Model_id Action ARO_name ARO_category Changes To Summary 3716 ADD Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv0191; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3726 ADD Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid isoniazid resistant inbR; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3718 ADD Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv2731; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3729 ADD Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid isoniazid resistant mshC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3720 ADD Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv3169; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3731 ADD Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid isoniazid resistant mymA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3707 ADD Mycobacterium tuberculosis eis mutations confer resistance to kanamycin kanamycin resistant eis; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; N/A N/A 3702 ADD Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide inhA with mutations with conferring resistance to ethionamide; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 3703 ADD Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid isoniazid resistant nudC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3706 ADD Mycobacterium tuberculosis ponA1 mutations confer resistance to rifabutin rifamycin resistant ponA1; rifampin; rifabutin; rifamycin antibiotic; antibiotic target alteration; N/A N/A 3735 ADD Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid isoniazid resistant sigI; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3709 ADD Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin streptomycin resistant whib7; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; N/A N/A 3742 ADD Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine cycloserine resistant ddlA; cycloserine; cycloserine-like antibiotic; antibiotic target alteration; N/A N/A 3746 ADD Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin rifampicin resistant rpoC; rifampin; rifabutin; rifamycin antibiotic; antibiotic target alteration; N/A N/A 3747 ADD Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin rifampicin resistant rpoA; rifampin; rifamycin antibiotic; antibiotic target alteration; N/A N/A 3712 ADD Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide antibiotic resistant polyketide synthase genes; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3738 ADD Mycobacterium tuberculosis mshC mutations conferring resistance to ethionamide ethionamide resistant mshC; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 3713 ADD Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide antibiotic resistant polyketide synthase genes; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3723 ADD Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid Isoniazid resistant ahpC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3724 ADD Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid isoniazid resistant fabG1; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3740 ADD Mycobacterium tuberculosis ubiA mutations confer resistance to ethambutol ethambutol resistant ubiA; ethambutol; polyamine antibiotic; antibiotic target alteration; N/A N/A 3715 ADD Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide pyrazinamide resistant mas; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3725 ADD Mycobacterium tuberculosis furA mutations confer resistance to isoniazid isoniazid resistant furA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3705 ADD Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide pyrazinamide resistant clpC1; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3739 ADD Mycobacterium tuberculosis fabG1 mutation conferring resistance to ethionamide ethionamide resistant fabG1; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 6065 ADD VRA-F ATP-binding cassette (ABC) antibiotic efflux pump; vancomycin; glycopeptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 6067 ADD SIE-1 SIE beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 6000 ADD Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics antibiotic resistant Mycobacterium tuberculosis nitroreductase; delamanid; pretomanid; nitroimidazole antibiotic; antibiotic target alteration; N/A N/A 6068 ADD NWM-1 NWM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 6066 ADD KPC-135 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 6070 ADD Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to clofazimine clofazimine resistant Rv0678; clofazimine; fluoroquinolone antibiotic; antibiotic target alteration; N/A N/A 6071 ADD Mycobacterium tuberculosis atpE with mutation conferring resistance to bedaquiline antibiotic resistant ATP synthase; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; N/A N/A 6072 ADD KPC-134 avibactam; KPC beta-lactamase; ceftazidime; ceftazidime-avibactam; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 6074 ADD BIM-1 BIM beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 6073 ADD CHM-1 CHM beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 6075 ADD DYB-1 DYB beta-lactamase; ceftazidime; meropenem; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 7301 ADD ACT-100 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7302 ADD ACT-101 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7303 ADD ACT-102 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7304 ADD ACT-103 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7305 ADD ACT-104 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7306 ADD ACT-105 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7307 ADD ACT-106 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7308 ADD ACT-107 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7309 ADD ACT-108 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7310 ADD ACT-109 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7311 ADD ACT-110 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7312 ADD ACT-111 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7313 ADD ACT-112 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7314 ADD ACT-113 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7315 ADD ACT-115 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7316 ADD ACT-116 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7317 ADD ACT-117 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7318 ADD ACT-118 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7319 ADD ACT-119 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7320 ADD ACT-120 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7321 ADD ACT-121 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7322 ADD ACT-122 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7323 ADD ACT-123 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7324 ADD ACT-124 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7325 ADD ACT-131 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7326 ADD ACT-140 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7327 ADD ACT-141 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7328 ADD ACT-142 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7329 ADD ACT-143 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7330 ADD ACT-144 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7331 ADD ACT-145 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7332 ADD ACT-146 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7333 ADD ACT-148 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7334 ADD ACT-150 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7335 ADD ACT-151 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7336 ADD ACT-153 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7337 ADD ACT-154 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7338 ADD ACT-155 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7339 ADD ACT-156 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7340 ADD ACT-157 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7341 ADD ACT-158 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7342 ADD ACT-159 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7343 ADD ACT-160 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7344 ADD ACT-161 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7345 ADD ACT-162 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7346 ADD ACT-165 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7347 ADD ACT-166 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7348 ADD ACT-167 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7349 ADD ACT-168 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7350 ADD ACT-169 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7351 ADD ACT-170 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7352 ADD ACT-171 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7353 ADD ACT-172 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7354 ADD ACT-173 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7355 ADD ACT-174 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7356 ADD ACT-175 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7357 ADD ACT-176 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7358 ADD ACT-177 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7359 ADD ACT-178 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7360 ADD ACT-179 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7361 ADD ACT-180 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7362 ADD ACT-181 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7363 ADD ACT-182 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7364 ADD ACT-183 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7365 ADD ACT-184 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7366 ADD ACT-185 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7367 ADD ACT-186 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7368 ADD ACT-187 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7369 ADD ACT-188 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7370 ADD ACT-189 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7371 ADD ACT-190 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7372 ADD ACT-191 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7373 ADD ACT-192 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7374 ADD ACT-193 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7375 ADD ACT-194 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7376 ADD ACT-85 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7377 ADD ACT-86 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7378 ADD ACT-88 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7379 ADD ACT-89 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7380 ADD ACT-90 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7381 ADD ACT-91 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7382 ADD ACT-92 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7383 ADD ACT-93 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7384 ADD ACT-94 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7385 ADD ACT-95 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7386 ADD ACT-96 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7387 ADD ACT-97 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7388 ADD ACT-98 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7389 ADD ACT-99 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7390 ADD ACT-GC1 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7391 ADD ADC-257 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7392 ADD ADC-258 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7393 ADD ADC-259 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7394 ADD ADC-260 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7395 ADD ADC-261 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7396 ADD ADC-262 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7397 ADD ADC-263 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7398 ADD ADC-264 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7399 ADD ADC-265 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7400 ADD ADC-266 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7401 ADD ADC-267 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7402 ADD ADC-268 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7403 ADD ADC-269 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7404 ADD ADC-270 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7405 ADD ADC-271 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7406 ADD ADC-272 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7407 ADD ADC-273 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7408 ADD ADC-274 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7409 ADD ADC-275 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7410 ADD ADC-276 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7411 ADD ADC-277 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7412 ADD ADC-278 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7413 ADD ADC-279 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7414 ADD ADC-280 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7415 ADD ADC-281 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7416 ADD ADC-282 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7417 ADD ADC-283 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7418 ADD ADC-284 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7419 ADD ADC-285 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7420 ADD ADC-286 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7421 ADD ADC-287 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7422 ADD ADC-288 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7423 ADD ADC-289 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7424 ADD ADC-290 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7425 ADD ADC-291 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7426 ADD ADC-292 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7427 ADD ADC-293 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7428 ADD ADC-294 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7429 ADD ADC-295 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7430 ADD ADC-302 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7431 ADD ADC-303 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7432 ADD ADC-304 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7433 ADD ADC-305 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7434 ADD ADC-306 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7435 ADD ADC-307 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7436 ADD ADC-308 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7437 ADD ADC-309 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7438 ADD ADC-310 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7439 ADD ADC-311 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7440 ADD ADC-312 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7441 ADD ADC-313 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7442 ADD ADC-314 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7443 ADD ADC-315 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7444 ADD ADC-316 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7445 ADD ADC-317 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7446 ADD ADC-318 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7447 ADD ADC-319 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7448 ADD ADC-320 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7449 ADD ADC-321 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7450 ADD ADC-322 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7451 ADD ADC-323 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7452 ADD ADC-324 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7453 ADD ADC-325 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7454 ADD ADC-326 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7455 ADD ADC-327 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7456 ADD ADC-328 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7457 ADD ADC-329 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7458 ADD ADC-330 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7459 ADD ADC-331 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7460 ADD ADC-332 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7461 ADD ADC-333 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7462 ADD ADC-334 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7463 ADD ADC-335 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7464 ADD ADC-336 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7465 ADD ADC-337 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7466 ADD ADC-338 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7467 ADD ADC-339 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7468 ADD ADC-340 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7469 ADD ADC-341 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7470 ADD ADC-342 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7471 ADD ADC-343 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7472 ADD ADC-344 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7473 ADD ADC-345 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7474 ADD ADC-346 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7475 ADD ADC-347 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7476 ADD ADC-348 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7477 ADD ADC-349 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7478 ADD ADC-350 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7479 ADD ADC-351 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7480 ADD ADC-352 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7481 ADD ADC-353 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7482 ADD ADC-354 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7483 ADD ADC-355 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7484 ADD ADC-356 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7485 ADD ADC-357 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7486 ADD ADC-358 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7487 ADD ADC-359 ADC beta-lactamases pending classification for carbapenemase activity; cephalosporin; antibiotic inactivation; N/A N/A 7488 ADD AFM-3 AFM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7489 ADD AFM-4 AFM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7490 ADD AFM-5 AFM beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7491 ADD AIM-2 AIM beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7492 ADD ASU1-1 ASU1 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7493 ADD AXC-6 AXC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7494 ADD AXC-7 AXC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7495 ADD AXC-8 AXC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7496 ADD B3SU1-1 B3SU1 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7497 ADD B3SU2-1 B3SU2 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7498 ADD BIC-2 BIC Beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7499 ADD BMHC-1 BMHC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7500 ADD BOR-1 BOR beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7501 ADD CAM-2 CAM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7502 ADD CME-3 CME beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7503 ADD CMH-10 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7504 ADD CMH-11 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7505 ADD CMH-12 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7506 ADD CMH-13 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7507 ADD CMH-14 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7508 ADD CMH-15 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7509 ADD CMH-16 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7510 ADD CMH-17 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7511 ADD CMH-18 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7512 ADD CMH-19 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7513 ADD CMH-20 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7514 ADD CMH-21 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7515 ADD CMH-24 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7516 ADD CMH-25 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7520 ADD CMH-29 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7521 ADD CMH-30 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7522 ADD CMH-31 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7523 ADD CMH-32 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7524 ADD CMH-33 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7525 ADD CMH-34 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7526 ADD CMH-7 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7527 ADD CMH-8 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7528 ADD CMH-9 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7529 ADD CMY-172 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7530 ADD CMY-175 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7531 ADD CMY-176 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7532 ADD CMY-177 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7533 ADD CMY-178 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7534 ADD CMY-179 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7535 ADD CMY-180 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7536 ADD CMY-181 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7537 ADD CMY-182 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7538 ADD CMY-183 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7539 ADD CMY-184 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7540 ADD CMY-186 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7541 ADD CMY-188 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7542 ADD CMY-189 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7543 ADD CMY-190 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7544 ADD CMY-191 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7545 ADD CMY-192 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7546 ADD CMY-194 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7547 ADD CMY-195 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7548 ADD CMY-196 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7549 ADD CMY-197 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7550 ADD CMY-198 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7551 ADD CMY-199 CMY beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7552 ADD CTX-M-243 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7553 ADD CTX-M-245 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7554 ADD CTX-M-246 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7555 ADD CTX-M-247 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7556 ADD CTX-M-248 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7557 ADD CTX-M-249 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7558 ADD CTX-M-251 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7559 ADD CTX-M-252 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7560 ADD CTX-M-253 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7561 ADD CTX-M-254 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7562 ADD CTX-M-255 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7563 ADD CTX-M-256 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7564 ADD CTX-M-257 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7565 ADD CTX-M-258 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7566 ADD CTX-M-259 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7568 ADD CTX-M-261 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7569 ADD CTX-M-262 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7570 ADD CTX-M-263 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7571 ADD CTX-M-264 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7572 ADD CTX-M-265 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7573 ADD CTX-M-266 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7574 ADD CTX-M-267 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7575 ADD CTX-M-268 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7576 ADD CTX-M-269 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7577 ADD CTX-M-270 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7578 ADD CTX-M-271 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7579 ADD CTX-M-272 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7580 ADD CTX-M-273 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7581 ADD CTX-M-274 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7582 ADD CTX-M-275 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7583 ADD CTX-M-276 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7584 ADD CTX-M-277 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7585 ADD CTX-M-278 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7586 ADD DHA-30 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7587 ADD DHA-31 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7588 ADD DHA-32 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7589 ADD DHA-33 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7590 ADD DHA-34 DHA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7591 ADD FONA-10 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7592 ADD FONA-11 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7593 ADD FONA-12 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7594 ADD FONA-13 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7595 ADD FONA-7 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7596 ADD FONA-8 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7597 ADD FONA-9 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7598 ADD FOX-18 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7599 ADD FOX-19 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7600 ADD FOX-20 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7601 ADD FOX-21 FOX beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7602 ADD FRI-12 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7603 ADD GES-58 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7604 ADD GES-59 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7605 ADD GES-60 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7606 ADD GES-61 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7607 ADD GES-62 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7608 ADD GES-65 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7609 ADD GES-66 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7610 ADD GIM-3 GIM beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7611 ADD GMA-1 GMA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7612 ADD GMA-2 GMA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7613 ADD GOB-17 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7614 ADD GOB-47 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7615 ADD GOB-52 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7616 ADD GOB-53 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7617 ADD HBL-1 HBL beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7618 ADD HER-1 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7619 ADD HER-2 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7620 ADD HER-3 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7621 ADD HER-4 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7622 ADD HER-5 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7623 ADD HER-6 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7624 ADD HER-8 HER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7625 ADD HMB-2 HMB beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7626 ADD IMI-10 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7627 ADD IMI-22 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7628 ADD IMI-23 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7629 ADD IMI-24 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7630 ADD IMI-25 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7631 ADD IMI-26 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7632 ADD IMI-27 IMI beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7633 ADD IMP-100 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7634 ADD IMP-101 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7635 ADD IMP-102 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7636 ADD IMP-104 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7637 ADD IMP-105 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7638 ADD IMP-86 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7639 ADD IMP-87 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7640 ADD IMP-90 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7641 ADD IMP-97 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7642 ADD IMP-98 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7643 ADD IMP-99 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7644 ADD IND-18 IND beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7645 ADD IND-19 IND beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 7646 ADD KHM-2 KHM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7647 ADD KLUC-6 KLUC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7648 ADD KLUG-1 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7649 ADD KPC-101 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7650 ADD KPC-102 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7651 ADD KPC-103 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7652 ADD KPC-104 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7653 ADD KPC-105 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7654 ADD KPC-106 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7655 ADD KPC-107 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7656 ADD KPC-108 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7657 ADD KPC-109 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7658 ADD KPC-110 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7659 ADD KPC-111 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7660 ADD KPC-112 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7661 ADD KPC-113 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7662 ADD KPC-114 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7663 ADD KPC-115 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7664 ADD KPC-116 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7665 ADD KPC-117 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7666 ADD KPC-118 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7667 ADD KPC-119 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7668 ADD KPC-120 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7669 ADD KPC-121 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7670 ADD KPC-122 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7671 ADD KPC-124 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7672 ADD KPC-126 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7673 ADD KPC-127 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7674 ADD KPC-128 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7675 ADD KPC-129 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7676 ADD KPC-130 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7677 ADD KPC-131 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7678 ADD KPC-132 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7679 ADD KPC-133 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7680 ADD KPC-136 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7681 ADD KPC-137 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7682 ADD KPC-138 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7683 ADD KPC-139 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7684 ADD KPC-140 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7685 ADD KPC-141 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7686 ADD KPC-142 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7687 ADD KPC-143 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7688 ADD KPC-144 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7689 ADD KPC-145 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7690 ADD KPC-146 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7691 ADD KPC-147 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7692 ADD KPC-148 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7693 ADD KPC-149 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7694 ADD KPC-150 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7695 ADD KPC-151 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7696 ADD KPC-152 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7697 ADD KPC-153 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7698 ADD KPC-154 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7699 ADD KPC-155 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7700 ADD KPC-156 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7701 ADD KPC-157 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7702 ADD KPC-158 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7703 ADD KPC-159 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7704 ADD KPC-160 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7705 ADD KPC-161 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7706 ADD KPC-162 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7707 ADD KPC-163 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7708 ADD KPC-164 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7709 ADD KPC-165 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7710 ADD KPC-166 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7711 ADD KPC-167 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7712 ADD KPC-168 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7713 ADD KPC-169 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7714 ADD KPC-170 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7715 ADD KPC-171 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7716 ADD KPC-172 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7717 ADD KPC-173 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7718 ADD KPC-174 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7719 ADD KPC-175 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7720 ADD KPC-176 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7721 ADD KPC-177 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7722 ADD KPC-178 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7723 ADD KPC-179 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7724 ADD KPC-180 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7725 ADD KPC-181 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7726 ADD KPC-182 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7727 ADD KPC-183 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7728 ADD KPC-184 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7729 ADD KPC-185 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7730 ADD KPC-186 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7731 ADD KPC-187 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7732 ADD KPC-188 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7733 ADD KPC-189 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7734 ADD KPC-190 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7735 ADD KPC-191 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7736 ADD KPC-192 