Model_id Action ARO_name ARO_category Changes To Summary 3716 ADD Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv0191; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3726 ADD Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid isoniazid resistant inbR; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3718 ADD Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv2731; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3729 ADD Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid isoniazid resistant mshC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3720 ADD Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv3169; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3731 ADD Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid isoniazid resistant mymA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3707 ADD Mycobacterium tuberculosis eis mutations confer resistance to kanamycin kanamycin resistant eis; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; N/A N/A 3702 ADD Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide inhA with mutations with conferring resistance to ethionamide; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 3703 ADD Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid isoniazid resistant nudC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3706 ADD Mycobacterium tuberculosis ponA1 mutations confer resistance to rifabutin rifamycin resistant ponA1; rifampin; rifabutin; rifamycin antibiotic; antibiotic target alteration; N/A N/A 3735 ADD Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid isoniazid resistant sigI; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3709 ADD Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin streptomycin resistant whib7; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; N/A N/A 3742 ADD Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine cycloserine resistant ddlA; cycloserine; cycloserine-like antibiotic; antibiotic target alteration; N/A N/A 3746 ADD Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin rifampicin resistant rpoC; rifampin; rifabutin; rifamycin antibiotic; antibiotic target alteration; N/A N/A 3747 ADD Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin rifampicin resistant rpoA; rifampin; rifamycin antibiotic; antibiotic target alteration; N/A N/A 3712 ADD Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide antibiotic resistant polyketide synthase genes; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3738 ADD Mycobacterium tuberculosis mshC mutations conferring resistance to ethionamide ethionamide resistant mshC; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 3713 ADD Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide antibiotic resistant polyketide synthase genes; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3723 ADD Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid Isoniazid resistant ahpC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3724 ADD Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid isoniazid resistant fabG1; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3740 ADD Mycobacterium tuberculosis ubiA mutations confer resistance to ethambutol ethambutol resistant ubiA; ethambutol; polyamine antibiotic; antibiotic target alteration; N/A N/A 3715 ADD Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide pyrazinamide resistant mas; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3725 ADD Mycobacterium tuberculosis furA mutations confer resistance to isoniazid isoniazid resistant furA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3705 ADD Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide pyrazinamide resistant clpC1; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3739 ADD Mycobacterium tuberculosis fabG1 mutation conferring resistance to ethionamide ethionamide resistant fabG1; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 6065 ADD VRA-F ATP-binding cassette (ABC) antibiotic efflux pump; vancomycin; glycopeptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 6067 ADD SIE-1 SIE beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 6000 ADD Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics antibiotic resistant Mycobacterium tuberculosis nitroreductase; delamanid; pretomanid; nitroimidazole antibiotic; antibiotic target alteration; N/A N/A 6068 ADD NWM-1 NWM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 6066 ADD KPC-135 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 6070 ADD Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to clofazimine clofazimine resistant Rv0678; clofazimine; fluoroquinolone antibiotic; antibiotic target alteration; N/A N/A 6071 ADD Mycobacterium tuberculosis atpE with mutation conferring resistance to bedaquiline antibiotic resistant ATP synthase; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; N/A N/A 6072 ADD KPC-134 avibactam; KPC beta-lactamase; ceftazidime; ceftazidime-avibactam; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 6074 ADD BIM-1 BIM beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 6073 ADD CHM-1 CHM beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 6075 ADD DYB-1 DYB beta-lactamase; ceftazidime; meropenem; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 7301 ADD ACT-100 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7302 ADD ACT-101 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7303 ADD ACT-102 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7304 ADD ACT-103 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7305 ADD ACT-104 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7306 ADD ACT-105 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7307 ADD ACT-106 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7308 ADD ACT-107 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7309 ADD ACT-108 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7310 ADD ACT-109 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7311 ADD ACT-110 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7312 ADD ACT-111 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7313 ADD ACT-112 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7314 ADD ACT-113 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7315 ADD ACT-115 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7316 ADD ACT-116 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7317 ADD ACT-117 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7318 ADD ACT-118 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7319 ADD ACT-119 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7320 ADD ACT-120 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7321 ADD ACT-121 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7322 ADD ACT-122 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7323 ADD ACT-123 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7324 ADD ACT-124 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7325 ADD ACT-131 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7326 ADD ACT-140 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7327 ADD ACT-141 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7328 ADD ACT-142 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7329 ADD ACT-143 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7330 ADD ACT-144 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7331 ADD ACT-145 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7332 ADD ACT-146 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7333 ADD ACT-148 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7334 ADD ACT-150 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7335 ADD ACT-151 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7336 ADD ACT-153 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7337 ADD ACT-154 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7338 ADD ACT-155 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7339 ADD ACT-156 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7340 ADD ACT-157 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7341 ADD ACT-158 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7342 ADD ACT-159 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7343 ADD ACT-160 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7344 ADD ACT-161 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7345 ADD ACT-162 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7346 ADD ACT-165 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7347 ADD ACT-166 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7348 ADD ACT-167 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7349 ADD ACT-168 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7350 ADD ACT-169 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7351 ADD ACT-170 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7352 ADD ACT-171 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7353 ADD ACT-172 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7354 ADD ACT-173 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7355 ADD ACT-174 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7356 ADD ACT-175 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7357 ADD ACT-176 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7358 ADD ACT-177 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7359 ADD ACT-178 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7360 ADD ACT-179 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7361 ADD ACT-180 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7362 ADD ACT-181 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7363 ADD ACT-182 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7364 ADD ACT-183 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7365 ADD ACT-184 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7366 ADD ACT-185 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7367 ADD ACT-186 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7368 ADD ACT-187 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7369 ADD ACT-188 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7370 ADD ACT-189 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7371 ADD ACT-190 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7372 ADD ACT-191 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7373 ADD ACT-192 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7374 ADD ACT-193 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7375 ADD ACT-194 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7376 ADD ACT-85 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7377 ADD ACT-86 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7378 ADD ACT-88 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7379 ADD ACT-89 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7380 ADD ACT-90 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7381 ADD ACT-91 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7382 ADD ACT-92 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7383 ADD ACT-93 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7384 ADD ACT-94 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7385 ADD ACT-95 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7386 ADD ACT-96 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7387 ADD ACT-97 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7388 ADD ACT-98 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7389 ADD ACT-99 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7390 ADD ACT-GC1 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7391 ADD ADC-257 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7392 ADD ADC-258 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7393 ADD ADC-259 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7394 ADD ADC-260 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7395 ADD ADC-261 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7396 ADD ADC-262 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7397 ADD ADC-263 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7398 ADD ADC-264 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7399 ADD ADC-265 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7400 ADD ADC-266 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7401 ADD ADC-267 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7402 ADD ADC-268 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7403 ADD ADC-269 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7404 ADD ADC-270 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7405 ADD ADC-271 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7406 ADD ADC-272 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7407 ADD ADC-273 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7408 ADD ADC-274 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7409 ADD ADC-275 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7410 ADD ADC-276 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7411 ADD ADC-277 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7412 ADD ADC-278 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7413 ADD ADC-279 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7414 ADD ADC-280 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7415 ADD ADC-281 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7416 ADD ADC-282 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7417 ADD ADC-283 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7418 ADD ADC-284 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7419 ADD ADC-285 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7420 ADD ADC-286 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7421 ADD ADC-287 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7422 ADD ADC-288 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7423 ADD ADC-289 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7424 ADD ADC-290 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7425 ADD ADC-291 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7426 ADD ADC-292 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7427 ADD ADC-293 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7428 ADD ADC-294 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7429 ADD ADC-295 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7430 ADD ADC-302 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7431 ADD ADC-303 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7432 ADD ADC-304 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7433 ADD ADC-305 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7434 ADD ADC-306 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7435 ADD ADC-307 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7436 ADD ADC-308 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7437 ADD ADC-309 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7438 ADD ADC-310 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7439 ADD ADC-311 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7440 ADD ADC-312 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7441 ADD ADC-313 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7442 ADD ADC-314 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7443 ADD ADC-315 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7444 ADD ADC-316 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7445 ADD ADC-317 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7446 ADD ADC-318 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7447 ADD ADC-319 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7448 ADD ADC-320 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7449 ADD ADC-321 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7450 ADD ADC-322 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7451 ADD ADC-323 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7452 ADD ADC-324 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7453 ADD ADC-325 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7454 ADD ADC-326 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7455 ADD ADC-327 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7456 ADD ADC-328 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7457 ADD ADC-329 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7458 ADD ADC-330 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7459 ADD ADC-331 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7460 ADD ADC-332 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7461 ADD ADC-333 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7462 ADD ADC-334 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7463 ADD ADC-335 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7464 ADD ADC-336 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7465 ADD ADC-337 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7466 ADD ADC-338 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7467 ADD ADC-339 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7468 ADD ADC-340 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7469 ADD ADC-341 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7470 ADD ADC-342 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7471 ADD ADC-343 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7472 ADD ADC-344 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7473 ADD ADC-345 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7474 ADD ADC-346 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7475 ADD ADC-347 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7476 ADD ADC-348 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7477 ADD ADC-349 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7478 ADD ADC-350 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7479 ADD ADC-351 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7480 ADD ADC-352 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7481 ADD ADC-353 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7482 ADD ADC-354 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7483 ADD ADC-355 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7484 ADD ADC-356 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7485 ADD ADC-357 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7486 ADD ADC-358 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7487 ADD ADC-359 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7488 ADD AFM-3 AFM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7489 ADD AFM-4 AFM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7490 ADD AFM-5 AFM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7491 ADD AIM-2 AIM beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7492 ADD ASU1-1 ASU1 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7493 ADD AXC-6 AXC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7494 ADD AXC-7 AXC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7495 ADD AXC-8 AXC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7496 ADD B3SU1-1 B3SU1 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7497 ADD B3SU2-1 B3SU2 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7498 ADD BIC-2 BIC Beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7499 ADD BMHC-1 BMHC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7500 ADD BOR-1 BOR beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7501 ADD CAM-2 CAM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7502 ADD CME-3 CME beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7503 ADD CMH-10 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7504 ADD CMH-11 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7505 ADD CMH-12 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7506 ADD CMH-13 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7507 ADD CMH-14 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7508 ADD CMH-15 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7509 ADD CMH-16 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7510 ADD CMH-17 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7511 ADD CMH-18 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7512 ADD CMH-19 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7513 ADD CMH-20 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7514 ADD CMH-21 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7515 ADD CMH-24 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7516 ADD CMH-25 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7520 ADD CMH-29 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7521 ADD CMH-30 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7522 ADD CMH-31 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7523 ADD CMH-32 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7524 ADD CMH-33 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7525 ADD CMH-34 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7526 ADD CMH-7 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7527 ADD CMH-8 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7528 ADD CMH-9 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7529 ADD CMY-172 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7530 ADD CMY-175 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7531 ADD CMY-176 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7532 