGTTCCTGGCGGCGTTATTCTTCCTGCTGGCGTTGTGTTGGGCCACCACCAACGGCTGGTGGTATGTCTCCAGCTACGGTGTGCCGTTCAACAGCGCGATGCCGAAGATCGACGGGATCACAGTCAGCACAATCTTTTTCGCCCTGTTTGCGATCGCCGCCGGCTATGCGGCCTGGCTGCACTTCGCGCCCCGCGGCGCCGGCGAAGGGCGGCTGATCCGCGCGCTGACGACAGCCCCGGTACCGATCGTGGCCGGTTTCATGGCGGCGGTGTTCGTCGCGTCCATGGTGGCCGGGATCGTGCGACAGTACCCGACCTACTCCAACGGCTGGTCCAACGTGCGGGCGTTTGTCGGCGGCTGCGGACTGGCCGACGACGTACTCGTCGAGCCTGATACCAATGCGGGTTTCATGAAGCCGCTGGACGGCGATTCGGGTTCTTGGGGCCCCTTGGGCCCGCTGGGTGGAGTCAACCCGGTCGGCTTCACGCCCAACGGCGTACCGGAACACACGGTGGCCGAGGCGATCGTGATGAAACCCAACCAGCCCGGCACCGACTACGACTGGGATGCGCCGACCAAGCTGACGAGTCCTGGCATCAATGGTTCTACGGTGCCGCTGCCCTATGGGCTCGATCCCGCCCGGGTACCGTTGGCAGGCACCTACACCACCGGCGCACAGCAACAGAGCACACTCGTCTCGGCGTGGTATCTCCTGCCTAAGCCGGACGACGGGCATCCGCTGGTCGTGGTGACCGCCGCGGGCAAGATCGCCGGCAACAGCGTGCTGCACGGGTACACCCCCGGGCAGACTGTGGTGCTCGAATACGCCATGCCGGGACCCGGAGCGCTGGTACCCGCCGGGCGGATGGTGCCCGACGACCTATACGGAGAGCAGCCCAAGGCGTGGCGCAACCTGCGCTTCGCCCGAGCAAAGATGCCCGCCGATGCCGTCGCGGTCCGGGTGGTGGCCGAGGATCTGTCGCTGACACCGGAGGACTGGATCGCGGTGACCCCGCCGCGGGTACCGGACCTGCGCTCACTGCAGGAATATGTGGGCTCGACGCAGCCGGTGCTGCTGGACTGGGCGGTCGGTTTGGCCTTCCCGTGCCAGCAGCCGATGCTGCACGCCAATGGCATCGCCGAAATCCCGAAGTTCCGCATCACACCGGACTACTCGGCTAAGAAGCTGGACACCGACACGTGGGAAGACGGCACTAACGGCGGCCTGCTCGGGATCACCGACCTGTTGCTGCGGGCCCACGTCATGGCCACCTACCTGTCCCGCGACTGGGCCCGCGATTGGGGTTCCCTGCGCAAGTTCGACACCCTGGTCGATGCCCCTCCCGCCCAGCTCGAGTTGGGCACCGCGACCCGCAGCGGCCTGTGGTCACCGGGCAAGATCCGAATTGGTCCATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["3327"]}}}}}, "1001": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["2205", "8711"]}, "clinical": {"$delete": ["2205", "8711"]}}}}}}}, "1203": {"$update": {"model_param": {"$update": {"43012": {"$update": {"param_value": {"$insert": {"9582": "-nt-134:G"}}}}, "43013": {"$update": {"param_value": {"$delete": ["9585", "9586"]}}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout.", "param_value": {"$update": {"10058": "+nt969:G"}}}}}, "$delete": ["42998"]}, "model_sequences": {"$update": {"sequence": {"$insert": {"8780": {"protein_sequence": {"accession": "NP_216370.1", "sequence": "MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2101650", "fmax": "2103042", "strand": "-", "sequence": "ATGAGTCCCCAGCAAGAACCCACAGCGCAACCACCTCGTAGGCATCGAGTTGTGATCATCGGATCTGGGTTCGGCGGGCTAAACGCGGCAAAGAAGCTCAAGCGGGCCGACGTTGACATCAAGCTGATCGCGCGCACCACCCATCACCTGTTCCAGCCGCTGCTGTACCAAGTGGCCACCGGGATTATCTCCGAGGGAGAAATCGCTCCGCCGACCCGGGTCGTGCTGCGTAAGCAGCGCAATGTCCAGGTACTGTTGGGCAACGTCACCCACATCGACCTGGCCGGGCAGTGCGTCGTCTCGGAATTGCTCGGTCACACCTACCAAACCCCCTACGACAGCCTGATCGTCGCCGCGGGTGCTGGCCAGTCTTATTTCGGCAACGACCATTTCGCCGAATTCGCACCCGGCATGAAGTCCATCGACGACGCGTTGGAGTTGCGTGGCCGCATATTGAGCGCTTTCGAGCAAGCCGAACGGTCCAGCGATCCGGAACGGCGGGCCAAGCTACTGACATTCACCGTTGTCGGGGCTGGCCCCACCGGTGTTGAAATGGCCGGACAGATCGCCGAGCTGGCCGAGCACACGTTGAAGGGCGCATTCCGGCACATCGACTCGACCAAGGCGCGGGTGATTCTGCTTGACGCCGCCCCGGCGGTGCTGCCACCGATGGGCGCAAAGCTCGGTCAGCGGGCGGCTGCCCGGTTGCAGAAGCTGGGCGTGGAAATCCAGCTGGGTGCGATGGTCACCGACGTCGACCGCAACGGCATCACCGTCAAGGACTCCGACGGCACCGTCCGGCGCATCGAGTCGGCCTGCAAGGTCTGGTCGGCCGGGGTTTCGGCCAGTCGGTTGGGCAGGGACCTTGCCGAGCAATCACGGGTTGAGCTCGACCGGGCCGGCCGGGTCCAAGTGCTGCCCGACCTGTCCATTCCCGGGTACCCGAACGTGTTCGTGGTGGGCGATATGGCCGCTGTGGAGGGTGTGCCGGGTGTGGCGCAGGGCGCCATCCAGGGGGCGAAATACGTCGCCAGCACGATCAAGGCCGAACTGGCCGGCGCCAACCCGGCGGAGCGTGAGCCATTCCAGTACTTCGACAAGGGATCGATGGCCACGGTTTCGAGGTTTTCGGCGGTGGCCAAGATCGGTCCCGTTGAGTTCAGCGGCTTTATCGCCTGGCTGATTTGGCTGGTGCTGCACCTGGCGTACCTGATCGGGTTCAAGACCAAGATCACCACTCTGCTGTCGTGGACGGTGACTTTCCTCAGTACTCGCCGCGGCCAGCTGACCATCACCGACCAGCAGGCATTTGCGCGAACGCGGCTCGAACAGCTGGCCGAGCTGGCCGCCGAGGCGCAGGGCTCAGCGGCAAGCGCTAAGGTGGCCAGCTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4726"]}}}}}, "1432": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$delete": ["3290"]}, "clinical": {"$delete": ["3290"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8808": {"protein_sequence": {"accession": "NP_218310.1", "sequence": "MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLNWPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRGLLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHPGAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVALTGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVISREVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAATVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLALVLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWSLTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEVVSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAGLSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLPYNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQWATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIALTPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEANSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTVTRSGLWSPAPLRRG"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4239862", "fmax": "4243147", "strand": "+", "sequence": "ATGGCTACCGAAGCCGCCCCACCCCGTATCGCCGTCCGGCTACCATCTACCTCCGTGCGCGACGCGGGAGCAAACTACCGGATCGCCCGGTACGTCGCTGTGGTGGCGGGTCTGCTAGGCGCTGTGCTGGCCATCGCCACCCCACTGCTGCCGGTCAACCAGACCACCGCGCAATTGAACTGGCCCCAAAACGGCACGTTCGCCAGTGTCGAGGCACCGCTGATTGGCTACGTGGCCACCGACTTGAACATCACCGTCCCCTGCCAGGCCGCCGCCGGACTGGCCGGATCGCAGAACACCGGCAAGACGGTGTTGTTGTCAACGGTGCCCAAGCAGGCGCCTAAGGCCGTCGATCGCGGGCTGCTGCTGCAACGGGCCAACGACGACCTGGTGCTTGTGGTGCGTAATGTCCCGTTGGTCACCGCCCCGCTGAGTCAGGTGCTCGGCCCGACCTGTCAGCGGTTGACATTCACCGCGCACGCCGATCGGGTCGCCGCCGAATTCGTCGGACTGGTGCAGGGACCCAATGCTGAGCACCCCGGTGCACCGCTGCGCGGTGAGCGCAGCGGCTACGACTTCCGCCCGCAGATCGTCGGGGTGTTCACCGACCTGGCCGGGCCGGCGCCACCGGGTCTGAGCTTCTCGGCGAGCGTGGATACCCGCTACAGCAGCAGCCCCACGCCGCTGAAGATGGCCGCCATGATCCTCGGGGTAGCGCTCACCGGCGCCGCCCTGGTGGCGCTGCACATCCTGGACACCGCCGACGGCATGCGGCACCGGCGGTTCCTGCCCGCGCGCTGGTGGTCGACCGGCGGTCTGGACACCCTGGTTATCGCCGTGCTGGTGTGGTGGCATTTCGTCGGGGCCAACACCTCCGACGACGGCTACATCCTGACCATGGCCCGGGTGTCCGAGCATGCGGGCTATATGGCCAACTACTACCGCTGGTTCGGCACACCCGAGGCGCCTTTCGGCTGGTACTACGACCTGCTGGCGCTGTGGGCTCATGTCAGCACGGCCAGTATCTGGATGCGCCTACCCACCCTGGCGATGGCGCTCACCTGCTGGTGGGTAATCAGCCGTGAGGTCATTCCCCGGCTGGGGCACGCCGTCAAGACGAGCCGGGCAGCGGCGTGGACGGCGGCGGGCATGTTTCTGGCTGTCTGGCTGCCGCTGGACAACGGCCTTCGGCCCGAGCCGATCATCGCCCTGGGCATCCTGCTGACCTGGTGCTCGGTGGAGCGGGCGGTGGCCACCAGCCGGCTGCTGCCGGTGGCAATCGCCTGCATCATCGGTGCCTTGACCCTGTTCTCCGGGCCGACGGGCATCGCCTCGATCGGTGCGCTGCTGGTCGCGATCGGGCCGCTACGGACCATCCTGCACCGGCGTTCCAGGCGGTTCGGCGTGCTACCACTGGTGGCGCCGATCCTGGCCGCGGCCACCGTCACCGCGATCCCGATCTTTCGTGATCAGACCTTCGCGGGCGAGATCCAGGCCAACCTCCTCAAGCGTGCCGTAGGGCCCAGCCTGAAGTGGTTCGACGAACACATCCGCTACGAGCGGCTGTTCATGGCCAGCCCCGACGGCTCGATCGCCCGCCGCTTCGCCGTGCTGGCCTTGGTGCTGGCGCTCGCGGTATCGGTGGCAATGTCGTTACGTAAGGGCCGCATTCCAGGTACCGCTGCTGGACCGAGCCGCCGCATCATCGGCATCACGATCATTTCCTTCCTCGCGATGATGTTCACCCCGACAAAGTGGACCCATCACTTCGGGGTGTTCGCGGGGTTGGCCGGGTCGCTGGGGGCGCTTGCCGCGGTCGCGGTGACGGGCGCTGCGATGCGCTCGCGGCGGAACCGGACCGTGTTCGCCGCCGTGGTGGTCTTCGTGTTGGCCCTGTCGTTCGCCAGTGTCAACGGCTGGTGGTACGTGTCCAACTTCGGTGTGCCATGGTCGAACTCGTTTCCGAAGTGGCGATGGTCGCTTACCACCGCACTCCTCGAGCTGACGGTGCTGGTGCTGCTGCTAGCGGCATGGTTCCACTTCGTCGCCAACGGTGACGGGCGCCGAACAGCCAGGCCAACCCGGTTTAGGGCACGACTAGCCGGAATTGTCCAGTCCCCGTTGGCAATTGCCACGTGGTTGCTGGTGCTTTTCGAGGTGGTATCGCTGACCCAGGCGATGATTTCCCAGTACCCGGCGTGGTCGGTTGGCCGGTCTAACCTACAGGCTTTGGCCGGCAAGACCTGCGGGCTGGCCGAAGACGTGCTGGTGGAGCTGGATCCCAACGCAGGCATGCTGGCGCCGGTGACCGCGCCGTTGGCCGACGCCCTGGGAGCCGGCCTGTCTGAAGCCTTCACACCCAACGGCATTCCCGCCGACGTCACCGCCGACCCGGTGATGGAACGTCCAGGGGATCGCAGTTTCCTCAACGACGACGGGCTGATCACCGGCAGCGAACCCGGCACCGAAGGGGGCACCACGGCCGCACCGGGAATCAACGGCTCCCGCGCCCGGCTGCCCTACAACCTGGACCCGGCCCGTACACCGGTGCTGGGCAGCTGGCGAGCCGGCGTGCAGGTGCCCGCCATGCTGCGGTCGGGCTGGTACCGGCTGCCCACCAACGAGCAGCGGGACAGGGCGCCGCTGCTGGTGGTGACGGCGGCCGGGCGATTCGACTCCCGCGAGGTCCGGTTGCAGTGGGCCACCGACGAGCAAGCGGCCGCCGGACACCACGGTGGGTCGATGGAATTCGCCGACGTCGGTGCCGCGCCGGCCTGGCGCAACCTGCGCGCACCACTGTCCGCCATCCCGAGCACCGCCACCCAGGTCCGGTTGGTCGCCGACGACCAGGATCTGGCGCCGCAGCACTGGATCGCCCTCACACCACCGCGGATTCCGCGGGTGCGCACGCTGCAGAACGTGGTGGGCGCAGCGGATCCGGTGTTCCTGGACTGGCTGGTGGGGCTGGCATTCCCCTGCCAACGCCCGTTCGGCCACCAATACGGCGTCGACGAGACACCCAAGTGGCGGATCCTGCCGGACCGGTTCGGCGCCGAAGCCAACTCACCGGTGATGGATCACAATGGCGGTGGCCCGCTGGGCATCACCGAGCTGCTGATGCGCGCAACCACGGTGGCCAGCTACCTCAAAGACGACTGGTTTAGGGACTGGGGCGCGTTACAGCGGTTGACGCCTTACTACCCCGACGCCCAGCCCGCTGATCTGAACCTAGGAACGGTGACTCGCAGCGGGCTGTGGAGTCCGGCGCCGTTGCGCCGCGGCTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["8264"]}}}}}, "2073": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4812": "T1406A"}}, "clinical": {"$update": {"4812": "T1406A"}}}}}}}}, "2074": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4810": "C1192T", "12949": "C1066T"}}, "clinical": {"$update": {"4810": "C1192T", "12949": "C1066T"}}}}}}}}, "2109": {"$update": {"model_param": {"$delete": ["43011"]}, "model_sequences": {"$update": {"sequence": {"$insert": {"8772": {"protein_sequence": {"accession": "NP_214519.2", "sequence": "MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "5239", "fmax": "7267", "strand": "+", "sequence": "GTGGCTGCCCAGAAAAAGAAGGCCCAAGACGAATACGGCGCTGCGTCTATCACCATTCTCGAAGGGCTGGAGGCCGTCCGCAAACGTCCCGGCATGTACATTGGCTCGACCGGTGAGCGCGGTTTACACCATCTCATTTGGGAGGTGGTCGACAACGCGGTCGACGAGGCGATGGCCGGTTATGCAACCACAGTGAACGTAGTGCTGCTTGAGGATGGCGGTGTCGAGGTCGCCGACGACGGCCGCGGCATTCCGGTCGCCACCCACGCCTCCGGCATACCGACCGTCGACGTGGTGATGACACAACTACATGCCGGCGGCAAGTTCGACTCGGACGCGTATGCGATATCTGGTGGTCTGCACGGCGTCGGCGTGTCGGTGGTTAACGCGCTATCCACCCGGCTCGAAGTCGAGATCAAGCGCGACGGGTACGAGTGGTCTCAGGTTTATGAGAAGTCGGAACCCCTGGGCCTCAAGCAAGGGGCGCCGACCAAGAAGACGGGGTCAACGGTGCGGTTCTGGGCCGACCCCGCTGTTTTCGAAACCACGGAATACGACTTCGAAACCGTCGCCCGCCGGCTGCAAGAGATGGCGTTCCTCAACAAGGGGCTGACCATCAACCTGACCGACGAGAGGGTGACCCAAGACGAGGTCGTCGACGAAGTGGTCAGCGACGTCGCCGAGGCGCCGAAGTCGGCAAGTGAACGCGCAGCCGAATCCACTGCACCGCACAAAGTTAAGAGCCGCACCTTTCACTATCCGGGTGGCCTGGTGGACTTCGTGAAACACATCAACCGCACCAAGAACGCGATTCATAGCAGCATCGTGGACTTTTCCGGCAAGGGCACCGGGCACGAGGTGGAGATCGCGATGCAATGGAACGCCGGGTATTCGGAGTCGGTGCACACCTTCGCCAACACCATCAACACCCACGAGGGCGGCACCCACGAAGAGGGCTTCCGCAGCGCGCTGACGTCGGTGGTGAACAAGTACGCCAAGGACCGCAAGCTACTGAAGGACAAGGACCCCAACCTCACCGGTGACGATATCCGGGAAGGCCTGGCCGCTGTGATCTCGGTGAAGGTCAGCGAACCGCAGTTCGAGGGCCAGACCAAGACCAAGTTGGGCAACACCGAGGTCAAATCGTTTGTGCAGAAGGTCTGTAACGAACAGCTGACCCACTGGTTTGAAGCCAACCCCACCGACGCGAAAGTCGTTGTGAACAAGGCTGTGTCCTCGGCGCAAGCCCGTATCGCGGCACGTAAGGCACGAGAGTTGGTGCGGCGTAAGAGCGCCACCGACATCGGTGGATTGCCCGGCAAGCTGGCCGATTGCCGTTCCACGGATCCGCGCAAGTCCGAACTGTATGTCGTAGAAGGTGACTCGGCCGGCGGTTCTGCAAAAAGCGGTCGCGATTCGATGTTCCAGGCGATACTTCCGCTGCGCGGCAAGATCATCAATGTGGAGAAAGCGCGCATCGACCGGGTGCTAAAGAACACCGAAGTTCAGGCGATCATCACGGCGCTGGGCACCGGGATCCACGACGAGTTCGATATCGGCAAGCTGCGCTACCACAAGATCGTGCTGATGGCCGACGCCGATGTTGACGGCCAACATATTTCCACGCTGTTGTTGACGTTGTTGTTCCGGTTCATGCGGCCGCTCATCGAGAACGGGCATGTGTTTTTGGCACAACCGCCGCTGTACAAACTCAAGTGGCAGCGCAGTGACCCGGAATTCGCATACTCCGACCGCGAGCGCGACGGTCTGCTGGAGGCGGGGCTGAAGGCCGGGAAGAAGATCAACAAGGAAGACGGCATTCAGCGGTACAAGGGTCTAGGTGAAATGGACGCTAAGGAGTTGTGGGAGACCACCATGGATCCCTCGGTTCGTGTGTTGCGTCAAGTGACGCTGGACGACGCCGCCGCCGCCGACGAGTTGTTCTCCATCCTGATGGGCGAGGACGTCGACGCGCGGCGCAGCTTTATCACCCGCAACGCCAAGGATGTTCGGTTCCTGGATGTCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5872"]}}}}}, "2113": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4827": "T1406A"}}, "clinical": {"$update": {"4827": "T1406A"}}}}}}}}, "2129": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4815": "G1064T", "4816": "C1192T", "4817": "C1066T"}}, "clinical": {"$update": {"4815": "G1064T", "4816": "C1192T", "4817": "C1066T"}}}}}}}}, "2133": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8767": {"protein_sequence": {"accession": "", "sequence": ""}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1471845", "fmax": "1473382", "strand": "+", "sequence": "TTTTGTTTGGAGAGTTTGATCCTGGCTCAGGACGAACGCTGGCGGCGTGCTTAACACATGCAAGTCGAACGGAAAGGTCTCTTCGGAGATACTCGAGTGGCGAACGGGTGAGTAACACGTGGGTGATCTGCCCTGCACTTCGGGATAAGCCTGGGAAACTGGGTCTAATACCGGATAGGACCACGGGATGCATGTCTTGTGGTGGAAAGCGCTTTAGCGGTGTGGGATGAGCCCGCGGCCTATCAGCTTGTTGGTGGGGTGACGGCCTACCAAGGCGACGACGGGTAGCCGGCCTGAGAGGGTGTCCGGCCACACTGGGACTGAGATACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCACAATGGGCGCAAGCCTGATGCAGCGACGCCGCGTGGGGGATGACGGCCTTCGGGTTGTAAACCTCTTTCACCATCGACGAAGGTCCGGGTTCTCTCGGATTGACGGTAGGTGGAGAAGAAGCACCGGCCAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGTGCGAGCGTTGTCCGGAATTACTGGGCGTAAAGAGCTCGTAGGTGGTTTGTCGCGTTGTTCGTGAAATCTCACGGCTTAACTGTGAGCGTGCGGGCGATACGGGCAGACTAGAGTACTGCAGGGGAGACTGGAATTCCTGGTGTAGCGGTGGAATGCGCAGATATCAGGAGGAACACCGGTGGCGAAGGCGGGTCTCTGGGCAGTAACTGACGCTGAGGAGCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGGTGGGTACTAGGTGTGGGTTTCCTTCCTTGGGATCCGTGCCGTAGCTAACGCATTAAGTACCCCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGCGGAGCATGTGGATTAATTCGATGCAACGCGAAGAACCTTACCTGGGTTTGACATGCACAGGACGCGTCTAGAGATAGGCGTTCCCTTGTGGCCTGTGTGCAGGTGGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCTCATGTTGCCAGCACGTAATGGTGGGGACTCGTGAGAGACTGCCGGGGTCAACTCGGAGGAAGGTGGGGATGACGTCAAGTCATCATGCCCCTTATGTCCAGGGCTTCACACATGCTACAATGGCCGGTACAAAGGGCTGCGATGCCGCGAGGTTAAGCGAATCCTTAAAAGCCGGTCTCAGTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTCGGAGTCGCTAGTAATCGCAGATCAGCAACGCTGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACGTCATGAAAGTCGGTAACACCCGAAGCCAGTGGCCTAACCCTCGGGAGGGAGCTGTCGAAGGTGGGATCGGCGATTGGGACGAAGTCGTAACAAGGTAGCCGTACCGGAAGGTGCGGCTGGATCACCTCCTTTCT", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["3260"]}}}}}, "3542": {"$update": {"ARO_description": "OXA-480 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2093": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4808": "C1193T"}}, "clinical": {"$update": {"4808": "C1193T"}}}}}}}}, "2132": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4799": "C1402T", "4800": "G1484T"}}, "clinical": {"$update": {"4799": "C1402T", "4800": "G1484T"}}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8765": {"protein_sequence": {"accession": "", "sequence": ""}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1471845", "fmax": "1473382", "strand": "+", "sequence": "TTTTGTTTGGAGAGTTTGATCCTGGCTCAGGACGAACGCTGGCGGCGTGCTTAACACATGCAAGTCGAACGGAAAGGTCTCTTCGGAGATACTCGAGTGGCGAACGGGTGAGTAACACGTGGGTGATCTGCCCTGCACTTCGGGATAAGCCTGGGAAACTGGGTCTAATACCGGATAGGACCACGGGATGCATGTCTTGTGGTGGAAAGCGCTTTAGCGGTGTGGGATGAGCCCGCGGCCTATCAGCTTGTTGGTGGGGTGACGGCCTACCAAGGCGACGACGGGTAGCCGGCCTGAGAGGGTGTCCGGCCACACTGGGACTGAGATACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCACAATGGGCGCAAGCCTGATGCAGCGACGCCGCGTGGGGGATGACGGCCTTCGGGTTGTAAACCTCTTTCACCATCGACGAAGGTCCGGGTTCTCTCGGATTGACGGTAGGTGGAGAAGAAGCACCGGCCAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGTGCGAGCGTTGTCCGGAATTACTGGGCGTAAAGAGCTCGTAGGTGGTTTGTCGCGTTGTTCGTGAAATCTCACGGCTTAACTGTGAGCGTGCGGGCGATACGGGCAGACTAGAGTACTGCAGGGGAGACTGGAATTCCTGGTGTAGCGGTGGAATGCGCAGATATCAGGAGGAACACCGGTGGCGAAGGCGGGTCTCTGGGCAGTAACTGACGCTGAGGAGCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGGTGGGTACTAGGTGTGGGTTTCCTTCCTTGGGATCCGTGCCGTAGCTAACGCATTAAGTACCCCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGCGGAGCATGTGGATTAATTCGATGCAACGCGAAGAACCTTACCTGGGTTTGACATGCACAGGACGCGTCTAGAGATAGGCGTTCCCTTGTGGCCTGTGTGCAGGTGGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCTCATGTTGCCAGCACGTAATGGTGGGGACTCGTGAGAGACTGCCGGGGTCAACTCGGAGGAAGGTGGGGATGACGTCAAGTCATCATGCCCCTTATGTCCAGGGCTTCACACATGCTACAATGGCCGGTACAAAGGGCTGCGATGCCGCGAGGTTAAGCGAATCCTTAAAAGCCGGTCTCAGTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTCGGAGTCGCTAGTAATCGCAGATCAGCAACGCTGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACGTCATGAAAGTCGGTAACACCCGAAGCCAGTGGCCTAACCCTCGGGAGGGAGCTGTCGAAGGTGGGATCGGCGATTGGGACGAAGTCGTAACAAGGTAGCCGTACCGGAAGGTGCGGCTGGATCACCTCCTTTCT", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["3263"]}}}}}, "2154": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4806": "C1185T"}}, "clinical": {"$update": {"4806": "C1185T"}}}}}}}}, "2128": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4796": "C1376T", "4797": "G1458T", "4798": "T1373A"}}, "clinical": {"$update": {"4796": "C1376T", "4797": "G1458T", "4798": "T1373A"}}}}}}}}, "2084": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4793": "G1458T", "4794": "T1373A", "4795": "C1376T"}}, "clinical": {"$update": {"4793": "G1458T", "4794": "T1373A", "4795": "C1376T"}}}}}}}}, "2090": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4786": "T1373A", "4787": "G1458T", "4788": "C1376T"}}, "clinical": {"$update": {"4786": "T1373A", "4787": "G1458T", "4788": "C1376T"}}}}}}}}, "2126": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4790": "C1376T", "4791": "G1458T", "4792": "T1373A"}}, "clinical": {"$update": {"4790": "C1376T", "4791": "G1458T", "4792": "T1373A"}}}}}}}}, "2136": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4813": "T1406A"}}, "clinical": {"$update": {"4813": "T1406A"}}}}}}}}, "2146": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4825": "C528T", "4826": "G527T"}}, "clinical": {"$update": {"4825": "C528T", "4826": "G527T"}}}}}}}}, "2096": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4822": "A794T", "4823": "A1519T", "4824": "G926T"}}, "clinical": {"$update": {"4822": "A794T", "4823": "A1519T", "4824": "G926T"}}}}}}}}, "2102": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7842": "T1348C", "7843": "C1439T", "7844": "T1441C"}}, "clinical": {"$update": {"7842": "T1348C", "7843": "C1439T", "7844": "T1441C"}}}}}}}}, "2149": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4830": "T1482C", "4831": "T1389C", "4832": "C1480T"}}, "clinical": {"$update": {"4830": "T1482C", "4831": "T1389C", "4832": "C1480T"}}}}}}}}, "2106": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4838": "T1389A"}}, "clinical": {"$update": {"4838": "T1389A"}}}}}}}}, "2088": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4828": "C502T", "4829": "C506T"}}, "clinical": {"$update": {"4828": "C502T", "4829": "C506T"}}}}}}}}, "2141": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4840": "T1389A"}}, "clinical": {"$update": {"4840": "T1389A"}}}}}}}}, "2099": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4837": "T1389A"}}, "clinical": {"$update": {"4837": "T1389A"}}}}}}}}, "2142": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"12985": "G1475T"}}, "clinical": {"$update": {"12985": "G1475T"}}}}}}}}, "2249": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}}}, "2251": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}}}, "3480": {"$update": {"ARO_description": "OXA-346 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3509": {"$update": {"ARO_description": "OXA-439 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3539": {"$update": {"ARO_description": "OXA-477 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2290": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"13249": "D117C"}, "$delete": ["8298"]}, "clinical": {"$insert": {"13249": "D117C"}, "$delete": ["8298"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8840": {"protein_sequence": {"accession": "NP_215831.1", "sequence": "MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNCPDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVGRCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPSVGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRLHPTEHRVIGDRIVAATWGIAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQTDASFRVTQYERPKAVNVATLPFPGFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGYPLFVENLVSLGAEIERVCC"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1470320", "fmax": "1471577", "strand": "+", "sequence": "GTGGCCGAGCGTTTCGTCGTGACTGGGGGCAACCGGTTATCAGGCGAAGTGGCCGTCGGCGGCGCCAAGAACAGCGTGCTCAAGCTCATGGCTGCGACGTTGTTGGCCGAGGGCACCAGCACGATCACCAACTGTCCCGACATCCTCGATGTGCCGCTGATGGCGGAGGTACTGCGTGGTCTGGGCGCCACCGTCGAACTCGACGGTGACGTGGCCCGGATCACCGCACCTGACGAGCCGAAGTACGATGCCGACTTCGCTGCGGTGCGGCAATTCCGCGCCTCGGTCTGTGTGCTGGGACCGCTGGTCGGGCGGTGCAAACGGGCCAGGGTCGCGCTGCCGGGCGGTGACGCGATCGGGTCGCGTCCGTTGGATATGCACCAGGCGGGCCTACGGCAATTGGGTGCCCACTGCAACATCGAGCACGGCTGCGTGGTAGCCCGAGCGGAAACGTTGCGCGGTGCGGAGATTCAGTTGGAGTTCCCCTCGGTGGGAGCCACCGAGAACATCTTGATGGCCGCCGTGGTGGCCGAGGGAGTCACCACTATTCACAATGCGGCTCGAGAACCCGACGTCGTCGACTTGTGCACGATGTTGAACCAGATGGGCGCACAGGTCGAAGGTGCGGGTTCGCCGACAATGACCATCACCGGTGTCCCGCGGCTGCATCCAACCGAGCACCGGGTGATCGGAGACCGTATCGTTGCCGCCACATGGGGCATCGCTGCCGCAATGACCCGTGGTGATATATCAGTGGCGGGCGTAGACCCGGCGCATCTGCAGCTGGTGCTGCACAAATTGCACGACGCGGGCGCAACCGTCACCCAGACTGACGCCAGCTTCCGGGTGACCCAGTACGAGCGTCCGAAGGCTGTCAACGTTGCGACCTTGCCGTTCCCCGGGTTTCCCACGGATCTGCAGCCGATGGCTATCGCTTTGGCGTCGATCGCCGACGGCACATCGATGATCACGGAGAACGTGTTCGAGGCGCGGTTCCGCTTCGTTGAAGAGATGATCCGGCTCGGTGCAGACGCTCGGACCGACGGGCACCACGCCGTGGTGCGGGGCCTCCCGCAGCTGTCGAGCGCTCCGGTGTGGTGTTCGGACATCCGTGCCGGGGCCGGCTTGGTGCTGGCGGGGCTCGTTGCCGACGGCGACACCGAGGTCCACGATGTATTCCACATCGATCGCGGATATCCGTTGTTCGTGGAGAACCTGGTGAGTCTCGGTGCCGAGATCGAACGGGTATGCTGTTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["3555"]}}}}}, "3313": {"$update": {"ARO_description": "ACT-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2288": {"$update": {"model