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7737 ADD KPC-193 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7738 ADD KPC-194 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7739 ADD KPC-195 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7740 ADD KPC-196 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7741 ADD KPC-197 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7742 ADD KPC-201 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7743 ADD KPC-202 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7744 ADD KPC-203 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7745 ADD KPC-204 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7746 ADD KPC-205 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7747 ADD KPC-206 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7748 ADD KPC-207 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7749 ADD KPC-208 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7750 ADD KPC-209 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7751 ADD KPC-211 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7752 ADD KPC-212 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7753 ADD KPC-213 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7754 ADD KPC-214 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7755 ADD KPC-215 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7756 ADD KPC-216 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7757 ADD KPC-217 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7758 ADD KPC-218 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7759 ADD KPC-223 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7760 ADD KPC-224 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7761 ADD KPC-225 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7762 ADD KPC-226 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7763 ADD KPC-227 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7764 ADD KPC-228 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7765 ADD KPC-230 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7766 ADD KPC-231 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7767 ADD KPC-232 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7768 ADD KPC-233 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7769 ADD KPC-234 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7770 ADD KPC-236 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7771 ADD KPC-237 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7772 ADD KPC-238 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7773 ADD KPC-239 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7774 ADD KPC-240 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7775 ADD KPC-241 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7776 ADD KPC-242 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7777 ADD KPC-47 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7778 ADD KPC-48 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7779 ADD KPC-53 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7780 ADD KPC-67 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7781 ADD KPC-68 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7782 ADD KPC-69 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7783 ADD KPC-70 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7784 ADD KPC-84 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7785 ADD KPC-85 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7786 ADD KPC-88 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7787 ADD KPC-89 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7788 ADD KPC-91 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7789 ADD KPC-92 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7790 ADD LHK-7 LHK beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 7791 ADD MIR-24 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7792 ADD MIR-25 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7793 ADD MIR-27 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7794 ADD MIR-28 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7795 ADD MIR-30 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7796 ADD MIR-31 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7797 ADD MIR-32 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7798 ADD MIR-33 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7799 ADD MIR-34 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7800 ADD MIR-35 MIR beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 7801 ADD MOX-15 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7802 ADD MOX-16 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7803 ADD MOX-17 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7804 ADD MOX-18 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7805 ADD MOX-19 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7806 ADD MOX-20 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7807 ADD MOX-21 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7808 ADD MOX-22 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7809 ADD MOX-23 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7810 ADD MOX-24 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7811 ADD MOX-25 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7812 ADD MUN-1 MUN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7813 ADD MUN-6 MUN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7814 ADD NDM-48 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7815 ADD NDM-49 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7816 ADD NDM-50 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7817 ADD NDM-51 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7818 ADD NDM-52 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7819 ADD NDM-53 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7820 ADD NDM-54 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7821 ADD NDM-55 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7822 ADD NDM-56 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7823 ADD NDM-57 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7824 ADD NDM-58 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7825 ADD NDM-60 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7826 ADD NDM-61 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7827 ADD NDM-64 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7828 ADD NDM-65 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7829 ADD NDM-66 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7830 ADD NDM-67 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7831 ADD NDM-68 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7832 ADD NDM-69 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7833 ADD NDM-70 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7834 ADD NDM-71 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7835 ADD NDM-72 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7836 ADD NDM-73 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7837 ADD NDM-74 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7839 ADD OXA-1000 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7840 ADD OXA-1001 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7841 ADD OXA-1002 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7842 ADD OXA-1003 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7843 ADD OXA-1004 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7844 ADD OXA-1005 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7845 ADD OXA-1006 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7846 ADD OXA-1007 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7847 ADD OXA-1008 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7848 ADD OXA-1009 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7849 ADD OXA-1010 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7851 ADD OXA-1012 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7852 ADD OXA-1013 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7853 ADD OXA-1014 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7854 ADD OXA-1015 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7855 ADD OXA-1016 OXA beta-lactamase; OXA-372-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7856 ADD OXA-1017 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7857 ADD OXA-1018 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7858 ADD OXA-1019 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7859 ADD OXA-1020 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7860 ADD OXA-1021 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7861 ADD OXA-1022 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7862 ADD OXA-1023 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7863 ADD OXA-1024 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7864 ADD OXA-1025 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7865 ADD OXA-1026 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7866 ADD OXA-1027 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7867 ADD OXA-1028 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7868 ADD OXA-1029 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7869 ADD OXA-1030 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7870 ADD OXA-1031 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7871 ADD OXA-1032 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7872 ADD OXA-1033 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7873 ADD OXA-1034 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7874 ADD OXA-1035 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7875 ADD OXA-1036 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7876 ADD OXA-1037 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7877 ADD OXA-1040 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7878 ADD OXA-1041 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7879 ADD OXA-1042 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7880 ADD OXA-1043 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7881 ADD OXA-1044 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7882 ADD OXA-1045 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7883 ADD OXA-1046 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7884 ADD OXA-1047 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7885 ADD OXA-1048 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7886 ADD OXA-1049 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7887 ADD OXA-1050 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7888 ADD OXA-1051 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7889 ADD OXA-1052 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7890 ADD OXA-1053 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7891 ADD OXA-1055 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7892 ADD OXA-1056 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7893 ADD OXA-1057 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7894 ADD OXA-1058 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7895 ADD OXA-1059 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7896 ADD OXA-1060 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7897 ADD OXA-1061 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7898 ADD OXA-1062 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7899 ADD OXA-1063 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7900 ADD OXA-1064 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7901 ADD OXA-1065 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7902 ADD OXA-1066 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7903 ADD OXA-1067 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7904 ADD OXA-1068 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7905 ADD OXA-1069 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7906 ADD OXA-1070 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7907 ADD OXA-1071 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7908 ADD OXA-1072 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7909 ADD OXA-1073 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7910 ADD OXA-1074 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7911 ADD OXA-1075 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7912 ADD OXA-1076 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7913 ADD OXA-1077 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7914 ADD OXA-1078 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7915 ADD OXA-1079 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7916 ADD OXA-1080 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7917 ADD OXA-1081 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7918 ADD OXA-1082 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7919 ADD OXA-1083 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7920 ADD OXA-1084 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7921 ADD OXA-1085 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7922 ADD OXA-1086 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7923 ADD OXA-1087 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7924 ADD OXA-1088 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7925 ADD OXA-1089 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7926 ADD OXA-1090 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7927 ADD OXA-1091 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7928 ADD OXA-1092 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7929 ADD OXA-1093 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7930 ADD OXA-1094 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7931 ADD OXA-1095 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7932 ADD OXA-1096 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7933 ADD OXA-1097 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7934 ADD OXA-1098 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7935 ADD OXA-1099 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7936 ADD OXA-1100 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7937 ADD OXA-1101 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7938 ADD OXA-1102 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7939 ADD OXA-1103 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7940 ADD OXA-1104 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7941 ADD OXA-1105 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7942 ADD OXA-1106 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7943 ADD OXA-1107 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7944 ADD OXA-1108 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7945 ADD OXA-1109 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7946 ADD OXA-1110 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7947 ADD OXA-1111 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7948 ADD OXA-1112 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7949 ADD OXA-1113 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7950 ADD OXA-1114 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7951 ADD OXA-1115 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7952 ADD OXA-1116 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7953 ADD OXA-1117 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7954 ADD OXA-1118 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7955 ADD OXA-1119 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7956 ADD OXA-1120 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7957 ADD OXA-1121 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7958 ADD OXA-1122 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7959 ADD OXA-1123 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7960 ADD OXA-1124 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7961 ADD OXA-1125 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7962 ADD OXA-1126 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7963 ADD OXA-1127 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7964 ADD OXA-1128 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7965 ADD OXA-1129 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7966 ADD OXA-1130 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7967 ADD OXA-1131 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7968 ADD OXA-1132 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7969 ADD OXA-1133 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7970 ADD OXA-1134 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7971 ADD OXA-1135 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7972 ADD OXA-1136 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7973 ADD OXA-1137 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7974 ADD OXA-1138 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7975 ADD OXA-1139 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7976 ADD OXA-1140 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7977 ADD OXA-1141 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7978 ADD OXA-1142 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7979 ADD OXA-1143 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7980 ADD OXA-1144 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7981 ADD OXA-1145 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7982 ADD OXA-1146 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7983 ADD OXA-1147 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7984 ADD OXA-1148 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7985 ADD OXA-1149 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7986 ADD OXA-1150 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7987 ADD OXA-1151 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7988 ADD OXA-1152 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7989 ADD OXA-1153 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7990 ADD OXA-1154 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7991 ADD OXA-1155 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7992 ADD OXA-1156 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7993 ADD OXA-1157 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7994 ADD OXA-1158 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7995 ADD OXA-1159 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7996 ADD OXA-1160 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7997 ADD OXA-1161 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7998 ADD OXA-1162 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7999 ADD OXA-1163 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8000 ADD OXA-1164 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8001 ADD OXA-1165 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8002 ADD OXA-1166 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8003 ADD OXA-1167 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8004 ADD OXA-1168 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8005 ADD OXA-1169 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8006 ADD OXA-1170 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8007 ADD OXA-1171 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8008 ADD OXA-1172 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8009 ADD OXA-1173 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8010 ADD OXA-1174 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8011 ADD OXA-1175 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8012 ADD OXA-1176 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8013 ADD OXA-1177 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8014 ADD OXA-1178 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8015 ADD OXA-1181 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8016 ADD OXA-1182 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8017 ADD OXA-1183 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8018 ADD OXA-1184 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8019 ADD OXA-1185 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8020 ADD OXA-1186 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8021 ADD OXA-1187 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8022 ADD OXA-1188 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8023 ADD OXA-1189 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8024 ADD OXA-1190 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8025 ADD OXA-1191 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8026 ADD OXA-1193 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8027 ADD OXA-1194 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8028 ADD OXA-1198 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8029 ADD OXA-1199 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8030 ADD OXA-1200 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8031 ADD OXA-1201 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8032 ADD OXA-1202 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8033 ADD OXA-1203 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8034 ADD OXA-1204 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8035 ADD OXA-1205 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8036 ADD OXA-1206 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8037 ADD OXA-1207 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8038 ADD OXA-1208 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8039 ADD OXA-1211 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8040 ADD OXA-1212 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8041 ADD OXA-1213 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8042 ADD OXA-1214 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8043 ADD OXA-1215 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8044 ADD OXA-1216 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8045 ADD OXA-1217 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8046 ADD OXA-1218 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8047 ADD OXA-1219 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8048 ADD OXA-1220 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8049 ADD OXA-1221 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8050 ADD OXA-1222 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8051 ADD OXA-1223 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8052 ADD OXA-1224 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8053 ADD OXA-1225 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8054 ADD OXA-1226 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8055 ADD OXA-1227 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8056 ADD OXA-1228 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8057 ADD OXA-1229 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8058 ADD OXA-1230 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8059 ADD OXA-1231 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8060 ADD OXA-1232 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8061 ADD OXA-1233 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8062 ADD OXA-1234 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8063 ADD OXA-1235 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8064 ADD OXA-1236 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8065 ADD OXA-1237 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8066 ADD OXA-1238 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8067 ADD OXA-1239 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8068 ADD OXA-1240 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8069 ADD OXA-1241 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8070 ADD OXA-1242 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8071 ADD OXA-1243 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8072 ADD OXA-1244 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8073 ADD OXA-1245 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8074 ADD OXA-1246 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8075 ADD OXA-1247 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8076 ADD OXA-1248 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8077 ADD OXA-1249 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8078 ADD OXA-1250 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8079 ADD OXA-1251 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8080 ADD OXA-1252 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8081 ADD OXA-1253 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8082 ADD OXA-1254 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8083 ADD OXA-1255 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8084 ADD OXA-1256 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8085 ADD OXA-1257 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8086 ADD OXA-1258 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8087 ADD OXA-1259 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8088 ADD OXA-1260 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8089 ADD OXA-1261 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8090 ADD OXA-1262 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8091 ADD OXA-1263 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8092 ADD OXA-1264 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8093 ADD OXA-1265 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8094 ADD OXA-1266 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8095 ADD OXA-1267 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8096 ADD OXA-1268 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8097 ADD OXA-1269 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8098 ADD OXA-1270 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8099 ADD OXA-1271 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8100 ADD OXA-1272 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8101 ADD OXA-1273 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8102 ADD OXA-1274 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8103 ADD OXA-1275 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8104 ADD OXA-1276 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8105 ADD OXA-1277 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8106 ADD OXA-1278 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8107 ADD OXA-1279 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8108 ADD OXA-1280 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8109 ADD OXA-1281 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8110 ADD OXA-1282 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8111 ADD OXA-1283 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8112 ADD OXA-1284 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8113 ADD OXA-1285 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8114 ADD OXA-1286 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8115 ADD OXA-1287 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8116 ADD OXA-1288 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8117 ADD OXA-1289 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8118 ADD OXA-1290 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8119 ADD OXA-1291 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8120 ADD OXA-1292 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8121 ADD OXA-1293 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8122 ADD OXA-1294 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8123 ADD OXA-1295 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8124 ADD OXA-1296 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8125 ADD OXA-1297 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8126 ADD OXA-1298 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8127 ADD OXA-1299 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8128 ADD OXA-1300 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8129 ADD OXA-1301 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8130 ADD OXA-1302 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8131 ADD OXA-1303 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8132 ADD OXA-1304 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8133 ADD OXA-1305 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8134 ADD OXA-1306 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8135 ADD OXA-1307 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8136 ADD OXA-1308 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8137 ADD OXA-1309 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8138 ADD OXA-725 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8139 ADD OXA-790 OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8140 ADD OXA-791 OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8141 ADD OXA-933 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8142 ADD OXA-934 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8143 ADD OXA-936 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8144 ADD OXA-944 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8145 ADD OXA-950 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8146 ADD OXA-951 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8147 ADD OXA-952 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8148 ADD OXA-953 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8149 ADD OXA-954 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8150 ADD OXA-955 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8151 ADD OXA-956 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8152 ADD OXA-957 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8153 ADD OXA-958 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8154 ADD OXA-959 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8155 ADD OXA-960 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8156 ADD OXA-961 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8157 ADD OXA-962 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8158 ADD OXA-963 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8159 ADD OXA-964 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8160 ADD OXA-965 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8161 ADD OXA-966 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8162 ADD OXA-967 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8163 ADD OXA-968 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8164 ADD OXA-969 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8165 ADD OXA-970 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8166 ADD OXA-971 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8167 ADD OXA-972 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8168 ADD OXA-973 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8169 ADD OXA-974 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8170 ADD OXA-975 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8171 ADD OXA-976 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8172 ADD OXA-977 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8173 ADD OXA-978 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8174 ADD OXA-979 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8175 ADD OXA-980 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8176 ADD OXA-981 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8177 ADD OXA-982 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8178 ADD OXA-983 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8179 ADD OXA-984 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8180 ADD OXA-985 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8181 ADD OXA-986 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8182 ADD OXA-987 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8183 ADD OXA-988 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8184 ADD OXA-989 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8185 ADD OXA-990 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8186 ADD OXA-991 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8187 ADD OXA-992 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8188 ADD OXA-993 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8189 ADD OXA-994 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8190 ADD OXA-995 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8191 ADD OXA-996 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8192 ADD OXA-997 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8193 ADD OXA-998 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8194 ADD OXA-999 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8195 ADD OXY-1-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8196 ADD OXY-1-12 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8197 ADD OXY-1-13 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8198 ADD OXY-1-16 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8199 ADD OXY-1-17 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8200 ADD OXY-1-18 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8201 ADD OXY-1-19 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8202 ADD OXY-10-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8203 ADD OXY-11-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8204 ADD OXY-12-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8205 ADD OXY-12-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8206 ADD OXY-2-17 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8207 ADD OXY-2-18 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8208 ADD OXY-2-19 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8209 ADD OXY-2-20 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8210 ADD OXY-2-21 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8211 ADD OXY-2-22 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8212 ADD OXY-2-23 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8213 ADD OXY-2-24 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8214 ADD OXY-2-25 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8215 ADD OXY-2-26 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8216 ADD OXY-2-27 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8217 ADD OXY-2-28 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8218 ADD OXY-2-30 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8219 ADD OXY-3-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8220 ADD OXY-3-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8221 ADD OXY-4-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8222 ADD OXY-4-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8223 ADD OXY-4-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8224 ADD OXY-4-5 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8225 ADD OXY-5-10 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8226 ADD OXY-5-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8227 ADD OXY-5-6 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8228 ADD OXY-5-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8229 ADD OXY-5-8 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8230 ADD OXY-6-10 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8231 ADD OXY-6-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8232 ADD OXY-6-5 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8233 ADD OXY-6-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8234 ADD OXY-7-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8235 ADD OXY-8-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8236 ADD OXY-8-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8237 ADD OXY-8-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8238 ADD OXY-9-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8239 ADD PAD-1 PAD beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8240 ADD PAM-5 PAM beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8241 ADD PC1 BlaZ beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8242 ADD PDC-477 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8243 