ADD CMY-177 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7533 ADD CMY-178 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7534 ADD CMY-179 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7535 ADD CMY-180 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7536 ADD CMY-181 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7537 ADD CMY-182 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7538 ADD CMY-183 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7539 ADD CMY-184 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7540 ADD CMY-186 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7541 ADD CMY-188 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7542 ADD CMY-189 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7543 ADD CMY-190 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7544 ADD CMY-191 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7545 ADD CMY-192 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7546 ADD CMY-194 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7547 ADD CMY-195 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7548 ADD CMY-196 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7549 ADD CMY-197 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7550 ADD CMY-198 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7551 ADD CMY-199 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7552 ADD CTX-M-243 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7553 ADD CTX-M-245 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7554 ADD CTX-M-246 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7555 ADD CTX-M-247 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7556 ADD CTX-M-248 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7557 ADD CTX-M-249 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7558 ADD CTX-M-251 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7559 ADD CTX-M-252 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7560 ADD CTX-M-253 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7561 ADD CTX-M-254 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7562 ADD CTX-M-255 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7563 ADD CTX-M-256 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7564 ADD CTX-M-257 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7565 ADD CTX-M-258 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7566 ADD CTX-M-259 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7568 ADD CTX-M-261 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7569 ADD CTX-M-262 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7570 ADD CTX-M-263 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7571 ADD CTX-M-264 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7572 ADD CTX-M-265 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7573 ADD CTX-M-266 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7574 ADD CTX-M-267 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7575 ADD CTX-M-268 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7576 ADD CTX-M-269 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7577 ADD CTX-M-270 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7578 ADD CTX-M-271 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7579 ADD CTX-M-272 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7580 ADD CTX-M-273 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7581 ADD CTX-M-274 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7582 ADD CTX-M-275 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7583 ADD CTX-M-276 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7584 ADD CTX-M-277 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7585 ADD CTX-M-278 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7586 ADD DHA-30 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7587 ADD DHA-31 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7588 ADD DHA-32 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7589 ADD DHA-33 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7590 ADD DHA-34 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7591 ADD FONA-10 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7592 ADD FONA-11 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7593 ADD FONA-12 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7594 ADD FONA-13 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7595 ADD FONA-7 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7596 ADD FONA-8 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7597 ADD FONA-9 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7598 ADD FOX-18 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7599 ADD FOX-19 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7600 ADD FOX-20 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7601 ADD FOX-21 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7602 ADD FRI-12 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7603 ADD GES-58 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7604 ADD GES-59 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7605 ADD GES-60 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7606 ADD GES-61 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7607 ADD GES-62 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7608 ADD GES-65 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7609 ADD GES-66 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7610 ADD GIM-3 GIM beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7611 ADD GMA-1 GMA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7612 ADD GMA-2 GMA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7613 ADD GOB-17 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7614 ADD GOB-47 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7615 ADD GOB-52 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7616 ADD GOB-53 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7617 ADD HBL-1 HBL beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7618 ADD HER-1 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7619 ADD HER-2 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7620 ADD HER-3 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7621 ADD HER-4 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7622 ADD HER-5 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7623 ADD HER-6 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7624 ADD HER-8 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7625 ADD HMB-2 HMB beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7626 ADD IMI-10 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7627 ADD IMI-22 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7628 ADD IMI-23 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7629 ADD IMI-24 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7630 ADD IMI-25 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7631 ADD IMI-26 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7632 ADD IMI-27 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7633 ADD IMP-100 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7634 ADD IMP-101 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7635 ADD IMP-102 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7636 ADD IMP-104 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7637 ADD IMP-105 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7638 ADD IMP-86 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7639 ADD IMP-87 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7640 ADD IMP-90 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7641 ADD IMP-97 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7642 ADD IMP-98 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7643 ADD IMP-99 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7644 ADD IND-18 IND beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7645 ADD IND-19 IND beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7646 ADD KHM-2 KHM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7647 ADD KLUC-6 KLUC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7648 ADD KLUG-1 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7649 ADD KPC-101 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7650 ADD KPC-102 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7651 ADD KPC-103 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7652 ADD KPC-104 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7653 ADD KPC-105 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7654 ADD KPC-106 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7655 ADD KPC-107 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7656 ADD KPC-108 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7657 ADD KPC-109 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7658 ADD KPC-110 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7659 ADD KPC-111 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7660 ADD KPC-112 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7661 ADD KPC-113 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7662 ADD KPC-114 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7663 ADD KPC-115 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7664 ADD KPC-116 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7665 ADD KPC-117 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7666 ADD KPC-118 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7667 ADD KPC-119 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7668 ADD KPC-120 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7669 ADD KPC-121 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7670 ADD KPC-122 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7671 ADD KPC-124 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7672 ADD KPC-126 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7673 ADD KPC-127 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7674 ADD KPC-128 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7675 ADD KPC-129 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7676 ADD KPC-130 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7677 ADD KPC-131 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7678 ADD KPC-132 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7679 ADD KPC-133 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7680 ADD KPC-136 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7681 ADD KPC-137 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7682 ADD KPC-138 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7683 ADD KPC-139 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7684 ADD KPC-140 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7685 ADD KPC-141 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7686 ADD KPC-142 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7687 ADD KPC-143 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7688 ADD KPC-144 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7689 ADD KPC-145 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7690 ADD KPC-146 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7691 ADD KPC-147 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7692 ADD KPC-148 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7693 ADD KPC-149 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7694 ADD KPC-150 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7695 ADD KPC-151 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7696 ADD KPC-152 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7697 ADD KPC-153 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7698 ADD KPC-154 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7699 ADD KPC-155 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7700 ADD KPC-156 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7701 ADD KPC-157 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7702 ADD KPC-158 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7703 ADD KPC-159 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7704 ADD KPC-160 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7705 ADD KPC-161 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7706 ADD KPC-162 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7707 ADD KPC-163 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7708 ADD KPC-164 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7709 ADD KPC-165 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7710 ADD KPC-166 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7711 ADD KPC-167 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7712 ADD KPC-168 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7713 ADD KPC-169 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7714 ADD KPC-170 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7715 ADD KPC-171 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7716 ADD KPC-172 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7717 ADD KPC-173 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7718 ADD KPC-174 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7719 ADD KPC-175 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7720 ADD KPC-176 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7721 ADD KPC-177 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7722 ADD KPC-178 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7723 ADD KPC-179 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7724 ADD KPC-180 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7725 ADD KPC-181 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7726 ADD KPC-182 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7727 ADD KPC-183 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7728 ADD KPC-184 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7729 ADD KPC-185 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7730 ADD KPC-186 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7731 ADD KPC-187 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7732 ADD KPC-188 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7733 ADD KPC-189 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7734 ADD KPC-190 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7735 ADD KPC-191 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7736 ADD KPC-192 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7737 ADD KPC-193 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7738 ADD KPC-194 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7739 ADD KPC-195 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7740 ADD KPC-196 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7741 ADD KPC-197 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7742 ADD KPC-201 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7743 ADD KPC-202 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7744 ADD KPC-203 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7745 ADD KPC-204 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7746 ADD KPC-205 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7747 ADD KPC-206 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7748 ADD KPC-207 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7749 ADD KPC-208 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7750 ADD KPC-209 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7751 ADD KPC-211 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7752 ADD KPC-212 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7753 ADD KPC-213 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7754 ADD KPC-214 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7755 ADD KPC-215 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7756 ADD KPC-216 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7757 ADD KPC-217 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7758 ADD KPC-218 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7759 ADD KPC-223 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7760 ADD KPC-224 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7761 ADD KPC-225 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7762 ADD KPC-226 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7763 ADD KPC-227 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7764 ADD KPC-228 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7765 ADD KPC-230 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7766 ADD KPC-231 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7767 ADD KPC-232 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7768 ADD KPC-233 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7769 ADD KPC-234 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7770 ADD KPC-236 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7771 ADD KPC-237 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7772 ADD KPC-238 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7773 ADD KPC-239 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7774 ADD KPC-240 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7775 ADD KPC-241 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7776 ADD KPC-242 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7777 ADD KPC-47 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7778 ADD KPC-48 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7779 ADD KPC-53 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7780 ADD KPC-67 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7781 ADD KPC-68 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7782 ADD KPC-69 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7783 ADD KPC-70 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7784 ADD KPC-84 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7785 ADD KPC-85 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7786 ADD KPC-88 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7787 ADD KPC-89 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7788 ADD KPC-91 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7789 ADD KPC-92 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7790 ADD LHK-7 LHK beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 7791 ADD MIR-24 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7792 ADD MIR-25 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7793 ADD MIR-27 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7794 ADD MIR-28 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7795 ADD MIR-30 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7796 ADD MIR-31 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7797 ADD MIR-32 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7798 ADD MIR-33 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7799 ADD MIR-34 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7800 ADD MIR-35 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7801 ADD MOX-15 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7802 ADD MOX-16 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7803 ADD MOX-17 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7804 ADD MOX-18 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7805 ADD MOX-19 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7806 ADD MOX-20 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7807 ADD MOX-21 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7808 ADD MOX-22 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7809 ADD MOX-23 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7810 ADD MOX-24 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7811 ADD MOX-25 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7812 ADD MUN-1 MUN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7813 ADD MUN-6 MUN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7814 ADD NDM-48 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7815 ADD NDM-49 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7816 ADD NDM-50 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7817 ADD NDM-51 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7818 ADD NDM-52 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7819 ADD NDM-53 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7820 ADD NDM-54 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7821 ADD NDM-55 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7822 ADD NDM-56 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7823 ADD NDM-57 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7824 ADD NDM-58 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7825 ADD NDM-60 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7826 ADD NDM-61 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7827 ADD NDM-64 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7828 ADD NDM-65 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7829 ADD NDM-66 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7830 ADD NDM-67 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7831 ADD NDM-68 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7832 ADD NDM-69 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7833 ADD NDM-70 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7834 ADD NDM-71 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7835 ADD NDM-72 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7836 ADD NDM-73 