_param": {"$update": {"41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8778": {"protein_sequence": {"accession": "NP_216370.1", "sequence": "MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2101650", "fmax": "2103042", "strand": "-", "sequence": "ATGAGTCCCCAGCAAGAACCCACAGCGCAACCACCTCGTAGGCATCGAGTTGTGATCATCGGATCTGGGTTCGGCGGGCTAAACGCGGCAAAGAAGCTCAAGCGGGCCGACGTTGACATCAAGCTGATCGCGCGCACCACCCATCACCTGTTCCAGCCGCTGCTGTACCAAGTGGCCACCGGGATTATCTCCGAGGGAGAAATCGCTCCGCCGACCCGGGTCGTGCTGCGTAAGCAGCGCAATGTCCAGGTACTGTTGGGCAACGTCACCCACATCGACCTGGCCGGGCAGTGCGTCGTCTCGGAATTGCTCGGTCACACCTACCAAACCCCCTACGACAGCCTGATCGTCGCCGCGGGTGCTGGCCAGTCTTATTTCGGCAACGACCATTTCGCCGAATTCGCACCCGGCATGAAGTCCATCGACGACGCGTTGGAGTTGCGTGGCCGCATATTGAGCGCTTTCGAGCAAGCCGAACGGTCCAGCGATCCGGAACGGCGGGCCAAGCTACTGACATTCACCGTTGTCGGGGCTGGCCCCACCGGTGTTGAAATGGCCGGACAGATCGCCGAGCTGGCCGAGCACACGTTGAAGGGCGCATTCCGGCACATCGACTCGACCAAGGCGCGGGTGATTCTGCTTGACGCCGCCCCGGCGGTGCTGCCACCGATGGGCGCAAAGCTCGGTCAGCGGGCGGCTGCCCGGTTGCAGAAGCTGGGCGTGGAAATCCAGCTGGGTGCGATGGTCACCGACGTCGACCGCAACGGCATCACCGTCAAGGACTCCGACGGCACCGTCCGGCGCATCGAGTCGGCCTGCAAGGTCTGGTCGGCCGGGGTTTCGGCCAGTCGGTTGGGCAGGGACCTTGCCGAGCAATCACGGGTTGAGCTCGACCGGGCCGGCCGGGTCCAAGTGCTGCCCGACCTGTCCATTCCCGGGTACCCGAACGTGTTCGTGGTGGGCGATATGGCCGCTGTGGAGGGTGTGCCGGGTGTGGCGCAGGGCGCCATCCAGGGGGCGAAATACGTCGCCAGCACGATCAAGGCCGAACTGGCCGGCGCCAACCCGGCGGAGCGTGAGCCATTCCAGTACTTCGACAAGGGATCGATGGCCACGGTTTCGAGGTTTTCGGCGGTGGCCAAGATCGGTCCCGTTGAGTTCAGCGGCTTTATCGCCTGGCTGATTTGGCTGGTGCTGCACCTGGCGTACCTGATCGGGTTCAAGACCAAGATCACCACTCTGCTGTCGTGGACGGTGACTTTCCTCAGTACTCGCCGCGGCCAGCTGACCATCACCGACCAGCAGGCATTTGCGCGAACGCGGCTCGAACAGCTGGCCGAGCTGGCCGCCGAGGCGCAGGGCTCAGCGGCAAGCGCTAAGGTGGCCAGCTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["4632"]}}}}}, "3481": {"$update": {"ARO_description": "OXA-364 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3510": {"$update": {"ARO_description": "OXA-440 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3540": {"$update": {"ARO_description": "OXA-478 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2372": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}}}, "2404": {"$update": {"model_name": "Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones", "model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"13182": "D95Y"}}, "clinical": {"$insert": {"13182": "D95Y"}}}}}}, "ARO_name": "Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones", "ARO_category": {"$insert": {"40338": {"category_aro_accession": "3003690", "category_aro_cvterm_id": "40338", "category_aro_name": "sitafloxacin", "category_aro_description": "Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}}}}}, "2396": {"$update": {"ARO_description": "OXA-368 is a beta-lactamase found in Aeromonas sobria. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2398": {"$update": {"ARO_description": "TEM-220 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3482": {"$update": {"ARO_description": "OXA-372 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3511": {"$update": {"ARO_description": "OXA-441 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3541": {"$update": {"ARO_description": "OXA-479 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2380": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}}}, "2381": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}}}, "2436": {"$update": {"model_param": {"$update": {"41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}}}, "3483": {"$update": {"ARO_description": "OXA-373 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3512": {"$update": {"ARO_description": "OXA-442 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2144": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8807": {"protein_sequence": {"accession": "NP_218312.1", "sequence": "MTQCASRRKSTPNRAILGAFASARGTRWVATIAGLIGFVLSVATPLLPVVQTTAMLDWPQRGQLGSVTAPLISLTPVDFTATVPCDVVRAMPPAGGVVLGTAPKQGKDANLQALFVVVSAQRVDVTDRNVVILSVPREQVTSPQCQRIEVTSTHAGTFANFVGLKDPSGAPLRSGFPDPNLRPQIVGVFTDLTGPAPPGLAVSATIDTRFSTRPTTLKLLAIIGAIVATVVALIALWRLDQLDGRGSIAQLLLRPFRPASSPGGMRRLIPASWRTFTLTDAVVIFGFLLWHVIGANSSDDGYILGMARVADHAGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASLWMRLPDLAAGLVCWLLLSREVLPRLGPAVEASKPAYWAAAMVLLTAWMPFNNGLRPEGIIALGSLVTYVLIERSMRYSRLTPAALAVVTAAFTLGVQPTGLIAVAALVAGGRPMLRILVRRHRLVGTLPLVSPMLAAGTVILTVVFADQTLSTVLEATRVRAKIGPSQAWYTENLRYYYLILPTVDGSLSRRFGFLITALCLFTAVFIMLRRKRIPSVARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFAAVGAAMAALTTVLVSPSVLRWSRNRMAFLAALFFLLALCWATTNGWWYVSSYGVPFNSAMPKIDGITVSTIFFALFAIAAGYAAWLHFAPRGAGEGRLIRALTTAPVPIVAGFMAAVFVASMVAGIVRQYPTYSNGWSNVRAFVGGCGLADDVLVEPDTNAGFMKPLDGDSGSWGPLGPLGGVNPVGFTPNGVPEHTVAEAIVMKPNQPGTDYDWDAPTKLTSPGINGSTVPLPYGLDPARVPLAGTYTTGAQQQSTLVSAWYLLPKPDDGHPLVVVTAAGKIAGNSVLHGYTPGQTVVLEYAMPGPGALVPAGRMVPDDLYGEQPKAWRNLRFARAKMPADAVAVRVVAEDLSLTPEDWIAVTPPRVPDLRSLQEYVGSTQPVLLDWAVGLAFPCQQPMLHANGIAEIPKFRITPDYSAKKLDTDTWEDGTNGGLLGITDLLLRAHVMATYLSRDWARDWGSLRKFDTLVDAPPAQLELGTATRSGLWSPGKIRIGP"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4246513", "fmax": "4249810", "strand": "+", "sequence": "ATGACACAGTGCGCGAGCAGACGCAAAAGCACCCCAAATCGGGCGATTTTGGGGGCTTTTGCGTCTGCTCGCGGGACGCGCTGGGTGGCCACCATCGCCGGGCTGATTGGCTTTGTGTTGTCGGTGGCGACGCCGCTGCTGCCCGTCGTGCAGACCACCGCGATGCTCGACTGGCCACAGCGGGGGCAACTGGGCAGCGTGACCGCCCCGCTGATCTCGCTGACGCCGGTCGACTTTACCGCCACCGTGCCGTGCGACGTGGTGCGCGCCATGCCACCCGCGGGCGGGGTGGTGCTGGGCACCGCACCCAAGCAAGGCAAGGACGCCAATTTGCAGGCGTTGTTCGTCGTCGTCAGCGCCCAGCGCGTGGACGTCACCGACCGCAACGTGGTGATCTTGTCCGTGCCGCGCGAGCAGGTGACGTCCCCGCAGTGTCAACGCATCGAGGTCACCTCTACCCACGCCGGCACCTTCGCCAACTTCGTCGGGCTCAAGGACCCGTCGGGCGCGCCGCTGCGCAGCGGCTTCCCCGACCCCAACCTGCGCCCGCAGATTGTCGGGGTGTTCACCGACCTGACCGGGCCCGCGCCGCCCGGGCTGGCGGTCTCGGCGACCATCGACACCCGGTTCTCCACCCGGCCGACCACGCTGAAACTGCTGGCGATCATCGGGGCGATCGTGGCCACCGTCGTCGCACTGATCGCGTTGTGGCGCCTGGACCAGTTGGACGGGCGGGGCTCAATTGCCCAGCTCCTCCTCAGGCCGTTCCGGCCTGCATCGTCGCCGGGCGGCATGCGCCGGCTGATTCCGGCAAGCTGGCGCACCTTCACCCTGACCGACGCCGTGGTGATATTCGGCTTCCTGCTCTGGCATGTCATCGGCGCGAATTCGTCGGACGACGGCTACATCCTGGGCATGGCCCGAGTCGCCGACCACGCCGGCTACATGTCCAACTATTTCCGCTGGTTCGGCAGCCCGGAGGATCCCTTCGGCTGGTATTACAACCTGCTGGCGCTGATGACCCATGTCAGCGACGCCAGTCTGTGGATGCGCCTGCCAGACCTGGCCGCCGGGCTAGTGTGCTGGCTGCTGCTGTCGCGTGAGGTGCTGCCCCGCCTCGGGCCGGCGGTGGAGGCCAGCAAACCCGCCTACTGGGCGGCGGCCATGGTCTTGCTGACCGCGTGGATGCCGTTCAACAACGGCCTGCGGCCGGAGGGCATCATCGCGCTCGGCTCGCTGGTCACCTATGTGCTGATCGAGCGGTCCATGCGGTACAGCCGGCTCACACCGGCGGCGCTGGCCGTCGTTACCGCCGCATTCACACTGGGTGTGCAGCCCACCGGCCTGATCGCGGTGGCCGCGCTGGTGGCCGGCGGCCGCCCGATGCTGCGGATCTTGGTGCGCCGTCATCGCCTGGTCGGCACGTTGCCGTTGGTGTCGCCGATGCTGGCCGCCGGCACCGTCATCCTGACCGTGGTGTTCGCCGACCAGACCCTGTCAACGGTGTTGGAAGCCACCAGGGTTCGCGCCAAAATCGGGCCGAGCCAGGCGTGGTATACCGAGAACCTGCGTTACTACTACCTCATCCTGCCCACCGTCGACGGTTCGCTGTCGCGGCGCTTCGGCTTTTTGATCACCGCGCTATGCCTGTTCACCGCGGTGTTCATCATGTTGCGGCGCAAGCGAATTCCCAGCGTGGCCCGCGGACCGGCGTGGCGGCTGATGGGCGTCATCTTCGGCACCATGTTCTTCCTGATGTTCACGCCCACCAAGTGGGTGCACCACTTCGGGCTGTTCGCCGCCGTAGGGGCGGCGATGGCCGCGCTGACGACGGTGTTGGTATCCCCATCGGTGCTGCGCTGGTCGCGCAACCGGATGGCGTTCCTGGCGGCGTTATTCTTCCTGCTGGCGTTGTGTTGGGCCACCACCAACGGCTGGTGGTATGTCTCCAGCTACGGTGTGCCGTTCAACAGCGCGATGCCGAAGATCGACGGGATCACAGTCAGCACAATCTTTTTCGCCCTGTTTGCGATCGCCGCCGGCTATGCGGCCTGGCTGCACTTCGCGCCCCGCGGCGCCGGCGAAGGGCGGCTGATCCGCGCGCTGACGACAGCCCCGGTACCGATCGTGGCCGGTTTCATGGCGGCGGTGTTCGTCGCGTCCATGGTGGCCGGGATCGTGCGACAGTACCCGACCTACTCCAACGGCTGGTCCAACGTGCGGGCGTTTGTCGGCGGCTGCGGACTGGCCGACGACGTACTCGTCGAGCCTGATACCAATGCGGGTTTCATGAAGCCGCTGGACGGCGATTCGGGTTCTTGGGGCCCCTTGGGCCCGCTGGGTGGAGTCAACCCGGTCGGCTTCACGCCCAACGGCGTACCGGAACACACGGTGGCCGAGGCGATCGTGATGAAACCCAACCAGCCCGGCACCGACTACGACTGGGATGCGCCGACCAAGCTGACGAGTCCTGGCATCAATGGTTCTACGGTGCCGCTGCCCTATGGGCTCGATCCCGCCCGGGTACCGTTGGCAGGCACCTACACCACCGGCGCACAGCAACAGAGCACACTCGTCTCGGCGTGGTATCTCCTGCCTAAGCCGGACGACGGGCATCCGCTGGTCGTGGTGACCGCCGCGGGCAAGATCGCCGGCAACAGCGTGCTGCACGGGTACACCCCCGGGCAGACTGTGGTGCTCGAATACGCCATGCCGGGACCCGGAGCGCTGGTACCCGCCGGGCGGATGGTGCCCGACGACCTATACGGAGAGCAGCCCAAGGCGTGGCGCAACCTGCGCTTCGCCCGAGCAAAGATGCCCGCCGATGCCGTCGCGGTCCGGGTGGTGGCCGAGGATCTGTCGCTGACACCGGAGGACTGGATCGCGGTGACCCCGCCGCGGGTACCGGACCTGCGCTCACTGCAGGAATATGTGGGCTCGACGCAGCCGGTGCTGCTGGACTGGGCGGTCGGTTTGGCCTTCCCGTGCCAGCAGCCGATGCTGCACGCCAATGGCATCGCCGAAATCCCGAAGTTCCGCATCACACCGGACTACTCGGCTAAGAAGCTGGACACCGACACGTGGGAAGACGGCACTAACGGCGGCCTGCTCGGGATCACCGACCTGTTGCTGCGGGCCCACGTCATGGCCACCTACCTGTCCCGCGACTGGGCCCGCGATTGGGGTTCCCTGCGCAAGTTCGACACCCTGGTCGATGCCCCTCCCGCCCAGCTCGAGTTGGGCACCGCGACCCGCAGCGGCCTGTGGTCACCGGGCAAGATCCGAATTGGTCCATAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["3355"]}}}}}, "2476": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7810": "C734T", "7811": "C735T"}}, "clinical": {"$update": {"7810": "C734T", "7811": "C735T"}}}}}}}}, "2478": {"$update": {"model_param": {"$update": {"40330": {"$update": {"param_value": {"$update": {"4760": "A965G,G966T", "4762": "A965T,G966T,A967C"}}}}}}}}, "3485": {"$update": {"ARO_description": "OXA-392 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3486": {"$update": {"ARO_description": "OXA-400 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3513": {"$update": {"ARO_description": "OXA-443 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3543": {"$update": {"ARO_description": "OXA-482 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3727": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8837": {"protein_sequence": {"accession": "NP_215000.1", "sequence": "MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "575347", "fmax": "576790", "strand": "+", "sequence": "ATGGCAGGTGTGCGGCACGATGACGGTTCAGGGTTGATCGCCCAGCGCCGTCCGGTCCGCGGCGAGGGTGCCACCCGCTCGCGCGGCCCATCCGGGCCATCCAATCGGAATGTTTCGGCAGCAGACGACCCGCGCCGGGTTGCGCTGCTGGCGGTGCACACCTCACCGCTGGCACAGCCGGGCACCGGTGACGCCGGCGGCATGAACGTCTACATGCTGCAAAGTGCGCTGCACCTGGCCCGTCGGGGCATCGAGGTGGAGATCTTCACCCGGGCCACCGCATCGGCAGATCCACCGGTGGTGCGGGTGGCACCCGGGGTGCTGGTGCGCAACGTGGTGGCGGGGCCCTTCGAGGGTTTGGACAAGTACGACCTGCCCACCCAGCTTTGTGCGTTCGCCGCCGGGGTGCTGCGCGCCGAGGCGGTCCACGAACCGGGTTACTACGACATCGTGCACTCGCACTACTGGCTGTCGGGTCAGGTCGGCTGGCTGGCGCGCGACCGCTGGGCGGTGCCGTTGGTGCACACCGCACACACGCTGGCCGCCGTGAAGAACGCGGCACTGGCCGACGGCGACGGACCCGAGCCGCCGCTGCGTACGGTCGGGGAGCAGCAGGTCGTCGACGAGGCGGATCGGTTGATCGTCAACACCGACGATGAAGCCAGGCAAGTGATTTCGCTTCATGGTGCCGATCCGGCACGAATCGACGTGGTCCATCCCGGTGTCGATCTGGACGTGTTCCGCCCGGGTGATCGGCGCGCGGCCCGGGCCGCGCTAGGACTACCAGTTGACGAGCGCGTGGTGGCCTTCGTCGGACGCATCCAGCCGCTGAAGGCACCCGACATTGTGCTGCGTGCGGCCGCCAAGTTGCCCGGGGTGCGCATCATCGTGGCCGGCGGACCGTCGGGCAGCGGTCTGGCTTCACCGGACGGACTGGTCCGGCTCGCCGACGAACTGGGCATCTCTGCACGGGTGACGTTTCTGCCGCCGCAGTCCCACACGGATCTGGCCACCTTGTTTCGGGCGGCGGACCTGGTTGCGGTGCCGAGCTACTCCGAGTCGTTCGGCCTGGTTGCTGTGGAGGCCCAAGCGTGCGGCACACCGGTGGTGGCCGCGGCGGTGGGCGGGCTGCCCGTCGCGGTGCGCGACGGGATCACCGGCACCCTGGTGTCCGGGCACGAGGTCGGTCAGTGGGCCGACGCCATCGATCACCTGCTGCGGTTGTGTGCCGGGCCACGGGGACGGGTGATGAGCCGGGCGGCGGCACGGCACGCCGCCACGTTCTCGTGGGAGAACACCACCGACGCGCTGTTGGCCAGTTATCGGCGTGCGATCGGCGAGTACAACGCCGAGCGCCAGCGCCGGGGCGGCGAGGTGATATCGGACCTGGTAGCGGTGGGCAAGCCCCGCCACTGGACGCCGCGTCGCGGGGTGGGCGCGTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["6003"]}}}}}, "3386": {"$update": {"ARO_description": "An unpublished MCR-1 variant."