ADD PDC-478 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8244 ADD PDC-479 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8245 ADD PDC-480 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8246 ADD PDC-481 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8247 ADD PDC-482 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8248 ADD PDC-483 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8249 ADD PDC-484 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8250 ADD PDC-485 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8251 ADD PDC-486 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8252 ADD PDC-487 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8253 ADD PDC-488 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8254 ADD PDC-489 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8255 ADD PDC-490 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8256 ADD PDC-491 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8257 ADD PDC-492 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8258 ADD PDC-493 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8259 ADD PDC-494 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8260 ADD PDC-495 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8261 ADD PDC-496 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8262 ADD PDC-497 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8263 ADD PDC-498 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8264 ADD PDC-499 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8265 ADD PDC-500 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8266 ADD PDC-501 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8267 ADD PDC-502 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8268 ADD PDC-503 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8269 ADD PDC-504 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8270 ADD PDC-505 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8271 ADD PDC-506 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8272 ADD PDC-507 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8273 ADD PDC-508 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8274 ADD PDC-509 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8275 ADD PDC-510 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8276 ADD PDC-511 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8277 ADD PDC-512 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8278 ADD PDC-513 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8279 ADD PDC-514 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8280 ADD PDC-515 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8281 ADD PDC-516 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8282 ADD PDC-517 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8283 ADD PDC-518 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8284 ADD PDC-519 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8285 ADD PDC-520 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8286 ADD PDC-521 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8287 ADD PDC-522 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8288 ADD PDC-523 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8289 ADD PDC-524 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8290 ADD PDC-525 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8291 ADD PDC-526 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8292 ADD PDC-527 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8293 ADD PDC-528 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8294 ADD PDC-529 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8295 ADD PDC-530 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8296 ADD PDC-531 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8297 ADD PDC-532 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8298 ADD PDC-533 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8299 ADD PDC-534 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8300 ADD PDC-535 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8301 ADD PDC-536 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8302 ADD PDC-537 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8303 ADD PDC-538 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8304 ADD PDC-539 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8305 ADD PDC-540 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8306 ADD PDC-541 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8307 ADD PDC-542 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8308 ADD PDC-543 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8309 ADD PDC-544 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8310 ADD PDC-545 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8311 ADD PDC-546 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8312 ADD PDC-547 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8313 ADD PDC-548 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8314 ADD PDC-549 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8315 ADD PDC-550 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8316 ADD PDC-551 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8317 ADD PDC-552 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8318 ADD PDC-553 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8319 ADD PDC-554 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8320 ADD PDC-555 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8321 ADD PDC-556 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8322 ADD PDC-557 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8323 ADD PDC-558 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8324 ADD PDC-559 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8325 ADD PDC-560 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8326 ADD PDC-561 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8327 ADD PDC-562 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8328 ADD PDC-563 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8329 ADD PDC-564 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8330 ADD PDC-565 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8331 ADD PDC-566 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8332 ADD PDC-567 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8333 ADD PDC-568 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8334 ADD PDC-569 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8335 ADD PDC-570 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8336 ADD PDC-571 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8337 ADD PDC-572 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8338 ADD PDC-573 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8339 ADD PDC-574 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8340 ADD PDC-575 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8341 ADD PDC-576 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8342 ADD PDC-577 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8343 ADD PDC-578 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8344 ADD PDC-579 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8345 ADD PDC-580 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8346 ADD PDC-581 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8347 ADD PDC-582 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8348 ADD PDC-583 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8349 ADD PDC-584 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8350 ADD PDC-585 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8351 ADD PDC-586 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8352 ADD PDC-587 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8353 ADD PDC-588 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8354 ADD PDC-589 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8355 ADD PDC-590 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8356 ADD PDC-591 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8357 ADD PDC-592 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8358 ADD PDC-593 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8359 ADD PDC-594 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8360 ADD PDC-595 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8361 ADD PDC-596 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8362 ADD PDC-597 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8363 ADD PDC-598 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8364 ADD PDC-599 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8365 ADD PDC-600 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8366 ADD PDC-601 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8367 ADD PDC-602 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8368 ADD PDC-603 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8369 ADD PDC-604 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8370 ADD PDC-605 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8371 ADD PDC-606 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8372 ADD PDC-607 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8373 ADD PDC-608 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8374 ADD PDC-609 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8375 ADD PDC-610 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8376 ADD PDC-611 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8377 ADD PDC-612 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8378 ADD PDC-613 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8379 ADD PDC-614 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8380 ADD PDC-615 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8381 ADD PDC-616 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8382 ADD PDC-617 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8383 ADD PDC-618 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8384 ADD PDC-619 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8385 ADD PDC-620 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8386 ADD PDC-621 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8387 ADD PDC-622 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8388 ADD PDC-623 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8389 ADD PDC-624 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8390 ADD PDC-625 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8391 ADD PDC-626 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8392 ADD PDC-627 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8393 ADD PDC-628 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8394 ADD PDC-629 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8395 ADD PDC-630 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8396 ADD PDC-631 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8397 ADD PDC-632 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8398 ADD PDC-633 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8399 ADD PDC-634 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8400 ADD PDC-635 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8401 ADD PDC-636 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8402 ADD PDC-637 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8403 ADD PDC-638 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8404 ADD PDC-639 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8405 ADD PDC-640 PDC beta-lactamase; monobactam; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8406 ADD PEN-A10 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8407 ADD PEN-A11 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8408 ADD PEN-A12 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8409 ADD PEN-A13 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8410 ADD PEN-A15 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8411 ADD PEN-A16 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8412 ADD PEN-A17 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8413 ADD PEN-A18 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8414 ADD PEN-A19 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8415 ADD PEN-A1 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8416 ADD PEN-A20 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8417 ADD PEN-A21 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8418 ADD PEN-A22 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8419 ADD PEN-A23 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8420 ADD PEN-A24 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8421 ADD PEN-A25 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8422 ADD PEN-A26 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8423 ADD PEN-A27 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8424 ADD PEN-A28 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8425 ADD PEN-A29 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8426 ADD PEN-A2 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8427 ADD PEN-A30 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8428 ADD PEN-A31 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8429 ADD PEN-A32 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8430 ADD PEN-A33 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8431 ADD PEN-A34 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8432 ADD PEN-A35 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8433 ADD PEN-A37 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8434 ADD PEN-A38 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8435 ADD PEN-A3 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8436 ADD PEN-A5 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8437 ADD PEN-A6 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8438 ADD PEN-A7 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8439 ADD PEN-A8 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8440 ADD PEN-A9 PEN-A beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8441 ADD PEN-B1 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8442 ADD PEN-B2 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8443 ADD PEN-B3 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8444 ADD PEN-B4 PEN-B beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8445 ADD PER-17 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8446 ADD PER-18 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8447 ADD PJM-2 PJM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8448 ADD PLA-4 PLA beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8449 ADD PLA-5 PLA beta-lactamase; carbapenem; cephalosporin; antibiotic inactivation; N/A N/A 8450 ADD PNC-1 PNC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8451 ADD PNC-2 PNC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8452 ADD PNC-3 PNC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8453 ADD RAA-1 RAA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8454 ADD RAHN-3 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8455 ADD RAHN-4 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8456 ADD RAHN-5 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8457 ADD RAHN-6 RAHN beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8458 ADD RASA-1 RASA beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8459 ADD RSC1-1 RSC1 beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8460 ADD RSD1-1 RSD1; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8462 ADD SED-2 SED beta-lactamase; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8463 ADD SFC-2 SFC beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8464 ADD SFDC-1 SFDC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8466 ADD SHV-229 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8467 ADD SHV-230 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8468 ADD SHV-231 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8469 ADD SHV-232 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8470 ADD SHV-233 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8471 ADD SHV-234 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8472 ADD SHV-235 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8473 ADD SHV-236 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8474 ADD SHV-237 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8475 ADD SHV-238 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8476 ADD SHV-239 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8477 ADD SHV-240 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8478 ADD SHV-241 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8479 ADD SHV-242 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8480 ADD SHV-243 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8481 ADD SHV-244 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8482 ADD SHV-245 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8483 ADD SRT-4 SRT beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 8484 ADD TEM-239 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8485 ADD TEM-248 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8486 ADD TEM-249 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8487 ADD TEM-250 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8488 ADD TEM-251 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8489 ADD TEM-252 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8490 ADD TEM-253 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8491 ADD TEM-254 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8492 ADD TEM-255 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8493 ADD TEM-256 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8494 ADD TEM-257 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8495 ADD TEM-258 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8497 ADD VEB-18 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8498 ADD VEB-28 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8499 ADD VEB-29 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8500 ADD VEB-30 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8501 ADD VEB-31 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8502 ADD VEB-32 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8503 ADD VEB-33 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8504 ADD VEB-34 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8505 ADD VEB-35 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8506 ADD VEB-36 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8507 ADD VEB-37 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8508 ADD VEB-38 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8509 ADD VEB-39 VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; N/A N/A 8510 ADD VIM-88 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8511 ADD VIM-89 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8512 ADD VIM-90 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8513 ADD VIM-91 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 8514 ADD YOC-1 YOC beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 6069 ADD Mycobacterium tuberculosis fgd1 with mutation conferring resistance to delamanid delamanid-resistant fgd1; delamanid; nitroimidazole antibiotic; antibiotic target alteration; N/A N/A 8516 ADD CfiA28 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8517 ADD CfiA29 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8518 ADD CfiA30 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 8519 ADD CfiA31 CfiA beta-lactamase; carbapenem; antibiotic inactivation; N/A N/A 4 UPDATE SHV-52 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 8 UPDATE NDM-6 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 9 UPDATE ACT-35 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 10 UPDATE CARB-5 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 12 UPDATE TEM-126 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 13 UPDATE LRA-12 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 14 UPDATE TEM-72 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 15 UPDATE TEM-59 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 16 UPDATE KPC-10 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 18 UPDATE OXA-212 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 19 UPDATE IMP-2 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 20 UPDATE CMY-1 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 21 UPDATE OXA-329 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 22 UPDATE ACT-10 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 23 UPDATE OXA-371 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 28 UPDATE OXA-45 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 30 UPDATE OXA-226 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 32 UPDATE DHA-15 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 34 UPDATE OXY-6-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 42 UPDATE OXY-6-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 44 UPDATE golS resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 46 UPDATE CMY-114 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 47 UPDATE OXA-60 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 48 UPDATE OXA-90 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 52 UPDATE OXY-2-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 53 UPDATE MOX-5 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 54 UPDATE TEM-34 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 55 UPDATE OXA-69 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 56 UPDATE TEM-7 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 57 UPDATE SHV-24 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 59 UPDATE OXA-256 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 61 UPDATE OXA-330 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 62 UPDATE CMY-42 CMY beta-lactamase; cefoxitin; ceftazidime; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 64 UPDATE CMY-70 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 65 UPDATE GES-21 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 66 UPDATE SHV-41 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 67 UPDATE OXA-391 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 68 UPDATE TEM-132 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 70 UPDATE NDM-10 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 72 UPDATE SHV-42 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 73 UPDATE OXA-35 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 74 UPDATE SHV-18 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 76 UPDATE SHV-79 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 77 UPDATE TEM-47 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 78 UPDATE TEM-16 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 79 UPDATE VIM-37 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 80 UPDATE ACT-29 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 81 UPDATE FOX-3 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 82 UPDATE PER-4 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 84 UPDATE GIM-1 GIM beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 85 UPDATE IMP-42 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 86 UPDATE TEM-102 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 87 UPDATE TEM-116 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 88 UPDATE CMY-55 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 91 UPDATE gadX resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 93 UPDATE SHV-105 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 94 UPDATE CMY-79 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 95 UPDATE CMY-56 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 96 UPDATE OXA-426 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 98 UPDATE CMY-48 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 101 UPDATE TEM-109 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 103 UPDATE SHV-12 SHV beta-lactamase; ceftazidime; ceftriaxone; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 104 UPDATE OXA-61 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 105 UPDATE CARB-4 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 107 UPDATE TEM-43 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 115 UPDATE TEM-87 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 118 UPDATE LRA-9 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 119 UPDATE VIM-12 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 121 UPDATE mdtF resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 122 UPDATE VIM-34 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 123 UPDATE SHV-64 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 125 UPDATE SHV-182 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 126 UPDATE TEM-183 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 132 UPDATE TEM-198 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 136 UPDATE CMY-9 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 144 UPDATE IMP-12 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 145 UPDATE OXA-229 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 146 UPDATE OXA-98 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 147 UPDATE OXA-27 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 148 UPDATE SHV-92 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 151 UPDATE OKP-A-15 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 154 UPDATE mgrA ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; methicillin; ciprofloxacin; acriflavine; tetracycline; daptomycin; moxifloxacin; cefotaxime; norfloxacin; sparfloxacin; moenomycin A1; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 155 UPDATE TEM-195 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 160 UPDATE OXA-236 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 161 UPDATE SHV-56 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 162 UPDATE KPC-8 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 163 UPDATE OXA-376 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 165 UPDATE VIM-29 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 167 UPDATE CMY-39 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 168 UPDATE VIM-17 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 169 UPDATE IMP-33 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 170 UPDATE IMP-19 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 171 UPDATE TEM-78 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 174 UPDATE CfxA2 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 176 UPDATE CMY-25 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 177 UPDATE IMP-51 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 180 UPDATE DHA-19 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 181 UPDATE GES-14 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 184 UPDATE OCH-1 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 185 UPDATE OXA-232 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 186 UPDATE OXA-12 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 187 UPDATE OXA-348 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 188 UPDATE SHV-89 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 190 UPDATE OXA-195 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 191 UPDATE OXA-199 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 193 UPDATE TEM-121 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 194 UPDATE SHV-61 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 198 UPDATE TEM-138 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 200 UPDATE LEN-14 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 201 UPDATE OCH-3 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 202 UPDATE SHV-101 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 203 UPDATE OXY-2-8 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 204 UPDATE VIM-43 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 207 UPDATE GES-12 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 208 UPDATE CMY-105 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 210 UPDATE SHV-35 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 211 UPDATE TEM-206 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 213 UPDATE OXA-21 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 214 UPDATE SHV-121 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 216 UPDATE LEN-9 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 219 UPDATE OKP-A-12 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 220 UPDATE TEM-92 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 221 UPDATE CMY-100 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 223 UPDATE GES-3 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 226 UPDATE OXA-113 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 227 UPDATE OKP-B-3 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 228 UPDATE sdiA resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 230 UPDATE OXA-422 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 231 UPDATE OXA-178 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 233 UPDATE LEN-21 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 235 UPDATE OXA-181 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 236 UPDATE ACT-19 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 238 UPDATE SHV-137 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 239 UPDATE OXA-83 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 241 UPDATE ACT-30 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 242 UPDATE SHV-152 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 243 UPDATE OXA-9 OXA beta-lactamase; OXA-9-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 244 UPDATE SHV-164 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 247 UPDATE TEM-158 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 248 UPDATE OKP-B-9 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 254 UPDATE OXA-150 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 256 UPDATE CMY-21 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 257 UPDATE ACT-37 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 258 UPDATE OXA-208 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 261 UPDATE CMY-65 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 262 UPDATE VIM-8 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 265 UPDATE SHV-128 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 267 UPDATE OXA-43 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 268 UPDATE CfxA6 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 269 UPDATE CMY-8 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 270 UPDATE LEN-20 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 271 UPDATE CMY-4 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 274 UPDATE OXA-174 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 275 UPDATE OKP-B-2 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 277 UPDATE TEM-91 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 281 UPDATE CMY-110 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 283 UPDATE CMY-85 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 285 UPDATE TEM-11 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 286 UPDATE SHV-162 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 287 UPDATE TEM-67 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 288 UPDATE CMY-60 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 289 UPDATE OXA-85 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 292 UPDATE TEM-17 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 293 UPDATE SHV-180 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 294 UPDATE CfxA4 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 295 UPDATE OXA-145 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 296 UPDATE VIM-23 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 297 UPDATE CMY-98 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 301 UPDATE CMY-95 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 302 UPDATE TEM-207 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 306 UPDATE SHV-32 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 308 UPDATE CMY-118 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 309 UPDATE CMY-35 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 310 UPDATE SHV-78 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 312 UPDATE OXA-167 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 313 UPDATE OXA-143 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 314 UPDATE TEM-176 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 315 UPDATE DHA-2 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 317 UPDATE TEM-148 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 318 UPDATE OXA-358 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 319 UPDATE OXA-366 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 325 UPDATE LEN-23 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 326 UPDATE OXA-225 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 327 UPDATE GES-17 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 222 UPDATE JOHN-1 JOHN beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 322 UPDATE FEZ-1 FEZ beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 330 UPDATE IMP-26 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 331 UPDATE TEM-166 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 333 UPDATE CARB-23 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 334 UPDATE mexX resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 338 UPDATE OXY-1-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3664 UPDATE NDM-23 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 340 UPDATE CMY-51 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 341 UPDATE IMP-1 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 342 UPDATE smeS resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 343 UPDATE OXA-31 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 344 UPDATE SHV-188 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 348 UPDATE OXY-3-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 351 UPDATE SHV-6 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 352 UPDATE PDC-5 PDC beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefixime; cefalotin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 357 UPDATE VIM-38 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 359 UPDATE TEM-112 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 361 UPDATE OXA-278 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 363 UPDATE TEM-155 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 364 UPDATE CMY-83 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 365 UPDATE TEM-122 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 368 UPDATE CARB-14 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 369 UPDATE SHV-15 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 371 UPDATE SHV-8 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 374 UPDATE SHV-21 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 378 UPDATE TEM-214 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 379 UPDATE OXA-148 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 385 UPDATE OXA-46 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 386 UPDATE LEN-8 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 391 UPDATE VIM-2 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 394 UPDATE OXA-130 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 397 UPDATE OXA-357 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 398 UPDATE TEM-71 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 401 UPDATE ACT-22 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 