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7837 ADD NDM-74 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7839 ADD OXA-1000 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7840 ADD OXA-1001 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7841 ADD OXA-1002 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7842 ADD OXA-1003 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7843 ADD OXA-1004 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7844 ADD OXA-1005 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7845 ADD OXA-1006 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7846 ADD OXA-1007 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7847 ADD OXA-1008 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7848 ADD OXA-1009 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7849 ADD OXA-1010 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7851 ADD OXA-1012 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7852 ADD OXA-1013 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7853 ADD OXA-1014 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7854 ADD OXA-1015 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7855 ADD OXA-1016 OXA beta-lactamase; OXA-372-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7856 ADD OXA-1017 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7857 ADD OXA-1018 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7858 ADD OXA-1019 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7859 ADD OXA-1020 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7860 ADD OXA-1021 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7861 ADD OXA-1022 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7862 ADD OXA-1023 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7863 ADD OXA-1024 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7864 ADD OXA-1025 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7865 ADD OXA-1026 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7866 ADD OXA-1027 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7867 ADD OXA-1028 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7868 ADD OXA-1029 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7869 ADD OXA-1030 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7870 ADD OXA-1031 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7871 ADD OXA-1032 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7872 ADD OXA-1033 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7873 ADD OXA-1034 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7874 ADD OXA-1035 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7875 ADD OXA-1036 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7876 ADD OXA-1037 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7877 ADD OXA-1040 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7878 ADD OXA-1041 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7879 ADD OXA-1042 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7880 ADD OXA-1043 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7881 ADD OXA-1044 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7882 ADD OXA-1045 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7883 ADD OXA-1046 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7884 ADD OXA-1047 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7885 ADD OXA-1048 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7886 ADD OXA-1049 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7887 ADD OXA-1050 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7888 ADD OXA-1051 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7889 ADD OXA-1052 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7890 ADD OXA-1053 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7891 ADD OXA-1055 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7892 ADD OXA-1056 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7893 ADD OXA-1057 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7894 ADD OXA-1058 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7895 ADD OXA-1059 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7896 ADD OXA-1060 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7897 ADD OXA-1061 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7898 ADD OXA-1062 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7899 ADD OXA-1063 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7900 ADD OXA-1064 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7901 ADD OXA-1065 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7902 ADD OXA-1066 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7903 ADD OXA-1067 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7904 ADD OXA-1068 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7905 ADD OXA-1069 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7906 ADD OXA-1070 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7907 ADD OXA-1071 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7908 ADD OXA-1072 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7909 ADD OXA-1073 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7910 ADD OXA-1074 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7911 ADD OXA-1075 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7912 ADD OXA-1076 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7913 ADD OXA-1077 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7914 ADD OXA-1078 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7915 ADD OXA-1079 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7916 ADD OXA-1080 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7917 ADD OXA-1081 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7918 ADD OXA-1082 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7919 ADD OXA-1083 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7920 ADD OXA-1084 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7921 ADD OXA-1085 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7922 ADD OXA-1086 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7923 ADD OXA-1087 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7924 ADD OXA-1088 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7925 ADD OXA-1089 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7926 ADD OXA-1090 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7927 ADD OXA-1091 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7928 ADD OXA-1092 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7929 ADD OXA-1093 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7930 ADD OXA-1094 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7931 ADD OXA-1095 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7932 ADD OXA-1096 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7933 ADD OXA-1097 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7934 ADD OXA-1098 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7935 ADD OXA-1099 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7936 ADD OXA-1100 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7937 ADD OXA-1101 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7938 ADD OXA-1102 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7939 ADD OXA-1103 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7940 ADD OXA-1104 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7941 ADD OXA-1105 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7942 ADD OXA-1106 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7943 ADD OXA-1107 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7944 ADD OXA-1108 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7945 ADD OXA-1109 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7946 ADD OXA-1110 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7947 ADD OXA-1111 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7948 ADD OXA-1112 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7949 ADD OXA-1113 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7950 ADD OXA-1114 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7951 ADD OXA-1115 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7952 ADD OXA-1116 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7953 ADD OXA-1117 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7954 ADD OXA-1118 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7955 ADD OXA-1119 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7956 ADD OXA-1120 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7957 ADD OXA-1121 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7958 ADD OXA-1122 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7959 ADD OXA-1123 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7960 ADD OXA-1124 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7961 ADD OXA-1125 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7962 ADD OXA-1126 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7963 ADD OXA-1127 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7964 ADD OXA-1128 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7965 ADD OXA-1129 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7966 ADD OXA-1130 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7967 ADD OXA-1131 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7968 ADD OXA-1132 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7969 ADD OXA-1133 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7970 ADD OXA-1134 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7971 ADD OXA-1135 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7972 ADD OXA-1136 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7973 ADD OXA-1137 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7974 ADD OXA-1138 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7975 ADD OXA-1139 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7976 ADD OXA-1140 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7977 ADD OXA-1141 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7978 ADD OXA-1142 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7979 ADD OXA-1143 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7980 ADD OXA-1144 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7981 ADD OXA-1145 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7982 ADD OXA-1146 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7983 ADD OXA-1147 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7984 ADD OXA-1148 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7985 ADD OXA-1149 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7986 ADD OXA-1150 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7987 ADD OXA-1151 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7988 ADD OXA-1152 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7989 ADD OXA-1153 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7990 ADD OXA-1154 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7991 ADD OXA-1155 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7992 ADD OXA-1156 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7993 ADD OXA-1157 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7994 ADD OXA-1158 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7995 ADD OXA-1159 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7996 ADD OXA-1160 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7997 ADD OXA-1161 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7998 ADD OXA-1162 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7999 ADD OXA-1163 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8000 ADD OXA-1164 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8001 ADD OXA-1165 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8002 ADD OXA-1166 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8003 ADD OXA-1167 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8004 ADD OXA-1168 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8005 ADD OXA-1169 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8006 ADD OXA-1170 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8007 ADD OXA-1171 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8008 ADD OXA-1172 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8009 ADD OXA-1173 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8010 ADD OXA-1174 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8011 ADD OXA-1175 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8012 ADD OXA-1176 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8013 ADD OXA-1177 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8014 ADD OXA-1178 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8015 ADD OXA-1181 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8016 ADD OXA-1182 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8017 ADD OXA-1183 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8018 ADD OXA-1184 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8019 ADD OXA-1185 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8020 ADD OXA-1186 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8021 ADD OXA-1187 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8022 ADD OXA-1188 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8023 ADD OXA-1189 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8024 ADD OXA-1190 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8025 ADD OXA-1191 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8026 ADD OXA-1193 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8027 ADD OXA-1194 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8028 ADD OXA-1198 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8029 ADD OXA-1199 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8030 ADD OXA-1200 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8031 ADD OXA-1201 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8032 ADD OXA-1202 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8033 ADD OXA-1203 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8034 ADD OXA-1204 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8035 ADD OXA-1205 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8036 ADD OXA-1206 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8037 ADD OXA-1207 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8038 ADD OXA-1208 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8039 ADD OXA-1211 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8040 ADD OXA-1212 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8041 ADD OXA-1213 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8042 ADD OXA-1214 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8043 ADD OXA-1215 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8044 ADD OXA-1216 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8045 ADD OXA-1217 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8046 ADD OXA-1218 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8047 ADD OXA-1219 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8048 ADD OXA-1220 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8049 ADD OXA-1221 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8050 ADD OXA-1222 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8051 ADD OXA-1223 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8052 ADD OXA-1224 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8053 ADD OXA-1225 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8054 ADD OXA-1226 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8055 ADD OXA-1227 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8056 ADD OXA-1228 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8057 ADD OXA-1229 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8058 ADD OXA-1230 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8059 ADD OXA-1231 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8060 ADD OXA-1232 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8061 ADD OXA-1233 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8062 ADD OXA-1234 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8063 ADD OXA-1235 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8064 ADD OXA-1236 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8065 ADD OXA-1237 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8066 ADD OXA-1238 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8067 ADD OXA-1239 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8068 ADD OXA-1240 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8069 ADD OXA-1241 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8070 ADD OXA-1242 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8071 ADD OXA-1243 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8072 ADD OXA-1244 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8073 ADD OXA-1245 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8074 ADD OXA-1246 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8075 ADD OXA-1247 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8076 ADD OXA-1248 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8077 ADD OXA-1249 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8078 ADD OXA-1250 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8079 ADD OXA-1251 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8080 ADD OXA-1252 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8081 ADD OXA-1253 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8082 ADD OXA-1254 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8083 ADD OXA-1255 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8084 ADD OXA-1256 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8085 ADD OXA-1257 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8086 ADD OXA-1258 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8087 ADD OXA-1259 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8088 ADD OXA-1260 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8089 ADD OXA-1261 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8090 ADD OXA-1262 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8091 ADD OXA-1263 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8092 ADD OXA-1264 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8093 ADD OXA-1265 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8094 ADD OXA-1266 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8095 ADD OXA-1267 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8096 ADD OXA-1268 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8097 ADD OXA-1269 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8098 ADD OXA-1270 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8099 ADD OXA-1271 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8100 ADD OXA-1272 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8101 ADD OXA-1273 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8102 ADD OXA-1274 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8103 ADD OXA-1275 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8104 ADD OXA-1276 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8105 ADD OXA-1277 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8106 ADD OXA-1278 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8107 ADD OXA-1279 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8108 ADD OXA-1280 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8109 ADD OXA-1281 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8110 ADD OXA-1282 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8111 ADD OXA-1283 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8112 ADD OXA-1284 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8113 ADD OXA-1285 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8114 ADD OXA-1286 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8115 ADD OXA-1287 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8116 ADD OXA-1288 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8117 ADD OXA-1289 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8118 ADD OXA-1290 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8119 ADD OXA-1291 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8120 ADD OXA-1292 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8121 ADD OXA-1293 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8122 ADD OXA-1294 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8123 ADD OXA-1295 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8124 ADD OXA-1296 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8125 ADD OXA-1297 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8126 ADD OXA-1298 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8127 ADD OXA-1299 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8128 ADD OXA-1300 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8129 ADD OXA-1301 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8130 ADD OXA-1302 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8131 ADD OXA-1303 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8132 ADD OXA-1304 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8133 ADD OXA-1305 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8134 ADD OXA-1306 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8135 ADD OXA-1307 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8136 ADD OXA-1308 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8137 ADD