}}, "3405": {"$update": {"ARO_description": "OXA-402 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3487": {"$update": {"ARO_description": "OXA-401 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3514": {"$update": {"ARO_description": "OXA-444 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3544": {"$update": {"ARO_description": "OXA-483 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2098": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4844": "G1475T"}}, "clinical": {"$update": {"4844": "G1475T"}}}}}}}}, "3406": {"$update": {"ARO_description": "OXA-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3488": {"$update": {"ARO_description": "OXA-403 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3489": {"$update": {"ARO_description": "OXA-404 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3515": {"$update": {"ARO_description": "OXA-446 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3545": {"$update": {"ARO_description": "OXA-484 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3408": {"$update": {"ARO_description": "OXA-122 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3490": {"$update": {"ARO_description": "OXA-405 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3516": {"$update": {"ARO_description": "OXA-447 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3546": {"$update": {"ARO_description": "OXA-485 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "1213": {"$update": {"model_param": {"$update": {"41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}}}, "3409": {"$update": {"ARO_description": "OXA-123 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3491": {"$update": {"ARO_description": "OXA-406 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3517": {"$update": {"ARO_description": "OXA-448 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3547": {"$update": {"ARO_description": "OXA-486 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2267": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}}}, "3410": {"$update": {"ARO_description": "OXA-124 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3492": {"$update": {"ARO_description": "OXA-407 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3518": {"$update": {"ARO_description": "OXA-449 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3522": {"$update": {"ARO_description": "OXA-453 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3548": {"$update": {"ARO_description": "OXA-488 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3411": {"$update": {"ARO_description": "OXA-125 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3493": {"$update": {"ARO_description": "OXA-408 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3519": {"$update": {"ARO_description": "OXA-450 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3523": {"$update": {"ARO_description": "OXA-455 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2805": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7891": "G2075T", "7893": "A2517T", "7895": "G2461T", "7896": "T2518G", "7897": "A2586T"}}, "clinical": {"$update": {"7891": "G2075T", "7893": "A2517T", "7895": "G2461T", "7896": "T2518G", "7897": "A2586T"}}}}}}}}, "2833": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"8199": "A2058T"}}, "clinical": {"$update": {"8199": "A2058T"}}}}}}}}, "2794": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7907": "A2146T"}}, "clinical": {"$update": {"7907": "A2146T"}}}}}}}}, "2807": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7899": "G2032T"}}, "clinical": {"$update": {"7899": "G2032T"}}}}}}}}, "2803": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout."}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8792": {"protein_sequence": {"accession": "NP_217280.1", "sequence": "MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "3073679", "fmax": "3074471", "strand": "-", "sequence": "GTGACGCCATACGAGGACCTGCTGCGCTTCGTGCTCGAAACGGGTACGCCCAAATCCGACCGCACCGGCACCGGAACCCGCAGCCTGTTCGGCCAGCAGATGCGCTATGATTTGTCGGCCGGTTTCCCGCTGCTCACTACCAAGAAAGTCCATTTCAAATCGGTAGCCTACGAGCTGCTGTGGTTTTTGCGCGGCGATTCCAATATCGGTTGGCTGCACGAGCACGGAGTCACCATCTGGGACGAATGGGCAAGTGATACAGGCGAACTCGGGCCGATCTACGGTGTACAATGGCGATCGTGGCCGGCTCCATCCGGTGAGCACATCGACCAGATCAGCGCGGCGCTGGATTTGCTGCGCACCGATCCCGATTCCCGGCGCATCATCGTGTCGGCCTGGAACGTCGGCGAAATCGAGCGGATGGCGCTGCCGCCCTGTCATGCGTTCTTCCAGTTCTACGTCGCCGATGGCCGGCTGAGCTGTCAGCTCTACCAACGCAGCGCCGACCTGTTTCTGGGTGTGCCGTTCAACATCGCCAGCTATGCGTTGCTCACCCACATGATGGCCGCCCAGGCCGGCTTGTCGGTCGGCGAGTTCATCTGGACCGGTGGCGACTGCCACATCTACGACAATCACGTCGAGCAAGTACGGCTGCAGCTCAGCCGCGAGCCGCGGCCATATCCGAAACTACTTCTAGCCGACCGGGATTCAATCTTCGAGTACACCTATGAAGACATCGTTGTGAAGAACTACGATCCGCATCCGGCGATCAAAGCTCCAGTCGCGGTATGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5390"]}}}}}, "2804": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8816": {"protein_sequence": {"accession": "NP_216963.1", "sequence": "MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2746134", "fmax": "2747598", "strand": "-", "sequence": "ATGAATTCGACGAATTCCGGCCCGCCTGACTCGGGATCGGCCACCGGCGTCGTGCCCACTCCGGACGAGATCGCGTCCCTGCTGCAGGTTGAGCATCTACTCGACCAACGCTGGCCGGAGACCCGCATCGATCCGAGCCTGACCCGGATCAGCGCGTTGATGGACCTGCTGGGCTCGCCCCAACGCAGCTATCCGTCGATCCATATCGCGGGCACCAACGGCAAGACCTCGGTGGCGCGCATGGTCGACGCGCTGGTCACCGCGCTGCACCGGCGCACCGGCCGAACCACCAGCCCACACCTGCAGTCACCGGTGGAACGCATTTCGATCGACGGCAAGCCGATCAGCCCGGCGCAGTATGTGGCGACCTACCGGGAGATCGAGCCGTTGGTGGCGCTGATCGACCAGCAGTCGCAGGCTTCTGCGGGTAAGGGTGGCCCGGCGATGAGCAAGTTCGAGGTGCTCACCGCGATGGCGTTCGCGGCCTTTGCGGACGCGCCCGTCGACGTGGCAGTGGTCGAGGTGGGCATGGGCGGACGTTGGGACGCCACCAACGTGATCAACGCACCGGTCGCCGTCATCACCCCGATCAGCATTGATCACGTCGACTATCTCGGTGCCGATATCGCCGGGATCGCCGGGGAGAAGGCGGGCATCATCACTCGGGCCCCCGACGGTTCGCCGGACACCGTCGCGGTCATCGGGCGTCAGGTCCCGAAGGTCATGGAGGTGCTGCTGGCCGAATCGGTGCGCGCCGACGCGTCGGTGGCCCGGGAGGATTCCGAATTCGCGGTGCTACGGCGACAGATCGCGGTCGGCGGTCAGGTACTGCAACTGCAGGGCCTCGGCGGGGTTTACTCCGACATCTACTTGCCGCTGCACGGTGAACACCAGGCGCACAACGCGGTGCTCGCCCTCGCTTCCGTCGAGGCCTTTTTCGGTGCCGGTGCGCAGCGTCAGCTCGACGGCGACGCCGTCCGGGCCGGCTTTGCCGCCGTCACCAGTCCCGGCCGGTTGGAGCGCATGCGCAGCGCACCCACGGTGTTCATCGACGCCGCGCACAATCCGGCCGGGGCGAGTGCTCTGGCACAAACGCTGGCGCATGAGTTCGACTTCCGATTTCTGGTCGGGGTGCTCAGCGTGCTGGGCGACAAGGACGTGGACGGCATCCTGGCCGCACTGGAGCCGGTGTTCGATTCCGTCGTCGTGACCCACAACGGGTCGCCGCGGGCGCTGGATGTCGAGGCCCTGGCGCTGGCGGCCGGCGAGCGGTTCGGACCCGACCGGGTGCGCACCGCCGAGAACCTGCGCGATGCTATCGACGTTGCCACCTCACTGGTCGACGACGCCGCCGCCGACCCGGATGTGGCCGGGGACGCATTCTCGAGAACCGGGATCGTCATCACCGGCTCGGTTGTCACCGCAGGGGCGGCTCGGACCTTGTTCGGTCGTGATCCGCAATGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5391"]}}}}}, "2811": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7915": "A2274T"}}, "clinical": {"$update": {"7915": "A2274T"}}}}}}}}, "2813": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"8172": "A2266T"}}, "clinical": {"$update": {"8172": "A2266T"}}}}}}}}, "2815": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"8171": "A2265T"}}, "clinical": {"$update": {"8171": "A2265T"}}}}}}}}, "2802": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7845": "T754A", "7849": "A2058T", "7850": "C2611T"}}, "clinical": {"$update": {"7845": "T754A", "7849": "A2058T", "7850": "C2611T"}}}}}}}}, "2819": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7933": "G2032T", "7935": "G2447T"}}, "clinical": {"$update": {"7933": "G2032T", "7935": "G2447T"}}}}}}}}, "3412": {"$update": {"ARO_description": "OXA-126 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2825": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7948": "C2471T"}}, "clinical": {"$update": {"7948": "C2471T"}}}}}}}}, "2827": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8796": {"protein_sequence": {"accession": "NP_217187.1", "sequence": "MPDSGQLGAADTPLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLDGGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQRQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEVIACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELCLTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2986838", "fmax": "2987615", "strand": "+", "sequence": "ATGCCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCCGCTAAGGCTGCTCAGCTCGGTGCATTACCTCACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGCTTGGACGGCGGCGCTACCGTCGATGGCACCAGCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCGGCGTGGGCACCGTGCGCATTGAGGGCTACTCCGGCGTCCGGATGGGTGTCGTCCAGCGCCAGCACCGGCAGGCCCGAGGCCAAAGCGAAGTTCCGCAACTGGCAATCGTCACCAGGTCCGGTCGCCTTGACCGTGACATGGCGGTATTCACCCGGACCGAGATGGCACCGTTGGTGCTCACCACCACGGCGGTCGCCGATGACACGCGCCAGCGGCTCGCGGGCCTCGCCGAGGTGATCGCGTGCTCCGGCGACGATCCGGGCACGGTCGATGAGGCAGTGCTCGTGTCCCAGCTCGCGGCTCGCGGTCTGCGCCGGATCCTTACCGAAGGCGGGCCGACGTTGCTCGGGACATTCGTCGAGCGTGACGTGCTCGACGAGCTGTGTCTGACGATCGCCCCCTACGTCGTCGGCGGCCTGGCGCGCCGCATAGTGACGGGACCCGGGCAGGTGCTGACCCGGATGCGCTGTGCCCATGTCCTCACCGACGACTCCGGCTACCTGTACACCCGCTACGTCAAGACCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5511"]}}}}}, "37": {"$update": {"ARO_category": {"$insert": {"36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}}}}}, "2834": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8830": {"protein_sequence": {"accession": "NP_214855.1", "sequence": "MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSVAANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAGLASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGTGLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGAGVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGGVGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "409361", "fmax": "410801", "strand": "+", "sequence": "ATGACCTCGCTTATCGATTACATCCTGAGCCTGTTCCGCAGCGAAGACGCCGCCCGGTCGTTCGTTGCCGCTCCGGGACGGGCCATGACCAGTGCCGGGCTGATCGATATCGCGCCGCACCAAATCTCATCGGTGGCGGCCAATGTGGTGCCGGGTCTGAATCTGGGTGCCGGCGACCCCATGAGCGGATTGCGGCAGGCCGTCGCCGCTCGGCATGGCTTTGCGCAGGACGTCGCCAATGTCGGCTTCGCCGGTGACGCGGGCGCGGGGGTGGCAAGCGTCATCACGACCGATGTCGGTGCGGGCCTGGCTAGCGGACTGGGTGCTGGGTTCCTGGGTCAGGGTGGCCTGGCTCTCGCCGCGTCAAGCGGTGGTTTCGGCGGTCAGGTCGGCTTGGCTGCCCAGGTCGGTCTGGGTTTTACTGCCGTGATTGAGGCCGAGGTCGGCGCTCAGGTTGGTGCTGGGTTAGGTATTGGGACGGGTCTGGGTGCTCAGGCCGGTATGGGCTTTGGCGGCGGGGTTGGCCTGGGTCTGGGTGGTCAGGCCGGCGGTGTGATCGGTGGGAGCGCGGCCGGGGCTATCGGTGCCGGCGTCGGCGGTCGCCTAGGCGGCAATGGCCAGATCGGAGTTGCCGGCCAGGGTGCCGTTGGCGCTGGTGTCGGCGCTGGTGTCGGCGGCCAGGCGGGCATCGCTAGCCAGATCGGTGTCTCAGCCGGTGGTGGGCTCGGCGGCGTCGGCAATGTCAGCGGCCTGACCGGGGTCAGCAGCAACGCAGTGTTGGCTTCCAACGCAAGCGGCCAGGCGGGGTTGATCGCCAGTGAAGGCGCTGCCTTGAACGGCGCTGCTATGCCTCATCTGTCGGGCCCGTTAGCCGGTGTCGGTGTGGGTGGTCAGGCCGGCGCCGCTGGCGGCGCCGGGTTGGGCTTCGGAGCGGTCGGGCACCCGACTCCTCAGCCGGCGGCCCTGGGCGCGGCTGGCGTGGTGGCCAAGACCGAGGCGGCTGCTGGAGTGGTTGGCGGGGTCGGCGGGGCAACCGCGGCCGGGGTCGGCGGGGCACACGGCGACATCCTGGGCCACGAGGGAGCCGCACTGGGCAGTGTCGACACGGTCAACGCCGGTGTCACGCCCGTCGAGCATGGCTTGGTCCTGCCCAGTGGCCCCCTGATCCACGGCGGTACCGGCGGCTATGGCGGCATGAACCCGCCAGTGACCGATGCGCCGGCACCGCAAGTTCCGGCGCGGGCCCAGCCGATGACCACGGCGGCCGAGCACACGCCGGCGGTTACCCAACCGCAGCACACGCCGGTCGAGCCGCCGGTCCACGATAAGCCGCCGAGCCATTCGGTGTTTGACGTCGGTCACGAGCCGCCGGTGACGCACACGCCGCCGGCGCCCATCGAACTGCCGTCGTACGGCCTTTTCGGACTACCCGGGTTCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5509"]}}}}}, "2822": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"7943": "A2578T"}}, "clinical": {"$update": {"7943": "A2578T"}}}}}}}}, "3413": {"$update": {"ARO_description": "OXA-127 