404 UPDATE OXA-217 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 405 UPDATE OXA-202 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 406 UPDATE ACC-4 ACC beta-lactamase; ceftazidime; cefuroxime; aztreonam; cefotaxime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 407 UPDATE OXA-352 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 408 UPDATE OXA-380 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 412 UPDATE OXA-117 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 413 UPDATE OXA-144 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 414 UPDATE OXA-377 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 415 UPDATE TEM-33 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 416 UPDATE OXA-204 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 418 UPDATE OXA-325 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 419 UPDATE SLB-1 SHW beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 421 UPDATE TEM-2 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 422 UPDATE FOX-10 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 423 UPDATE DHA-16 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 424 UPDATE SHV-36 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 425 UPDATE TEM-182 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 427 UPDATE OCH-7 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 428 UPDATE OXY-2-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 429 UPDATE mdsA resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 430 UPDATE OXA-87 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 433 UPDATE ACT-25 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 434 UPDATE LEN-16 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 435 UPDATE OKP-A-9 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 436 UPDATE OXY-4-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 437 UPDATE SHV-69 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 438 UPDATE VIM-6 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 439 UPDATE SHV-83 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 441 UPDATE OXA-54 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 443 UPDATE OKP-B-10 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 445 UPDATE TEM-22 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 447 UPDATE SHV-67 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 449 UPDATE SHV-133 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 450 UPDATE OXA-51 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; BAL30072; monobactam; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 451 UPDATE LRA-5 class A LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 453 UPDATE mtrE resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35971 " 454 UPDATE KPC-4 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 457 UPDATE OXA-93 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 460 UPDATE CMY-29 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 461 UPDATE OXA-13 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 464 UPDATE NDM-13 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 467 UPDATE CARB-3 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 469 UPDATE SHV-49 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 470 UPDATE OXA-4 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 471 UPDATE TEM-151 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 472 UPDATE TEM-128 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 475 UPDATE OXA-106 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 479 UPDATE IMP-29 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 480 UPDATE GES-9 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 481 UPDATE VIM-30 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 482 UPDATE LEN-1 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 483 UPDATE GES-7 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 485 UPDATE TEM-191 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 440 UPDATE MexA resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 276 UPDATE tetR major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 395 UPDATE blaF blaF family beta-lactamase; amoxicillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 488 UPDATE SHV-156 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 490 UPDATE TEM-188 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 392 UPDATE TUS-1 TUS beta-lactamase; amoxicillin; piperacillin; ticarcillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 491 UPDATE PER-2 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 493 UPDATE TEM-84 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 494 UPDATE KPC-14 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 495 UPDATE CMY-28 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 496 UPDATE KPC-16 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 497 UPDATE OXA-79 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 500 UPDATE OXA-164 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 504 UPDATE TEM-52 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 506 UPDATE IMP-5 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 509 UPDATE FOX-1 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 513 UPDATE CARB-19 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 514 UPDATE LEN-10 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3665 UPDATE NDM-24 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 519 UPDATE VIM-26 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 521 UPDATE OXA-386 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 523 UPDATE OXA-75 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 525 UPDATE CMY-13 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 526 UPDATE ACT-2 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 527 UPDATE SHV-38 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 528 UPDATE OCH-8 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 529 UPDATE SHV-185 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 530 UPDATE VIM-11 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 533 UPDATE CARB-16 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 536 UPDATE TEM-95 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 537 UPDATE OXA-120 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 541 UPDATE TEM-133 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 543 UPDATE TEM-106 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 545 UPDATE GES-22 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 549 UPDATE TEM-107 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 550 UPDATE CMY-71 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 553 UPDATE VIM-35 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 554 UPDATE OXA-163 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 555 UPDATE OXA-133 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 557 UPDATE SHV-9 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 560 UPDATE OXA-77 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 561 UPDATE OKP-B-8 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 562 UPDATE TEM-187 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 563 UPDATE OKP-B-6 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 564 UPDATE IMP-22 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 565 UPDATE SHV-82 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 566 UPDATE OXA-32 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 569 UPDATE OXA-228 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 572 UPDATE OXA-137 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 573 UPDATE OXA-136 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 578 UPDATE SHV-11 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 580 UPDATE TEM-110 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 582 UPDATE FOX-7 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 583 UPDATE SHV-100 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 585 UPDATE NDM-7 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 586 UPDATE VIM-20 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 587 UPDATE TEM-73 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 588 UPDATE OKP-A-7 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 589 UPDATE TEM-145 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 595 UPDATE SHV-75 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 596 UPDATE ROB-1 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 599 UPDATE OKP-A-3 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 600 UPDATE CMY-2 CMY beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ertapenem; ampicillin; cefixime; cefalotin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 602 UPDATE VIM-16 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 604 UPDATE OXA-385 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 605 UPDATE OXA-96 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 607 UPDATE TEM-201 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 608 UPDATE OXA-361 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 610 UPDATE SHV-153 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 611 UPDATE OXA-328 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 614 UPDATE SFB-1 SHW beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 615 UPDATE OXA-211 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 616 UPDATE NDM-8 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 617 UPDATE OXA-147 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 619 UPDATE SHV-30 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 620 UPDATE OXA-320 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 622 UPDATE DHA-7 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 623 UPDATE OXA-68 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 629 UPDATE VIM-28 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 630 UPDATE adeJ resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 631 UPDATE TEM-21 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 633 UPDATE OXA-355 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 635 UPDATE OXA-332 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 636 UPDATE CFE-1 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 637 UPDATE OXY-6-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 638 UPDATE ACT-16 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 641 UPDATE CARB-6 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 643 UPDATE OXY-2-5 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 644 UPDATE OXY-2-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 645 UPDATE mecR1 methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 646 UPDATE OXA-349 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 647 UPDATE TEM-89 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 648 UPDATE GES-4 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 649 UPDATE OXA-115 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 655 UPDATE OXA-243 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 656 UPDATE OXA-219 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 520 UPDATE AcrS resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 657 UPDATE SHV-142 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 658 UPDATE CMY-104 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 661 UPDATE VIM-5 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 662 UPDATE TEM-162 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 663 UPDATE ACT-36 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 664 UPDATE CMY-43 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 665 UPDATE TEM-10 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 667 UPDATE ACT-1 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 672 UPDATE CMY-27 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 673 UPDATE IMP-48 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 674 UPDATE OXA-15 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 675 UPDATE OXA-25 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 677 UPDATE OXA-171 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 679 UPDATE SHV-108 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 680 UPDATE CMY-54 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 681 UPDATE TEM-120 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 683 UPDATE CMY-75 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 684 UPDATE SHV-37 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 685 UPDATE OXA-239 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 686 UPDATE OXA-162 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 688 UPDATE MOX-2 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 690 UPDATE OXA-347 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 692 UPDATE TEM-159 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 693 UPDATE OXA-22 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 695 UPDATE CMY-66 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 698 UPDATE TEM-205 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 700 UPDATE ACT-31 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 701 UPDATE SHV-129 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 705 UPDATE CMY-116 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 707 UPDATE AIM-1 AIM beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 709 UPDATE TEM-213 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 711 UPDATE SHV-62 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 715 UPDATE PDC-3 PDC beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefixime; cefalotin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 718 UPDATE LRA-8 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 719 UPDATE CMY-33 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 720 UPDATE BcI class A Bacillus cereus Bc beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 40360 " 721 UPDATE OXA-28 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 723 UPDATE SHV-72 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 725 UPDATE GES-11 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 726 UPDATE PC1 beta-lactamase (blaZ) BlaZ beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 728 UPDATE TEM-192 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 731 UPDATE IMP-11 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 732 UPDATE OXA-237 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3666 UPDATE NDM-25 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 735 UPDATE TEM-30 TEM beta-lactamase; amoxicillin; ampicillin; cefalotin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 739 UPDATE LRA-18 class C LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 741 UPDATE CfxA CfxA beta-lactamase; cefoxitin; cefmetazole; cefotetan; flomoxef; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. DELETED 35962 " 745 UPDATE CMY-40 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 749 UPDATE SHV-97 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 750 UPDATE SHV-172 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 751 UPDATE TEM-217 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 755 UPDATE KPC-9 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 757 UPDATE CMY-80 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 758 UPDATE OXA-198 OXA beta-lactamase; OXA-198-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 759 UPDATE OCH-2 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 760 UPDATE TEM-6 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 761 UPDATE GES-13 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 764 UPDATE FOX-2 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 766 UPDATE SHV-102 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 767 UPDATE OXA-207 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 768 UPDATE SHV-43 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 769 UPDATE KPC-11 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 770 UPDATE SHV-57 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 771 UPDATE CMY-24 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 772 UPDATE LEN-6 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 773 UPDATE OCH-4 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 775 UPDATE CMY-113 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 783 UPDATE NDM-1 NDM beta-lactamase; ertapenem; meropenem; imipenem; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 778 UPDATE IMP-25 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 779 UPDATE OXA-350 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 780 UPDATE CARB-9 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 782 UPDATE OXA-63 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 785 UPDATE OXY-2-9 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 788 UPDATE SHV-46 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 789 UPDATE IMP-43 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 790 UPDATE CMY-32 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 791 UPDATE SHV-14 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 792 UPDATE OXY-1-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 793 UPDATE IMP-34 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 795 UPDATE OXA-324 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 797 UPDATE TEM-55 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 806 UPDATE SHV-150 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 807 UPDATE OKP-B-1 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 808 UPDATE TEM-171 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 810 UPDATE mecC methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 632 UPDATE basR pmr phosphoethanolamine transferase; polymyxin B; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 805 UPDATE MexC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 704 UPDATE OprJ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 811 UPDATE TEM-26 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 812 UPDATE CMY-10 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 813 UPDATE OXA-216 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 814 UPDATE TEM-113 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 753 UPDATE SMB-1 SMB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 815 UPDATE GOB-1 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 816 UPDATE OXA-3 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 818 UPDATE SHV-141 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 825 UPDATE SHV-20 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 828 UPDATE TEM-83 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 829 UPDATE DHA-17 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 830 UPDATE SHV-157 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 831 UPDATE OKP-B-13 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 832 UPDATE SHV-161 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 833 UPDATE CfxA5 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 836 UPDATE TEM-68 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 839 UPDATE CMY-44 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 840 UPDATE CMY-20 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 844 UPDATE CMY-117 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 845 UPDATE TEM-163 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 846 UPDATE DHA-12 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 848 UPDATE OKP-A-2 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 849 UPDATE OXA-138 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 850 UPDATE OXA-26 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 853 UPDATE OXA-160 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 854 UPDATE CMY-58 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 855 UPDATE TEM-142 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 860 UPDATE TEM-42 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 861 UPDATE OXA-215 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 862 UPDATE IMP-16 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 863 UPDATE PER-7 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 864 UPDATE CMY-61 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 865 UPDATE OXA-244 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 867 UPDATE OXA-175 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 868 UPDATE DHA-1 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 869 UPDATE CRP resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 873 UPDATE KPC-19 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 877 UPDATE SHV-124 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 879 UPDATE TEM-185 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 883 UPDATE LRA-17 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 885 UPDATE TEM-63 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 887 UPDATE SHV-33 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 889 UPDATE CMY-74 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 890 UPDATE SHV-53 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 894 UPDATE CMY-90 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 895 UPDATE SHV-122 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 897 UPDATE OXA-383 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 899 UPDATE OXA-94 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 901 UPDATE LCR-1 LCR beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 902 UPDATE OXA-92 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 906 UPDATE CARB-21 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 909 UPDATE OXA-5 OXA beta-lactamase; OXA-5-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 911 UPDATE CMY-50 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 912 UPDATE LEN-13 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 913 UPDATE OXY-6-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 915 UPDATE SHV-106 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 916 UPDATE OXA-36 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 917 UPDATE SHV-186 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 918 UPDATE TEM-49 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 919 UPDATE PER-1 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 920 UPDATE TEM-152 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 921 UPDATE OKP-A-11 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 923 UPDATE VIM-25 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 926 UPDATE KPC-15 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 927 UPDATE OXA-381 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 929 UPDATE GES-10 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 948 UPDATE mecI methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 931 UPDATE OXA-316 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 932 UPDATE GES-8 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 933 UPDATE OKP-A-14 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 934 UPDATE IMP-8 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 935 UPDATE OXA-314 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 936 UPDATE OKP-A-13 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 937 UPDATE OXA-242 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 940 UPDATE TEM-125 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 941 UPDATE GES-1 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 942 UPDATE OXA-104 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 947 UPDATE OXA-100 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 951 UPDATE ACT-15 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 955 UPDATE SHV-96 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 956 UPDATE TEM-88 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 958 UPDATE OXA-418 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 959 UPDATE OXA-64 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 960 UPDATE TEM-137 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 961 UPDATE SHV-93 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 962 UPDATE OXA-356 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 963 UPDATE CMY-69 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 964 UPDATE OXA-129 OXA beta-lactamase; OXA-5-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 965 UPDATE OXA-333 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 882 UPDATE RCP-1 RCP beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 970 UPDATE OKP-B-18 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 972 UPDATE CMY-23 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 973 UPDATE OXA-378 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 871 UPDATE CGB-1 CGB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 977 UPDATE OXA-112 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 978 UPDATE OXA-134 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 979 UPDATE TEM-96 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 980 UPDATE y56 beta-lactamase BlaA beta-lactamase; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 981 UPDATE OXA-86 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 982 UPDATE TEM-153 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 983 UPDATE GES-20 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 990 UPDATE FOX-9 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 992 UPDATE SHV-66 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 994 UPDATE SHV-77 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 986 UPDATE baeS resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin; aminoglycoside antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 996 UPDATE CMY-77 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 997 UPDATE VIM-31 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 998 UPDATE SHV-134 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 999 UPDATE LEN-2 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1003 UPDATE OXA-18 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1007 UPDATE OKP-A-8 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1008 UPDATE BEL-1 BEL beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1010 UPDATE TEM-209 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1011 UPDATE TEM-29 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1012 UPDATE KPC-5 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1014 UPDATE SHV-25 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1015 UPDATE evgA major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; tetracycline; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1016 UPDATE OXA-255 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1019 UPDATE IMP-21 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1020 UPDATE OXA-241 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1022 UPDATE TEM-28 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1023 UPDATE IMP-14 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1025 UPDATE TEM-136 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1026 UPDATE SHV-74 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1028 UPDATE SHV-1 SHV beta-lactamase; ampicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1029 UPDATE CMY-102 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1032 UPDATE OXA-365 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1040 UPDATE OXA-95 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1043 UPDATE SHV-76 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1049 UPDATE MOX-1 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1051 UPDATE LEN-12 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1052 UPDATE OXA-206 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1053 UPDATE SHV-2 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1056 UPDATE VIM-19 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1058 UPDATE VIM-27 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1060 UPDATE SHV-103 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1061 UPDATE OXY-2-10 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1062 UPDATE SHV-71 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1065 UPDATE OXA-384 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1066 UPDATE TEM-118 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1069 UPDATE IMP-35 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1071 UPDATE DHA-22 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1072 UPDATE OXA-37 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1073 UPDATE OKP-B-19 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1074 UPDATE LEN-3 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1075 UPDATE TEM-20 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1076 UPDATE IMP-37 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1077 UPDATE OXA-420 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1078 UPDATE VIM-4 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1079 UPDATE OXA-161 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1080 UPDATE SHV-158 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1081 UPDATE IMP-30 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1083 UPDATE OXA-323 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1084 UPDATE LEN-5 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1085 UPDATE OKP-B-5 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1086 UPDATE CMY-41 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1087 UPDATE OXA-253 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1089 UPDATE CMY-14 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1090 UPDATE TEM-169 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1091 UPDATE IMP-6 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1094 UPDATE CARB-17 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1095 UPDATE SHV-59 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1096 UPDATE TEM-79 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1099 UPDATE OXA-48 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; temocillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1100 UPDATE OXA-245 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1103 UPDATE CMY-17 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1104 UPDATE acrB resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; acriflavine; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1106 UPDATE NDM-5 NDM beta-lactamase; cefoxitin; ceftazidime; ertapenem; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1110 UPDATE LEN-19 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1112 UPDATE OXA-58 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1114 UPDATE ACT-17 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1115 UPDATE OXA-435 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1118 UPDATE OXA-2 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; ceftazidime; amoxicillin; meropenem; ampicillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1122 UPDATE OXA-180 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1123 UPDATE FOX-8 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1124 UPDATE TEM-186 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1125 UPDATE OKP-B-11 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1126 UPDATE OXA-184 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1128 UPDATE OXA-23 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1129 UPDATE CMY-19 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1041 UPDATE MexS resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1132 UPDATE OXA-88 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1133 UPDATE SHV-109 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1137 UPDATE TEM-90 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1140 UPDATE CMY-86 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1141 UPDATE OXA-169 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1143 UPDATE OXA-7 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1109 UPDATE CAU-1 CAU beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1119 UPDATE EBR-1 EBR beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1146 UPDATE TEM-156 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1147 UPDATE CMY-63 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1148 UPDATE OXA-363 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1149 UPDATE AER-1 AER beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1151 UPDATE OXA-240 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1153 UPDATE KPC-3 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1154 UPDATE TEM-146 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1155 UPDATE ACT-9 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1158 UPDATE SHV-22 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1159 UPDATE TEM-129 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1163 UPDATE CMY-94 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1165 UPDATE OKP-A-4 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1168 UPDATE NDM-9 taniborbactam; NDM beta-lactamase; cefepime; cefepime-taniborbactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1169 UPDATE OXA-360 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1170 UPDATE CMY-46 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1172 UPDATE OXA-194 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1173 UPDATE TEM-54 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1177 UPDATE KPC-12 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1178 UPDATE CMY-81 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1179 UPDATE IMP-4 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1180 UPDATE mdsC resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1184 UPDATE OXA-182 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1185 UPDATE OXA-176 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1186 UPDATE OXA-327 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1187 UPDATE OXA-248 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1190 UPDATE OXA-354 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1194 UPDATE OXA-16 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1195 UPDATE SHV-55 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1196 UPDATE OXA-71 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1199 UPDATE SHV-168 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1201 UPDATE CARB-22 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1205 UPDATE VIM-39 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1207 UPDATE DHA-13 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1208 UPDATE SHV-173 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1211 UPDATE VIM-1 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1212 UPDATE OXA-141 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1214 UPDATE TEM-134 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1216 UPDATE SHV-119 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1217 UPDATE OXA-139 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1218 UPDATE TEM-219 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1220 UPDATE OCH-5 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1221 UPDATE OXA-231 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1225 UPDATE TEM-178 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1228 UPDATE CMY-30 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1236 UPDATE CMY-53 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1238 UPDATE OXA-397 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1239 