OXA-1309 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8138 ADD OXA-725 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8139 ADD OXA-790 OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8140 ADD OXA-791 OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8141 ADD OXA-933 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8142 ADD OXA-934 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8143 ADD OXA-936 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8144 ADD OXA-944 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8145 ADD OXA-950 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8146 ADD OXA-951 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8147 ADD OXA-952 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8148 ADD OXA-953 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8149 ADD OXA-954 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8150 ADD OXA-955 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8151 ADD OXA-956 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8152 ADD OXA-957 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8153 ADD OXA-958 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8154 ADD OXA-959 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8155 ADD OXA-960 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8156 ADD OXA-961 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8157 ADD OXA-962 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8158 ADD OXA-963 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8159 ADD OXA-964 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8160 ADD OXA-965 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8161 ADD OXA-966 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8162 ADD OXA-967 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8163 ADD OXA-968 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8164 ADD OXA-969 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8165 ADD OXA-970 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8166 ADD OXA-971 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8167 ADD OXA-972 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8168 ADD OXA-973 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8169 ADD OXA-974 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8170 ADD OXA-975 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8171 ADD OXA-976 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8172 ADD OXA-977 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8173 ADD OXA-978 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8174 ADD OXA-979 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8175 ADD OXA-980 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8176 ADD OXA-981 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8177 ADD OXA-982 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8178 ADD OXA-983 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8179 ADD OXA-984 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8180 ADD OXA-985 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8181 ADD OXA-986 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8182 ADD OXA-987 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8183 ADD OXA-988 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8184 ADD OXA-989 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8185 ADD OXA-990 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8186 ADD OXA-991 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8187 ADD OXA-992 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8188 ADD OXA-993 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8189 ADD OXA-994 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8190 ADD OXA-995 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8191 ADD OXA-996 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8192 ADD OXA-997 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8193 ADD OXA-998 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8194 ADD OXA-999 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8195 ADD OXY-1-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8196 ADD OXY-1-12 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8197 ADD OXY-1-13 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8198 ADD OXY-1-16 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8199 ADD OXY-1-17 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8200 ADD OXY-1-18 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8201 ADD OXY-1-19 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8202 ADD OXY-10-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8203 ADD OXY-11-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8204 ADD OXY-12-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8205 ADD OXY-12-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8206 ADD OXY-2-17 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8207 ADD OXY-2-18 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8208 ADD OXY-2-19 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8209 ADD OXY-2-20 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8210 ADD OXY-2-21 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8211 ADD OXY-2-22 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8212 ADD OXY-2-23 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8213 ADD OXY-2-24 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8214 ADD OXY-2-25 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8215 ADD OXY-2-26 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8216 ADD OXY-2-27 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8217 ADD OXY-2-28 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8218 ADD OXY-2-30 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8219 ADD OXY-3-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8220 ADD OXY-3-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8221 ADD OXY-4-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8222 ADD OXY-4-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8223 ADD OXY-4-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8224 ADD OXY-4-5 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8225 ADD OXY-5-10 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8226 ADD OXY-5-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8227 ADD OXY-5-6 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8228 ADD OXY-5-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8229 ADD OXY-5-8 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8230 ADD OXY-6-10 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8231 ADD OXY-6-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8232 ADD OXY-6-5 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8233 ADD OXY-6-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8234 ADD OXY-7-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8235 ADD OXY-8-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8236 ADD OXY-8-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8237 ADD OXY-8-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8238 ADD OXY-9-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8239 ADD PAD-1 PAD beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8240 ADD PAM-5 PAM beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8241 ADD PC1 BlaZ beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8242 ADD PDC-477 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8243 ADD PDC-478 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8244 ADD PDC-479 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8245 ADD PDC-480 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8246 ADD PDC-481 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8247 ADD PDC-482 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8248 ADD PDC-483 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8249 ADD PDC-484 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8250 ADD PDC-485 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8251 ADD PDC-486 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8252 ADD PDC-487 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8253 ADD PDC-488 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8254 ADD PDC-489 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8255 ADD PDC-490 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8256 ADD PDC-491 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8257 ADD PDC-492 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8258 ADD PDC-493 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8259 ADD PDC-494 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8260 ADD PDC-495 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8261 ADD PDC-496 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8262 ADD PDC-497 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8263 ADD PDC-498 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8264 ADD PDC-499 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8265 ADD PDC-500 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8266 ADD PDC-501 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8267 ADD PDC-502 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8268 ADD PDC-503 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8269 ADD PDC-504 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8270 ADD PDC-505 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8271 ADD PDC-506 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8272 ADD PDC-507 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8273 ADD PDC-508 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8274 ADD PDC-509 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8275 ADD PDC-510 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8276 ADD PDC-511 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8277 ADD PDC-512 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8278 ADD PDC-513 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8279 ADD PDC-514 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8280 ADD PDC-515 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8281 ADD PDC-516 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8282 ADD PDC-517 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8283 ADD PDC-518 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8284 ADD PDC-519 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8285 ADD PDC-520 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8286 ADD PDC-521 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8287 ADD PDC-522 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8288 ADD PDC-523 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8289 ADD PDC-524 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8290 ADD PDC-525 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8291 ADD PDC-526 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8292 ADD PDC-527 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8293 ADD PDC-528 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8294 ADD PDC-529 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8295 ADD PDC-530 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8296 ADD PDC-531 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8297 ADD PDC-532 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8298 ADD PDC-533 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8299 ADD PDC-534 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8300 ADD PDC-535 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8301 ADD PDC-536 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8302 ADD PDC-537 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8303 ADD PDC-538 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8304 ADD PDC-539 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8305 ADD PDC-540 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8306 ADD PDC-541 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8307 ADD PDC-542 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8308 ADD PDC-543 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8309 ADD PDC-544 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8310 ADD PDC-545 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8311 ADD PDC-546 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8312 ADD PDC-547 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8313 ADD PDC-548 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8314 ADD PDC-549 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8315 ADD PDC-550 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8316 ADD PDC-551 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8317 ADD PDC-552 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8318 ADD PDC-553 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8319 ADD PDC-554 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8320 ADD PDC-555 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8321 ADD PDC-556 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8322 ADD PDC-557 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8323 ADD PDC-558 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8324 ADD PDC-559 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8325 ADD PDC-560 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8326 ADD PDC-561 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8327 ADD PDC-562 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8328 ADD PDC-563 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8329 ADD PDC-564 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8330 ADD PDC-565 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8331 ADD PDC-566 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8332 ADD PDC-567 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8333 ADD PDC-568 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8334 ADD PDC-569 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8335 ADD PDC-570 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8336 ADD PDC-571 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8337 ADD PDC-572 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8338 ADD PDC-573 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8339 ADD PDC-574 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8340 ADD PDC-575 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8341 ADD PDC-576 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8342 ADD PDC-577 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8343 ADD PDC-578 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8344 ADD PDC-579 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8345 ADD PDC-580 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8346 ADD PDC-581 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8347 ADD PDC-582 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8348 ADD PDC-583 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8349 ADD PDC-584 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8350 ADD PDC-585 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8351 ADD PDC-586 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8352 ADD PDC-587 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8353 ADD PDC-588 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8354 ADD PDC-589 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8355 ADD PDC-590 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8356 ADD PDC-591 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8357 ADD PDC-592 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8358 ADD PDC-593 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8359 ADD PDC-594 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8360 ADD PDC-595 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8361 ADD PDC-596 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8362 ADD PDC-597 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8363 ADD PDC-598 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8364 ADD PDC-599 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8365 ADD PDC-600 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8366 ADD PDC-601 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8367 ADD PDC-602 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8368 ADD PDC-603 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8369 ADD PDC-604 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8370 ADD PDC-605 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8371 ADD PDC-606 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8372 ADD PDC-607 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8373 ADD PDC-608 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8374 ADD PDC-609 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8375 ADD PDC-610 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8376 ADD PDC-611 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8377 ADD PDC-612 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8378 ADD PDC-613 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8379 ADD PDC-614 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8380 ADD PDC-615 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8381 ADD PDC-616 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8382 ADD PDC-617 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8383 ADD PDC-618 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8384 ADD PDC-619 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8385 ADD PDC-620 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8386 ADD PDC-621 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8387 ADD PDC-622 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8388 ADD PDC-623 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8389 ADD PDC-624 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8390 ADD PDC-625 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8391 ADD PDC-626 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8392 ADD PDC-627 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8393 ADD PDC-628 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8394 ADD PDC-629 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8395 ADD PDC-630 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8396 ADD PDC-631 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8397 ADD PDC-632 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8398 ADD PDC-633 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8399 ADD PDC-634 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8400 ADD PDC-635 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8401 ADD PDC-636 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8402 ADD PDC-637 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8403 ADD PDC-638 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8404 ADD PDC-639 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8405 ADD PDC-640 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8406 ADD PEN-A10 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8407 ADD PEN-A11 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8408 ADD PEN-A12 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8409 ADD PEN-A13 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8410 ADD PEN-A15 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8411 ADD PEN-A16 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8412 ADD PEN-A17 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8413 ADD PEN-A18 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8414 ADD PEN-A19 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8415 ADD PEN-A1 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8416 ADD PEN-A20 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8417 ADD PEN-A21 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8418 ADD PEN-A22 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8419 ADD PEN-A23 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8420 ADD PEN-A24 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8421 ADD PEN-A25 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8422 ADD PEN-A26 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8423 ADD PEN-A27 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8424 ADD PEN-A28 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8425 ADD PEN-A29 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8426 ADD PEN-A2 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8427 ADD PEN-A30 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8428 ADD PEN-A31 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8429 ADD PEN-A32 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8430 ADD PEN-A33 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8431 ADD PEN-A34 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8432 ADD PEN-A35 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8433 ADD PEN-A37 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8434 ADD PEN-A38 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8435 ADD PEN-A3 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8436 ADD PEN-A5 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8437 ADD PEN-A6 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8438 ADD PEN-A7 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8439 ADD PEN-A8 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8440 ADD PEN-A9 