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3494": {"$update": {"ARO_description": "OXA-409 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3520": {"$update": {"ARO_description": "OXA-451 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3524": {"$update": {"ARO_description": "OXA-457 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3415": {"$update": {"ARO_description": "OXA-151 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3495": {"$update": {"ARO_description": "OXA-411 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3521": {"$update": {"ARO_description": "OXA-452 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3525": {"$update": {"ARO_description": "OXA-458 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3416": {"$update": {"ARO_description": "OXA-152 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3496": {"$update": {"ARO_description": "OXA-412 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3526": {"$update": {"ARO_description": "OXA-459 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3417": {"$update": {"ARO_description": "OXA-153 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3497": {"$update": {"ARO_description": "OXA-413 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3527": {"$update": {"ARO_description": "OXA-460 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3418": {"$update": {"ARO_description": "OXA-154 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3498": {"$update": {"ARO_description": "OXA-414 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3528": {"$update": {"ARO_description": "OXA-461 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3419": {"$update": {"ARO_description": "OXA-155 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3499": {"$update": {"ARO_description": "OXA-416 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3529": {"$update": {"ARO_description": "OXA-464 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3420": {"$update": {"ARO_description": "OXA-156 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3471": {"$update": {"ARO_description": "OXA-336 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3503": {"$update": {"ARO_description": "OXA-430 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3500": {"$update": {"ARO_description": "OXA-417 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3530": {"$update": {"ARO_description": "OXA-465 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3617": {"$update": {"ARO_description": "IMI-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3421": {"$update": {"ARO_description": "OXA-157 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3472": {"$update": {"ARO_description": "OXA-337 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3501": {"$update": {"ARO_description": "OXA-427 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3531": {"$update": {"ARO_description": "OXA-466 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3422": {"$update": {"ARO_description": "OXA-158 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3473": {"$update": {"ARO_description": "OXA-339 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3502": {"$update": {"ARO_description": "OXA-429 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3532": {"$update": {"ARO_description": "OXA-470 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3618": {"$update": {"ARO_description": "IMP-49 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3627": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "3423": {"$update": {"ARO_description": "OXA-185 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3474": {"$update": {"ARO_description": "OXA-340 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3533": {"$update": {"ARO_description": "OXA-471 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3577": {"$update": {"ARO_description": "CMY-132 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3651": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8768": {"protein_sequence": {"accession": "", "sequence": ""}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1471845", "fmax": "1473382", "strand": "+", "sequence": "TTTTGTTTGGAGAGTTTGATCCTGGCTCAGGACGAACGCTGGCGGCGTGCTTAACACATGCAAGTCGAACGGAAAGGTCTCTTCGGAGATACTCGAGTGGCGAACGGGTGAGTAACACGTGGGTGATCTGCCCTGCACTTCGGGATAAGCCTGGGAAACTGGGTCTAATACCGGATAGGACCACGGGATGCATGTCTTGTGGTGGAAAGCGCTTTAGCGGTGTGGGATGAGCCCGCGGCCTATCAGCTTGTTGGTGGGGTGACGGCCTACCAAGGCGACGACGGGTAGCCGGCCTGAGAGGGTGTCCGGCCACACTGGGACTGAGATACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCACAATGGGCGCAAGCCTGATGCAGCGACGCCGCGTGGGGGATGACGGCCTTCGGGTTGTAAACCTCTTTCACCATCGACGAAGGTCCGGGTTCTCTCGGATTGACGGTAGGTGGAGAAGAAGCACCGGCCAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGTGCGAGCGTTGTCCGGAATTACTGGGCGTAAAGAGCTCGTAGGTGGTTTGTCGCGTTGTTCGTGAAATCTCACGGCTTAACTGTGAGCGTGCGGGCGATACGGGCAGACTAGAGTACTGCAGGGGAGACTGGAATTCCTGGTGTAGCGGTGGAATGCGCAGATATCAGGAGGAACACCGGTGGCGAAGGCGGGTCTCTGGGCAGTAACTGACGCTGAGGAGCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGGTGGGTACTAGGTGTGGGTTTCCTTCCTTGGGATCCGTGCCGTAGCTAACGCATTAAGTACCCCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGCGGAGCATGTGGATTAATTCGATGCAACGCGAAGAACCTTACCTGGGTTTGACATGCACAGGACGCGTCTAGAGATAGGCGTTCCCTTGTGGCCTGTGTGCAGGTGGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCTCATGTTGCCAGCACGTAATGGTGGGGACTCGTGAGAGACTGCCGGGGTCAACTCGGAGGAAGGTGGGGATGACGTCAAGTCATCATGCCCCTTATGTCCAGGGCTTCACACATGCTACAATGGCCGGTACAAAGGGCTGCGATGCCGCGAGGTTAAGCGAATCCTTAAAAGCCGGTCTCAGTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTCGGAGTCGCTAGTAATCGCAGATCAGCAACGCTGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACGTCATGAAAGTCGGTAACACCCGAAGCCAGTGGCCTAACCCTCGGGAGGGAGCTGTCGAAGGTGGGATCGGCGATTGGGACGAAGTCGTAACAAGGTAGCCGTACCGGAAGGTGCGGCTGGATCACCTCCTTTCT", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5921"]}}}}}, "3475": {"$update": {"ARO_description": "OXA-341 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3504": {"$update": {"ARO_description": "OXA-431 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3534": {"$update": {"ARO_description": "OXA-472 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3578": {"$update": {"ARO_description": "CMY-133 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3476": {"$update": {"ARO_description": "OXA-342 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3505": {"$update": {"ARO_description": "OXA-432 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3535": {"$update": {"ARO_description": "OXA-473 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3477": {"$update": {"ARO_description": "OXA-343 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3506": {"$update": {"ARO_description": "OXA-433 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3536": {"$update": {"ARO_description": "OXA-474 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3478": {"$update": {"ARO_description": "OXA-344 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3507": {"$update": {"ARO_description": "OXA-437 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3537": {"$update": {"ARO_description": "OXA-475 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3581": {"$update": {"ARO_description": "DHA-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4129": {"$update": {"ARO_description": "ACT-34 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3254": {"$update": {"ARO_description": "NDM-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3479": {"$update": {"ARO_description": "OXA-345 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3508": {"$update": {"ARO_description": "OXA-438 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3538": {"$update": {"ARO_description": "OXA-476 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3773": {"$update": {"ARO_description": "CTX-M-161 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3774": {"$update": {"ARO_description": "CTX-M-162 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3775": {"$update": {"ARO_description": "CTX-M-163 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3776": {"$update": {"ARO_description": "CTX-M-164 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3777": {"$update": {"ARO_description": "CTX-M-165 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3778": {"$update": {"ARO_description": "CTX-M-166 