UPDATE SHV-81 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1241 UPDATE TEM-144 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1244 UPDATE OXY-5-1 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1245 UPDATE TEM-114 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1247 UPDATE CMY-72 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1248 UPDATE H-NS major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; ciprofloxacin; tetracycline; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1249 UPDATE FOX-5 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1253 UPDATE GES-23 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1255 UPDATE OXA-119 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1258 UPDATE OXA-55 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1259 UPDATE SHV-31 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1262 UPDATE SHV-149 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1264 UPDATE smeC resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1268 UPDATE CMY-115 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1269 UPDATE OXA-192 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1274 UPDATE VIM-10 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1276 UPDATE OXA-210 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1277 UPDATE GES-16 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1278 UPDATE TEM-45 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1279 UPDATE TEM-104 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1281 UPDATE OXA-110 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1283 UPDATE KPC-6 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1286 UPDATE SHV-34 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1288 UPDATE OXA-82 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1289 UPDATE OKP-B-7 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1290 UPDATE TEM-141 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1291 UPDATE TEM-177 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1293 UPDATE OXA-197 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1296 UPDATE OKP-B-12 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1303 UPDATE BEL-2 BEL beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1282 UPDATE SIM-1 SIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1294 UPDATE Sed-1 SED beta-lactamase; cefuroxime; amoxicillin; piperacillin; cefalotin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; model_name; ARO_name; CARD_short_name; ARO_description; ARO_category "UPDATED model_name with SED-1 UPDATED ARO_name with SED-1 UPDATED CARD_short_name with SED-1 UPDATED ARO_description with SED-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii. UPDATED category_aro_accession with 3007880 UPDATED category_aro_cvterm_id with 46671 UPDATED category_aro_name with SED beta-lactamase UPDATED category_aro_description with SED is a family of broad-spectrum class A beta-lactamases. UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 41357 " 1307 UPDATE OXY-1-6 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1309 UPDATE ACT-20 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1310 UPDATE IMP-10 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1311 UPDATE OXY-5-2 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1312 UPDATE OXA-111 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1314 UPDATE OXA-214 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1317 UPDATE CTX-M-3 CTX-M beta-lactamase; cefoxitin; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefixime; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1318 UPDATE evgS major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; tetracycline; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1319 UPDATE SHV-147 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1321 UPDATE mecA methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1322 UPDATE SHV-65 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1324 UPDATE LRA-2 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1325 UPDATE OXA-65 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1326 UPDATE OXA-170 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1334 UPDATE SHV-126 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1336 UPDATE BcII subclass B1 Bacillus cereus Bc beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1340 UPDATE mtrC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35971 " 1341 UPDATE OXA-53 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1343 UPDATE OXA-166 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1346 UPDATE SHV-94 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1347 UPDATE OXA-425 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1350 UPDATE TEM-93 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1352 UPDATE OXA-251 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1353 UPDATE GES-5 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1355 UPDATE TEM-149 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1358 UPDATE VIM-24 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1359 UPDATE OXA-233 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1361 UPDATE OXA-223 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1362 UPDATE IMP-31 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1363 UPDATE CARB-1 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1364 UPDATE CMY-101 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1373 UPDATE CMY-26 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1375 UPDATE CMY-11 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1376 UPDATE MOX-6 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1379 UPDATE OXA-313 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1380 UPDATE TEM-193 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1384 UPDATE OXA-382 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1385 UPDATE mdsB resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1387 UPDATE OXA-99 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1389 UPDATE KPC-22 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1394 UPDATE OXA-257 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1396 UPDATE OXA-11 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1398 UPDATE OXA-108 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1399 UPDATE OXA-315 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1402 UPDATE OXA-390 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1403 UPDATE OXA-388 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1404 UPDATE IMP-3 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1406 UPDATE OXA-121 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1407 UPDATE CMY-62 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1408 UPDATE TEM-124 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1409 UPDATE CMY-6 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1410 UPDATE OXA-19 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1411 UPDATE OXA-62 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1412 UPDATE SHV-167 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1413 UPDATE OXA-172 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1416 UPDATE OXA-89 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1417 UPDATE OXA-131 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1418 UPDATE DHA-6 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1419 UPDATE OXA-454 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1421 UPDATE TEM-85 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1422 UPDATE ACC-3 ACC beta-lactamase; ceftazidime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1423 UPDATE TEM-15 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1424 UPDATE OXY-2-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1426 UPDATE IMP-7 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1429 UPDATE SHV-60 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1430 UPDATE SHV-125 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1431 UPDATE GES-15 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1433 UPDATE CMY-18 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1436 UPDATE TEM-40 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1438 UPDATE SHV-19 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1439 UPDATE SHV-80 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1443 UPDATE CARB-7 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1447 UPDATE OKP-A-10 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1448 UPDATE SHV-26 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1449 UPDATE OXA-59 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1452 UPDATE TEM-216 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1454 UPDATE CMY-112 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1456 UPDATE IMP-15 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1458 UPDATE TEM-157 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1461 UPDATE SHV-63 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1462 UPDATE LRA-19 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1463 UPDATE GES-19 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1466 UPDATE SHV-13 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1467 UPDATE LEN-22 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1468 UPDATE SHV-135 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1471 UPDATE adeI resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 1338 UPDATE Bla1 class A Bacillus anthracis Bla beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1393 UPDATE THIN-B THIN-B beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1437 UPDATE AcrF resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1445 UPDATE AcrE resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1472 UPDATE DHA-18 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1475 UPDATE SHV-99 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1476 UPDATE TEM-199 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1478 UPDATE CARB-10 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1479 UPDATE IMP-40 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1481 UPDATE OXY-1-4 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1484 UPDATE ACT-27 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1485 UPDATE MOX-8 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1486 UPDATE CARB-12 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1487 UPDATE SHV-48 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1488 UPDATE TEM-75 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1489 UPDATE CMY-37 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1490 UPDATE SHV-107 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1492 UPDATE MOX-3 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1493 UPDATE PER-6 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1494 UPDATE LAT-1 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1495 UPDATE ACT-4 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1496 UPDATE OXA-224 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1501 UPDATE CMY-49 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1337 UPDATE baeR resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin; aminoglycoside antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1502 UPDATE OXA-209 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1503 UPDATE LEN-4 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1504 UPDATE CMY-108 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1506 UPDATE ACT-12 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1507 UPDATE smeA resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1511 UPDATE OXA-423 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1514 UPDATE IMP-28 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1515 UPDATE NDM-3 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1516 UPDATE CMY-45 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1517 UPDATE OXA-33 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1520 UPDATE SHV-85 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1521 UPDATE VIM-32 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1522 UPDATE IMP-38 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1525 UPDATE TEM-160 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1527 UPDATE SHV-51 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1528 UPDATE TEM-168 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1529 UPDATE TEM-130 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1530 UPDATE OXA-67 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1531 UPDATE TEM-81 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1532 UPDATE OXA-249 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1533 UPDATE SHV-143 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1534 UPDATE PER-5 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1535 UPDATE CMY-16 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1536 UPDATE OXA-421 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1537 UPDATE GES-2 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1538 UPDATE SHV-104 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1541 UPDATE ACT-14 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1543 UPDATE CMY-22 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1550 UPDATE smeR resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1551 UPDATE OXA-78 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1555 UPDATE SHV-140 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1556 UPDATE VIM-13 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1557 UPDATE SHV-187 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1559 UPDATE mtrA resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "DELETED 35971 " 1560 UPDATE OKP-B-20 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1565 UPDATE ACT-18 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1568 UPDATE OXA-183 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1572 UPDATE OXA-205 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1573 UPDATE SHV-110 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1575 UPDATE OXA-91 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1576 UPDATE OXA-17 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1578 UPDATE SHV-123 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1581 UPDATE ACT-3 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1585 UPDATE CMY-73 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1587 UPDATE OXA-10 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1589 UPDATE PER-3 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1591 UPDATE CMY-64 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1593 UPDATE CMY-99 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1595 UPDATE mecB methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1596 UPDATE OXA-24 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; BAL30072; monobactam; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1597 UPDATE SHV-2A SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1598 UPDATE OXA-101 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1599 UPDATE SHV-23 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1601 UPDATE LRA-1 class A LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1603 UPDATE SHV-86 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1610 UPDATE OXA-74 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1613 UPDATE CMY-38 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1614 UPDATE TEM-194 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1618 UPDATE OXA-362 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1621 UPDATE SHV-45 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1608 UPDATE MexT resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1523 UPDATE MexD resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1623 UPDATE GIM-2 GIM beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1625 UPDATE OXA-179 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1628 UPDATE SHV-154 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1629 UPDATE TEM-197 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1630 UPDATE IMP-13 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1480 UPDATE EXO-1 EXO beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1552 UPDATE MUS-1 MUS beta-lactamase; amoxicillin; piperacillin; ticarcillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1634 UPDATE CMY-78 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1637 UPDATE MOX-7 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1638 UPDATE CMY-111 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1639 UPDATE SHV-84 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1641 UPDATE OXA-203 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1644 UPDATE SHV-70 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1645 UPDATE ACT-23 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1646 UPDATE TEM-139 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1649 UPDATE DHA-21 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1650 UPDATE CMY-15 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1652 UPDATE IMP-20 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1654 UPDATE SHV-95 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1655 UPDATE TEM-117 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1658 UPDATE OKP-B-4 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1659 UPDATE OXA-258 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1660 UPDATE OXA-375 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1661 UPDATE CARB-8 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1662 UPDATE OKP-B-17 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1663 UPDATE ACC-1 ACC beta-lactamase; cefepime; ceftazidime; piperacillin; aztreonam; cefotaxime; cefotetan; flomoxef; moxalactam; cefpirome; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1664 UPDATE adeK resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 1665 UPDATE ramA resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1667 UPDATE TEM-80 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1668 UPDATE CMY-68 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1672 UPDATE TEM-211 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1676 UPDATE GES-18 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1679 UPDATE OXA-49 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1684 UPDATE LEN-18 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1685 UPDATE SHV-40 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1686 UPDATE OXA-34 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1690 UPDATE OXA-317 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1691 UPDATE CMY-31 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1693 UPDATE TEM-143 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1694 UPDATE OXA-353 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1695 UPDATE DHA-5 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1697 UPDATE TEM-135 TEM beta-lactamase; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 1698 UPDATE OCH-6 OCH beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1700 UPDATE ACT-28 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1704 UPDATE CMY-57 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1705 UPDATE SHV-111 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1706 UPDATE OXA-142 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1709 UPDATE TEM-115 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1712 UPDATE IMP-41 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1715 UPDATE OXA-73 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1716 UPDATE OXA-398 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1717 UPDATE OXA-230 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1722 UPDATE TEM-184 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1723 UPDATE IMP-44 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1725 UPDATE TEM-101 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1726 UPDATE FOX-4 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1727 UPDATE SHV-73 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1728 UPDATE OXA-42 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1730 UPDATE OXA-235 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1732 UPDATE SHV-151 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1733 UPDATE OXA-415 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1736 UPDATE GES-24 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1739 UPDATE SHV-16 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1740 UPDATE TEM-53 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1741 UPDATE OXA-359 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1742 UPDATE SHV-28 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1743 UPDATE OXA-338 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1746 UPDATE IMP-24 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1747 UPDATE CMY-103 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1749 UPDATE IMP-18 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1750 UPDATE OXA-254 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1753 UPDATE SHV-148 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1756 UPDATE CMY-93 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1758 UPDATE OXA-326 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1761 UPDATE OXA-351 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1763 UPDATE NDM-2 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1764 UPDATE OXA-97 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1765 UPDATE OXA-56 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1766 UPDATE VIM-14 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1767 UPDATE OKP-A-16 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1770 UPDATE TEM-127 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1771 UPDATE TEM-19 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1776 UPDATE SHV-159 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1777 UPDATE OXA-177 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1778 UPDATE OKP-A-5 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1780 UPDATE OXA-146 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1607 UPDATE Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1782 UPDATE TEM-12 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1783 UPDATE VIM-36 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1784 UPDATE OXA-334 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1785 UPDATE TEM-48 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1786 UPDATE mexY resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1787 UPDATE VIM-42 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1788 UPDATE ACT-6 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1791 UPDATE TEM-164 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1792 UPDATE DHA-20 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1793 UPDATE DHA-14 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1796 UPDATE CMY-119 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1798 UPDATE SHV-183 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1799 UPDATE TEM-147 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1800 UPDATE SHV-120 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1802 UPDATE OXA-168 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1804 UPDATE OXA-107 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1805 UPDATE TEM-131 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1806 UPDATE OXA-14 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1807 UPDATE OXA-70 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1810 UPDATE VIM-15 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1811 UPDATE CARB-2 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1813 UPDATE MOX-4 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1816 UPDATE TEM-8 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1818 UPDATE GES-26 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1819 UPDATE TEM-3 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1823 UPDATE OXY-1-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1825 UPDATE CTX-M-27 CTX-M beta-lactamase; cefazolin; ceftazidime; ertapenem; ampicillin; cefixime; cefalotin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1827 UPDATE SHV-5 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1828 UPDATE GES-6 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1829 UPDATE CMY-87 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1833 UPDATE OXA-374 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1834 UPDATE TEM-94 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1836 UPDATE OXA-201 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1838 UPDATE ACT-5 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1840 UPDATE CMY-59 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1841 UPDATE OXA-76 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1844 UPDATE OXA-128 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1845 UPDATE OXA-312 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1851 UPDATE KPC-13 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1853 UPDATE OXA-20 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1857 UPDATE VIM-9 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1858 UPDATE OXA-387 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1860 UPDATE OXA-165 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1861 UPDATE LEN-15 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1862 UPDATE OXA-109 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1863 UPDATE VIM-3 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1864 UPDATE CMY-67 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1865 UPDATE ACC-5 ACC beta-lactamase; ceftazidime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1866 UPDATE KPC-7 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1868 UPDATE TEM-82 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1869 UPDATE OXY-2-6 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1870 UPDATE OXA-66 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1871 UPDATE OXA-389 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1874 UPDATE OXA-196 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1876 UPDATE LEN-7 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1877 UPDATE CMY-12 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1880 UPDATE adeN resistance-nodulation-cell division (RND) antibiotic efflux pump; tetracycline; rifampin; imipenem; trimethoprim; chloramphenicol; ticarcillin; macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 40360 " 1881 UPDATE OXA-72 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1882 UPDATE OXA-80 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1883 UPDATE DHA-10 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 1886 UPDATE LEN-24 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1887 UPDATE TEM-70 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1889 UPDATE NDM-4 NDM beta-lactamase; ticarcillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1890 UPDATE TEM-86 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1892 UPDATE OXA-114a OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1893 UPDATE SHV-127 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1895 UPDATE CfxA3 CfxA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1896 UPDATE NDM-12 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1898 UPDATE OXA-379 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1900 UPDATE ACT-13 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1902 UPDATE OXA-246 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1903 UPDATE mdtE resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1904 UPDATE ACT-32 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1905 UPDATE ACT-21 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1908 UPDATE OKP-A-6 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1912 UPDATE LRA-13 class C LRA beta-lactamase; class D LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1914 UPDATE BEL-3 BEL beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1915 UPDATE CMY-47 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1916 UPDATE TEM-208 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1919 UPDATE SHV-27 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1922 UPDATE marA resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1926 UPDATE CMY-34 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1927 UPDATE SHV-29 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1928 UPDATE OXA-50 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; ampicillin; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1929 UPDATE ACT-24 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1931 UPDATE TEM-150 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1932 UPDATE IMP-32 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1933 UPDATE SHV-160 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1937 UPDATE OXA-118 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1938 UPDATE mtrD resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35971 " 1925 UPDATE MexB resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1941 UPDATE SHV-98 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1945 UPDATE SHV-50 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1948 UPDATE TEM-167 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1951 UPDATE TEM-76 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1952 UPDATE OXA-1 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; amoxicillin; piperacillin; ampicillin; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1953 UPDATE SHV-155 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1954 UPDATE TEM-154 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1955 UPDATE OXA-29 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1957 UPDATE VIM-18 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1958 UPDATE VIM-33 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1959 UPDATE ACT-7 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1960 UPDATE smeB resistance-nodulation-cell division (RND) antibiotic efflux pump; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1961 UPDATE TEM-105 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1962 UPDATE OXA-47 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1963 UPDATE TEM-190 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1964 UPDATE IMP-45 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1965 UPDATE LEN-11 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1967 UPDATE OXA-116 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1968 UPDATE SHV-189 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1970 UPDATE SHV-44 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1972 UPDATE OXA-149 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1973 UPDATE TEM-111 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 1978 UPDATE OXA-200 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1980 UPDATE OXA-247 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1982 UPDATE IMP-9 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1984 UPDATE SHV-144 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1985 UPDATE SHV-7 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1986 UPDATE OXA-309 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1988 UPDATE CMY-7 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1990 UPDATE CMY-82 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1999 UPDATE TEM-215 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2000 UPDATE TEM-24 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2001 UPDATE OXA-250 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2004 UPDATE TEM-189 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2006 UPDATE IMP-27 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2007 UPDATE OXA-335 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2008 UPDATE SHV-145 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2012 UPDATE SHV-178 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2015 UPDATE DHA-3 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 2016 UPDATE OXA-370 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2018 UPDATE CMY-76 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 2019 UPDATE OXA-213 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2021 UPDATE SHV-165 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2023 UPDATE OXA-132 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2024 UPDATE ACC-2 ACC beta-lactamase; ceftazidime; cefotaxime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2025 UPDATE TEM-57 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2026 UPDATE OXA-84 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2027 UPDATE CMY-84 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 2029 UPDATE TEM-123 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2031 UPDATE OXA-173 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2034 UPDATE TEM-108 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2035 UPDATE CTX-M-15 CTX-M beta-lactamase; cefazolin; ceftazidime; ceftriaxone; ampicillin; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2036 UPDATE SHV-163 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2038 UPDATE KPC-17 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2039 UPDATE CARB-18 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2040 UPDATE TEM-60 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2041 UPDATE OXA-424 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2045 UPDATE OXY-2-3 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2047 UPDATE OXA-322 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2048 UPDATE OXA-57 OXA beta-lactamase; OXA-42-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2050 UPDATE OXA-331 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2055 UPDATE LRA-3 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2057 UPDATE SHV-179 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2059 UPDATE OKP-A-1 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2061 UPDATE VIM-7 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2063 UPDATE blaR1 BlaZ beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2064 UPDATE TEM-196 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2065 UPDATE CMY-5 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 1966 UPDATE lmrA ATP-binding cassette (ABC) antibiotic efflux pump; lincomycin; puromycin; lincosamide antibiotic; nucleoside antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2072 UPDATE NmcR IMI beta-lactamase; cefoxitin; cefazolin; ampicillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 3000018 UPDATED category_aro_cvterm_id with 36027 UPDATED category_aro_name with IMI beta-lactamase UPDATED category_aro_description with IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam. UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 41359 " 2103 UPDATE SHV-3 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2110 UPDATE CARB-20 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2115 UPDATE TEM-4 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2119 UPDATE LRA-10 class C LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2121 UPDATE LRA-7 subclass B3 LRA beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2134 