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8441 ADD PEN-B1 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8442 ADD PEN-B2 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8443 ADD PEN-B3 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8444 ADD PEN-B4 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8445 ADD PER-17 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8446 ADD PER-18 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8447 ADD PJM-2 PJM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8448 ADD PLA-4 PLA beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8449 ADD PLA-5 PLA beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8450 ADD PNC-1 PNC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8451 ADD PNC-2 PNC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8452 ADD PNC-3 PNC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8453 ADD RAA-1 RAA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8454 ADD RAHN-3 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8455 ADD RAHN-4 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8456 ADD RAHN-5 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8457 ADD RAHN-6 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8458 ADD RASA-1 RASA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8459 ADD RSC1-1 RSC1 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8460 ADD RSD1-1 RSD1; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8462 ADD SED-2 SED beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8463 ADD SFC-2 SFC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8464 ADD SFDC-1 SFDC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8466 ADD SHV-229 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8467 ADD SHV-230 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8468 ADD SHV-231 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8469 ADD SHV-232 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8470 ADD SHV-233 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8471 ADD SHV-234 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8472 ADD SHV-235 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8473 ADD SHV-236 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8474 ADD SHV-237 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8475 ADD SHV-238 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8476 ADD SHV-239 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8477 ADD SHV-240 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8478 ADD SHV-241 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8479 ADD SHV-242 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8480 ADD SHV-243 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8481 ADD SHV-244 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8482 ADD SHV-245 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8483 ADD SRT-4 SRT beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8484 ADD TEM-239 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8485 ADD TEM-248 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8486 ADD TEM-249 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8487 ADD TEM-250 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8488 ADD TEM-251 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8489 ADD TEM-252 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8490 ADD TEM-253 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8491 ADD TEM-254 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8492 ADD TEM-255 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8493 ADD TEM-256 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8494 ADD TEM-257 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8495 ADD TEM-258 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8497 ADD VEB-18 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8498 ADD VEB-28 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8499 ADD VEB-29 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8500 ADD VEB-30 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8501 ADD VEB-31 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8502 ADD VEB-32 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8503 ADD VEB-33 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8504 ADD VEB-34 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8505 ADD VEB-35 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8506 ADD VEB-36 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8507 ADD VEB-37 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8508 ADD VEB-38 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8509 ADD VEB-39 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8510 ADD VIM-88 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8511 ADD VIM-89 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8512 ADD VIM-90 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8513 ADD VIM-91 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8514 ADD YOC-1 YOC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 6069 ADD Mycobacterium tuberculosis fgd1 with mutation conferring resistance to delamanid delamanid-resistant fgd1; delamanid; nitroimidazole antibiotic; antibiotic target alteration; N/A N/A 8516 ADD CfiA28 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8517 ADD CfiA29 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8518 ADD CfiA30 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8519 ADD CfiA31 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 4 UPDATE SHV-52 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 8 UPDATE NDM-6 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 9 UPDATE ACT-35 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 10 UPDATE CARB-5 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 12 UPDATE TEM-126 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 13 UPDATE LRA-12 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 14 UPDATE TEM-72 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 15 UPDATE TEM-59 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 16 UPDATE KPC-10 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 18 UPDATE OXA-212 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 19 UPDATE IMP-2 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 20 UPDATE CMY-1 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 21 UPDATE OXA-329 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 22 UPDATE ACT-10 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 23 UPDATE OXA-371 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 28 UPDATE OXA-45 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 30 UPDATE OXA-226 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 32 UPDATE DHA-15 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 34 UPDATE OXY-6-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 42 UPDATE OXY-6-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 44 UPDATE golS resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 46 UPDATE CMY-114 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 47 UPDATE OXA-60 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 48 UPDATE OXA-90 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 52 UPDATE OXY-2-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 53 UPDATE MOX-5 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 54 UPDATE TEM-34 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 55 UPDATE OXA-69 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 56 UPDATE TEM-7 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 57 UPDATE SHV-24 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 59 UPDATE OXA-256 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 61 UPDATE OXA-330 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 62 UPDATE CMY-42 CMY beta-lactamase; cefoxitin; ceftazidime; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 64 UPDATE CMY-70 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 65 UPDATE GES-21 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 66 UPDATE SHV-41 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 67 UPDATE OXA-391 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 68 UPDATE TEM-132 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 70 UPDATE NDM-10 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 72 UPDATE SHV-42 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 73 UPDATE OXA-35 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 74 UPDATE SHV-18 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 76 UPDATE SHV-79 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 77 UPDATE TEM-47 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 78 UPDATE TEM-16 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 79 UPDATE VIM-37 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 80 UPDATE ACT-29 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 81 UPDATE FOX-3 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 82 UPDATE PER-4 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 84 UPDATE GIM-1 GIM beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 85 UPDATE IMP-42 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 86 UPDATE TEM-102 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 87 UPDATE TEM-116 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 88 UPDATE CMY-55 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 91 UPDATE gadX resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 93 UPDATE SHV-105 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 94 UPDATE CMY-79 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 95 UPDATE CMY-56 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 96 UPDATE OXA-426 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 98 UPDATE CMY-48 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 101 UPDATE TEM-109 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 103 UPDATE SHV-12 SHV beta-lactamase; ceftazidime; ceftriaxone; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 104 UPDATE OXA-61 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 105 UPDATE CARB-4 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 107 UPDATE TEM-43 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 115 UPDATE TEM-87 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 118 UPDATE LRA-9 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 119 UPDATE VIM-12 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 121 UPDATE mdtF resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 122 UPDATE VIM-34 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 123 UPDATE SHV-64 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 125 UPDATE SHV-182 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 126 UPDATE TEM-183 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 132 UPDATE TEM-198 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 136 UPDATE CMY-9 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 144 UPDATE IMP-12 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 145 UPDATE OXA-229 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 146 UPDATE OXA-98 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 147 UPDATE OXA-27 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 148 UPDATE SHV-92 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 151 UPDATE OKP-A-15 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 154 UPDATE mgrA ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; methicillin; ciprofloxacin; acriflavine; tetracycline; daptomycin; moxifloxacin; cefotaxime; norfloxacin; sparfloxacin; moenomycin A1; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 155 UPDATE TEM-195 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 160 UPDATE OXA-236 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 161 UPDATE SHV-56 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 162 UPDATE KPC-8 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 163 UPDATE OXA-376 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 165 UPDATE VIM-29 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 167 UPDATE CMY-39 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 168 UPDATE VIM-17 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 169 UPDATE IMP-33 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 170 UPDATE IMP-19 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 171 UPDATE TEM-78 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 174 UPDATE CfxA2 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 176 UPDATE CMY-25 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 177 UPDATE IMP-51 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 180 UPDATE DHA-19 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 181 UPDATE GES-14 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 184 UPDATE OCH-1 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 185 UPDATE OXA-232 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 186 UPDATE OXA-12 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 187 UPDATE OXA-348 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 188 UPDATE SHV-89 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 190 UPDATE OXA-195 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 191 UPDATE OXA-199 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 193 UPDATE TEM-121 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 194 UPDATE SHV-61 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 198 UPDATE TEM-138 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 200 UPDATE LEN-14 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 201 UPDATE OCH-3 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 202 UPDATE SHV-101 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 203 UPDATE OXY-2-8 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 204 UPDATE VIM-43 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 207 UPDATE GES-12 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 208 UPDATE CMY-105 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 210 UPDATE SHV-35 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 211 UPDATE TEM-206 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 213 UPDATE OXA-21 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 214 UPDATE SHV-121 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 216 UPDATE LEN-9 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 219 UPDATE OKP-A-12 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 220 UPDATE TEM-92 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 221 UPDATE CMY-100 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 223 UPDATE GES-3 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 226 UPDATE OXA-113 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 227 UPDATE OKP-B-3 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 228 UPDATE sdiA resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 230 UPDATE OXA-422 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 231 UPDATE OXA-178 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 233 UPDATE LEN-21 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 235 UPDATE OXA-181 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 236 UPDATE ACT-19 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 238 UPDATE SHV-137 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 239 UPDATE OXA-83 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 241 UPDATE ACT-30 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 242 UPDATE SHV-152 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 243 UPDATE OXA-9 OXA beta-lactamase; OXA-9-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 244 UPDATE SHV-164 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 247 UPDATE TEM-158 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 248 UPDATE OKP-B-9 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 254 UPDATE OXA-150 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 256 UPDATE CMY-21 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 257 UPDATE ACT-37 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 258 UPDATE OXA-208 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 261 UPDATE CMY-65 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 262 UPDATE VIM-8 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 265 UPDATE SHV-128 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 267 UPDATE OXA-43 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 268 UPDATE CfxA6 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 269 UPDATE CMY-8 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 270 UPDATE LEN-20 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 271 UPDATE CMY-4 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 274 UPDATE OXA-174 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 275 UPDATE OKP-B-2 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 277 UPDATE TEM-91 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 281 UPDATE CMY-110 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 283 UPDATE CMY-85 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 285 UPDATE TEM-11 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 286 UPDATE SHV-162 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 287 UPDATE TEM-67 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 288 UPDATE CMY-60 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 289 UPDATE OXA-85 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 292 UPDATE TEM-17 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 293 UPDATE SHV-180 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 294 UPDATE CfxA4 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 295 UPDATE OXA-145 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 296 UPDATE VIM-23 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 297 UPDATE CMY-98 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 301 UPDATE CMY-95 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 302 UPDATE TEM-207 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 306 UPDATE SHV-32 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 308 UPDATE CMY-118 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 309 UPDATE CMY-35 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 310 UPDATE SHV-78 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 312 UPDATE OXA-167 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 313 UPDATE OXA-143 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 314 UPDATE TEM-176 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 315 UPDATE DHA-2 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 317 UPDATE TEM-148 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 318 UPDATE OXA-358 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 319 UPDATE OXA-366 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 325 UPDATE LEN-23 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 326 UPDATE OXA-225 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 327 UPDATE GES-17 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 222 UPDATE JOHN-1 JOHN beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 322 UPDATE FEZ-1 FEZ beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 330 UPDATE IMP-26 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 331 UPDATE TEM-166 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 333 UPDATE CARB-23 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 334 UPDATE mexX resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 338 UPDATE OXY-1-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3664 UPDATE NDM-23 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 340 UPDATE CMY-51 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 341 UPDATE IMP-1 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 342 UPDATE smeS resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 343 UPDATE OXA-31 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 344 UPDATE SHV-188 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 348 UPDATE OXY-3-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 351 UPDATE SHV-6 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 352 UPDATE PDC-5 PDC beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefixime; cefalotin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 357 UPDATE VIM-38 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 359 UPDATE TEM-112 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 361 UPDATE OXA-278 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 363 UPDATE TEM-155 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 364 UPDATE CMY-83 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 365 UPDATE TEM-122 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 368 UPDATE CARB-14 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 369 UPDATE SHV-15 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 371 UPDATE SHV-8 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 374 UPDATE SHV-21 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 378 UPDATE TEM-214 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 379 UPDATE OXA-148 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 385 UPDATE OXA-46 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 386 UPDATE LEN-8 