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "3818": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"9966": "G2061T", "9967": "A2451T", "9968": "C2452T", "9969": "T2500A", "9970": "T2504G"}}, "clinical": {"$update": {"9966": "G2061T", "9967": "A2451T", "9968": "C2452T", "9969": "T2500A", "9970": "T2504G"}}}}}}}}, "3834": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11.", "param_value": {"$update": {"10039": "-nt1384:A"}}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8834": {"protein_sequence": {"accession": "NP_216424.1", "sequence": "MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAVQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "2153888", "fmax": "2156111", "strand": "-", "sequence": "GTGCCCGAGCAACACCCACCCATTACAGAAACCACCACCGGAGCCGCTAGCAACGGCTGTCCCGTCGTGGGTCATATGAAATACCCCGTCGAGGGCGGCGGAAACCAGGACTGGTGGCCCAACCGGCTCAATCTGAAGGTACTGCACCAAAACCCGGCCGTCGCTGACCCGATGGGTGCGGCGTTCGACTATGCCGCGGAGGTCGCGACCATCGACGTTGACGCCCTGACGCGGGACATCGAGGAAGTGATGACCACCTCGCAGCCGTGGTGGCCCGCCGACTACGGCCACTACGGGCCGCTGTTTATCCGGATGGCGTGGCACGCTGCCGGCACCTACCGCATCCACGACGGCCGCGGCGGCGCCGGGGGCGGCATGCAGCGGTTCGCGCCGCTTAACAGCTGGCCCGACAACGCCAGCTTGGACAAGGCGCGCCGGCTGCTGTGGCCGGTCAAGAAGAAGTACGGCAAGAAGCTCTCATGGGCGGACCTGATTGTTTTCGCCGGCAACTGCGCGCTGGAATCGATGGGCTTCAAGACGTTCGGGTTCGGCTTCGGCCGGGTCGACCAGTGGGAGCCCGATGAGGTCTATTGGGGCAAGGAAGCCACCTGGCTCGGCGATGAGCGTTACAGCGGTAAGCGGGATCTGGAGAACCCGCTGGCCGCGGTGCAGATGGGGCTGATCTACGTGAACCCGGAGGGGCCGAACGGCAACCCGGACCCCATGGCCGCGGCGGTCGACATTCGCGAGACGTTTCGGCGCATGGCCATGAACGACGTCGAAACAGCGGCGCTGATCGTCGGCGGTCACACTTTCGGTAAGACCCATGGCGCCGGCCCGGCCGATCTGGTCGGCCCCGAACCCGAGGCTGCTCCGCTGGAGCAGATGGGCTTGGGCTGGAAGAGCTCGTATGGCACCGGAACCGGTAAGGACGCGATCACCAGCGGCATCGAGGTCGTATGGACGAACACCCCGACGAAATGGGACAACAGTTTCCTCGAGATCCTGTACGGCTACGAGTGGGAGCTGACGAAGAGCCCTGCTGGCGCTTGGCAATACACCGCCAAGGACGGCGCCGGTGCCGGCACCATCCCGGACCCGTTCGGCGGGCCAGGGCGCTCCCCGACGATGCTGGCCACTGACCTCTCGCTGCGGGTGGATCCGATCTATGAGCGGATCACGCGTCGCTGGCTGGAACACCCCGAGGAATTGGCCGACGAGTTCGCCAAGGCCTGGTACAAGCTGATCCACCGAGACATGGGTCCCGTTGCGAGATACCTTGGGCCGCTGGTCCCCAAGCAGACCCTGCTGTGGCAGGATCCGGTCCCTGCGGTCAGCCACGACCTCGTCGGCGAAGCCGAGATTGCCAGCCTTAAGAGCCAGATCCGGGCATCGGGATTGACTGTCTCACAGCTAGTTTCGACCGCATGGGCGGCGGCGTCGTCGTTCCGTGGTAGCGACAAGCGCGGCGGCGCCAACGGTGGTCGCATCCGCCTGCAGCCACAAGTCGGGTGGGAGGTCAACGACCCCGACGGGGATCTGCGCAAGGTCATTCGCACCCTGGAAGAGATCCAGGAGTCATTCAACTCCGCGGCGCCGGGGAACATCAAAGTGTCCTTCGCCGACCTCGTCGTGCTCGGTGGCTGTGCCGCCATAGAGAAAGCAGCAAAGGCGGCTGGCCACAACATCACGGTGCCCTTCACCCCGGGCCGCACGGATGCGTCGCAGGAACAAACCGACGTGGAATCCTTTGCCGTGCTGGAGCCCAAGGCAGATGGCTTCCGAAACTACCTCGGAAAGGGCAACCCGTTGCCGGCCGAGTACATGCTGCTCGACAAGGCGAACCTGCTTACGCTCAGTGCCCCTGAGATGACGGTGCTGGTAGGTGGCCTGCGCGTCCTCGGCGCAAACTACAAGCGCTTACCGCTGGGCGTGTTCACCGAGGCCTCCGAGTCACTGACCAACGACTTCTTCGTGAACCTGCTCGACATGGGTATCACCTGGGAGCCCTCGCCAGCAGATGACGGGACCTACCAGGGCAAGGATGGCAGTGGCAAGGTGAAGTGGACCGGCAGCCGCGTGGACCTGGTCTTCGGGTCCAACTCGGAGTTGCGGGCGCTTGTCGAGGTCTATGGCGCCGATGACGCGCAGCCGAAGTTCGTGCAGGACTTCGTCGCTGCCTGGGACAAGGTGATGAACCTCGACAGGTTCGACGTGCGCTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["6146"]}}}}}, "3836": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11.", "param_value": {"$update": {"10089": "-nt822:G", "10098": "-nt751:A", "10099": "-nt884:T", "10100": "-nt1043:T", "10101": "-nt1133:C", "10105": "-nt385:A", "10106": "-nt1339:C", "10108": "-nt455:C", "10109": "-nt697:T", "10116": "-nt43:G", "10119": "-nt34:G"}}}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout.", "param_value": {"$update": {"10091": "+nt213:A", "10092": "+nt342:A", "10093": "+nt672:G", "10094": "+nt755:G", "10095": "+nt756:G", "10097": "+nt757:C", "10103": "+nt11:A", "10104": "+nt797:G", "10112": "+nt1247:A", "10114": "+nt673:G", "10118": "+nt1219:A"}}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8810": {"protein_sequence": {"accession": "NP_218371.1", "sequence": "MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4326003", "fmax": "4327473", "strand": "-", "sequence": "ATGACCGAGCACCTCGACGTTGTCATCGTGGGCGCTGGAATCTCCGGTGTCAGCGCGGCCTGGCACCTGCAGGACCGTTGCCCGACCAAGAGCTACGCCATCCTGGAAAAGCGGGAATCCATGGGCGGCACCTGGGATTTGTTCCGTTATCCCGGAATTCGCTCCGACTCCGACATGTACACGCTAGGTTTCCGATTCCGTCCCTGGACCGGACGGCAGGCGATCGCCGACGGCAAGCCCATCCTCGAGTACGTCAAGAGCACCGCGGCCATGTATGGAATCGACAGGCATATCCGGTTCCACCACAAGGTGATCAGTGCCGATTGGTCGACCGCGGAAAACCGCTGGACCGTTCACATCCAAAGCCACGGCACGCTCAGCGCCCTCACCTGCGAATTCCTCTTTCTGTGCAGCGGCTACTACAACTACGACGAGGGCTACTCGCCGAGATTCGCCGGCTCGGAGGATTTCGTCGGGCCGATCATCCATCCGCAGCACTGGCCCGAGGACCTCGACTACGACGCTAAGAACATCGTCGTGATCGGCAGTGGCGCAACGGCGGTCACGCTCGTGCCGGCGCTGGCGGACTCGGGCGCCAAGCACGTCACGATGCTGCAGCGCTCACCCACCTACATCGTGTCGCAGCCAGACCGGGACGGCATCGCCGAGAAGCTCAACCGCTGGCTGCCGGAGACCATGGCCTACACCGCGGTACGGTGGAAGAACGTGCTGCGCCAGGCGGCCGTGTACAGCGCCTGCCAGAAGTGGCCACGGCGCATGCGGAAGATGTTCCTGAGCCTGATCCAGCGCCAGCTACCCGAGGGGTACGACGTGCGAAAGCACTTCGGCCCGCACTACAACCCCTGGGACCAGCGATTGTGCTTGGTGCCCAACGGCGACCTGTTCCGGGCCATTCGTCACGGGAAGGTCGAGGTGGTGACCGACACCATTGAACGGTTCACCGCGACCGGAATCCGGCTGAACTCAGGTCGCGAACTGCCGGCTGACATCATCATTACCGCAACGGGGTTGAACCTGCAGCTTTTTGGTGGGGCGACGGCGACTATCGACGGACAACAAGTGGACATCACCACGACGATGGCCTACAAGGGCATGATGCTTTCCGGCATCCCCAACATGGCCTACACGGTTGGCTACACCAATGCCTCCTGGACGCTGAAGGCCGACCTGGTGTCGGAGTTTGTCTGTCGCTTGTTGAATTACATGGACGACAACGGTTTTGACACCGTGGTCGTCGAGCGACCGGGCTCAGATGTCGAAGAGCGGCCCTTCATGGAGTTCACCCCAGGTTACGTGCTGCGCTCGCTGGACGAGCTGCCCAAGCAGGGTTCGCGTACACCGTGGCGCCTGAATCAGAACTACCTACGTGACATCCGGCTCATCCGGCGCGGCAAGATCGACGACGAGGGTCTGCGGTTCGCCAAAAGGCCTGCCCCGGTGGGGGTTTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["6148"]}}}}}, "3837": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11.", "param_value": {"$insert": {"10165": "nt385-1:A", "10166": "nt1339-1:C"}, "$update": {"10148": "-nt822:G", "10158": "-nt751:A", "10159": "-nt884:T", "10160": "-nt1043:T", "10161": "-nt1133:C", "10168": "-nt455:C", "10169": "-nt697:T", "10176": "-nt1043:T", "10177": "-nt34:G", "10181": "-nt1033:A"}}}}, "41345": {"$update": {"param_description": "A subtype of the insertion mutation detection model parameter used when a set of insertion mutations are reported in a nucleotide sequence format, encoded as [+]nt[position]:[nucleotides], for example +nt391:GG or +nt368:18. Such mutations may be of variable length, possibly causing a frameshift but not causing premature termination or a functional knockout.", "param_value": {"$update": {"10151": "+nt213:A", "10152": "+nt342:A", "10153": "+nt672:G", "10154": "+nt755:C", "10155": "+nt756:C", "10156": "+nt757:C", "10163": "+nt11:A", "10164": "+nt797:G", "10172": "+nt1247:A", "10174": "+nt673:G", "10179": "+nt1219:A", "10180": "+nt1336:C"}, "$delete": ["10165", "10166"]}}}}}, "model_sequences": {"$update": {"sequence": {"$insert": {"8812": {"protein_sequence": {"accession": "NP_218371.1", "sequence": "MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "4326003", "fmax": "4327473", "strand": "-", "sequence": "ATGACCGAGCACCTCGACGTTGTCATCGTGGGCGCTGGAATCTCCGGTGTCAGCGCGGCCTGGCACCTGCAGGACCGTTGCCCGACCAAGAGCTACGCCATCCTGGAAAAGCGGGAATCCATGGGCGGCACCTGGGATTTGTTCCGTTATCCCGGAATTCGCTCCGACTCCGACATGTACACGCTAGGTTTCCGATTCCGTCCCTGGACCGGACGGCAGGCGATCGCCGACGGCAAGCCCATCCTCGAGTACGTCAAGAGCACCGCGGCCATGTATGGAATCGACAGGCATATCCGGTTCCACCACAAGGTGATCAGTGCCGATTGGTCGACCGCGGAAAACCGCTGGACCGTTCACATCCAAAGCCACGGCACGCTCAGCGCCCTCACCTGCGAATTCCTCTTTCTGTGCAGCGGCTACTACAACTACGACGAGGGCTACTCGCCGAGATTCGCCGGCTCGGAGGATTTCGTCGGGCCGATCATCCATCCGCAGCACTGGCCCGAGGACCTCGACTACGACGCTAAGAACATCGTCGTGATCGGCAGTGGCGCAACGGCGGTCACGCTCGTGCCGGCGCTGGCGGACTCGGGCGCCAAGCACGTCACGATGCTGCAGCGCTCACCCACCTACATCGTGTCGCAGCCAGACCGGGACGGCATCGCCGAGAAGCTCAACCGCTGGCTGCCGGAGACCATGGCCTACACCGCGGTACGGTGGAAGAACGTGCTGCGCCAGGCGGCCGTGTACAGCGCCTGCCAGAAGTGGCCACGGCGCATGCGGAAGATGTTCCTGAGCCTGATCCAGCGCCAGCTACCCGAGGGGTACGACGTGCGAAAGCACTTCGGCCCGCACTACAACCCCTGGGACCAGCGATTGTGCTTGGTGCCCAACGGCGACCTGTTCCGGGCCATTCGTCACGGGAAGGTCGAGGTGGTGACCGACACCATTGAACGGTTCACCGCGACCGGAATCCGGCTGAACTCAGGTCGCGAACTGCCGGCTGACATCATCATTACCGCAACGGGGTTGAACCTGCAGCTTTTTGGTGGGGCGACGGCGACTATCGACGGACAACAAGTGGACATCACCACGACGATGGCCTACAAGGGCATGATGCTTTCCGGCATCCCCAACATGGCCTACACGGTTGGCTACACCAATGCCTCCTGGACGCTGAAGGCCGACCTGGTGTCGGAGTTTGTCTGTCGCTTGTTGAATTACATGGACGACAACGGTTTTGACACCGTGGTCGTCGAGCGACCGGGCTCAGATGTCGAAGAGCGGCCCTTCATGGAGTTCACCCCAGGTTACGTGCTGCGCTCGCTGGACGAGCTGCCCAAGCAGGGTTCGCGTACACCGTGGCGCCTGAATCAGAACTACCTACGTGACATCCGGCTCATCCGGCGCGGCAAGATCGACGACGAGGGTCTGCGGTTCGCCAAAAGGCCTGCCCCGGTGGGGGTTTAG", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["6149"]}}}}}, "3840": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8752": {"protein_sequence": {"accession": "WP_071766621.1", "sequence": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVVMGQTRQAFERTRSDA"}, "dna_sequence": {"accession": "NG_052123.1", "fmin": "100", "fmax": "655", "strand": "+", "sequence": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGAAGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAAAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGGTAATGGGTCAAACACGCCAAGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39526", "NCBI_taxonomy_name": "Aeromonas media", "NCBI_taxonomy_id": "651"}}}, "$delete": ["6153"]}}}}}, "3841": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8753": {"protein_sequence": {"accession": "WP_065187000.1", "sequence": "MTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA"}, "dna_sequence": {"accession": "NG_052463.1", "fmin": "100", "fmax": "655", "strand": "+", "sequence": "GTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "43330", "NCBI_taxonomy_name": "Enterobacter hormaechei subsp. steigerwaltii", "NCBI_taxonomy_id": "299766"}}}, "$delete": ["6154"]}}}}}, "3843": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8754": {"protein_sequence": {"accession": "WP_063840320.1", "sequence": "MTNCNDSVTLRLMTEHDLAMLYGWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA"}, "dna_sequence": {"accession": "NG_047292.1", "fmin": "100", "fmax": "655", "strand": "+", "sequence": "GTGACCAACTGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGGGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "35914", "NCBI_taxonomy_name": "Escherichia coli", "NCBI_taxonomy_id": "562"}}}, "$delete": ["6156"]}}}}}, "3857": {"$update": {"ARO_description": "An NDM metallo-beta-lactamase variant reported in Klebsiella pneumoniae."