UPDATE CMY-36 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 2135 UPDATE ACT-33 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2156 UPDATE NDM-14 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3451 UPDATE OXA-287 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 29 UPDATE Escherichia coli folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfadiazine; sulfadimidine; sulfadoxine; sulfamethoxazole; sulfisoxazole; sulfacetamide; mafenide; sulfasalazine; sulfamethizole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2033 UPDATE mtrR major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; palmitic acid; oleic acid; linoleic acid; macrolide antibiotic; antibacterial free fatty acids; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. DELETED 35971 " 90 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 111 UPDATE Escherichia coli gyrB conferring resistance to aminocoumarin aminocoumarin resistant gyrB; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 335 UPDATE Staphylococcus aureus parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 462 UPDATE Staphylococcus aureus pgsA mutations conferring resistance to daptomycin daptomycin resistant pgsA; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 489 UPDATE Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin antibiotic resistant gidB; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_type with frameshift mutation UPDATED param_description with A frameshift mutation, caused by a nucleotide insertion or deletion that does not equal 3 bases, encoded as [wild-type][position]fs, for example S531fs. Termination can also be denoted as: Ter[position]fs. UPDATED param_type_id with 40494 UPDATED 9842 with R118fs UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 15748 with M1Var UPDATED 15756 with A200E UPDATED 15824 with A134E UPDATED 15854 with V105E UPDATED 15897 with P84L UPDATED 15922 with G73A UPDATED 15925 with G73E UPDATED 15933 with S70N UPDATED 15942 with D67H UPDATED 15967 with H48Q UPDATED 9840 with L79S UPDATED 9841 with E92D UPDATED 15748 with M1Var UPDATED 15756 with A200E UPDATED 15824 with A134E UPDATED 15854 with V105E UPDATED 15897 with P84L UPDATED 15922 with G73A UPDATED 15925 with G73E UPDATED 15933 with S70N UPDATED 15942 with D67H UPDATED 15967 with H48Q UPDATED 9840 with L79S UPDATED 9841 with E92D UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 15750 with R213Ter UPDATED 15751 with R206Ter UPDATED 15759 with Y195Ter UPDATED 15768 with S181Ter UPDATED 15775 with E173Ter UPDATED 15779 with E170Ter UPDATED 15782 with E165Ter UPDATED 15786 with K163Ter UPDATED 15794 with R158Ter UPDATED 15802 with W148Ter UPDATED 15806 with K144Ter UPDATED 15821 with S136Ter UPDATED 15830 with Q127Ter UPDATED 15831 with Q125Ter UPDATED 15836 with W123Ter UPDATED 15837 with E121Ter UPDATED 15856 with E103Ter UPDATED 15857 with R102Ter UPDATED 15863 with E99Ter UPDATED 15877 with E92Ter UPDATED 15889 with Q87Ter UPDATED 15907 with L79Ter UPDATED 15920 with L74Ter UPDATED 15928 with G71Ter UPDATED 15953 with E60Ter UPDATED 15958 with C52Ter UPDATED 15978 with W45Ter UPDATED 15984 with E40Ter UPDATED 15989 with G37Ter UPDATED 15999 with G28Ter UPDATED 16001 with L26Ter UPDATED 16008 with Y22Ter UPDATED 16017 with G13Ter UPDATED 3677 with C52Ter UPDATED 8037 with +nt350:g UPDATED 8038 with +nt351:g UPDATED 8039 with -nt115:c DELETED 42998 " 2138 UPDATE NmcA IMI beta-lactamase; cefoxitin; cefazolin; ampicillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 3000018 UPDATED category_aro_cvterm_id with 36027 UPDATED category_aro_name with IMI beta-lactamase UPDATED category_aro_description with IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam. UPDATED category_aro_class_name with AMR Gene Family UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 41359 " 196 UPDATE Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol ethambutol resistant embB; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13302 with D328Y UPDATED 13303 with D354A UPDATED 13340 with G406A UPDATED 13341 with G406D UPDATED 13342 with G406S UPDATED 13392 with M306I UPDATED 13394 with M306V UPDATED 13411 with Q497K UPDATED 13412 with Q497R UPDATED 13626 with N1033K UPDATED 13680 with M306Var UPDATED 15432 with M306L UPDATED 15433 with M306V UPDATED 15434 with M306I UPDATED 15435 with Y319S UPDATED 15437 with Y319C UPDATED 15438 with D328Y UPDATED 15444 with D354A UPDATED 15450 with G406S UPDATED 15451 with G406C UPDATED 15452 with G406D UPDATED 15453 with G406A UPDATED 15458 with Q497R UPDATED 15459 with Q497K UPDATED 9465 with Y334H UPDATED 9466 with S347I UPDATED 9467 with D354A UPDATED 9469 with L402V UPDATED 9470 with G406S UPDATED 9471 with G406C UPDATED 9472 with G406D UPDATED 9473 with G406A UPDATED 9474 with A454T UPDATED 9475 with Q497K UPDATED 9476 with Q497R UPDATED 9477 with D1024N UPDATED 9481 with S22C UPDATED 9482 with N296H UPDATED 9483 with M306L UPDATED 9485 with M306I UPDATED 9486 with Y319S UPDATED 9487 with Y319C UPDATED 9488 with D328Y UPDATED 9489 with F330S UPDATED 9484 with M306V UPDATED 13302 with D328Y UPDATED 13303 with D354A UPDATED 13340 with G406A UPDATED 13341 with G406D UPDATED 13342 with G406S UPDATED 13392 with M306I UPDATED 13394 with M306V UPDATED 13411 with Q497K UPDATED 13412 with Q497R UPDATED 13626 with N1033K UPDATED 13680 with M306Var UPDATED 15432 with M306L UPDATED 15433 with M306V UPDATED 15434 with M306I UPDATED 15435 with Y319S UPDATED 15437 with Y319C UPDATED 15438 with D328Y UPDATED 15444 with D354A UPDATED 15450 with G406S UPDATED 15451 with G406C UPDATED 15452 with G406D UPDATED 15453 with G406A UPDATED 15458 with Q497R UPDATED 15459 with Q497K UPDATED 9465 with Y334H UPDATED 9466 with S347I UPDATED 9467 with D354A UPDATED 9469 with L402V UPDATED 9470 with G406S UPDATED 9471 with G406C UPDATED 9472 with G406D UPDATED 9473 with G406A UPDATED 9474 with A454T UPDATED 9475 with Q497K UPDATED 9476 with Q497R UPDATED 9477 with D1024N UPDATED 9481 with S22C UPDATED 9482 with N296H UPDATED 9483 with M306L UPDATED 9485 with M306I UPDATED 9486 with Y319S UPDATED 9487 with Y319C UPDATED 9488 with D328Y UPDATED 9489 with F330S UPDATED 9484 with M306V DELETED 42998 " 366 UPDATE Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol ethambutol resistant iniA; ethambutol; polyamine antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 505 UPDATE Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol Ethambutol resistant iniC; ethambutol; polyamine antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 3530 with Q351Ter UPDATED 8017 with +nt98:a UPDATED 8018 with +nt79:t " 597 UPDATE Klebsiella pneumoniae ramR mutants resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 627 UPDATE Escherichia coli rpoB mutants conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 756 UPDATE Enterococcus faecium liaR mutant conferring daptomycin resistance daptomycin resistant liaR; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 794 UPDATE Staphylococcus aureus rpoC conferring resistance to daptomycin daptomycin-resistant beta prime subunit of RNA polymerase (rpoC); daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 851 UPDATE Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide Pyrazinamide resistant pncA; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_type with snp in promoter region UPDATED param_description with A SNP in the promoter region of a gene which alters transcription of that gene, encoded as [wild-type][-][position][mutation], for example t-11c. Var represents any possible substitution. This is a pilot parameter in need of further documentation. UPDATED param_type_id with 41339 UPDATED 13253 with a-11g UPDATED 13854 with t-12c UPDATED 13855 with t-7c UPDATED 15398 with t-7c UPDATED 15399 with a-11g UPDATED 15400 with a-11t UPDATED 15401 with a-11c UPDATED 15402 with t-12c UPDATED 9702 with a-11g UPDATED 9701 with a-11c UPDATED param_type with frameshift mutation UPDATED param_description with A frameshift mutation, caused by a nucleotide insertion or deletion that does not equal 3 bases, encoded as [wild-type][position]fs, for example S531fs. Termination can also be denoted as: Ter[position]fs. UPDATED param_type_id with 40494 UPDATED 9678 with T114fs UPDATED 9680 with L117fs UPDATED 9683 with V131fs UPDATED 9687 with D136fs UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13254 with A134V UPDATED 13261 with A146E UPDATED 13263 with A146V UPDATED 13264 with A161P UPDATED 13266 with A171T UPDATED 13269 with A3E UPDATED 13271 with A46E UPDATED 13272 with A46V UPDATED 13278 with C138R UPDATED 13280 with C138Y UPDATED 13283 with C14R UPDATED 13285 with C14Y UPDATED 13290 with C72R UPDATED 13292 with C72W UPDATED 13295 with D12A UPDATED 13296 with D12E UPDATED 13297 with D12N UPDATED 13299 with D136N UPDATED 13300 with D136Y UPDATED 13307 with D49G UPDATED 13308 with D49N UPDATED 13309 with D49V UPDATED 13310 with D63G UPDATED 13311 with D63H UPDATED 13314 with D8G UPDATED 13315 with D8H UPDATED 13316 with D8N UPDATED 13317 with D8Y UPDATED 13323 with E174G UPDATED 13325 with F58L UPDATED 13326 with F58S UPDATED 13335 with G17D UPDATED 13338 with G23V UPDATED 13346 with G78D UPDATED 13350 with G97S UPDATED 13351 with H137P UPDATED 13352 with H137R UPDATED 13357 with H51Q UPDATED 13358 with H51R UPDATED 13360 with H57D UPDATED 13361 with H57Q UPDATED 13362 with H57R UPDATED 13363 with H71R UPDATED 13364 with H82R UPDATED 13365 with I133T UPDATED 13368 with I5T UPDATED 13369 with I6T UPDATED 13373 with K96E UPDATED 13375 with K96N UPDATED 13376 with K96Q UPDATED 13377 with L116R UPDATED 13378 with L151S UPDATED 13379 with L172P UPDATED 13382 with L19P UPDATED 13383 with L27P UPDATED 13386 with L4S UPDATED 13387 with L4W UPDATED 13388 with L85P UPDATED 13390 with M175V UPDATED 13402 with P54L UPDATED 13403 with P54T UPDATED 13407 with Q10P UPDATED 13408 with Q10R UPDATED 13409 with Q141P UPDATED 13414 with S104C UPDATED 13422 with S66P UPDATED 13423 with S67P UPDATED 13427 with T135P UPDATED 13428 with T142K UPDATED 13429 with T142M UPDATED 13430 with T160P UPDATED 13432 with T47A UPDATED 13434 with T76I UPDATED 13435 with T76P UPDATED 13437 with V125D UPDATED 13438 with V128G UPDATED 13439 with V139A UPDATED 13440 with V139G UPDATED 13441 with V139L UPDATED 13442 with V139M UPDATED 13443 with V155G UPDATED 13444 with V180F UPDATED 13445 with V180G UPDATED 13450 with V7D UPDATED 13451 with V7F UPDATED 13452 with V7G UPDATED 13453 with W119R UPDATED 13455 with W68C UPDATED 13456 with W68G UPDATED 13457 with W68L UPDATED 13458 with W68R UPDATED 13461 with Y103H UPDATED 13462 with Y34D UPDATED 13463 with Y41H UPDATED 13796 with G78C UPDATED 13797 with G97R UPDATED 13799 with K48E UPDATED 13800 with L159V UPDATED 13803 with A171E UPDATED 13804 with P54Q UPDATED 13807 with D12G UPDATED 13812 with S32I UPDATED 13813 with F94L UPDATED 13814 with F94S UPDATED 13816 with G108R UPDATED 13817 with G132A UPDATED 13818 with G132D UPDATED 13819 with G162D UPDATED 13821 with G24D UPDATED 13822 with G97C UPDATED 13823 with G97D UPDATED 13826 with H57P UPDATED 13827 with H57Y UPDATED 13828 with H71D UPDATED 13829 with H71Q UPDATED 13830 with H71Y UPDATED 13833 with K96R UPDATED 13834 with K96T UPDATED 13836 with L120P UPDATED 13837 with L159P UPDATED 13841 with M175I UPDATED 13842 with M175T UPDATED 13844 with V21G UPDATED 13845 with P54S UPDATED 13846 with P62L UPDATED 13847 with P62Q UPDATED 13849 with V7L UPDATED 13852 with S104R UPDATED 13853 with S59P UPDATED 13858 with T135N UPDATED 13859 with T142A UPDATED 13861 with T168P UPDATED 13867 with V125G UPDATED 13934 with F106S UPDATED 13935 with F106Y UPDATED 13936 with F13I UPDATED 13937 with F13V UPDATED 13938 with F13Y UPDATED 13939 with F50F UPDATED 13940 with F58I UPDATED 13941 with F81S UPDATED 13942 with F94C UPDATED 13945 with G101E UPDATED 13946 with G105D UPDATED 13947 with G105R UPDATED 13948 with G105V UPDATED 13949 with G108E UPDATED 13950 with G124S UPDATED 13951 with G132C UPDATED 13952 with G132R UPDATED 13953 with G132V UPDATED 13954 with G150G UPDATED 13955 with G162A UPDATED 13956 with G162V UPDATED 13957 with G16G UPDATED 13958 with G16R UPDATED 13960 with G17C UPDATED 13961 with G24V UPDATED 13962 with G55C UPDATED 13963 with G75V UPDATED 13965 with H137D UPDATED 13966 with H42N UPDATED 13968 with H43P UPDATED 13969 with H43Q UPDATED 13970 with H51D UPDATED 13971 with H51L UPDATED 13972 with H51N UPDATED 13973 with H57L UPDATED 13974 with H57N UPDATED 13975 with H71H UPDATED 13976 with H71L UPDATED 13977 with H71N UPDATED 13978 with H82L UPDATED 13979 with I133F UPDATED 13980 with I133N UPDATED 13981 with I31F UPDATED 13983 with I31T UPDATED 13984 with I52T UPDATED 13985 with I5F UPDATED 13986 with I5M UPDATED 13987 with I5N UPDATED 13988 with I6F UPDATED 13989 with I6M UPDATED 13991 with K48T UPDATED 13993 with L116Q UPDATED 13994 with L117Q UPDATED 13995 with L120Q UPDATED 13997 with L156P UPDATED 13998 with L156R UPDATED 13999 with L159Q UPDATED 14001 with L19Q UPDATED 14002 with L27Q UPDATED 14003 with L35P UPDATED 14005 with L4F UPDATED 14006 with L4V UPDATED 14007 with L85Q UPDATED 14008 with M175K UPDATED 14009 with M1L UPDATED 14010 with N112S UPDATED 14011 with N118N UPDATED 14012 with A134P UPDATED 14013 with N118Y UPDATED 14014 with N11T UPDATED 14015 with N149I UPDATED 14017 with P115A UPDATED 14018 with P115R UPDATED 14019 with P54R UPDATED 14020 with P62A UPDATED 14021 with P62P UPDATED 14022 with A143D UPDATED 14023 with P62R UPDATED 14024 with P69L UPDATED 14025 with P69Q UPDATED 14026 with P70A UPDATED 14027 with P70S UPDATED 14028 with P77S UPDATED 14030 with Q10E UPDATED 14031 with Q10H UPDATED 14034 with Q122K UPDATED 14035 with Q122Q UPDATED 14036 with R123S UPDATED 14037 with R140P UPDATED 14038 with R154M UPDATED 14039 with R176P UPDATED 14040 with R29C UPDATED 14041 with A146S UPDATED 14042 with S164S UPDATED 14043 with S164T UPDATED 14044 with S179N UPDATED 14046 with S186F UPDATED 14047 with S18L UPDATED 14048 with S18T UPDATED 14050 with S59F UPDATED 14051 with S65F UPDATED 14055 with S88T UPDATED 14056 with T114A UPDATED 14057 with T114T UPDATED 14058 with T135I UPDATED 14059 with T135S UPDATED 14060 with A152V UPDATED 14061 with T142R UPDATED 14062 with T142T UPDATED 14063 with T153N UPDATED 14064 with T160K UPDATED 14065 with T160R UPDATED 14066 with T177T UPDATED 14068 with T76S UPDATED 14069 with V109L UPDATED 14070 with V125A UPDATED 14071 with V125V UPDATED 14072 with V128A UPDATED 14073 with V128D UPDATED 14074 with V130E UPDATED 14075 with V131D UPDATED 14076 with V131F UPDATED 14077 with V131I UPDATED 14078 with A165D UPDATED 14079 with V139E UPDATED 14080 with V147A UPDATED 14081 with V155E UPDATED 14083 with V163E UPDATED 14084 with V180D UPDATED 14085 with V183D UPDATED 14086 with V183V UPDATED 14087 with V21A UPDATED 14088 with A170S UPDATED 14089 with V21E UPDATED 14090 with V44D UPDATED 14091 with V7A UPDATED 14092 with V93E UPDATED 14093 with V93L UPDATED 14095 with W119G UPDATED 14096 with W119L UPDATED 14097 with A170V UPDATED 14101 with Y41Y UPDATED 14104 with A171A UPDATED 14105 with A26V UPDATED 14106 with A28S UPDATED 14107 with A30P UPDATED 14108 with A30S UPDATED 14109 with A30V UPDATED 14110 with A36D UPDATED 14111 with A36S UPDATED 14112 with A38A UPDATED 14113 with A38G UPDATED 14114 with A38S UPDATED 15094 with M1Var UPDATED 14116 with A46A UPDATED 14120 with A46P UPDATED 14121 with A79A UPDATED 14122 with A79P UPDATED 14124 with A89V UPDATED 14127 with C138F UPDATED 14128 with C138G UPDATED 14130 with C14W UPDATED 14131 with C184R UPDATED 14133 with C72F UPDATED 14134 with C72Y UPDATED 14140 with D110E UPDATED 14142 with D110H UPDATED 14144 with D129E UPDATED 14145 with D12H UPDATED 14146 with D12Y UPDATED 14147 with D136V UPDATED 14148 with D145E UPDATED 14149 with D158G UPDATED 14150 with D166V UPDATED 14151 with D49E UPDATED 14152 with D49H UPDATED 14153 with D49Y UPDATED 14154 with D56D UPDATED 14157 with D63E UPDATED 14159 with D80H UPDATED 14160 with D86V UPDATED 14161 with D8A UPDATED 14168 with D8V UPDATED 14169 with E107E UPDATED 14172 with E127D UPDATED 14176 with E173G UPDATED 14177 with E174K UPDATED 15095 with L182S UPDATED 15096 with L182W UPDATED 15098 with V180G UPDATED 15101 with V180A UPDATED 15102 with V180F UPDATED 15103 with T177P UPDATED 15104 with M175T UPDATED 15105 with M175I UPDATED 15106 with M175R UPDATED 15107 with M175V UPDATED 15111 with L172P UPDATED 15112 with A171P UPDATED 15114 with A171E UPDATED 15117 with T168P UPDATED 15119 with S164P UPDATED 15121 with V163A UPDATED 15122 with G162D UPDATED 15126 with T160P UPDATED 15127 with T160K UPDATED 15129 with L159V UPDATED 15130 with L159R UPDATED 15131 with L159P UPDATED 15134 with V155G UPDATED 15135 with V155A UPDATED 15136 with V155M UPDATED 15137 with R154G UPDATED 15138 with R154M UPDATED 15139 with L151S UPDATED 15140 with A146T UPDATED 15141 with A146V UPDATED 15142 with A146E UPDATED 15144 with A143G UPDATED 15145 with T142A UPDATED 15146 with T142K UPDATED 15147 with T142P UPDATED 15148 with T142M UPDATED 15149 with Q141P UPDATED 15151 with R140P UPDATED 15152 with V139L UPDATED 15153 with V139G UPDATED 15154 with V139A UPDATED 15155 with V139M UPDATED 15156 with C138R UPDATED 15158 with H137P UPDATED 15161 with D136V UPDATED 15162 with D136G UPDATED 15166 with T135P UPDATED 15167 with T135N UPDATED 15168 with A134V UPDATED 15171 with I133T UPDATED 15174 with G132A UPDATED 15175 with G132D UPDATED 15176 with G132S UPDATED 15177 with G132C UPDATED 15178 with V131G UPDATED 15179 with V131F UPDATED 15180 with V130G UPDATED 15181 with V130M UPDATED 15182 with D129N UPDATED 15183 with V128G UPDATED 15184 with V125F UPDATED 15185 with V125G UPDATED 15188 with R121P UPDATED 15189 with L120R UPDATED 15190 with L120P UPDATED 15191 with L120Q UPDATED 15193 with W119L UPDATED 15194 with W119R UPDATED 15195 with W119G UPDATED 15196 with W119C UPDATED 15197 with L116R UPDATED 15198 with L116P UPDATED 15199 with T114P UPDATED 15202 with G108R UPDATED 15203 with G108E UPDATED 15205 with F106S UPDATED 15206 with F106L UPDATED 15207 with G105V UPDATED 15208 with G105D UPDATED 15209 with S104G UPDATED 15210 with S104I UPDATED 15211 with S104R UPDATED 15212 with Y103C UPDATED 15215 with Y103H UPDATED 15216 with Y103D UPDATED 15217 with A102T UPDATED 15220 with A102P UPDATED 15222 with T100P UPDATED 15224 with G97R UPDATED 15225 with G97S UPDATED 15226 with G97D UPDATED 15227 with G97V UPDATED 15228 with G97C UPDATED 15229 with K96Q UPDATED 15230 with K96E UPDATED 15231 with K96R UPDATED 15232 with K96T UPDATED 15233 with K96N UPDATED 15235 with Y95D UPDATED 15237 with F94L UPDATED 15238 with F94S UPDATED 15239 with F94C UPDATED 15241 with V93L UPDATED 15242 with V93A UPDATED 15245 with I90S UPDATED 15246 with I90N UPDATED 15247 with I90T UPDATED 15249 with L85R UPDATED 15250 with L85P UPDATED 15251 with H82R UPDATED 15253 with G78S UPDATED 15254 with G78D UPDATED 15255 with G78V UPDATED 15257 with T76I UPDATED 15258 with T76P UPDATED 15259 with C72R UPDATED 15261 with C72Y UPDATED 15263 with H71P UPDATED 15264 with H71R UPDATED 15266 with H71Y UPDATED 15269 with P69L UPDATED 15270 with W68C UPDATED 15271 with W68L UPDATED 15272 with W68G UPDATED 15275 with W68R UPDATED 15276 with S67P UPDATED 15278 with S66P UPDATED 15282 with Y64D UPDATED 15283 with D63A UPDATED 15285 with D63G UPDATED 15286 with P62R UPDATED 15288 with P62S UPDATED 15289 with P62T UPDATED 15290 with P62L UPDATED 15291 with T61P UPDATED 15293 with S59P UPDATED 15294 with F58C UPDATED 15295 with F58S UPDATED 15296 with F58L UPDATED 15298 with H57Q UPDATED 15300 with H57R UPDATED 15301 with H57L UPDATED 15302 with H57Y UPDATED 15303 with H57D UPDATED 15304 with P54R UPDATED 15305 with P54L UPDATED 15306 with P54Q UPDATED 15307 with P54S UPDATED 15308 with P54T UPDATED 15309 with H51R UPDATED 15310 with H51D UPDATED 15311 with H51P UPDATED 15312 with H51Y UPDATED 15313 with H51Q UPDATED 15315 with D49G UPDATED 15316 with D49N UPDATED 15317 with D49A UPDATED 15318 with D49E UPDATED 15319 with K48T UPDATED 15320 with K48E UPDATED 15321 with T47P UPDATED 15322 with T47A UPDATED 15324 with A46E UPDATED 15325 with A46V UPDATED 15327 with V44G UPDATED 15328 with H43P UPDATED 15330 with L35P UPDATED 15332 with Y34S UPDATED 15334 with Y34D UPDATED 15336 with I31S UPDATED 15337 with I31T UPDATED 15339 with L27P UPDATED 15341 with G24D UPDATED 15343 with V21G UPDATED 15344 with L19P UPDATED 15348 with G17D UPDATED 15353 with C14W UPDATED 15356 with C14R UPDATED 15357 with F13L UPDATED 15358 with F13S UPDATED 15359 with F13I UPDATED 15361 with D12G UPDATED 15362 with D12E UPDATED 15363 with D12A UPDATED 15364 with D12N UPDATED 15366 with Q10H UPDATED 15367 with Q10R UPDATED 15368 with Q10P UPDATED 15372 with V9G UPDATED 15374 with D8E UPDATED 15375 with D8H UPDATED 15376 with D8G UPDATED 15377 with D8N UPDATED 15378 with D8A UPDATED 15379 with D8Y UPDATED 15380 with V7G UPDATED 15381 with V7A UPDATED 15382 with V7F UPDATED 15383 with V7L UPDATED 15386 with I6T UPDATED 15388 with I5S UPDATED 15389 with L4S UPDATED 15390 with L4W UPDATED 15391 with A3E UPDATED 16053 with H71D UPDATED 9646 with Y34D UPDATED 9647 with L4S UPDATED 9648 with D49N UPDATED 9649 with D49G UPDATED 9650 with I5T UPDATED 9651 with H51R UPDATED 9652 with P54L UPDATED 9653 with H57D UPDATED 9656 with F58S UPDATED 9657 with I6T UPDATED 9658 with P62S UPDATED 9659 with D63G UPDATED 9660 with S67P UPDATED 9661 with W68R UPDATED 9662 with W68G UPDATED 9663 with P69R UPDATED 9664 with V7G UPDATED 9665 with H71R UPDATED 9666 with T76P UPDATED 9667 with D8N UPDATED 9668 with D8H UPDATED 9669 with H82R UPDATED 9670 with D8E UPDATED 9671 with L85R UPDATED 9673 with T100P UPDATED 9674 with Q10P UPDATED 9675 with Q10R UPDATED 9679 with L116R UPDATED 9681 with D12A UPDATED 9682 with V128G UPDATED 9684 with I133T UPDATED 9685 with T135P UPDATED 9686 with D136Y UPDATED 9688 with C14R UPDATED 9689 with C138R UPDATED 9690 with V139G UPDATED 9692 with A146E UPDATED 9693 with A146V UPDATED 9694 with L151S UPDATED 9696 with M175V UPDATED 9697 with V180F UPDATED 9698 with V180A UPDATED 9699 with V180G UPDATED 9700 with L182S UPDATED 13279 with C138S UPDATED 13298 with D136H UPDATED 13313 with D8E UPDATED 13329 with G132S UPDATED 13359 with H51Y UPDATED 13374 with K96M UPDATED 13389 with L85R UPDATED 13404 with P62S UPDATED 13416 with S164P UPDATED 13433 with T47S UPDATED 13794 with F81V UPDATED 13810 with S104G UPDATED 13825 with T114P UPDATED 13835 with L116P UPDATED 13851 with R123P UPDATED 13866 with V125F UPDATED 13943 with F94F UPDATED 13959 with G16V UPDATED 13964 with G78V UPDATED 13967 with H42Q UPDATED 13982 with I31N UPDATED 14000 with L19L UPDATED 14016 with N149Y UPDATED 14032 with Q10L UPDATED 14049 with S32N UPDATED 14067 with T22I UPDATED 14082 with V155M UPDATED 14099 with Y34Y UPDATED 14115 with A3A UPDATED 14125 with A92E UPDATED 14143 with D110N UPDATED 14158 with D63Y UPDATED 14179 with E181K UPDATED 9655 with H57R UPDATED 9672 with G97S UPDATED 9691 with Q141P UPDATED 13254 with A134V UPDATED 13261 with A146E UPDATED 13263 with A146V UPDATED 13264 with A161P UPDATED 13266 with A171T UPDATED 13269 with A3E UPDATED 13271 with A46E UPDATED 13272 with A46V UPDATED 13278 with C138R UPDATED 13280 with C138Y UPDATED 13283 with C14R UPDATED 13285 with C14Y UPDATED 13290 with C72R UPDATED 13292 with C72W UPDATED 13295 with D12A UPDATED 13296 with D12E UPDATED 13297 with D12N UPDATED 13299 with D136N UPDATED 13300 with D136Y UPDATED 13307 with D49G UPDATED 13308 with D49N UPDATED 13309 with D49V UPDATED 13310 with D63G UPDATED 13311 with D63H UPDATED 13314 with D8G UPDATED 13315 with D8H UPDATED 13316 with D8N UPDATED 13317 with D8Y UPDATED 13323 with E174G UPDATED 13325 with F58L UPDATED 13326 with F58S UPDATED 13335 with G17D UPDATED 13338 with G23V UPDATED 13346 with G78D UPDATED 13350 with G97S UPDATED 13351 with H137P UPDATED 13352 with H137R UPDATED 13357 with H51Q UPDATED 13358 with H51R UPDATED 13360 with H57D UPDATED 13361 with H57Q UPDATED 13362 with H57R UPDATED 13363 with H71R UPDATED 13364 with H82R UPDATED 13365 with I133T UPDATED 13368 with I5T UPDATED 13369 with I6T UPDATED 13373 with K96E UPDATED 13375 with K96N UPDATED 13376 with K96Q UPDATED 13377 with L116R UPDATED 13378 with L151S UPDATED 13379 with L172P UPDATED 13382 with L19P UPDATED 13383 with L27P UPDATED 13386 with L4S UPDATED 13387 with L4W UPDATED 13388 with L85P UPDATED 13390 with M175V UPDATED 13402 with P54L UPDATED 13403 with P54T UPDATED 13407 with Q10P UPDATED 13408 with Q10R UPDATED 13409 with Q141P UPDATED 13414 with S104C UPDATED 13422 with S66P UPDATED 13423 with S67P UPDATED 13427 with T135P UPDATED 13428 with T142K UPDATED 13429 with T142M UPDATED 13430 with T160P UPDATED 13432 with T47A UPDATED 13434 with T76I UPDATED 13435 with T76P UPDATED 13437 with V125D UPDATED 13438 with V128G UPDATED 13439 with V139A UPDATED 13440 with V139G UPDATED 13441 with V139L UPDATED 13442 with V139M UPDATED 13443 with V155G UPDATED 13444 with V180F UPDATED 13445 with V180G UPDATED 13450 with V7D UPDATED 13451 with V7F UPDATED 13452 with V7G UPDATED 13453 with W119R UPDATED 13455 with W68C UPDATED 13456 with W68G UPDATED 13457 with W68L UPDATED 13458 with W68R UPDATED 13461 with Y103H UPDATED 13462 with Y34D UPDATED 13463 with Y41H UPDATED 13796 with G78C UPDATED 13797 with G97R UPDATED 13799 with K48E UPDATED 13800 with L159V UPDATED 13803 with A171E UPDATED 13804 with P54Q UPDATED 13807 with D12G UPDATED 13812 with S32I UPDATED 13813 with F94L UPDATED 13814 with F94S UPDATED 13816 with G108R UPDATED 13817 with G132A UPDATED 13818 with G132D UPDATED 13819 with G162D UPDATED 13821 with G24D UPDATED 13822 with G97C UPDATED 13823 with G97D UPDATED 13826 with H57P UPDATED 13827 with H57Y UPDATED 13828 with H71D UPDATED 13829 with H71Q UPDATED 13830 with H71Y UPDATED 13833 with K96R UPDATED 13834 with K96T UPDATED 13836 with L120P UPDATED 13837 with L159P UPDATED 13841 with M175I UPDATED 13842 with M175T UPDATED 13844 with V21G UPDATED 13845 with P54S UPDATED 13846 with P62L UPDATED 13847 with P62Q UPDATED 13849 with V7L UPDATED 13852 with S104R UPDATED 13853 with S59P UPDATED 13858 with T135N UPDATED 13859 with T142A UPDATED 13861 with T168P UPDATED 13867 with V125G UPDATED 13934 with F106S UPDATED 13935 with F106Y UPDATED 13936 with F13I UPDATED 13937 with F13V UPDATED 13938 with F13Y UPDATED 13939 with F50F UPDATED 13940 with F58I UPDATED 13941 with F81S UPDATED 13942 with F94C UPDATED 13945 with G101E UPDATED 13946 with G105D UPDATED 13947 with G105R UPDATED 13948 with G105V UPDATED 13949 with G108E UPDATED 13950 with G124S UPDATED 13951 with G132C UPDATED 13952 with G132R UPDATED 13953 with G132V UPDATED 13954 with G150G UPDATED 13955 with G162A UPDATED 13956 with G162V UPDATED 13957 with G16G UPDATED 13958 with G16R UPDATED 13960 with G17C UPDATED 13961 with G24V UPDATED 13962 with G55C UPDATED 13963 with G75V UPDATED 13965 with H137D UPDATED 13966 with H42N UPDATED 13968 with H43P UPDATED 13969 with H43Q UPDATED 13970 with H51D UPDATED 13971 with H51L UPDATED 13972 with H51N UPDATED 13973 with H57L UPDATED 13974 with H57N UPDATED 13975 with H71H UPDATED 13976 with H71L UPDATED 13977 with H71N UPDATED 13978 with H82L UPDATED 13979 with I133F UPDATED 13980 with I133N UPDATED 13981 with I31F UPDATED 13983 with I31T UPDATED 13984 with I52T UPDATED 13985 with I5F UPDATED 13986 with I5M UPDATED 13987 with I5N UPDATED 13988 with I6F UPDATED 13989 with I6M UPDATED 13991 with K48T UPDATED 13993 with L116Q UPDATED 13994 with L117Q UPDATED 13995 with L120Q UPDATED 13997 with L156P UPDATED 13998 with L156R UPDATED 13999 with L159Q UPDATED 14001 with L19Q UPDATED 14002 with L27Q UPDATED 14003 with L35P UPDATED 14005 with L4F UPDATED 14006 with L4V UPDATED 14007 with L85Q UPDATED 14008 with M175K UPDATED 14009 with M1L UPDATED 14010 with N112S UPDATED 14011 with N118N UPDATED 14012 with A134P UPDATED 14013 with N118Y UPDATED 14014 with N11T UPDATED 14015 with N149I UPDATED 14017 with P115A UPDATED 14018 with P115R UPDATED 14019 with P54R UPDATED 14020 with P62A UPDATED 14021 with P62P UPDATED 14022 with A143D UPDATED 14023 with P62R UPDATED 14024 with P69L UPDATED 14025 with P69Q UPDATED 14026 with P70A UPDATED 14027 with P70S UPDATED 14028 with P77S UPDATED 14030 with Q10E UPDATED 14031 with Q10H UPDATED 14034 with Q122K UPDATED 14035 with Q122Q UPDATED 14036 with R123S UPDATED 14037 with R140P UPDATED 14038 with R154M UPDATED 14039 with R176P UPDATED 14040 with R29C UPDATED 14041 with A146S UPDATED 14042 with S164S UPDATED 14043 with S164T UPDATED 14044 with S179N UPDATED 14046 with S186F UPDATED 14047 with S18L UPDATED 14048 with S18T UPDATED 14050 with S59F UPDATED 14051 with S65F UPDATED 14055 with S88T UPDATED 14056 with T114A UPDATED 14057 with T114T UPDATED 14058 with T135I UPDATED 14059 with T135S UPDATED 14060 with A152V UPDATED 14061 with T142R UPDATED 14062 with T142T UPDATED 14063 with T153N UPDATED 14064 with T160K UPDATED 14065 with T160R UPDATED 14066 with T177T UPDATED 14068 with T76S UPDATED 14069 with V109L UPDATED 14070 with V125A UPDATED 14071 with V125V UPDATED 14072 with V128A UPDATED 14073 with V128D UPDATED 14074 with V130E UPDATED 14075 with V131D UPDATED 14076 with V131F UPDATED 14077 with V131I UPDATED 14078 with A165D UPDATED 14079 with V139E UPDATED 14080 with V147A UPDATED 14081 with V155E UPDATED 14083 with V163E UPDATED 14084 with V180D UPDATED 14085 with V183D UPDATED 14086 with V183V UPDATED 14087 with V21A UPDATED 14088 with A170S UPDATED 14089 with V21E UPDATED 14090 with V44D UPDATED 14091 with V7A UPDATED 14092 with V93E UPDATED 14093 with V93L UPDATED 14095 with W119G UPDATED 14096 with W119L UPDATED 14097 with A170V UPDATED 14101 with Y41Y UPDATED 14104 with A171A UPDATED 14105 with A26V UPDATED 14106 with A28S UPDATED 14107 with A30P UPDATED 14108 with A30S UPDATED 14109 with A30V UPDATED 14110 with A36D UPDATED 14111 with A36S UPDATED 14112 with A38A UPDATED 14113 with A38G UPDATED 14114 with A38S UPDATED 15094 with M1Var UPDATED 14116 with A46A UPDATED 14120 with A46P UPDATED 14121 with A79A UPDATED 14122 with A79P UPDATED 14124 with A89V UPDATED 14127 with C138F UPDATED 14128 with C138G UPDATED 14130 with C14W UPDATED 14131 with C184R UPDATED 14133 with C72F UPDATED 14134 with C72Y UPDATED 14140 with D110E UPDATED 14142 with D110H UPDATED 14144 with D129E UPDATED 14145 with D12H UPDATED 14146 with D12Y UPDATED 14147 with D136V UPDATED 14148 with D145E UPDATED 14149 with D158G UPDATED 14150 with D166V UPDATED 14151 with D49E UPDATED 14152 with D49H UPDATED 14153 with D49Y UPDATED 14154 with D56D UPDATED 14157 with D63E UPDATED 14159 with D80H UPDATED 14160 with D86V UPDATED 14161 with D8A UPDATED 14168 with D8V UPDATED 14169 with E107E UPDATED 14172 with E127D UPDATED 14176 with E173G UPDATED 14177 with E174K UPDATED 15095 with L182S UPDATED 15096 with L182W UPDATED 15098 with V180G UPDATED 15101 with V180A UPDATED 15102 with V180F UPDATED 15103 with T177P UPDATED 15104 with M175T UPDATED 15105 with M175I UPDATED 15106 with M175R UPDATED 15107 with M175V UPDATED 15111 with L172P UPDATED 15112 with A171P UPDATED 15114 with A171E UPDATED 15117 with T168P UPDATED 15119 with S164P UPDATED 15121 with V163A UPDATED 15122 with G162D UPDATED 15126 with T160P UPDATED 15127 with T160K UPDATED 15129 with L159V UPDATED 15130 with L159R UPDATED 15131 with L159P UPDATED 15134 with V155G UPDATED 15135 with V155A UPDATED 15136 with V155M UPDATED 15137 with R154G UPDATED 15138 with R154M UPDATED 15139 with L151S UPDATED 15140 with A146T UPDATED 15141 with A146V UPDATED 15142 with A146E UPDATED 15144 with A143G UPDATED 15145 with T142A UPDATED 15146 with T142K UPDATED 15147 with T142P UPDATED 15148 with T142M UPDATED 15149 with Q141P UPDATED 15151 with R140P UPDATED 15152 with V139L UPDATED 15153 with V139G UPDATED 15154 with V139A UPDATED 15155 with V139M UPDATED 15156 with C138R UPDATED 15158 with H137P UPDATED 15161 with D136V UPDATED 15162 with D136G UPDATED 15166 with T135P UPDATED 15167 with T135N UPDATED 15168 with A134V UPDATED 15171 with I133T UPDATED 15174 with G132A UPDATED 15175 with G132D UPDATED 15176 with G132S UPDATED 15177 with G132C UPDATED 15178 with V131G UPDATED 15179 with V131F UPDATED 15180 with V130G UPDATED 15181 with V130M UPDATED 15182 with D129N UPDATED 15183 with V128G UPDATED 15184 with V125F UPDATED 15185 with V125G UPDATED 15188 with R121P UPDATED 15189 with L120R UPDATED 15190 with L120P UPDATED 15191 with L120Q UPDATED 15193 with W119L UPDATED 15194 with W119R UPDATED 15195 with W119G UPDATED 15196 with W119C UPDATED 15197 with L116R UPDATED 15198 with L116P UPDATED 15199 with T114P UPDATED 15202 with G108R UPDATED 15203 with G108E UPDATED 15205 with F106S UPDATED 15206 with F106L UPDATED 15207 with G105V UPDATED 15208 with G105D UPDATED 15209 with S104G UPDATED 15210 with S104I UPDATED 15211 with S104R UPDATED 15212 with Y103C UPDATED 15215 with Y103H UPDATED 15216 with Y103D UPDATED 15217 with A102T UPDATED 15220 with A102P UPDATED 15222 with T100P UPDATED 15224 with G97R UPDATED 15225 with G97S UPDATED 15226 with G97D UPDATED 15227 with G97V UPDATED 15228 with G97C UPDATED 15229 with K96Q UPDATED 15230 with K96E UPDATED 15231 with K96R UPDATED 15232 with K96T UPDATED 15233 with K96N UPDATED 15235 with Y95D UPDATED 15237 with F94L UPDATED 15238 with F94S UPDATED 15239 with F94C UPDATED 15241 with V93L UPDATED 15242 with V93A UPDATED 15245 with I90S UPDATED 15246 with I90N UPDATED 15247 with I90T UPDATED 15249 with L85R UPDATED 15250 with L85P UPDATED 15251 with H82R UPDATED 15253 with G78S UPDATED 15254 with G78D UPDATED 15255 with G78V UPDATED 15257 with T76I UPDATED 15258 with T76P UPDATED 15259 with C72R UPDATED 15261 with C72Y UPDATED 15263 with H71P UPDATED 15264 with H71R UPDATED 15266 with H71Y UPDATED 15269 with P69L UPDATED 15270 with W68C UPDATED 15271 with W68L UPDATED 15272 with W68G UPDATED 15275 with W68R UPDATED 15276 with S67P UPDATED 15278 with S66P UPDATED 15282 with Y64D UPDATED 15283 with D63A UPDATED 15285 with D63G UPDATED 15286 with P62R UPDATED 15288 with P62S UPDATED 15289 with P62T UPDATED 15290 with P62L UPDATED 15291 with T61P UPDATED 15293 with S59P UPDATED 15294 with F58C UPDATED 15295 with F58S UPDATED 15296 with F58L UPDATED 15298 with H57Q UPDATED 15300 with H57R UPDATED 15301 with H57L UPDATED 15302 with H57Y UPDATED 15303 with H57D UPDATED 15304 with P54R UPDATED 15305 with P54L UPDATED 15306 with P54Q UPDATED 15307 with P54S UPDATED 15308 with P54T UPDATED 15309 with H51R UPDATED 15310 with H51D UPDATED 15311 with H51P UPDATED 15312 with H51Y UPDATED 15313 with H51Q UPDATED 15315 with D49G UPDATED 15316 with D49N UPDATED 15317 with D49A UPDATED 15318 with D49E UPDATED 15319 with K48T UPDATED 15320 with K48E UPDATED 15321 with T47P UPDATED 15322 with T47A UPDATED 15324 with A46E UPDATED 15325 with A46V UPDATED 15327 with V44G UPDATED 15328 with H43P UPDATED 15330 with L35P UPDATED 15332 with Y34S UPDATED 15334 with Y34D UPDATED 15336 with I31S UPDATED 15337 with I31T UPDATED 15339 with L27P UPDATED 15341 with G24D UPDATED 15343 with V21G UPDATED 15344 with L19P UPDATED 15348 with G17D UPDATED 15353 with C14W UPDATED 15356 with C14R UPDATED 15357 with F13L UPDATED 15358 with F13S UPDATED 15359 with F13I UPDATED 15361 with D12G UPDATED 15362 with D12E UPDATED 15363 with D12A UPDATED 15364 with D12N UPDATED 15366 with Q10H UPDATED 15367 with Q10R UPDATED 15368 with Q10P UPDATED 15372 with V9G UPDATED 15374 with D8E UPDATED 15375 with D8H UPDATED 15376 with D8G UPDATED 15377 with D8N