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 391 UPDATE VIM-2 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 394 UPDATE OXA-130 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 397 UPDATE OXA-357 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 398 UPDATE TEM-71 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 401 UPDATE ACT-22 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 404 UPDATE OXA-217 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 405 UPDATE OXA-202 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 406 UPDATE ACC-4 ACC beta-lactamase; ceftazidime; cefuroxime; aztreonam; cefotaxime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 407 UPDATE OXA-352 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 408 UPDATE OXA-380 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 412 UPDATE OXA-117 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 413 UPDATE OXA-144 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 414 UPDATE OXA-377 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 415 UPDATE TEM-33 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 416 UPDATE OXA-204 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 418 UPDATE OXA-325 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 419 UPDATE SLB-1 SHW beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 421 UPDATE TEM-2 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 422 UPDATE FOX-10 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 423 UPDATE DHA-16 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 424 UPDATE SHV-36 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 425 UPDATE TEM-182 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 427 UPDATE OCH-7 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 428 UPDATE OXY-2-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 429 UPDATE mdsA resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 430 UPDATE OXA-87 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 433 UPDATE ACT-25 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 434 UPDATE LEN-16 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 435 UPDATE OKP-A-9 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 436 UPDATE OXY-4-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 437 UPDATE SHV-69 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 438 UPDATE VIM-6 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 439 UPDATE SHV-83 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 441 UPDATE OXA-54 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 443 UPDATE OKP-B-10 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 445 UPDATE TEM-22 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 447 UPDATE SHV-67 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 449 UPDATE SHV-133 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 450 UPDATE OXA-51 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; BAL30072; monobactam; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 451 UPDATE LRA-5 class A LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 453 UPDATE mtrE resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35971 " 454 UPDATE KPC-4 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 457 UPDATE OXA-93 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 460 UPDATE CMY-29 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 461 UPDATE OXA-13 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 464 UPDATE NDM-13 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 467 UPDATE CARB-3 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 469 UPDATE SHV-49 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 470 UPDATE OXA-4 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 471 UPDATE TEM-151 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 472 UPDATE TEM-128 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 475 UPDATE OXA-106 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 479 UPDATE IMP-29 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 480 UPDATE GES-9 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 481 UPDATE VIM-30 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 482 UPDATE LEN-1 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 483 UPDATE GES-7 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 485 UPDATE TEM-191 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 440 UPDATE MexA resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 276 UPDATE tetR major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 395 UPDATE blaF blaF family beta-lactamase; amoxicillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 488 UPDATE SHV-156 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 490 UPDATE TEM-188 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 392 UPDATE TUS-1 TUS beta-lactamase; amoxicillin; piperacillin; ticarcillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 491 UPDATE PER-2 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 493 UPDATE TEM-84 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 494 UPDATE KPC-14 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 495 UPDATE CMY-28 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 496 UPDATE KPC-16 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 497 UPDATE OXA-79 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 500 UPDATE OXA-164 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 504 UPDATE TEM-52 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 506 UPDATE IMP-5 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 509 UPDATE FOX-1 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 513 UPDATE CARB-19 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 514 UPDATE LEN-10 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3665 UPDATE NDM-24 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 519 UPDATE VIM-26 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 521 UPDATE OXA-386 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 523 UPDATE OXA-75 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 525 UPDATE CMY-13 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 526 UPDATE ACT-2 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 527 UPDATE SHV-38 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 528 UPDATE OCH-8 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 529 UPDATE SHV-185 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 530 UPDATE VIM-11 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 533 UPDATE CARB-16 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 536 UPDATE TEM-95 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 537 UPDATE OXA-120 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 541 UPDATE TEM-133 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 543 UPDATE TEM-106 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 545 UPDATE GES-22 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 549 UPDATE TEM-107 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 550 UPDATE CMY-71 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 553 UPDATE VIM-35 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 554 UPDATE OXA-163 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 555 UPDATE OXA-133 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 557 UPDATE SHV-9 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 560 UPDATE OXA-77 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 561 UPDATE OKP-B-8 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 562 UPDATE TEM-187 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 563 UPDATE OKP-B-6 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 564 UPDATE IMP-22 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 565 UPDATE SHV-82 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 566 UPDATE OXA-32 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 569 UPDATE OXA-228 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 572 UPDATE OXA-137 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 573 UPDATE OXA-136 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 578 UPDATE SHV-11 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 580 UPDATE TEM-110 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 582 UPDATE FOX-7 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 583 UPDATE SHV-100 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 585 UPDATE NDM-7 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 586 UPDATE VIM-20 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 587 UPDATE TEM-73 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 588 UPDATE OKP-A-7 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 589 UPDATE TEM-145 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 595 UPDATE SHV-75 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 596 UPDATE ROB-1 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 599 UPDATE OKP-A-3 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 600 UPDATE CMY-2 CMY beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ertapenem; ampicillin; cefixime; cefalotin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 602 UPDATE VIM-16 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 604 UPDATE OXA-385 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 605 UPDATE OXA-96 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 607 UPDATE TEM-201 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 608 UPDATE OXA-361 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 610 UPDATE SHV-153 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 611 UPDATE OXA-328 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 614 UPDATE SFB-1 SHW beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 615 UPDATE OXA-211 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 616 UPDATE NDM-8 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 617 UPDATE OXA-147 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 619 UPDATE SHV-30 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 620 UPDATE OXA-320 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 622 UPDATE DHA-7 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 623 UPDATE OXA-68 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 629 UPDATE VIM-28 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 630 UPDATE adeJ resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 631 UPDATE TEM-21 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 633 UPDATE OXA-355 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 635 UPDATE OXA-332 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 636 UPDATE CFE-1 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 637 UPDATE OXY-6-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 638 UPDATE ACT-16 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 641 UPDATE CARB-6 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 643 UPDATE OXY-2-5 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 644 UPDATE OXY-2-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 645 UPDATE mecR1 methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 646 UPDATE OXA-349 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 647 UPDATE TEM-89 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 648 UPDATE GES-4 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 649 UPDATE OXA-115 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 655 UPDATE OXA-243 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 656 UPDATE OXA-219 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 520 UPDATE AcrS resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 657 UPDATE SHV-142 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 658 UPDATE CMY-104 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 661 UPDATE VIM-5 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 662 UPDATE TEM-162 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 663 UPDATE ACT-36 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 664 UPDATE CMY-43 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 665 UPDATE TEM-10 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 667 UPDATE ACT-1 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 672 UPDATE CMY-27 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 673 UPDATE IMP-48 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 674 UPDATE OXA-15 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 675 UPDATE OXA-25 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 677 UPDATE OXA-171 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 679 UPDATE SHV-108 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 680 UPDATE CMY-54 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 681 UPDATE TEM-120 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 683 UPDATE CMY-75 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 684 UPDATE SHV-37 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 685 UPDATE OXA-239 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 686 UPDATE OXA-162 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 688 UPDATE MOX-2 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 690 UPDATE OXA-347 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 692 UPDATE TEM-159 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 693 UPDATE OXA-22 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 695 UPDATE CMY-66 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 698 UPDATE TEM-205 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 700 UPDATE ACT-31 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 701 UPDATE SHV-129 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 705 UPDATE CMY-116 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 707 UPDATE AIM-1 AIM beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 709 UPDATE TEM-213 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 711 UPDATE SHV-62 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 715 UPDATE PDC-3 PDC beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefixime; cefalotin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 718 UPDATE LRA-8 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 719 UPDATE CMY-33 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 720 UPDATE BcI class A Bacillus cereus Bc beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 40360 " 721 UPDATE OXA-28 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 723 UPDATE SHV-72 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 725 UPDATE GES-11 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 726 UPDATE PC1 beta-lactamase (blaZ) BlaZ beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 728 UPDATE TEM-192 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 731 UPDATE IMP-11 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 732 UPDATE OXA-237 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3666 UPDATE NDM-25 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 735 UPDATE TEM-30 TEM beta-lactamase; amoxicillin; ampicillin; cefalotin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 739 UPDATE LRA-18 class C LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 741 UPDATE CfxA CfxA beta-lactamase; cefoxitin; cefmetazole; cefotetan; flomoxef; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. DELETED 35962 " 745 UPDATE CMY-40 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 749 UPDATE SHV-97 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 750 UPDATE SHV-172 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 751 UPDATE TEM-217 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 755 UPDATE KPC-9 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 757 UPDATE CMY-80 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 758 UPDATE OXA-198 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 759 UPDATE OCH-2 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 760 UPDATE TEM-6 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 761 UPDATE GES-13 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 764 UPDATE FOX-2 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 766 UPDATE SHV-102 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 767 UPDATE OXA-207 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 768 UPDATE SHV-43 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 769 UPDATE KPC-11 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 770 UPDATE SHV-57 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 771 UPDATE CMY-24 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 772 UPDATE LEN-6 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 773 UPDATE OCH-4 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 775 UPDATE CMY-113 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 783 UPDATE NDM-1 NDM beta-lactamase; ertapenem; meropenem; imipenem; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 778 UPDATE IMP-25 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 779 UPDATE OXA-350 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 780 UPDATE CARB-9 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 782 UPDATE OXA-63 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 785 UPDATE OXY-2-9 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 788 UPDATE SHV-46 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 789 UPDATE IMP-43 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 790 UPDATE CMY-32 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 791 UPDATE SHV-14 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 792 UPDATE OXY-1-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 793 UPDATE IMP-34 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 795 UPDATE OXA-324 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 797 UPDATE TEM-55 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 806 UPDATE SHV-150 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 807 UPDATE OKP-B-1 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 808 UPDATE TEM-171 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 810 UPDATE mecC methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 632 UPDATE basR pmr phosphoethanolamine transferase; polymyxin B; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 805 UPDATE MexC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 704 UPDATE OprJ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 811 UPDATE TEM-26 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 812 UPDATE CMY-10 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 813 UPDATE OXA-216 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 814 UPDATE TEM-113 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 753 UPDATE SMB-1 SMB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 815 UPDATE GOB-1 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 816 UPDATE OXA-3 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 818 UPDATE SHV-141 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 825 UPDATE SHV-20 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 828 UPDATE TEM-83 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 829 UPDATE DHA-17 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 830 UPDATE SHV-157 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 831 UPDATE OKP-B-13 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 832 UPDATE SHV-161 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 833 UPDATE CfxA5 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 836 UPDATE TEM-68 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 839 UPDATE CMY-44 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 840 UPDATE CMY-20 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 844 UPDATE CMY-117 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 845 UPDATE TEM-163 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 846 UPDATE DHA-12 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 848 UPDATE OKP-A-2 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 849 UPDATE OXA-138 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 850 UPDATE OXA-26 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 853 UPDATE OXA-160 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 854 UPDATE CMY-58 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 855 UPDATE TEM-142 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 860 UPDATE TEM-42 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 861 UPDATE OXA-215 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 862 UPDATE IMP-16 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 863 UPDATE PER-7 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 864 UPDATE CMY-61 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 865 UPDATE OXA-244 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 867 UPDATE OXA-175 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 868 UPDATE DHA-1 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 869 UPDATE CRP resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 873 UPDATE KPC-19 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 877 UPDATE SHV-124 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 879 UPDATE TEM-185 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 883 UPDATE LRA-17 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 