}}, "3890": {"$update": {"ARO_description": "CMY-134 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3891": {"$update": {"ARO_description": "CMY-143 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3892": {"$update": {"ARO_description": "CMY-107 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3893": {"$update": {"ARO_description": "CMY-158 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3894": {"$update": {"ARO_description": "CMY-173 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3896": {"$update": {"ARO_description": "CMY-147 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3897": {"$update": {"ARO_description": "CMY-146 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3898": {"$update": {"ARO_description": "CMY-156 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3899": {"$update": {"ARO_description": "CMY-160 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3900": {"$update": {"ARO_description": "CMY-162 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3901": {"$update": {"ARO_description": "CMY-140 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3902": {"$update": {"ARO_description": "CMY-164 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3903": {"$update": {"ARO_description": "CMY-161 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3904": {"$update": {"ARO_description": "CMY-165 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3905": {"$update": {"ARO_description": "CMY-166 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3906": {"$update": {"ARO_description": "CMY-149 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin."}}, "3907": {"$update": {"ARO_description": "CMY-139 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3908": {"$update": {"ARO_description": "CMY-148 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3909": {"$update": {"ARO_description": "CMY-163 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3910": {"$update": {"ARO_description": "CMY-154 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3911": {"$update": {"ARO_description": "CMY-142 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3912": {"$update": {"ARO_description": "CMY-141 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3913": {"$update": {"ARO_description": "CMY-124 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3914": {"$update": {"ARO_description": "CMY-125 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3915": {"$update": {"ARO_description": "CMY-145 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3916": {"$update": {"ARO_description": "CMY-122 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3917": {"$update": {"ARO_description": "CMY-96 is a beta-lactamase found in Citrobacter sp. It confers resistance to cephamycin."}}, "3918": {"$update": {"ARO_description": "CMY-171 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3919": {"$update": {"ARO_description": "CMY-155 is a beta-lactamase found in Klebsiella sp. KF07. It confers resistance to cephamycin."}}, "3920": {"$update": {"ARO_description": "CMY-96 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3922": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3923": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3924": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3925": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3926": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3927": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3928": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3929": {"$update": {"ARO_description": "A beta-lactamase gene from Escherichia coli.", "ARO_category": {"$delete": ["35939"]}}}, "3930": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3931": {"$update": {"ARO_description": "CMY-121 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3932": {"$update": {"ARO_description": "CMY-152 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3933": {"$update": {"ARO_description": "CMY-97 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3934": {"$update": {"ARO_description": "CMY-151 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3935": {"$update": {"ARO_description": "CMY-128 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3936": {"$update": {"ARO_description": "CMY-129 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3937": {"$update": {"ARO_description": "CMY-127 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3939": {"$update": {"ARO_description": "CMY-89 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin."}}, "3941": {"$update": {"ARO_description": "CMY-144 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin."}}, "3942": {"$update": {"ARO_description": "CMY-138 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin."}}, "3945": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3946": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3947": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3948": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3949": {"$update": {"ARO_description": "A beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3950": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3951": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3952": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3953": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3954": {"$update": {"ARO_description": "A beta-lactamase gene found in Escherichia coli.", "ARO_category": {"$delete": ["35939"]}}}, "3955": {"$update": {"ARO_description": "Beta-lactamase gene from Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3956": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumonia.", "ARO_category": {"$delete": ["35939"]}}}, "3957": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3958": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella penumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3959": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3960": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3961": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3962": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3963": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3964": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3965": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3969": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3970": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3971": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3972": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3973": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3974": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumonia.", "ARO_category": {"$delete": ["35939"]}}}, "3975": {"$update": {"ARO_description": "A beta-lactamase gene found in Klebsiella pneumoniae.", "ARO_category": {"$delete": ["35939"]}}}, "3986": {"$update": {"ARO_description": "TEM-212 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4066": {"$update": {"ARO_description": "DfrA42 is a dihydrofolate reductase that confers resistant to Trimethoprim."}}, "4078": {"$update": {"ARO_description": "DfrA34 is a dihydrofolate reductase that confers resistant to Trimethoprim."}}, "4079": {"$update": {"ARO_description": "DfrA37 is a dihydrofolate reductase that confers resistant to Trimethoprim."}}, "4081": {"$update": {"ARO_description": "DfrA38 is a dihydrofolate reductase that confers resistant to Trimethoprim."}}, "4082": {"$update": {"ARO_description": "DfrB9 is a dihydrofolate reductase that confers resistant to Trimethoprim."}}, "4083": {"$update": {"ARO_description": "DfrA39 is a dihydrofolate reductase that confers resistant to Trimethoprim."}}, "4091": {"$update": {"ARO_description": "KPC-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4469": {"$update": {"ARO_description": "CMY-106 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4470": {"$update": {"ARO_description": "CMY-109 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4471": {"$update": {"ARO_description": "CMY-131 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4488": {"$update": {"ARO_description": "CTX-M-127 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4489": {"$update": {"ARO_description": "CTX-M-138 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4490": {"$update": {"ARO_description": "CTX-M-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4491": {"$update": {"ARO_description": "CTX-M-143 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4492": {"$update": {"ARO_description": "CTX-M-146 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4493": {"$update": {"ARO_description": "CTX-M-150 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4494": {"$update": {"ARO_description": "CTX-M-153 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4495": {"$update": {"ARO_description": "CTX-M-154 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4573": {"$update": {"ARO_description": "CTX-M-73 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4576": {"$update": {"ARO_description": "DHA-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4583": {"$update": {"ARO_description": "DHA-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4602": {"$update": {"ARO_description": "FOX-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4609": {"$update": {"ARO_description": "GES-25 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4676": {"$update": {"ARO_description": "IMI-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4677": {"$update": {"ARO_description": "IMI-6 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4678": {"$update": {"ARO_description": "IMI-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4679": {"$update": {"ARO_description": "IMP-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4680": {"$update": {"ARO_description": "IMP-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4681": {"$update": {"ARO_description": "IMP-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4682": {"$update": {"ARO_description": "IMP-46 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4719": {"$update": {"ARO_description": "KPC-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4763": {"$update": {"ARO_description": "MIR-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4768": {"$update": {"ARO_description": "MIR-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4771": {"$update": {"ARO_description": "MOX-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4772": {"$update": {"ARO_description": "MOX-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4824": {"$update": {"ARO_description": "OXA-159 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4825": {"$update": {"ARO_description": "OXA-193 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4827": {"$update": {"ARO_description": "OXA-395 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "4828": {"$update": {"ARO_description": "OXA-396 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5620": {"$update": {"ARO_description": "PER-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5652": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "5653": {"$update": {"ARO_category": {"$delete": ["35939"]}}}, "5654": {"$update": {"ARO_description": "SHV-132 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "5655": {"$update": {"ARO_description": "SHV-146 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "5656": {"$update": {"ARO_description": "SHV-171 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "5657": {"$update": {"ARO_description": "SHV-190 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "5658": {"$update": {"ARO_description": "SHV-191 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data.", "ARO_category": {"$delete": ["35939"]}}}, "5673": {"$update": {"ARO_description": "VEB-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5691": {"$update": {"ARO_description": "VIM-40 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5692": {"$update": {"ARO_description": "VIM-41 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5693": {"$update": {"ARO_description": "VIM-44 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5694": {"$update": {"ARO_description": "VIM-45 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "5695": {"$update": {"ARO_description": "VIM-46 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data."