UPDATED 15378 with D8A UPDATED 15379 with D8Y UPDATED 15380 with V7G UPDATED 15381 with V7A UPDATED 15382 with V7F UPDATED 15383 with V7L UPDATED 15386 with I6T UPDATED 15388 with I5S UPDATED 15389 with L4S UPDATED 15390 with L4W UPDATED 15391 with A3E UPDATED 16053 with H71D UPDATED 9646 with Y34D UPDATED 9647 with L4S UPDATED 9648 with D49N UPDATED 9649 with D49G UPDATED 9650 with I5T UPDATED 9651 with H51R UPDATED 9652 with P54L UPDATED 9653 with H57D UPDATED 9656 with F58S UPDATED 9657 with I6T UPDATED 9658 with P62S UPDATED 9659 with D63G UPDATED 9660 with S67P UPDATED 9661 with W68R UPDATED 9662 with W68G UPDATED 9663 with P69R UPDATED 9664 with V7G UPDATED 9665 with H71R UPDATED 9666 with T76P UPDATED 9667 with D8N UPDATED 9668 with D8H UPDATED 9669 with H82R UPDATED 9670 with D8E UPDATED 9671 with L85R UPDATED 9673 with T100P UPDATED 9674 with Q10P UPDATED 9675 with Q10R UPDATED 9679 with L116R UPDATED 9681 with D12A UPDATED 9682 with V128G UPDATED 9684 with I133T UPDATED 9685 with T135P UPDATED 9686 with D136Y UPDATED 9688 with C14R UPDATED 9689 with C138R UPDATED 9690 with V139G UPDATED 9692 with A146E UPDATED 9693 with A146V UPDATED 9694 with L151S UPDATED 9696 with M175V UPDATED 9697 with V180F UPDATED 9698 with V180A UPDATED 9699 with V180G UPDATED 9700 with L182S UPDATED 13279 with C138S UPDATED 13298 with D136H UPDATED 13313 with D8E UPDATED 13329 with G132S UPDATED 13359 with H51Y UPDATED 13374 with K96M UPDATED 13389 with L85R UPDATED 13404 with P62S UPDATED 13416 with S164P UPDATED 13433 with T47S UPDATED 13794 with F81V UPDATED 13810 with S104G UPDATED 13825 with T114P UPDATED 13835 with L116P UPDATED 13851 with R123P UPDATED 13866 with V125F UPDATED 13943 with F94F UPDATED 13959 with G16V UPDATED 13964 with G78V UPDATED 13967 with H42Q UPDATED 13982 with I31N UPDATED 14000 with L19L UPDATED 14016 with N149Y UPDATED 14032 with Q10L UPDATED 14049 with S32N UPDATED 14067 with T22I UPDATED 14082 with V155M UPDATED 14099 with Y34Y UPDATED 14115 with A3A UPDATED 14125 with A92E UPDATED 14143 with D110N UPDATED 14158 with D63Y UPDATED 14179 with E181K UPDATED 9655 with H57R UPDATED 9672 with G97S UPDATED 9691 with Q141P UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 14094 with W119Ter UPDATED 14098 with W68Ter UPDATED 14100 with Y41Ter UPDATED 14102 with Y64Ter UPDATED 14103 with Y95Ter UPDATED 14126 with C138Ter UPDATED 14129 with C14Ter UPDATED 14132 with C72Ter UPDATED 14170 with E111Ter UPDATED 14171 with E127Ter UPDATED 14173 with E144Ter UPDATED 14174 with E15Ter UPDATED 14178 with E181Ter UPDATED 15097 with E181Ter UPDATED 15108 with E174Ter UPDATED 15109 with E173Ter UPDATED 15120 with S164Ter UPDATED 15143 with E144Ter UPDATED 15150 with Q141Ter UPDATED 15187 with Q122Ter UPDATED 15192 with W119Ter UPDATED 15201 with E111Ter UPDATED 15204 with E107Ter UPDATED 15213 with Y103Ter UPDATED 15221 with G101Ter UPDATED 15223 with Y99Ter UPDATED 15236 with Y95Ter UPDATED 15244 with E91Ter UPDATED 15273 with W68Ter UPDATED 15277 with S67Ter UPDATED 15279 with S66Ter UPDATED 15281 with Y64Ter UPDATED 15345 with S18Ter UPDATED 15350 with E15Ter UPDATED 15352 with C14Ter UPDATED 15370 with Q10Ter UPDATED 13415 with S164Ter UPDATED 13460 with Y103Ter UPDATED 13808 with Q141Ter UPDATED 13850 with Y99Ter UPDATED 13932 with E37Ter UPDATED 13933 with E91Ter UPDATED 13944 with G101Ter UPDATED 13990 with K48Ter UPDATED 13992 with K96Ter UPDATED 13996 with L151Ter UPDATED 14004 with L4Ter UPDATED 14029 with Q10Ter UPDATED 14033 with Q122Ter UPDATED 14052 with S66Ter UPDATED 14053 with S67Ter UPDATED 14054 with S88Ter UPDATED 15329 with Y41Ter UPDATED 15333 with Y34Ter UPDATED 9676 with Y103Ter UPDATED 9677 with G108Ter UPDATED 9695 with S164Ter UPDATED 14175 with E173Ter UPDATED 13327 with G108Ter UPDATED 14045 with S18Ter UPDATED 3433 with Y99Ter UPDATED 3436 with Y41Ter UPDATED 4160 with Q10Ter UPDATED 4168 with Y103Ter UPDATED 4230 with W68Ter UPDATED 4238 with W119Ter UPDATED 4243 with Q141Ter UPDATED 4309 with S88Ter UPDATED 9933 with Q122Ter UPDATED 8096 with +nt420:g UPDATED 8098 with +nt193:a UPDATED 8099 with +nt52:g UPDATED 8100 with +nt493:c UPDATED 8102 with +nt218:cgcattgccg UPDATED 8104 with +nt221:g UPDATED 8105 with +nt407:c UPDATED 8108 with +nt392:g UPDATED 8109 with +nt532:c UPDATED 8110 with +nt480:tgac UPDATED 8111 with +nt465:t UPDATED 8112 with +nt414:g UPDATED 8113 with +nt391:gg UPDATED 8114 with +nt382:ag UPDATED 8116 with +nt287:t UPDATED 8128 with +nt388:aggtcgatg UPDATED 8129 with +nt403:c UPDATED 8130 with +nt397:t UPDATED 8131 with +nt475:c UPDATED 8097 with -nt301:g UPDATED 8101 with -nt386:atg UPDATED 8107 with -nt512:c UPDATED 8117 with -nt452:t UPDATED 8118 with -nt406:g UPDATED 8119 with -nt386:atgt UPDATED 8120 with -nt381:gg UPDATED 8121 with -nt341:c UPDATED 8122 with -nt307:tacag UPDATED 8123 with -nt161:c UPDATED 8124 with -nt158:a UPDATED 8126 with -nt77:g UPDATED 8132 with -nt70:g UPDATED 8135 with -nt443:g UPDATED 8137 with -nt416:tg UPDATED 8138 with -nt391:g UPDATED 8139 with -nt104:c UPDATED 8140 with -nt71:g UPDATED 8141 with -nt28:c UPDATED 8143 with -nt84:c DELETED 42998 " 984 UPDATE Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1088 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to daptomycin daptomycin-resistant beta-subunit of RNA polymerase (rpoB); daptomycin; peptide antibiotic; rifamycin antibiotic; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with daptomycin-resistant beta-subunit of RNA polymerase (rpoB) UPDATED category_aro_description with Daptomycin-resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. " 1108 UPDATE Enterococcus faecium liaS mutant conferring daptomycin resistance daptomycin resistant liaS; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1166 UPDATE Staphylococcus aureus gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1175 UPDATE Enterococcus faecium cls conferring resistance to daptomycin daptomycin resistant cls; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid isoniazid resistant katG; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13301 with D142G UPDATED 13337 with G182R UPDATED 13417 with S315I UPDATED 13419 with S315T UPDATED 13454 with W191R UPDATED 13459 with W90R UPDATED 13709 with A109V UPDATED 13717 with A614E UPDATED 13729 with G125D UPDATED 13732 with G297V UPDATED 13737 with L141F UPDATED 13738 with L159P UPDATED 13743 with L704S UPDATED 13757 with R104Q UPDATED 13760 with S481L UPDATED 13762 with S700P UPDATED 13765 with T180K UPDATED 13780 with W191G UPDATED 13781 with W300C UPDATED 13782 with W328L UPDATED 14855 with V1Var UPDATED 13784 with S315Var UPDATED 14956 with W328L UPDATED 14965 with S315T UPDATED 14966 with S315R UPDATED 14968 with S315I UPDATED 14969 with S315N UPDATED 9552 with R463L UPDATED 9554 with T667P UPDATED 9555 with W191R UPDATED 9556 with S315N UPDATED 9558 with S315R UPDATED 9560 with I317V UPDATED 13418 with S315N UPDATED 13748 with P232R UPDATED 13778 with V633A UPDATED 9557 with S315T UPDATED 13301 with D142G UPDATED 13337 with G182R UPDATED 13417 with S315I UPDATED 13419 with S315T UPDATED 13454 with W191R UPDATED 13459 with W90R UPDATED 13709 with A109V UPDATED 13717 with A614E UPDATED 13729 with G125D UPDATED 13732 with G297V UPDATED 13737 with L141F UPDATED 13738 with L159P UPDATED 13743 with L704S UPDATED 13757 with R104Q UPDATED 13760 with S481L UPDATED 13762 with S700P UPDATED 13765 with T180K UPDATED 13780 with W191G UPDATED 13781 with W300C UPDATED 13782 with W328L UPDATED 14855 with V1Var UPDATED 13784 with S315Var UPDATED 14956 with W328L UPDATED 14965 with S315T UPDATED 14966 with S315R UPDATED 14968 with S315I UPDATED 14969 with S315N UPDATED 9552 with R463L UPDATED 9554 with T667P UPDATED 9555 with W191R UPDATED 9556 with S315N UPDATED 9558 with S315R UPDATED 9560 with I317V UPDATED 13418 with S315N UPDATED 13748 with P232R UPDATED 13778 with V633A UPDATED 9557 with S315T UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 13783 with W505Ter UPDATED 14858 with W728Ter UPDATED 14872 with W689Ter UPDATED 14873 with S671Ter UPDATED 14874 with W668Ter UPDATED 14885 with E607Ter UPDATED 14889 with E588Ter UPDATED 14903 with W505Ter UPDATED 14914 with W477Ter UPDATED 14923 with W438Ter UPDATED 14929 with Y413Ter UPDATED 14930 with W412Ter UPDATED 14934 with W397Ter UPDATED 14945 with Q352Ter UPDATED 14946 with W351Ter UPDATED 14962 with W321Ter UPDATED 14977 with W300Ter UPDATED 15008 with W204Ter UPDATED 15009 with W198Ter UPDATED 15020 with S175Ter UPDATED 15023 with C171Ter UPDATED 15027 with W161Ter UPDATED 15033 with Y155Ter UPDATED 15036 with W149Ter UPDATED 15062 with Y113Ter UPDATED 15068 with W107Ter UPDATED 15082 with W90Ter UPDATED 15083 with Q88Ter UPDATED 15086 with W39Ter UPDATED 15087 with Y28Ter UPDATED 3694 with E454Ter UPDATED 3763 with E506Ter UPDATED 8241 with Y304Ter UPDATED 10019 with W91Ter UPDATED 8040 with -nt571:ggcggc UPDATED 8041 with -nt1501:g UPDATED 8043 with -nt1525:a UPDATED 8045 with -nt1293:g UPDATED 8053 with -nt249:g UPDATED 8054 with -nt368:g UPDATED 8055 with -nt126:g UPDATED 8056 with -nt81:c UPDATED 8065 with -nt54:c UPDATED 8069 with -nt241:g UPDATED 8070 with -nt60:a UPDATED 10007 with -nt1384:a UPDATED 8051 with +nt392:t UPDATED 8066 with +nt325:t UPDATED 8067 with +nt518:ggtc UPDATED 8068 with +nt135:t DELETED 43011 " 1197 UPDATE Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin antibiotic-resistant rpsL; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13370 with K43R UPDATED 13371 with K88Q UPDATED 13372 with K88R UPDATED 14616 with K43R UPDATED 14620 with K88R UPDATED 14621 with K88Q UPDATED 14622 with K88M UPDATED 9844 with K43R UPDATED 9845 with K88R UPDATED 13370 with K43R UPDATED 13371 with K88Q UPDATED 13372 with K88R UPDATED 14616 with K43R UPDATED 14620 with K88R UPDATED 14621 with K88Q UPDATED 14622 with K88M UPDATED 9844 with K43R UPDATED 9845 with K88R DELETED 42998 " 1237 UPDATE Mycobacterium tuberculosis rpoB mutations conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_name; model_param; ARO_name "UPDATED model_name with Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13304 with D435G UPDATED 13305 with D435V UPDATED 13306 with D435Y UPDATED 13353 with H445D UPDATED 13354 with H445L UPDATED 13355 with H445R UPDATED 13356 with H445Y UPDATED 13384 with L430P UPDATED 13385 with L452P UPDATED 13395 with M434I UPDATED 13410 with Q432P UPDATED 13420 with S450L UPDATED 13421 with S450W UPDATED 13887 with G981D UPDATED 13915 with T676P UPDATED 13920 with V170F UPDATED 13922 with V359A UPDATED 16044 with T444Var UPDATED 16045 with H445Var UPDATED 16046 with K446Var UPDATED 16047 with R447Var UPDATED 16048 with R448Var UPDATED 16049 with L449Var UPDATED 14117 with D435A UPDATED 14118 with D435F UPDATED 14119 with D435N UPDATED 14123 with D545E UPDATED 14135 with H445C UPDATED 14136 with H445F UPDATED 14137 with H445G UPDATED 14138 with H445N UPDATED 14139 with H445P UPDATED 14141 with I491F UPDATED 14155 with Q432K UPDATED 14156 with Q432L UPDATED 14162 with S431T UPDATED 14163 with S441L UPDATED 14164 with S441Q UPDATED 14165 with S450F UPDATED 14166 with S450Q UPDATED 14167 with S450Y UPDATED 14198 with L440Var UPDATED 14200 with G442Var UPDATED 14201 with L443Var UPDATED 14202 with T444Var UPDATED 14203 with H445Var UPDATED 14204 with K446Var UPDATED 14205 with R447Var UPDATED 14206 with R448Var UPDATED 14207 with L449Var UPDATED 14208 with S450Var UPDATED 14209 with A451Var UPDATED 14210 with L452Var UPDATED 14184 with G426Var UPDATED 14185 with T427Var UPDATED 14186 with S428Var UPDATED 14187 with Q429Var UPDATED 14188 with L430Var UPDATED 14189 with S431Var UPDATED 14190 with Q432Var UPDATED 14191 with F433Var UPDATED 14192 with M434Var UPDATED 14193 with D435Var UPDATED 14194 with Q436Var UPDATED 14195 with N437Var UPDATED 14196 with N438Var UPDATED 14197 with P439Var UPDATED 16050 with S450Var UPDATED 16051 with A451Var UPDATED 16052 with L452Var UPDATED 16028 with S428Var UPDATED 16029 with Q429Var UPDATED 16030 with L430Var UPDATED 16031 with S431Var UPDATED 16032 with Q432Var UPDATED 16033 with F433Var UPDATED 16034 with M434Var UPDATED 16035 with D435Var UPDATED 16036 with Q436Var UPDATED 16037 with N437Var UPDATED 16038 with N438Var UPDATED 16039 with P439Var UPDATED 16040 with L440Var UPDATED 16041 with S441Var UPDATED 16042 with G442Var UPDATED 16043 with L443Var UPDATED 14327 with V170F UPDATED 14333 with G426S UPDATED 14334 with T427P UPDATED 14335 with T427S UPDATED 14336 with T427A UPDATED 14337 with T427G UPDATED 14338 with T427N UPDATED 14339 with T427I UPDATED 14340 with S428G UPDATED 14341 with S428R UPDATED 14342 with S428T UPDATED 14343 with S428I UPDATED 14344 with Q429L UPDATED 14345 with Q429P UPDATED 14346 with Q429H UPDATED 14347 with L430R UPDATED 14348 with L430P UPDATED 14349 with S431G UPDATED 14350 with S431T UPDATED 14351 with S431R UPDATED 14352 with S431N UPDATED 14353 with Q432L UPDATED 14354 with Q432E UPDATED 14355 with Q432N UPDATED 14356 with Q432K UPDATED 14357 with Q432P UPDATED 14358 with Q432H UPDATED 14359 with M434L UPDATED 14360 with M434R UPDATED 14361 with M434V UPDATED 14362 with M434T UPDATED 14363 with D435G UPDATED 14364 with D435Y UPDATED 14365 with M434I UPDATED 14366 with Q436N UPDATED 14367 with N437Y UPDATED 14368 with D435A UPDATED 14369 with D435N UPDATED 14370 with D435F UPDATED 14371 with D435H UPDATED 14372 with D435L UPDATED 14373 with D435V UPDATED 14374 with D435E UPDATED 14375 with Q436R UPDATED 14376 with Q436P UPDATED 14377 with N437H UPDATED 14378 with N437D UPDATED 14379 with N437S UPDATED 14380 with N437I UPDATED 14381 with N438H UPDATED 14382 with P439S UPDATED 14383 with P439L UPDATED 14384 with P439A UPDATED 14385 with S441A UPDATED 14386 with S441L UPDATED 14387 with S441V UPDATED 14388 with S441Q UPDATED 14389 with S441M UPDATED 14390 with S441K UPDATED 14391 with G442E UPDATED 14392 with S441W UPDATED 14393 with L443S UPDATED 14394 with T444P UPDATED 14395 with L443W UPDATED 14396 with L443F UPDATED 14397 with T444S UPDATED 14398 with T444I UPDATED 14399 with H445Y UPDATED 14400 with H445S UPDATED 14401 with K446Q UPDATED 14402 with H445P UPDATED 14403 with H445N UPDATED 14404 with H445F UPDATED 14405 with H445L UPDATED 14406 with H445R UPDATED 14407 with H445C UPDATED 14408 with H445G UPDATED 14409 with H445T UPDATED 14410 with H445D UPDATED 14411 with H445Q UPDATED 14412 with K446R UPDATED 14413 with K446E UPDATED 14414 with K446T UPDATED 14415 with R448L UPDATED 14416 with R448K UPDATED 14417 with R448Q UPDATED 14418 with L449M UPDATED 14419 with S450F UPDATED 14420 with S450A UPDATED 14421 with S450L UPDATED 14422 with S450G UPDATED 14423 with S450Q UPDATED 14424 with A451G UPDATED 14425 with S450V UPDATED 14426 with S450M UPDATED 14427 with S450C UPDATED 14428 with S450Y UPDATED 14429 with S450W UPDATED 14430 with A451V UPDATED 14431 with L452V UPDATED 14432 with L452M UPDATED 14433 with L452P UPDATED 14435 with I491F UPDATED 9742 with S450L UPDATED 9743 with H445Y UPDATED 9775 with H445D UPDATED 9776 with H445L UPDATED 9778 with L430P UPDATED 9779 with Q432P UPDATED 9780 with M434I UPDATED 9781 with D435Y UPDATED 9782 with D435G UPDATED 9783 with D435V UPDATED 9787 with S450W UPDATED 9788 with P45L UPDATED 9789 with L452P UPDATED 9790 with I480V UPDATED 9791 with F503S UPDATED 9792 with L731P UPDATED 9793 with R827H UPDATED 9794 with H835R UPDATED 9795 with G836S UPDATED 9796 with Q975H UPDATED 14199 with S441Var UPDATED 14183 with F425Var UPDATED 9785 with H445R UPDATED 9786 with P45S UPDATED 9797 with I1106T UPDATED 13304 with D435G UPDATED 13305 with D435V UPDATED 13306 with D435Y UPDATED 13353 with H445D UPDATED 13354 with H445L UPDATED 13355 with H445R UPDATED 13356 with H445Y UPDATED 13384 with L430P UPDATED 13385 with L452P UPDATED 13395 with M434I UPDATED 13410 with Q432P UPDATED 13420 with S450L UPDATED 13421 with S450W UPDATED 13887 with G981D UPDATED 13915 with T676P UPDATED 13920 with V170F UPDATED 13922 with V359A UPDATED 16044 with T444Var UPDATED 16045 with H445Var UPDATED 16046 with K446Var UPDATED 16047 with R447Var UPDATED 16048 with R448Var UPDATED 16049 with L449Var UPDATED 14117 with D435A UPDATED 14118 with D435F UPDATED 14119 with D435N UPDATED 14123 with D545E UPDATED 14135 with H445C UPDATED 14136 with H445F UPDATED 14137 with H445G UPDATED 14138 with H445N UPDATED 14139 with H445P UPDATED 14141 with I491F UPDATED 14155 with Q432K UPDATED 14156 with Q432L UPDATED 14162 with S431T UPDATED 14163 with S441L UPDATED 14164 with S441Q UPDATED 14165 with S450F UPDATED 14166 with S450Q UPDATED 14167 with S450Y UPDATED 14198 with L440Var UPDATED 14200 with G442Var UPDATED 14201 with L443Var UPDATED 14202 with T444Var UPDATED 14203 with H445Var UPDATED 14204 with K446Var UPDATED 14205 with R447Var UPDATED 14206 with R448Var UPDATED 14207 with L449Var UPDATED 14208 with S450Var UPDATED 14209 with A451Var UPDATED 14210 with L452Var UPDATED 14184 with G426Var UPDATED 14185 with T427Var UPDATED 14186 with S428Var UPDATED 14187 with Q429Var UPDATED 14188 with L430Var UPDATED 14189 with S431Var UPDATED 14190 with Q432Var UPDATED 14191 with F433Var UPDATED 14192 with M434Var UPDATED 14193 with D435Var UPDATED 14194 with Q436Var UPDATED 14195 with N437Var UPDATED 14196 with N438Var UPDATED 14197 with P439Var UPDATED 16050 with S450Var UPDATED 16051 with A451Var UPDATED 16052 with L452Var UPDATED 16028 with S428Var UPDATED 16029 with Q429Var UPDATED 16030 with L430Var UPDATED 16031 with S431Var UPDATED 16032 with Q432Var UPDATED 16033 with F433Var UPDATED 16034 with M434Var UPDATED 16035 with D435Var UPDATED 16036 with Q436Var UPDATED 16037 with N437Var UPDATED 16038 with N438Var UPDATED 16039 with P439Var UPDATED 16040 with L440Var UPDATED 16041 with S441Var UPDATED 16042 with G442Var UPDATED 16043 with L443Var UPDATED 14327 with V170F UPDATED 14333 with G426S UPDATED 14334 with T427P UPDATED 14335 with T427S UPDATED 14336 with T427A UPDATED 14337 with T427G UPDATED 14338 with T427N UPDATED 14339 with T427I UPDATED 14340 with S428G UPDATED 14341 with S428R UPDATED 14342 with S428T UPDATED 14343 with S428I UPDATED 14344 with Q429L UPDATED 14345 with Q429P UPDATED 14346 with Q429H UPDATED 14347 with L430R UPDATED 14348 with L430P UPDATED 14349 with S431G UPDATED 14350 with S431T UPDATED 14351 with S431R UPDATED 14352 with S431N UPDATED 14353 with Q432L UPDATED 14354 with Q432E UPDATED 14355 with Q432N UPDATED 14356 with Q432K UPDATED 14357 with Q432P UPDATED 14358 with Q432H UPDATED 14359 with M434L UPDATED 14360 with M434R UPDATED 14361 with M434V UPDATED 14362 with M434T UPDATED 14363 with D435G UPDATED 14364 with D435Y UPDATED 14365 with M434I UPDATED 14366 with Q436N UPDATED 14367 with N437Y UPDATED 14368 with D435A UPDATED 14369 with D435N UPDATED 14370 with D435F UPDATED 14371 with D435H UPDATED 14372 with D435L UPDATED 14373 with D435V UPDATED 14374 with D435E UPDATED 14375 with Q436R UPDATED 14376 with Q436P UPDATED 14377 with N437H UPDATED 14378 with N437D UPDATED 14379 with N437S UPDATED 14380 with N437I UPDATED 14381 with N438H UPDATED 14382 with P439S UPDATED 14383 with P439L UPDATED 14384 with P439A UPDATED 14385 with S441A UPDATED 14386 with S441L UPDATED 14387 with S441V UPDATED 14388 with S441Q UPDATED 14389 with S441M UPDATED 14390 with S441K UPDATED 14391 with G442E UPDATED 14392 with S441W UPDATED 14393 with L443S UPDATED 14394 with T444P UPDATED 14395 with L443W UPDATED 14396 with L443F UPDATED 14397 with T444S UPDATED 14398 with T444I UPDATED 14399 with H445Y UPDATED 14400 with H445S UPDATED 14401 with K446Q UPDATED 14402 with H445P UPDATED 14403 with H445N UPDATED 14404 with H445F UPDATED 14405 with H445L UPDATED 14406 with H445R UPDATED 14407 with H445C UPDATED 14408 with H445G UPDATED 14409 with H445T UPDATED 14410 with H445D UPDATED 14411 with H445Q UPDATED 14412 with K446R UPDATED 14413 with K446E UPDATED 14414 with K446T UPDATED 14415 with R448L UPDATED 14416 with R448K UPDATED 14417 with R448Q UPDATED 14418 with L449M UPDATED 14419 with S450F UPDATED 14420 with S450A UPDATED 14421 with S450L UPDATED 14422 with S450G UPDATED 14423 with S450Q UPDATED 14424 with A451G UPDATED 14425 with S450V UPDATED 14426 with S450M UPDATED 14427 with S450C UPDATED 14428 with S450Y UPDATED 14429 with S450W UPDATED 14430 with A451V UPDATED 14431 with L452V UPDATED 14432 with L452M UPDATED 14433 with L452P UPDATED 14435 with I491F UPDATED 9742 with S450L UPDATED 9743 with H445Y UPDATED 9775 with H445D UPDATED 9776 with H445L UPDATED 9778 with L430P UPDATED 9779 with Q432P UPDATED 9780 with M434I UPDATED 9781 with D435Y UPDATED 9782 with D435G UPDATED 9783 with D435V UPDATED 9787 with S450W UPDATED 9788 with P45L UPDATED 9789 with L452P UPDATED 9790 with I480V UPDATED 9791 with F503S UPDATED 9792 with L731P UPDATED 9793 with R827H UPDATED 9794 with H835R UPDATED 9795 with G836S UPDATED 9796 with Q975H UPDATED 14199 with S441Var UPDATED 14183 with F425Var UPDATED 9785 with H445R UPDATED 9786 with P45S UPDATED 9797 with I1106T UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 4045 with Q513Ter UPDATED 4074 with S522Ter DELETED 42998 UPDATED ARO_name with Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin " 1301 UPDATE Staphylococcus aureus cls conferring resistance to daptomycin daptomycin resistant cls; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1320 UPDATE Klebsiella mutant PhoP conferring antibiotic resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1339 UPDATE Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol ethambutol resistant embR; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. DELETED 43012 " 1354 UPDATE Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol ethambutol resistant embA; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED param_type with snp in promoter region UPDATED param_description with A SNP in the promoter region of a gene which alters transcription of that gene, encoded as [wild-type][-][position][mutation], for example t-11c. Var represents any possible substitution. This is a pilot parameter in need of further documentation. UPDATED param_type_id with 41339 UPDATED 13480 with c-12t UPDATED 13482 with c-16g UPDATED 13483 with c-16t UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. DELETED 43012 " 1360 UPDATE Bartonella bacilliformis gyrB conferring resistance to aminocoumarin aminocoumarin resistant gyrB; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 4132 UPDATE ACT-41 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1574 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid isoniazid resistant inhA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13366 with I194T UPDATED 13367 with I21T UPDATED 13425 with S94A UPDATED 14807 with S94A UPDATED 9548 with S94A UPDATED 9549 with T162S UPDATED 9550 with I194T UPDATED 13366 with I194T UPDATED 13367 with I21T UPDATED 13425 with S94A UPDATED 14807 with S94A UPDATED 9548 with S94A UPDATED 9549 with T162S UPDATED 9550 with I194T DELETED 43011 " 1822 UPDATE Staphylococcus aureus gyrB conferring resistance to aminocoumarin aminocoumarin resistant gyrB; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1849 UPDATE Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides Antibiotic resistant tlyA; streptomycin; capreomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_type with frameshift mutation UPDATED param_description with A frameshift mutation, caused by a nucleotide insertion or deletion that does not equal 3 bases, encoded as [wild-type][position]fs, for example S531fs. Termination can also be denoted as: Ter[position]fs. UPDATED param_type_id with 40494 UPDATED 9448 with K31fs UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 3828 with R18Ter UPDATED 3829 with Q22Ter UPDATED 3835 with Q184Ter UPDATED 3908 with R3Ter UPDATED 8027 with -nt758:g UPDATED 8028 with -nt673:gt UPDATED 8029 with -nt653:t UPDATED 8030 with -nt586:g UPDATED 8031 with -nt477:g UPDATED 8032 with -nt400:a UPDATED 8033 with -nt23:a UPDATED 8034 with -nt26:c UPDATED 8035 with -nt310:g UPDATED 8036 with +nt397:c DELETED 42998 " 1935 UPDATE Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13275 with A90V UPDATED 13318 with D94A UPDATED 13319 with D94G UPDATED 13320 with D94H UPDATED 13321 with D94N UPDATED 13322 with D94Y UPDATED 13347 with G88A UPDATED 13349 with G88C UPDATED 13424 with S91P UPDATED 14269 with G88C UPDATED 14271 with G88A UPDATED 14272 with D89N UPDATED 14274 with A90V UPDATED 14276 with S91P UPDATED 14278 with D94N UPDATED 14281 with D94H UPDATED 14282 with D94Y UPDATED 14283 with D94A UPDATED 14284 with D94G UPDATED 9603 with D94N UPDATED 9605 with D94G UPDATED 9609 with G88C UPDATED 9612 with D94H UPDATED 9622 with D94A UPDATED 9625 with D89N UPDATED 9626 with A90V UPDATED 9627 with S91P UPDATED 13275 with A90V UPDATED 13318 with D94A UPDATED 13319 with D94G UPDATED 13320 with D94H UPDATED 13321 with D94N UPDATED 13322 with D94Y UPDATED 13347 with G88A UPDATED 13349 with G88C UPDATED 13424 with S91P UPDATED 14269 with G88C UPDATED 14271 with G88A UPDATED 14272 with D89N UPDATED 14274 with A90V UPDATED 14276 with S91P UPDATED 14278 with D94N UPDATED 14281 with D94H UPDATED 14282 with D94Y UPDATED 14283 with D94A UPDATED 14284 with D94G UPDATED 9603 with D94N UPDATED 9605 with D94G UPDATED 9609 with G88C UPDATED 9612 with D94H UPDATED 9622 with D94A UPDATED 9625 with D89N UPDATED 9626 with A90V UPDATED 9627 with S91P UPDATED param_description with A set of nucleotide or amino acid substitutions in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[SNP 1],[SNP 2],etc+[cvterm_id gene 2],[SNP 1],[SNP 2],etc. For example: 39879,A90V,M94V+40052,D472H. A nucleotide substitution resulting in a change from an amino acid codon to a stop codon is encoded as [wild type amino acid][position][Ter], for example Q42Ter. DELETED 42998 " 1943 UPDATE Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid antibiotic resistant kasA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. DELETED 43012 " 2068 UPDATE Escherichia coli 16S rRNA mutation conferring resistance to edeine 16s rRNA with mutation conferring resistance to peptide antibiotics; edeine A; edeine B; edeine D; edeine F; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3073 with a1499g UPDATED 4842 with t1506a UPDATED 3073 with a1499g UPDATED 4842 with t1506a " 2070 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13256 with a1401g UPDATED 13331 with g1484t UPDATED 14741 with a1401g UPDATED 14745 with c1402t UPDATED 14756 with g1484t UPDATED 9439 with a1401g UPDATED 9440 with g1484t UPDATED 9442 with a514c UPDATED 12973 with a1401g UPDATED 13256 with a1401g UPDATED 13331 with g1484t UPDATED 14741 with a1401g UPDATED 14745 with c1402t UPDATED 14756 with g1484t UPDATED 9439 with a1401g UPDATED 9440 with g1484t UPDATED 9442 with a514c UPDATED 12973 with a1401g DELETED 42998 " 2076 UPDATE Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12974 with c1198t UPDATED 12974 with c1198t " 2137 UPDATE Escherichia coli EF-Tu mutants conferring resistance to kirromycin elfamycin resistant EF-Tu; kirromycin; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2158 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin elfamycin resistant EF-Tu; pulvomycin; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2078 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12951 with a1408g UPDATED 12951 with a1408g " 2124 UPDATE Clostridioides difficile EF-Tu mutants conferring resistance to elfamycin elfamycin resistant EF-Tu; LFF571; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1545 UPDATE Escherichia coli gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1005 UPDATE Escherichia coli soxR with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; nalidixic acid; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1055 UPDATE Escherichia coli parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2066 UPDATE Escherichia coli soxS with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; enrofloxacin; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1989 UPDATE Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1721 UPDATE Mycobacterium leprae folP with mutation conferring resistance to dapsone dapsone resistant dihydropteroate synthase folP; dapsone; sulfone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 100 UPDATE Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide ethionamide resistant ethA; ethionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED param_type with nonsense mutation UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED param_type_id with 40394 UPDATED 15480 with E476Ter UPDATED 15482 with Y461Ter UPDATED 15485 with W455Ter UPDATED 15489 with Q449Ter UPDATED 15492 with Y438Ter UPDATED 15494 with E427Ter UPDATED 15497 with R421Ter UPDATED 15499 with Y408Ter UPDATED 15504 with S399Ter UPDATED 15511 with K394Ter UPDATED 15515 with W391Ter UPDATED 15517 with Y386Ter UPDATED 15522 with Y382Ter UPDATED 15531 with Y369Ter UPDATED 15533 with Q360Ter UPDATED 15534 with Q359Ter UPDATED 15537 with Q347Ter UPDATED 15546 with E332Ter UPDATED 15554 with C294Ter UPDATED 15557 with L293Ter UPDATED 15558 with R292Ter UPDATED 15559 with Q291Ter UPDATED 15561 with W289Ter UPDATED 15565 with R279Ter UPDATED 15566 with Y276Ter UPDATED 15570 with Q271Ter UPDATED 15571 with Q269Ter UPDATED 15579 with W256Ter UPDATED 15581 with Q254Ter UPDATED 15583 with C253Ter UPDATED 15587 with Y250Ter UPDATED 15589 with Q246Ter UPDATED 15593 with K241Ter UPDATED 15644 with E155Ter UPDATED 15645 with Y147Ter UPDATED 15646 with Y143Ter UPDATED 15647 with Y140Ter UPDATED 15659 with E132Ter UPDATED 15661 with C131Ter UPDATED 15663 with Q121Ter UPDATED 15666 with W116Ter UPDATED 15668 with W109Ter UPDATED 15670 with K103Ter UPDATED 15672 with Y92Ter UPDATED 15674 with K86Ter UPDATED 15677 with Y84Ter UPDATED 15682 with Q73Ter UPDATED 15683 with W69Ter UPDATED 15685 with R65Ter UPDATED 15691 with Y60Ter UPDATED 15704 with W45Ter UPDATED 15718 with Y32Ter UPDATED 15720 with Q24Ter UPDATED 15725 with W21Ter UPDATED 15594 with W240Ter UPDATED 15599 with W228Ter UPDATED 15602 with Q215Ter UPDATED 15603 with Y211Ter UPDATED 15608 with S208Ter UPDATED 15613 with Q206Ter UPDATED 15618 with S197Ter UPDATED 15639 with W167Ter UPDATED 15640 with Q165Ter UPDATED 9508 with Y147Ter UPDATED param_type with frameshift mutation UPDATED param_description with A frameshift mutation, caused by a nucleotide insertion or deletion that does not equal 3 bases, encoded as [wild-type][position]fs, for example S531fs. Termination can also be denoted as: Ter[position]fs. UPDATED param_type_id with 40494 UPDATED 9506 with P422fs UPDATED 9507 with G11fs UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 15477 with M1Var UPDATED 15503 with C403Y UPDATED 15516 with S390F UPDATED 15526 with N379D UPDATED 15544 with A341V UPDATED 15611 with R207G UPDATED 15617 with V202G UPDATED 15673 with T88I UPDATED 15696 with S57Y UPDATED 15715 with L35R UPDATED 9504 with T342K UPDATED 9505 with N379D UPDATED 9510 with H281P UPDATED 15477 with M1Var UPDATED 15503 with C403Y UPDATED 15516 with S390F UPDATED 15526 with N379D UPDATED 15544 with A341V UPDATED 15611 with R207G UPDATED 15617 with V202G UPDATED 15673 with T88I UPDATED 15696 with S57Y UPDATED 15715 with L35R UPDATED 9504 with T342K UPDATED 9505 with N379D UPDATED 9510 with H281P UPDATED 8087 with -nt1290:c UPDATED 8088 with -nt768:g UPDATED 8089 with -nt110:a UPDATED 8093 with -nt703:t UPDATED 8090 with +nt338:a UPDATED param_description with A SNP in the promoter region of a gene which alters transcription of that gene, encoded as [wild-type][-][position][mutation], for example t-11c. Var represents any possible substitution. This is a pilot parameter in need of further documentation. UPDATED 15743 with t-7c UPDATED 8312 with t-11c DELETED 42998 " 1323 UPDATE Salmonella serovars parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1671 UPDATE Salmonella serovars soxS with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 953 UPDATE Enterococcus faecalis liaF mutant conferring daptomycin resistance daptomycin resistant liaF; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1135 UPDATE Staphylococcus aureus parE conferring resistance to aminocoumarin aminocoumarin resistant parE; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 570 UPDATE Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfadiazine; sulfadimidine; sulfadoxine; sulfamethoxazole; sulfisoxazole; sulfacetamide; mafenide; sulfasalazine; sulfamethizole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 431 UPDATE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 3898 with E31Ter UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2116 UPDATE Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12981 with c1194g UPDATED 12981 with c1194g " 2147 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa elfamycin resistant EF-Tu; enacyloxin IIa; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2131 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13273 with a514c UPDATED 13288 with c517t UPDATED 14665 with a514c UPDATED 14668 with c517t UPDATED 14687 with g878a UPDATED 9846 with a1401g UPDATED 9848 with a514c UPDATED 9849 with c517t UPDATED 2911 with a1401g UPDATED 2949 with g427c UPDATED 3052 with a514c UPDATED 3054 with a906g UPDATED 4801 with c517t UPDATED 4802 with c513t UPDATED 4804 with c492t UPDATED 4805 with a514t UPDATED 7820 with c516t UPDATED 12595 with g878a UPDATED 13273 with a514c UPDATED 13288 with c517t UPDATED 14665 with a514c UPDATED 14668 with c517t UPDATED 14687 with g878a UPDATED 9846 with a1401g UPDATED 9848 with a514c UPDATED 9849 with c517t UPDATED 2911 with a1401g UPDATED 2949 with g427c UPDATED 3052 with a514c UPDATED 3054 with a906g UPDATED 4801 with c517t UPDATED 4802 with c513t UPDATED 4804 with c492t UPDATED 4805 with a514t UPDATED 7820 with c516t UPDATED 12595 with g878a DELETED 43010 " 821 UPDATE Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin rifamycin-resistant arabinosyltransferase; rifampin; rifamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1001 UPDATE Staphylococcus aureus mprF with mutation conferring resistance to daptomycin daptomycin resistant mprF; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1203 UPDATE Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid antibiotic resistant ndh; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9583 with R268H UPDATED 9583 with R268H UPDATED 10058 with +nt969:g DELETED 43012 " 1395 UPDATE Neisseria gonorrhoeae porin PIB (por) General Bacterial Porin with reduced permeability to beta-lactams; tetracycline; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; reduced permeability to antibiotic; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 1432 UPDATE Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol ethambutol resistant embC; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9492 with V987G UPDATED 9492 with V987G DELETED 43012 " 1710 UPDATE Mycobacterium leprae gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2069 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3060 with a1408g UPDATED 3060 with a1408g " 2073 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; G418; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4812 with t1406a UPDATED 4812 with t1406a " 2074 UPDATE Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4810 with c1192t UPDATED 12949 with c1066t UPDATED 4810 with c1192t UPDATED 12949 with c1066t " 2109 UPDATE Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 14218 with A504V UPDATED 14237 with S447F UPDATED 14240 with D461H UPDATED 