885 UPDATE TEM-63 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 887 UPDATE SHV-33 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 889 UPDATE CMY-74 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 890 UPDATE SHV-53 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 894 UPDATE CMY-90 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 895 UPDATE SHV-122 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 897 UPDATE OXA-383 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 899 UPDATE OXA-94 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 901 UPDATE LCR-1 LCR beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 902 UPDATE OXA-92 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 906 UPDATE CARB-21 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 909 UPDATE OXA-5 OXA beta-lactamase; OXA-5-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 911 UPDATE CMY-50 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 912 UPDATE LEN-13 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 913 UPDATE OXY-6-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 915 UPDATE SHV-106 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 916 UPDATE OXA-36 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 917 UPDATE SHV-186 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 918 UPDATE TEM-49 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 919 UPDATE PER-1 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 920 UPDATE TEM-152 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 921 UPDATE OKP-A-11 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 923 UPDATE VIM-25 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 926 UPDATE KPC-15 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 927 UPDATE OXA-381 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 929 UPDATE GES-10 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 948 UPDATE mecI methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 931 UPDATE OXA-316 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 932 UPDATE GES-8 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 933 UPDATE OKP-A-14 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 934 UPDATE IMP-8 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 935 UPDATE OXA-314 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 936 UPDATE OKP-A-13 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 937 UPDATE OXA-242 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 940 UPDATE TEM-125 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 941 UPDATE GES-1 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 942 UPDATE OXA-104 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 947 UPDATE OXA-100 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 951 UPDATE ACT-15 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 955 UPDATE SHV-96 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 956 UPDATE TEM-88 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 958 UPDATE OXA-418 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 959 UPDATE OXA-64 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 960 UPDATE TEM-137 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 961 UPDATE SHV-93 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 962 UPDATE OXA-356 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 963 UPDATE CMY-69 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 964 UPDATE OXA-129 OXA beta-lactamase; OXA-5-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 965 UPDATE OXA-333 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 882 UPDATE RCP-1 RCP beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 970 UPDATE OKP-B-18 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 972 UPDATE CMY-23 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 973 UPDATE OXA-378 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 871 UPDATE CGB-1 CGB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 977 UPDATE OXA-112 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 978 UPDATE OXA-134 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 979 UPDATE TEM-96 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 980 UPDATE y56 beta-lactamase BlaA beta-lactamase; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 981 UPDATE OXA-86 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 982 UPDATE TEM-153 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 983 UPDATE GES-20 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 990 UPDATE FOX-9 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 992 UPDATE SHV-66 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 994 UPDATE SHV-77 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 986 UPDATE baeS resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin; aminoglycoside antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 996 UPDATE CMY-77 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 997 UPDATE VIM-31 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 998 UPDATE SHV-134 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 999 UPDATE LEN-2 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1003 UPDATE OXA-18 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1007 UPDATE OKP-A-8 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1008 UPDATE BEL-1 BEL beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1010 UPDATE TEM-209 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1011 UPDATE TEM-29 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1012 UPDATE KPC-5 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1014 UPDATE SHV-25 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1015 UPDATE evgA major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; tetracycline; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1016 UPDATE OXA-255 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1019 UPDATE IMP-21 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1020 UPDATE OXA-241 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1022 UPDATE TEM-28 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1023 UPDATE IMP-14 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1025 UPDATE TEM-136 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1026 UPDATE SHV-74 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1028 UPDATE SHV-1 SHV beta-lactamase; ampicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1029 UPDATE CMY-102 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1032 UPDATE OXA-365 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1040 UPDATE OXA-95 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1043 UPDATE SHV-76 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1049 UPDATE MOX-1 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1051 UPDATE LEN-12 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1052 UPDATE OXA-206 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1053 UPDATE SHV-2 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1056 UPDATE VIM-19 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1058 UPDATE VIM-27 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1060 UPDATE SHV-103 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1061 UPDATE OXY-2-10 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1062 UPDATE SHV-71 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1065 UPDATE OXA-384 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1066 UPDATE TEM-118 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1069 UPDATE IMP-35 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1071 UPDATE DHA-22 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1072 UPDATE OXA-37 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1073 UPDATE OKP-B-19 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1074 UPDATE LEN-3 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1075 UPDATE TEM-20 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1076 UPDATE IMP-37 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1077 UPDATE OXA-420 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1078 UPDATE VIM-4 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1079 UPDATE OXA-161 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1080 UPDATE SHV-158 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1081 UPDATE IMP-30 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1083 UPDATE OXA-323 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1084 UPDATE LEN-5 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1085 UPDATE OKP-B-5 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1086 UPDATE CMY-41 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1087 UPDATE OXA-253 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1089 UPDATE CMY-14 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1090 UPDATE TEM-169 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1091 UPDATE IMP-6 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1094 UPDATE CARB-17 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1095 UPDATE SHV-59 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1096 UPDATE TEM-79 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1099 UPDATE OXA-48 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; temocillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1100 UPDATE OXA-245 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1103 UPDATE CMY-17 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1104 UPDATE acrB resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; acriflavine; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1106 UPDATE NDM-5 NDM beta-lactamase; cefoxitin; ceftazidime; ertapenem; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1110 UPDATE LEN-19 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1112 UPDATE OXA-58 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1114 UPDATE ACT-17 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1115 UPDATE OXA-435 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1118 UPDATE OXA-2 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; ceftazidime; amoxicillin; meropenem; ampicillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1122 UPDATE OXA-180 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1123 UPDATE FOX-8 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1124 UPDATE TEM-186 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1125 UPDATE OKP-B-11 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1126 UPDATE OXA-184 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1128 UPDATE OXA-23 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1129 UPDATE CMY-19 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1041 UPDATE MexS resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1132 UPDATE OXA-88 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1133 UPDATE SHV-109 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1137 UPDATE TEM-90 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1140 UPDATE CMY-86 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1141 UPDATE OXA-169 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1143 UPDATE OXA-7 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1109 UPDATE CAU-1 CAU beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1119 UPDATE EBR-1 EBR beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1146 UPDATE TEM-156 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1147 UPDATE CMY-63 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1148 UPDATE OXA-363 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1149 UPDATE AER-1 AER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1151 UPDATE OXA-240 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1153 UPDATE KPC-3 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1154 UPDATE TEM-146 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1155 UPDATE ACT-9 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1158 UPDATE SHV-22 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1159 UPDATE TEM-129 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1163 UPDATE CMY-94 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1165 UPDATE OKP-A-4 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1168 UPDATE NDM-9 taniborbactam; NDM beta-lactamase; cefepime; cefepime-taniborbactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1169 UPDATE OXA-360 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1170 UPDATE CMY-46 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1172 UPDATE OXA-194 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1173 UPDATE TEM-54 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1177 UPDATE KPC-12 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1178 UPDATE CMY-81 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1179 UPDATE IMP-4 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1180 UPDATE mdsC resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1184 UPDATE OXA-182 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1185 UPDATE OXA-176 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1186 UPDATE OXA-327 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1187 UPDATE OXA-248 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1190 UPDATE OXA-354 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1194 UPDATE OXA-16 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1195 UPDATE SHV-55 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1196 UPDATE OXA-71 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1199 UPDATE SHV-168 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1201 UPDATE CARB-22 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1205 UPDATE VIM-39 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1207 UPDATE DHA-13 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1208 UPDATE SHV-173 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1211 UPDATE VIM-1 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1212 UPDATE OXA-141 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1214 UPDATE TEM-134 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1216 UPDATE SHV-119 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1217 UPDATE OXA-139 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1218 UPDATE TEM-219 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1220 UPDATE OCH-5 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1221 UPDATE OXA-231 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1225 UPDATE TEM-178 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1228 UPDATE CMY-30 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1236 UPDATE CMY-53 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1238 UPDATE OXA-397 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1239 UPDATE SHV-81 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1241 UPDATE TEM-144 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1244 UPDATE OXY-5-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1245 UPDATE TEM-114 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1247 UPDATE CMY-72 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1248 UPDATE H-NS major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; ciprofloxacin; tetracycline; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1249 UPDATE FOX-5 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1253 UPDATE GES-23 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1255 UPDATE OXA-119 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1258 UPDATE OXA-55 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1259 UPDATE SHV-31 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1262 UPDATE SHV-149 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1264 UPDATE smeC resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1268 UPDATE CMY-115 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1269 UPDATE OXA-192 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1274 UPDATE VIM-10 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1276 UPDATE OXA-210 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1277 UPDATE GES-16 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1278 UPDATE TEM-45 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1279 UPDATE TEM-104 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1281 UPDATE OXA-110 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1283 UPDATE KPC-6 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1286 UPDATE SHV-34 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1288 UPDATE OXA-82 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1289 UPDATE OKP-B-7 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1290 UPDATE TEM-141 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1291 UPDATE TEM-177 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1293 UPDATE OXA-197 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1296 UPDATE OKP-B-12 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1303 UPDATE BEL-2 BEL beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1282 UPDATE SIM-1 SIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1294 UPDATE Sed-1 SED beta-lactamase; cefuroxime; amoxicillin; piperacillin; cefalotin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; model_name; ARO_name; CARD_short_name; ARO_description; ARO_category "UPDATED model_name with SED-1 UPDATED ARO_name with SED-1 UPDATED CARD_short_name with SED-1 UPDATED ARO_description with SED-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii. UPDATED category_aro_accession with 3007880 UPDATED category_aro_cvterm_id with 46671 UPDATED category_aro_name with SED beta-lactamase UPDATED category_aro_description with SED is a family of broad-spectrum class A beta-lactamases. UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 41357 " 1307 UPDATE OXY-1-6 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1309 UPDATE ACT-20 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1310 UPDATE IMP-10 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1311 UPDATE OXY-5-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1312 UPDATE OXA-111 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1314 UPDATE OXA-214 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1317 UPDATE CTX-M-3 CTX-M beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefixime; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1318 UPDATE evgS major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; tetracycline; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1319 UPDATE SHV-147 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1321 UPDATE mecA methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1322 UPDATE SHV-65 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1324 UPDATE LRA-2 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1325 UPDATE OXA-65 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1326 UPDATE OXA-170 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1334 UPDATE SHV-126 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1336 UPDATE BcII subclass B1 Bacillus cereus Bc beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1340 UPDATE mtrC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35971 " 1341 UPDATE OXA-53 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1343 UPDATE OXA-166 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1346 UPDATE SHV-94 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1347 UPDATE OXA-425 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1350 UPDATE TEM-93 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1352 UPDATE OXA-251 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1353 UPDATE GES-5 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1355 UPDATE TEM-149 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1358 UPDATE VIM-24 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1359 UPDATE OXA-233 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1361 UPDATE OXA-223 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1362 UPDATE IMP-31 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1363 UPDATE CARB-1 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1364 UPDATE CMY-101 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1373 UPDATE CMY-26 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1375 UPDATE CMY-11 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1376 UPDATE MOX-6 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1379 UPDATE OXA-313 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1380 UPDATE TEM-193 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1384 UPDATE OXA-382 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1385 UPDATE mdsB resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1387 UPDATE OXA-99 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1389 UPDATE KPC-22 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1394 UPDATE OXA-257 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1396 UPDATE OXA-11 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1398 UPDATE OXA-108 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1399 UPDATE OXA-315 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1402 UPDATE OXA-390 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1403 UPDATE OXA-388 