}}, "2086": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"12978": "C1054T"}}, "clinical": {"$update": {"12978": "C1054T"}}}}}}}}, "2080": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4818": "C1192T"}}, "clinical": {"$update": {"4818": "C1192T"}}}}}}}}, "2405": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$insert": {"13183": "S87N"}}, "clinical": {"$insert": {"13183": "S87N"}}}}}}, "ARO_category": {"$insert": {"40338": {"category_aro_accession": "3003690", "category_aro_cvterm_id": "40338", "category_aro_name": "sitafloxacin", "category_aro_description": "Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}}}}}, "2482": {"$update": {"model_param": {"$update": {"snp": {"$update": {"param_value": {"$update": {"4748": "T14G", "4750": "C856T"}}, "clinical": {"$update": {"4748": "T14G", "4750": "C856T"}}}}}}}}, "3403": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8802": {"protein_sequence": {"accession": "NP_216146.1", "sequence": "MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAETNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSSASSAPSEKTAGGSLASDAQLAALREKLAGSA"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1833541", "fmax": "1834987", "strand": "+", "sequence": "ATGCCGAGTCCCACCGTCACCTCGCCGCAAGTAGCCGTCAACGACATAGGCTCTAGCGAGGACTTTCTCGCCGCAATAGACAAAACGATCAAGTACTTCAACGATGGCGACATCGTCGAAGGCACCATCGTCAAAGTGGACCGGGACGAGGTGCTCCTCGACATCGGCTACAAGACCGAAGGCGTGATCCCCGCCCGCGAACTGTCCATCAAGCACGACGTCGACCCCAACGAGGTCGTTTCCGTCGGTGACGAGGTCGAAGCCCTGGTGCTCACCAAGGAGGACAAAGAGGGCCGGCTCATCCTCTCCAAGAAACGCGCGCAGTACGAGCGTGCCTGGGGCACCATCGAGGCGCTCAAGGAGAAGGACGAGGCCGTCAAGGGCACGGTCATCGAGGTCGTCAAGGGTGGCCTGATCCTCGACATCGGGCTGCGCGGTTTCCTGCCCGCCTCGCTGGTGGAGATGCGCCGGGTGCGCGACCTGCAGCCCTACATCGGCAAGGAGATCGAGGCCAAGATCATCGAGCTGGACAAGAACCGCAACAACGTGGTGCTGTCCCGTCGCGCCTGGCTGGAGCAGACCCAGTCCGAGGTGCGCAGCGAGTTCCTGAATAACTTGCAAAAAGGCACCATCCGAAAGGGTGTCGTGTCCTCGATCGTCAACTTCGGCGCGTTCGTCGATCTCGGCGGTGTGGACGGTCTGGTGCATGTCTCCGAGCTATCGTGGAAGCACATCGACCACCCGTCCGAGGTGGTCCAGGTTGGTGACGAGGTCACCGTCGAGGTGCTCGACGTCGACATGGACCGTGAGCGGGTTTCGTTGTCACTCAAGGCGACTCAGGAAGACCCGTGGCGGCACTTCGCCCGCACTCACGCGATCGGGCAGATCGTGCCGGGCAAGGTCACCAAGTTGGTTCCGTTCGGTGCATTCGTCCGCGTCGAGGAGGGTATCGAGGGCCTGGTGCACATCTCCGAGCTGGCCGAGCGTCACGTCGAGGTGCCCGATCAGGTGGTTGCCGTCGGCGACGACGCGATGGTCAAGGTCATCGACATCGACCTGGAGCGCCGTCGGATCTCGTTGTCGCTCAAGCAAGCCAATGAGGACTACACCGAGGAGTTCGACCCGGCGAAGTACGGCATGGCCGACAGTTACGACGAGCAGGGCAACTACATCTTCCCCGAGGGCTTCGATGCCGAAACCAACGAATGGCTTGAGGGATTCGAAAAGCAGCGCGCCGAATGGGAAGCTCGGTACGCCGAGGCCGAGCGCCGGCACAAGATGCACACCGCGCAGATGGAGAAGTTCGCCGCCGCCGAGGCGGCTGGACGCGGCGCGGACGATCAGTCGTCGGCCAGTAGCGCACCGTCGGAAAAGACCGCGGGTGGATCACTGGCCAGCGACGCCCAGCTGGCGGCCCTGCGGGAAAAACTCGCCGGCAGCGCTTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["5598"]}}}}}, "5753": {"$update": {"model_param": {"$update": {"40438": {"$update": {"param_value": {"$insert": {"13239": "45612,D91G,V199I+45613,D481E"}, "$delete": ["12372"]}}}}}}}, "5771": {"$update": {"ARO_description": "KPC-83 is a KPC beta-lactamase."}}, "5801": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8790": {"protein_sequence": {"accession": "NP_215774.1", "sequence": "MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1406080", "fmax": "1407340", "strand": "-", "sequence": "ATGAGAAACAGCAACCGCGGCCCGGCATTCCTGATCCTGTTCGCAACGCTGATGGCGGCCGCGGGTGATGGCGTCTCGATAGTCGCGTTTCCGTGGCTGGTGTTGCAGCGCGAGGGCAGCGCTGGGCAGGCCTCGATCGTGGCCAGTGCGACCATGCTGCCGCTGTTGTTCGCCACGCTGGTCGCCGGCACCGCGGTCGACTACTTCGGGCGTCGCCGGGTGTCGATGGTGGCCGATGCGCTGTCGGGTGCGGCGGTGGCCGGCGTCCCCCTGGTGGCGTGGGGGTACGGCGGCGACGCGGTCAACGTGCTGGTGCTGGCCGTATTGGCCGCCCTGGCGGCCGCCTTCGGCCCGGCAGGCATGACGGCTCGTGACTCGATGCTGCCCGAGGCCGCCGCTCGGGCAGGCTGGTCGTTGGACCGCATCAACGGCGCCTACGAGGCGATCCTCAACCTGGCCTTTATTGTCGGCCCGGCCATCGGTGGCTTGATGATCGCGACGGTTGGCGGCATCACCACAATGTGGATTACCGCGACGGCATTCGGGTTGTCCATCCTCGCGATTGCCGCCCTGCAACTCGAGGGTGCCGGCAAGCCGCACCACACCTCGCGGCCCCAAGGGTTGGTATCCGGGATCGCCGAGGGGCTGCGCTTCGTCTGGAACCTGCGGGTATTGCGCACCCTCGGGATGATTGACCTGACCGTCACCGCGCTGTATCTGCCGATGGAGAGCGTGCTGTTCCCGAAATACTTCACCGACCACCAGCAACCGGTGCAGCTGGGTTGGGCGTTGATGGCGATCGCCGGCGGCGGCCTGGTGGGAGCGCTGGGGTATGCCGTGTTGGCTATCCGCGTTCCCCGTCGCGTGACCATGTCGACCGCGGTTCTTACCCTGGGTTTGGCATCGATGGTCATCGCGTTCCTGCCGCCACTGCCGGTCATCATGGTGTTGTGCGCGGTGGTCGGCCTGGTGTACGGACCCATCCAGCCGATCTATAACTACGTGATACAGACGCGGGCAGCACAGCATCTGCGCGGCCGGGTAGTCGGGGTGATGACGTCGCTGGCCTACGCCGCCGGCCCGTTGGGTCTGTTGCTGGCCGGTCCACTGACCGACGCCGCTGGACTGCATGCCACGTTTCTCGCGTTGGCACTGCCCATCGTGTGCACCGGGCTGGTCGCGATCCGGCTGCCCGCGCTGCGCGAACTGGATCTGGCGCCCCAAGCGGACATCGATCGGCCCGTAGGATCGGCTCAGTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["8482"]}}}}}, "5802": {"$update": {"model_sequences": {"$update": {"sequence": {"$insert": {"8788": {"protein_sequence": {"accession": "NP_215774.1", "sequence": "MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ"}, "dna_sequence": {"accession": "NC_000962.3", "fmin": "1406080", "fmax": "1407340", "strand": "-", "sequence": "ATGAGAAACAGCAACCGCGGCCCGGCATTCCTGATCCTGTTCGCAACGCTGATGGCGGCCGCGGGTGATGGCGTCTCGATAGTCGCGTTTCCGTGGCTGGTGTTGCAGCGCGAGGGCAGCGCTGGGCAGGCCTCGATCGTGGCCAGTGCGACCATGCTGCCGCTGTTGTTCGCCACGCTGGTCGCCGGCACCGCGGTCGACTACTTCGGGCGTCGCCGGGTGTCGATGGTGGCCGATGCGCTGTCGGGTGCGGCGGTGGCCGGCGTCCCCCTGGTGGCGTGGGGGTACGGCGGCGACGCGGTCAACGTGCTGGTGCTGGCCGTATTGGCCGCCCTGGCGGCCGCCTTCGGCCCGGCAGGCATGACGGCTCGTGACTCGATGCTGCCCGAGGCCGCCGCTCGGGCAGGCTGGTCGTTGGACCGCATCAACGGCGCCTACGAGGCGATCCTCAACCTGGCCTTTATTGTCGGCCCGGCCATCGGTGGCTTGATGATCGCGACGGTTGGCGGCATCACCACAATGTGGATTACCGCGACGGCATTCGGGTTGTCCATCCTCGCGATTGCCGCCCTGCAACTCGAGGGTGCCGGCAAGCCGCACCACACCTCGCGGCCCCAAGGGTTGGTATCCGGGATCGCCGAGGGGCTGCGCTTCGTCTGGAACCTGCGGGTATTGCGCACCCTCGGGATGATTGACCTGACCGTCACCGCGCTGTATCTGCCGATGGAGAGCGTGCTGTTCCCGAAATACTTCACCGACCACCAGCAACCGGTGCAGCTGGGTTGGGCGTTGATGGCGATCGCCGGCGGCGGCCTGGTGGGAGCGCTGGGGTATGCCGTGTTGGCTATCCGCGTTCCCCGTCGCGTGACCATGTCGACCGCGGTTCTTACCCTGGGTTTGGCATCGATGGTCATCGCGTTCCTGCCGCCACTGCCGGTCATCATGGTGTTGTGCGCGGTGGTCGGCCTGGTGTACGGACCCATCCAGCCGATCTATAACTACGTGATACAGACGCGGGCAGCACAGCATCTGCGCGGCCGGGTAGTCGGGGTGATGACGTCGCTGGCCTACGCCGCCGGCCCGTTGGGTCTGTTGCTGGCCGGTCCACTGACCGACGCCGCTGGACTGCATGCCACGTTTCTCGCGTTGGCACTGCCCATCGTGTGCACCGGGCTGGTCGCGATCCGGCTGCCCGCGCTGCGCGAACTGGATCTGGCGCCCCAAGCGGACATCGATCGGCCCGTAGGATCGGCTCAGTGA", "partial": "0"}, "NCBI_taxonomy": {"NCBI_taxonomy_cvterm_id": "39507", "NCBI_taxonomy_name": "Mycobacterium tuberculosis H37Rv", "NCBI_taxonomy_id": "83332"}}}, "$delete": ["8483"]}}}}}, "5755": {"$update": {"model_param": {"$delete": ["41342", "41344"]}}}, "2092": {"$update": {"model_param": {"$update": {"41343": {"$update": {"param_description": "A subtype of the deletion mutation detection model parameter used when a set of deletion mutations are reported in a nucleotide sequence format, encoded as [-]nt[position]:[nucleotides], for example -nt25:T or -nt25:11."}}}}}}, "5814": {"$update": {"ARO_description": "PAM-3 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus."}}, "5948": {"$update": {"ARO_category": {"$insert": {"46238": {"category_aro_accession": "3007472", "category_aro_cvterm_id": "46238", "category_aro_name": "tilmicosin", "category_aro_description": "Tilmicosin is a macrolide antibiotic used for livestock and poultry synthesized from tylomycin. It is mainly used to treat common bacterial infections and diseases caused by mycoplasma infection in livestock and poultry breeding. Tilmicosin has broad-spectrum antibacterial properties and has a strong inhibitory effect on most Gram positive and negative bacteria.", "category_aro_class_name": "Antibiotic"}}, "$delete": ["35949", "35960", "36189"]}}}, "5961": {"$update": {"ARO_category": {"$insert": {"46581": {"category_aro_accession": "3007797", "category_aro_cvterm_id": "46581", "category_aro_name": "ampR transcriptional regulator with mutation conferring resistance to monobactam antibiotics", "category_aro_description": "ampR is a LysR-type transcriptional regulator for beta-lactamase-encoding gene expression. Mutations in ampR of certain organisms have been shown to confer resistance to antibiotics due to beta-lactamase overexpression.", "category_aro_class_name": "AMR Gene Family"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "$delete": ["41396", "36017"]}}}, "6007": {"$update": {"ARO_category": {"$insert": {"35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}}}}}, "6008": {"$update": {"ARO_category": {"$insert": {"35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36989": {"category_aro_accession": "3000645", "category_aro_cvterm_id": "36989", "category_aro_name": "cefotaxime", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups.", "category_aro_class_name": "Antibiotic"}}}}}, "6012": {"$update": {"model_param": {"$update": {"40494": {"$update": {"param_value": {"$insert": {"13202": "A15fs"}, "$delete": ["13153"]}}}}}}}, "6011": {"$update": {"ARO_description": "MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem-resistant Klebsiella pneumoniae."}}, "_version": "3.3.0", "_timestamp": "2024-08-26T14:00:54+00:00"}, "$delete": ["3745"]}