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1404 UPDATE IMP-3 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1406 UPDATE OXA-121 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1407 UPDATE CMY-62 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1408 UPDATE TEM-124 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1409 UPDATE CMY-6 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1410 UPDATE OXA-19 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1411 UPDATE OXA-62 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1412 UPDATE SHV-167 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1413 UPDATE OXA-172 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1416 UPDATE OXA-89 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1417 UPDATE OXA-131 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1418 UPDATE DHA-6 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1419 UPDATE OXA-454 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1421 UPDATE TEM-85 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1422 UPDATE ACC-3 ACC beta-lactamase; ceftazidime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1423 UPDATE TEM-15 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1424 UPDATE OXY-2-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1426 UPDATE IMP-7 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1429 UPDATE SHV-60 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1430 UPDATE SHV-125 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1431 UPDATE GES-15 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1433 UPDATE CMY-18 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1436 UPDATE TEM-40 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1438 UPDATE SHV-19 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1439 UPDATE SHV-80 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1443 UPDATE CARB-7 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1447 UPDATE OKP-A-10 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1448 UPDATE SHV-26 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1449 UPDATE OXA-59 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1452 UPDATE TEM-216 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1454 UPDATE CMY-112 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1456 UPDATE IMP-15 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1458 UPDATE TEM-157 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1461 UPDATE SHV-63 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1462 UPDATE LRA-19 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1463 UPDATE GES-19 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1466 UPDATE SHV-13 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1467 UPDATE LEN-22 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1468 UPDATE SHV-135 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1471 UPDATE adeI resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 1338 UPDATE Bla1 class A Bacillus anthracis Bla beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1393 UPDATE THIN-B THIN-B beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1437 UPDATE AcrF resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1445 UPDATE AcrE resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1472 UPDATE DHA-18 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1475 UPDATE SHV-99 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1476 UPDATE TEM-199 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1478 UPDATE CARB-10 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1479 UPDATE IMP-40 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1481 UPDATE OXY-1-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1484 UPDATE ACT-27 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1485 UPDATE MOX-8 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1486 UPDATE CARB-12 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1487 UPDATE SHV-48 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1488 UPDATE TEM-75 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1489 UPDATE CMY-37 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1490 UPDATE SHV-107 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1492 UPDATE MOX-3 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1493 UPDATE PER-6 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1494 UPDATE LAT-1 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1495 UPDATE ACT-4 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1496 UPDATE OXA-224 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1501 UPDATE CMY-49 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1337 UPDATE baeR resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin; aminoglycoside antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1502 UPDATE OXA-209 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1503 UPDATE LEN-4 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1504 UPDATE CMY-108 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1506 UPDATE ACT-12 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1507 UPDATE smeA resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1511 UPDATE OXA-423 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1514 UPDATE IMP-28 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1515 UPDATE NDM-3 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1516 UPDATE CMY-45 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1517 UPDATE OXA-33 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1520 UPDATE SHV-85 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1521 UPDATE VIM-32 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1522 UPDATE IMP-38 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1525 UPDATE TEM-160 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1527 UPDATE SHV-51 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1528 UPDATE TEM-168 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1529 UPDATE TEM-130 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1530 UPDATE OXA-67 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1531 UPDATE TEM-81 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1532 UPDATE OXA-249 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1533 UPDATE SHV-143 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1534 UPDATE PER-5 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1535 UPDATE CMY-16 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1536 UPDATE OXA-421 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1537 UPDATE GES-2 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1538 UPDATE SHV-104 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1541 UPDATE ACT-14 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1543 UPDATE CMY-22 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1550 UPDATE smeR resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1551 UPDATE OXA-78 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1555 UPDATE SHV-140 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1556 UPDATE VIM-13 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1557 UPDATE SHV-187 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1559 UPDATE mtrA resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "DELETED 35971 " 1560 UPDATE OKP-B-20 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1565 UPDATE ACT-18 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1568 UPDATE OXA-183 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1572 UPDATE OXA-205 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1573 UPDATE SHV-110 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1575 UPDATE OXA-91 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1576 UPDATE OXA-17 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1578 UPDATE SHV-123 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1581 UPDATE ACT-3 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1585 UPDATE CMY-73 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1587 UPDATE OXA-10 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1589 UPDATE PER-3 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1591 UPDATE CMY-64 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1593 UPDATE CMY-99 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1595 UPDATE mecB methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1596 UPDATE OXA-24 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; BAL30072; monobactam; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1597 UPDATE SHV-2A SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1598 UPDATE OXA-101 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1599 UPDATE SHV-23 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1601 UPDATE LRA-1 class A LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1603 UPDATE SHV-86 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1610 UPDATE OXA-74 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1613 UPDATE CMY-38 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1614 UPDATE TEM-194 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1618 UPDATE OXA-362 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1621 UPDATE SHV-45 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1608 UPDATE MexT resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1523 UPDATE MexD resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1623 UPDATE GIM-2 GIM beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1625 UPDATE OXA-179 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1628 UPDATE SHV-154 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1629 UPDATE TEM-197 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1630 UPDATE IMP-13 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1480 UPDATE EXO-1 EXO beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1552 UPDATE MUS-1 MUS beta-lactamase; amoxicillin; piperacillin; ticarcillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1634 UPDATE CMY-78 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1637 UPDATE MOX-7 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1638 UPDATE CMY-111 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1639 UPDATE SHV-84 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1641 UPDATE OXA-203 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1644 UPDATE SHV-70 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1645 UPDATE ACT-23 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1646 UPDATE TEM-139 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1649 UPDATE DHA-21 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1650 UPDATE CMY-15 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1652 UPDATE IMP-20 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1654 UPDATE SHV-95 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1655 UPDATE TEM-117 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1658 UPDATE OKP-B-4 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1659 UPDATE OXA-258 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1660 UPDATE OXA-375 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1661 UPDATE CARB-8 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1662 UPDATE OKP-B-17 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1663 UPDATE ACC-1 ACC beta-lactamase; cefepime; ceftazidime; piperacillin; aztreonam; cefotaxime; cefotetan; flomoxef; moxalactam; cefpirome; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1664 UPDATE adeK resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 1665 UPDATE ramA resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1667 UPDATE TEM-80 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1668 UPDATE CMY-68 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1672 UPDATE TEM-211 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1676 UPDATE GES-18 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1679 UPDATE OXA-49 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1684 UPDATE LEN-18 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1685 UPDATE SHV-40 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1686 UPDATE OXA-34 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1690 UPDATE OXA-317 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1691 UPDATE CMY-31 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1693 UPDATE TEM-143 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1694 UPDATE OXA-353 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1695 UPDATE DHA-5 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1697 UPDATE TEM-135 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 1698 UPDATE OCH-6 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1700 UPDATE ACT-28 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1704 UPDATE CMY-57 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1705 UPDATE SHV-111 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1706 UPDATE OXA-142 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1709 UPDATE TEM-115 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1712 UPDATE IMP-41 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1715 UPDATE OXA-73 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1716 UPDATE OXA-398 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1717 UPDATE OXA-230 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1722 UPDATE TEM-184 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1723 UPDATE IMP-44 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1725 UPDATE TEM-101 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1726 UPDATE FOX-4 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1727 UPDATE SHV-73 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1728 UPDATE OXA-42 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1730 UPDATE OXA-235 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1732 UPDATE SHV-151 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1733 UPDATE OXA-415 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1736 UPDATE GES-24 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1739 UPDATE SHV-16 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1740 UPDATE TEM-53 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1741 UPDATE OXA-359 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1742 UPDATE SHV-28 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1743 UPDATE OXA-338 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1746 UPDATE IMP-24 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1747 UPDATE CMY-103 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1749 UPDATE IMP-18 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1750 UPDATE OXA-254 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1753 UPDATE SHV-148 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1756 UPDATE CMY-93 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1758 UPDATE OXA-326 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1761 UPDATE OXA-351 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1763 UPDATE NDM-2 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1764 UPDATE OXA-97 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1765 UPDATE OXA-56 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1766 UPDATE VIM-14 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1767 UPDATE OKP-A-16 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1770 UPDATE TEM-127 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1771 UPDATE TEM-19 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1776 UPDATE SHV-159 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1777 UPDATE OXA-177 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1778 UPDATE OKP-A-5 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1780 UPDATE OXA-146 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1607 UPDATE Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1782 UPDATE TEM-12 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1783 UPDATE VIM-36 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1784 UPDATE OXA-334 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1785 UPDATE TEM-48 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1786 UPDATE mexY resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1787 UPDATE VIM-42 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1788 UPDATE ACT-6 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1791 UPDATE TEM-164 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1792 UPDATE DHA-20 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1793 UPDATE DHA-14 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1796 UPDATE CMY-119 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1798 UPDATE SHV-183 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1799 UPDATE TEM-147 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1800 UPDATE SHV-120 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1802 UPDATE OXA-168 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1804 UPDATE OXA-107 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1805 UPDATE TEM-131 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1806 UPDATE OXA-14 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1807 UPDATE OXA-70 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1810 UPDATE VIM-15 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1811 UPDATE CARB-2 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1813 UPDATE MOX-4 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1816 UPDATE TEM-8 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1818 UPDATE GES-26 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1819 UPDATE TEM-3 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1823 UPDATE OXY-1-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1825 UPDATE CTX-M-27 CTX-M beta-lactamase; cefazolin; ceftazidime; ertapenem; ampicillin; cefixime; cefalotin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1827 UPDATE SHV-5 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1828 UPDATE GES-6 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1829 UPDATE CMY-87 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1833 UPDATE OXA-374 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1834 UPDATE TEM-94 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1836 UPDATE OXA-201 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1838 UPDATE ACT-5 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1840 UPDATE CMY-59 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1841 UPDATE OXA-76 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1844 UPDATE OXA-128 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1845 UPDATE OXA-312 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1851 UPDATE KPC-13 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1853 UPDATE OXA-20 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1857 UPDATE VIM-9 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1858 UPDATE OXA-387 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1860 UPDATE OXA-165 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1861 UPDATE LEN-15 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1862 UPDATE OXA-109 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1863 UPDATE VIM-3 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1864 UPDATE CMY-67 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1865 UPDATE ACC-5 ACC beta-lactamase; ceftazidime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1866 UPDATE KPC-7 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1868 UPDATE TEM-82 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1869 UPDATE OXY-2-6 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1870 UPDATE OXA-66 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1871 UPDATE OXA-389 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1874 UPDATE OXA-196 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1876 UPDATE LEN-7 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1877 UPDATE CMY-12 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1880 UPDATE adeN resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 1881 UPDATE OXA-72 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1882 UPDATE OXA-80 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1883 UPDATE DHA-10 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1886 UPDATE LEN-24 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1887 UPDATE TEM-70 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1889 UPDATE NDM-4 NDM beta-lactamase; ticarcillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1890 UPDATE TEM-86 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1892 UPDATE OXA-114a OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1893 UPDATE SHV-127 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1895 UPDATE CfxA3 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1896 UPDATE NDM-12 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1898 UPDATE OXA-379 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1900 UPDATE ACT-13 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1902 UPDATE OXA-246 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1903 UPDATE mdtE resistance-nodulation-cell division (RND) antibiotic effl