14241 with D461N UPDATED 14243 with N499D UPDATED 14245 with N499T UPDATED 14249 with E501V UPDATED 14250 with E501D UPDATED 14252 with A504V UPDATED 9616 with E501D UPDATED 9630 with N499T UPDATED 9615 with V457L UPDATED 14218 with A504V UPDATED 14237 with S447F UPDATED 14240 with D461H UPDATED 14241 with D461N UPDATED 14243 with N499D UPDATED 14245 with N499T UPDATED 14249 with E501V UPDATED 14250 with E501D UPDATED 14252 with A504V UPDATED 9616 with E501D UPDATED 9630 with N499T UPDATED 9615 with V457L UPDATED param_description with A set of nucleotide or amino acid substitutions in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[SNP 1],[SNP 2],etc+[cvterm_id gene 2],[SNP 1],[SNP 2],etc. For example: 39879,A90V,M94V+40052,D472H. A nucleotide substitution resulting in a change from an amino acid codon to a stop codon is encoded as [wild type amino acid][position][Ter], for example Q42Ter. DELETED 43010 " 2077 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12950 with a1389g UPDATED 12950 with a1389g " 212 UPDATE Staphylococcus aureus parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 535 UPDATE Morganella morganii gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 36 UPDATE Mycobacterium leprae gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1696 UPDATE Salmonella serovars gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1441 UPDATE Klebsiella aerogenes Omp36 General Bacterial Porin with reduced permeability to beta-lactams; cefepime; imipenem; cefpirome; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2085 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2925 with g1068a UPDATED 2925 with g1068a " 2097 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; paromomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2995 with a1408g UPDATED 2995 with a1408g " 2113 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4827 with t1406a UPDATED 4827 with t1406a " 2129 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2910 with c1192a UPDATED 2919 with g1064a UPDATED 2959 with g1064c UPDATED 3070 with c1192g UPDATED 4815 with g1064t UPDATED 4816 with c1192t UPDATED 4817 with c1066t UPDATED 2910 with c1192a UPDATED 2919 with g1064a UPDATED 2959 with g1064c UPDATED 3070 with c1192g UPDATED 4815 with g1064t UPDATED 4816 with c1192t UPDATED 4817 with c1066t " 1894 UPDATE Salmonella enterica ramR mutants resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2133 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12983 with a1401g UPDATED 12983 with a1401g " 2152 UPDATE Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2897 with g1065c UPDATED 2897 with g1065c " 3542 UPDATE OXA-480 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4133 UPDATE ACT-42 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2196 UPDATE Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; ofloxacin; sparfloxacin; pefloxacin; sitafloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2075 UPDATE Salmonella enterica soxR with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2093 UPDATE Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2932 with g1194c UPDATED 3010 with a1192g UPDATED 3027 with c1193g UPDATED 4808 with c1193t UPDATED 2932 with g1194c UPDATED 3010 with a1192g UPDATED 3027 with c1193g UPDATED 4808 with c1193t " 2143 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12986 with a1401g UPDATED 12986 with a1401g " 2132 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13258 with a1401g UPDATED 14743 with a1401g UPDATED 14747 with c1402t UPDATED 14758 with g1484t UPDATED 9599 with a1401g UPDATED 9600 with a514c UPDATED 9601 with c517t UPDATED 2923 with c1402a UPDATED 3014 with a1401g UPDATED 4799 with c1402t UPDATED 4800 with g1484t UPDATED 13258 with a1401g UPDATED 14743 with a1401g UPDATED 14747 with c1402t UPDATED 14758 with g1484t UPDATED 9599 with a1401g UPDATED 9600 with a514c UPDATED 9601 with c517t UPDATED 2923 with c1402a UPDATED 3014 with a1401g UPDATED 4799 with c1402t UPDATED 4800 with g1484t DELETED 42998 " 2127 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13021 with a1402g UPDATED 13021 with a1402g " 2154 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2975 with a1184g UPDATED 4806 with c1185t UPDATED 2975 with a1184g UPDATED 4806 with c1185t " 2122 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12982 with a1355g UPDATED 12982 with a1355g " 2128 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2958 with a1375g UPDATED 4796 with c1376t UPDATED 4797 with g1458t UPDATED 4798 with t1373a UPDATED 2958 with a1375g UPDATED 4796 with c1376t UPDATED 4797 with g1458t UPDATED 4798 with t1373a " 2111 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12980 with a1355g UPDATED 12980 with a1355g " 2084 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3036 with a1375g UPDATED 4793 with g1458t UPDATED 4795 with c1376t UPDATED 4794 with t1373a UPDATED 3036 with a1375g UPDATED 4793 with g1458t UPDATED 4795 with c1376t UPDATED 4794 with t1373a " 2105 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2896 with a1375g UPDATED 2896 with a1375g " 2155 UPDATE Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2931 with g1032c UPDATED 2931 with g1032c " 2100 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2981 with a1355g UPDATED 2981 with a1355g " 2091 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3008 with a1355g UPDATED 3008 with a1355g " 2090 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3075 with a1375g UPDATED 4786 with t1373a UPDATED 4787 with g1458t UPDATED 4788 with c1376t UPDATED 3075 with a1375g UPDATED 4786 with t1373a UPDATED 4787 with g1458t UPDATED 4788 with c1376t " 2126 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3049 with a1375g UPDATED 4790 with c1376t UPDATED 4791 with g1458t UPDATED 4792 with t1373a UPDATED 3049 with a1375g UPDATED 4790 with c1376t UPDATED 4791 with g1458t UPDATED 4792 with t1373a " 2198 UPDATE Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2136 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2904 with a1408g UPDATED 4813 with t1406a UPDATED 2904 with a1408g UPDATED 4813 with t1406a " 2140 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2966 with a523c UPDATED 2966 with a523c " 2146 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4825 with c528t UPDATED 4826 with g527t UPDATED 4825 with c528t UPDATED 4826 with g527t " 2157 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3018 with a1408g UPDATED 3018 with a1408g " 1450 UPDATE Escherichia coli parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2096 UPDATE Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kasugamycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2941 with g926c UPDATED 2951 with a1519c UPDATED 2979 with a794g UPDATED 2998 with a1519g UPDATED 3050 with g926a UPDATED 4822 with a794t UPDATED 4823 with a1519t UPDATED 4824 with g926t UPDATED 2941 with g926c UPDATED 2951 with a1519c UPDATED 2979 with a794g UPDATED 2998 with a1519g UPDATED 3050 with g926a UPDATED 4822 with a794t UPDATED 4823 with a1519t UPDATED 4824 with g926t " 2145 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3061 with g1058c UPDATED 3061 with g1058c " 2102 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; hygromycin B; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7842 with t1348c UPDATED 7843 with c1439t UPDATED 7844 with t1441c UPDATED 7842 with t1348c UPDATED 7843 with c1439t UPDATED 7844 with t1441c " 2149 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; hygromycin B; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4830 with t1482c UPDATED 4831 with t1389c UPDATED 4832 with c1480t UPDATED 4830 with t1482c UPDATED 4831 with t1389c UPDATED 4832 with c1480t " 2106 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2929 with a1391g UPDATED 4838 with t1389a UPDATED 2929 with a1391g UPDATED 4838 with t1389a " 2088 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2948 with a503c UPDATED 3056 with g504c UPDATED 4828 with c502t UPDATED 4829 with c506t UPDATED 2948 with a503c UPDATED 3056 with g504c UPDATED 4828 with c502t UPDATED 4829 with c506t " 2141 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4840 with t1389a UPDATED 4840 with t1389a " 2099 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 3029 with a1391g UPDATED 4837 with t1389a UPDATED 3029 with a1391g UPDATED 4837 with t1389a " 2142 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 12984 with g1475a UPDATED 12985 with g1475t UPDATED 12984 with g1475a UPDATED 12985 with g1475t " 2222 UPDATE VEB-1b VEB beta-lactamase; monobactam; cephalosporin; antibiotic inactivation; model_name; ARO_name; CARD_short_name; ARO_description "UPDATED model_name with VEB-16 UPDATED ARO_name with VEB-16 UPDATED CARD_short_name with VEB-16 UPDATED ARO_description with VEB-16 (VEB-1b) is a beta-lactamase that is found in Pseudomonas aeruginosa. " 2227 UPDATE VCC-1 VCC beta-lactamase; ertapenem; meropenem; imipenem; aztreonam; doripenem; monobactam; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3452 UPDATE OXA-288 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3586 UPDATE FONA-2 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2249 UPDATE LpxA Acinetobacter mutant Lpx gene conferring resistance to colistin; colistin A; colistin B; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2251 UPDATE LpxC Acinetobacter mutant Lpx gene conferring resistance to colistin; colistin A; colistin B; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2257 UPDATE Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A elfamycin resistant EF-Tu; GE2270A; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2224 UPDATE Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem Outer Membrane Porin (Opr); imipenem; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3480 UPDATE OXA-346 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3509 UPDATE OXA-439 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3539 UPDATE OXA-477 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3311 UPDATE ACT-38 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2201 UPDATE PvrR phenotypic variant regulator; amikacin; carbenicillin; kanamycin A; tetracycline; tobramycin; gentamicin A; gentamicin; aminoglycoside antibiotic; penicillin beta-lactam; tetracycline antibiotic; resistance by absence; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2276 UPDATE Staphylococcus aureus ileS with mutation conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); mupirocin; mupirocin-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2284 UPDATE Escherichia coli murA with mutation conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2290 UPDATE Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3312 UPDATE Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; moxifloxacin; azithromycin; macrolide antibiotic; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8730 with a2071c UPDATED 8731 with a2071g UPDATED 8732 with a2071t UPDATED 8733 with a2072g UPDATED 8730 with a2071c UPDATED 8731 with a2071g UPDATED 8732 with a2071t UPDATED 8733 with a2072g " 651 UPDATE Staphylococcus aureus mprF defensin resistant mprF; defensin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2268 UPDATE eatAv Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; pleuromutilin; pleuromutilin antibiotic; antibiotic target protection; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2285 UPDATE Staphylococcus aureus murA with mutation conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 3638 with L42Ter " 3313 UPDATE ACT-8 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2286 UPDATE Borreliella burgdorferi murA with mutation conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2288 UPDATE Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid antibiotic resistant ndh; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 8072 with +nt272:a UPDATED 8073 with +nt439:t UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2324 UPDATE gadW resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3481 UPDATE OXA-364 OXA beta-lactamase; OXA-364-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2310 UPDATE Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin elfamycin resistant EF-Tu; kirromycin; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2294 UPDATE Campylobacter jejuni gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2314 UPDATE Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2305 UPDATE Enterococcus faecalis gshF with mutation conferring daptomycin resistance daptomycin resistant gshF; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2301 UPDATE Enterococcus faecalis YybT with mutation conferring daptomycin resistance daptomycin resistant YybT; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2306 UPDATE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; ceftazidime; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3510 UPDATE OXA-440 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2295 UPDATE Enterococcus faecium liaF mutant conferring daptomycin resistance daptomycin resistant liaF; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2296 UPDATE Enterococcus faecalis liaS mutant conferring daptomycin resistance daptomycin resistant liaS; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2297 UPDATE Enterococcus faecalis liaR mutant conferring daptomycin resistance daptomycin resistant liaR; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3540 UPDATE OXA-478 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3583 UPDATE FAR-1 FAR beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3640 UPDATE LEN-41 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2329 UPDATE MOX-9 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3592 UPDATE FRI-1 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2333 UPDATE LEN-26 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2293 UPDATE Bacillus subtilis pgsA with mutation conferring resistance to daptomycin daptomycin resistant pgsA; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2299 UPDATE Staphylococcus aureus walK with mutation conferring resistance to daptomycin daptomycin resistant walK; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2315 UPDATE Acinetobacter baumannii parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2308 UPDATE Acinetobacter baumannii OprD conferring resistance to imipenem Outer Membrane Porin (Opr); imipenem; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; resistance by absence; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2328 UPDATE MUS-2 MUS beta-lactamase; amoxicillin; piperacillin; ticarcillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3337 UPDATE Corynebacterium striatum tetA major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; oxacillin; oxytetracycline; penicillin beta-lactam; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1670 UPDATE nalC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2373 UPDATE Escherichia coli UhpT with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2372 UPDATE Escherichia coli GlpT with mutation conferring resistance to fosfomycin antibiotic-resistant GlpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 383 UPDATE Pseudomonas mutant PhoQ conferring resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2374 UPDATE Escherichia coli uhpA with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2379 UPDATE Escherichia coli cyaA with mutation conferring resistance to fosfomycin antibiotic-resistant cya adenylate cyclase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3622 UPDATE LEN-17 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2396 UPDATE OXA-368 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2398 UPDATE TEM-220 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 660 UPDATE Streptococcus pneumoniae parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2104 UPDATE Ureaplasma urealyticum parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2401 UPDATE Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2402 UPDATE Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2403 UPDATE Salmonella enterica gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2406 UPDATE rpsJ tetracycline-resistant ribosomal protection protein; tetracycline; tetracycline antibiotic; antibiotic target protection; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2407 UPDATE Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3454 UPDATE OXA-291 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2410 UPDATE Salmonella enterica parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2411 UPDATE Shigella flexneri gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; nalidixic acid; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2412 UPDATE Shigella flexneri parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; nalidixic acid; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2409 UPDATE Neisseria meningititis PBP2 conferring resistance to beta-lactam Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; cefixime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2416 UPDATE abcA ATP-binding cassette (ABC) antibiotic efflux pump; methicillin; daptomycin; cefotaxime; moenomycin A1; cephalosporin; penicillin beta-lactam; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3482 UPDATE OXA-372 OXA beta-lactamase; OXA-372-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 1035 UPDATE Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3511 UPDATE OXA-441 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3541 UPDATE OXA-479 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3585 UPDATE FONA-1 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3591 UPDATE FPH-1 FPH beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2394 UPDATE Staphylococcus aureus menA with mutation conferring resistance to lysocin lysocin resistant menA; Lysocin E; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2380 UPDATE Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin antibiotic-resistant GlpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 4391 with W355Ter UPDATED 8145 with -nt248:g UPDATED 8146 with -nt225:tggattta UPDATED 8147 with +nt392:t " 2462 UPDATE Cutibacterium acnes gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2381 UPDATE Staphylococcus aureus UhpT with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 4399 with Y314Ter UPDATED 4400 with W228Ter UPDATED 8148 with -nt431:attcaacgattt UPDATED 8149 with -nt27:t UPDATED 8150 with +nt904:t " 3353 UPDATE Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; clindamycin; macrolide antibiotic; lincosamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8802 with c656t UPDATED 8802 with c656t " 3661 UPDATE NDM-20 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1600 UPDATE Pseudomonas mutant PhoP conferring resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2436 UPDATE D-Ala-D-Ala ligase Van ligase; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8151 with +nt41:gagca " 2432 UPDATE Klebsiella pneumoniae OmpK35 General Bacterial Porin with reduced permeability to beta-lactams; cefoxitin; cefepime; ceftazidime; ceftriaxone; ertapenem; imipenem; benzylpenicillin; ampicillin; cefalotin; cefamandole; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; resistance by absence; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2434 UPDATE Klebsiella pneumoniae OmpK36 General Bacterial Porin with reduced permeability to beta-lactams; ceftriaxone; cefalotin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; resistance by absence; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3356 UPDATE OXA-296 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3269 UPDATE Clostridioides difficile rpoB with mutation conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3455 UPDATE OXA-292 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3483 UPDATE OXA-373 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3512 UPDATE OXA-442 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4134 UPDATE ACT-43 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2144 UPDATE Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol ethambutol resistant embB; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2476 UPDATE Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin 16S rRNA with mutation conferring resistance to pactamycin; pactamycin; pactamycin-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7809 with a633g UPDATED 7810 with c734t UPDATED 7811 with c735t UPDATED 7809 with a633g UPDATED 7810 with c734t UPDATED 7811 with c735t " 2478 UPDATE Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4758 with a965g UPDATED 4759 with a967c UPDATED 12458 with a928c UPDATED 12459 with a926g UPDATED 4758 with a965g UPDATED 4759 with a967c UPDATED 12458 with a928c UPDATED 12459 with a926g UPDATED 4761 with a965g,a967c UPDATED 4760 with a965g,g966t UPDATED 4762 with a965t,g966t,a967c UPDATED 12555 with a926t,g927t,a928c UPDATED 12556 with a926g,g927g,a928c " 3641 UPDATE LEN-42 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3456 UPDATE OXA-293 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2812 UPDATE Mycobacteroides chelonae 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7916 with a2272c UPDATED 7917 with a2272g UPDATED 7918 with a2273c UPDATED 7919 with a2273g UPDATED 7916 with a2272c UPDATED 7917 with a2272g UPDATED 7918 with a2273c UPDATED 7919 with a2273g " 3380 UPDATE Clostridioides difficile rpoC with mutation conferring resistance to vancomycin vancomycin-resistant beta prime subunit of RNA polymerase (rpoC); vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3485 UPDATE OXA-392 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2550 UPDATE Clostridioides difficile gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; ofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3457 UPDATE OXA-294 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3486 UPDATE OXA-400 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3513 UPDATE OXA-443 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3543 UPDATE OXA-482 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3587 UPDATE FONA-3 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3593 UPDATE FRI-2 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3642 UPDATE LEN-43 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3668 UPDATE NDM-27 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3727 UPDATE Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid isoniazid resistant mshA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9563 with A187V UPDATED 9563 with A187V DELETED 43013 " 3405 UPDATE OXA-402 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3428 UPDATE OXA-261 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3458 UPDATE OXA-295 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3487 UPDATE OXA-401 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3514 UPDATE OXA-444 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3544 UPDATE OXA-483 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3588 UPDATE FONA-4 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3594 UPDATE FRI-3 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3595 UPDATE FTU-1 FTU beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3596 UPDATE GOB-10 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3643 UPDATE LEN-51 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3669 UPDATE NDM-28 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2098 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2985 with g1475a UPDATED 4844 with g1475t UPDATED 2985 with g1475a UPDATED 4844 with g1475t " 3406 UPDATE OXA-140 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3429 UPDATE OXA-262 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3459 UPDATE OXA-297 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3488 UPDATE OXA-403 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3407 UPDATE OXA-103 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3430 UPDATE OXA-263 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3460 UPDATE OXA-298 OXA beta-lactamase; OXA-294-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2685 UPDATE Pseudomonas aeruginosa CpxR resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; erythromycin; amikacin; ciprofloxacin; kanamycin A; tetracycline; tobramycin; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3489 UPDATE OXA-404 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3515 UPDATE OXA-446 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3545 UPDATE OXA-484 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3589 UPDATE FONA-5 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3597 UPDATE GOB-11 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3644 UPDATE LEN-55 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2713 UPDATE MexXY-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3408 UPDATE OXA-122 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2659 UPDATE Klebsiella pneumoniae acrA resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2660 UPDATE Enterobacter cloacae acrA resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2661 UPDATE Escherichia coli acrA resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3431 UPDATE OXA-264 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3461 UPDATE OXA-299 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3490 UPDATE OXA-405 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3516 UPDATE OXA-447 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3546 UPDATE OXA-485 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3590 UPDATE FONA-6 FONA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3598 UPDATE GOB-12 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3645 UPDATE LEN-58 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 320 UPDATE Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1474 UPDATE MexR resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2682 UPDATE MexAB-OprM with NalC mutations conferring resistance to aztreonam resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2680 UPDATE MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1213 UPDATE nalD resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8153 with +nt410:tgttcatcgaactctgcgagcag UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2686 UPDATE MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3409 UPDATE OXA-123 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2688 UPDATE ArmR resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3432 UPDATE OXA-265 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2689 UPDATE Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid 23S rRNA with mutation conferring resistance to linezolid antibiotics; linezolid; macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; oxazolidinone antibiotic; glycopeptide antibiotic; phenicol antibiotic; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7940 with c2579t UPDATED 7941 with g2604t UPDATED 7940 with c2579t UPDATED 7941 with g2604t " 2691 UPDATE Type A NfxB resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3462 UPDATE OXA-300 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2693 UPDATE Type B NfxB resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3491 UPDATE OXA-406 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3517 UPDATE OXA-448 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3547 UPDATE OXA-486 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3599 UPDATE GOB-13 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2267 UPDATE Escherichia coli nfsA mutations conferring resistance to nitrofurantoin antibiotic resistant nfsA; nitrofurantoin; nitrofuran antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8189 with -nt25:t UPDATED 8190 with -nt603:c UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 8192 with Q44Ter UPDATED 8193 with K141Ter UPDATED 8194 with E233Ter " 2108 UPDATE Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A elfamycin resistant EF-Tu; GE2270A; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 624 UPDATE Mycobacterium leprae rpoB mutations conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1305 UPDATE OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; thiamphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; norfloxacin; ofloxacin; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2679 UPDATE MexAB-OprM with MexR mutations confers resistance to multiple antibiotics resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2695 UPDATE MexCD-OprJ with type B NfxB mutation resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2711 UPDATE MexXY-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4135 UPDATE ACT-44 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3410 UPDATE OXA-124 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3433 UPDATE OXA-266 OXA beta-lactamase; OXA-266-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3463 UPDATE OXA-301 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3492 UPDATE OXA-407 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3518 UPDATE OXA-449 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3522 UPDATE OXA-453 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3548 UPDATE OXA-488 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3549 UPDATE ARL-1 ARL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3559 UPDATE BCL-1 BCL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3565 UPDATE BRO-1 BRO Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3600 UPDATE GOB-14 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2743 UPDATE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; ceftazidime; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2744 UPDATE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2745 UPDATE AcrAB-TolC resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2756 UPDATE NDM-17 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3411 UPDATE OXA-125 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2901 UPDATE CFE-2 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3434 UPDATE OXA-267 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2768 UPDATE MdtEF-TolC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3464 UPDATE OXA-302 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2773 UPDATE TMB-1 TMB beta-lactamase; ceftazidime; carbapenem; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 2774 UPDATE TMB-2 TMB beta-lactamase; ceftazidime; carbapenem; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 2775 UPDATE Pseudomonas aeruginosa soxR ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; acriflavine; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3493 UPDATE OXA-408 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2787 UPDATE Moraxella catarrhalis M35 General Bacterial Porin with reduced permeability to beta-lactams; amoxicillin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; resistance by absence; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2781 UPDATE porin OmpC General Bacterial Porin with reduced permeability to beta-lactams; cefazolin; cephaloridine; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3519 UPDATE OXA-450 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3523 UPDATE OXA-455 OXA beta-lactamase; OXA-364-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2747 UPDATE AcrEF-TolC confers resistance to ciprofloxacin resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2786 UPDATE Burkholderia pseudomallei Omp38 General Bacterial Porin with reduced permeability to beta-lactams; cefoxitin; ceftazidime; imipenem; benzylpenicillin; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3550 UPDATE ARL-2 ARL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3560 UPDATE BES-1 BES Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3566 UPDATE BRO-2 BRO Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2790 UPDATE Serratia marcescens Omp1 General Bacterial Porin with reduced permeability to beta-lactams; cefoxitin; ciprofloxacin; tetracycline; ceftriaxone; chloramphenicol; cefotaxime; moxalactam; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; reduced permeability to antibiotic; resistance by absence; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2805 UPDATE Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; pleuromutilin; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7889 with a2072g UPDATED 7890 with a2073g UPDATED 7892 with g2461a UPDATED 7894 with c2069a UPDATED 7891 with g2075t UPDATED 7893 with a2517t UPDATED 7895 with g2461t UPDATED 7897 with a2586t UPDATED 7896 with t2518g UPDATED 7889 with a2072g UPDATED 7890 with a2073g UPDATED 7892 with g2461a UPDATED 7894 with c2069a UPDATED 7891 with g2075t UPDATED 7893 with a2517t UPDATED 7895 with g2461t UPDATED 7897 with a2586t UPDATED 7896 with t2518g " 2791 UPDATE Streptococcus mitis CdsA with mutation conferring daptomycin resistance daptomycin resistant CdsA; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2833 UPDATE Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin 23S rRNA with mutation conferring resistance to macrolide antibiotics; tylosin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8198 with a2058g UPDATED 8199 with a2058t UPDATED 8198 with a2058g UPDATED 8199 with a2058t " 2792 UPDATE Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7794 with a2330t UPDATED 7794 with a2330t " 2794 UPDATE Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7905 with a2146c UPDATED 7906 with a2146g UPDATED 7908 with a2147g UPDATED 7909 with a2147c UPDATED 7907 with a2146t UPDATED 12514 with a2143g UPDATED 12515 with a1410g UPDATED 12516 with a2167g UPDATED 12517 with c1707t UPDATED 12518 with c2922t UPDATED 12597 with a2144g UPDATED 13112 with a2142g UPDATED 7905 with a2146c UPDATED 7906 with a2146g UPDATED 7908 with a2147g UPDATED 7909 with a2147c UPDATED 7907 with a2146t UPDATED 12514 with a2143g UPDATED 12515 with a1410g UPDATED 12516 with a2167g UPDATED 12517 with c1707t UPDATED 12518 with c2922t UPDATED 12597 with a2144g UPDATED 13112 with a2142g UPDATED 12519 with c2248t,g2287a " 2798 UPDATE AxyZ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cefepime; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2806 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin 23S rRNA with mutation conferring resistance to lincosamide antibiotics; clindamycin; lincosamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7898 with g2032a UPDATED 7898 with g2032a " 2807 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7899 with g2032t UPDATED 7899 with g2032t " 2808 UPDATE Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7900 with g2281a UPDATED 7901 with g2294a UPDATED 7902 with g2295a UPDATED 7900 with g2281a UPDATED 7901 with g2294a UPDATED 7902 with g2295a " 2803 UPDATE Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid aminosalicylate resistant thymidylate synthase; para-aminosalicylic acid; salicylic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 7856 with G76Ter UPDATED 7859 with W83Ter UPDATED 7861 with W98Ter UPDATED 8076 with -nt260:c UPDATED 8077 with -nt111:t UPDATED 8082 with -nt472:c UPDATED 8079 with +nt217:cacgagcac UPDATED 8080 with +nt372:t " 2804 UPDATE Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid aminosalicylate resistant dihydrofolate synthase; para-aminosalicylic acid; salicylic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2816 UPDATE Mycolicibacterium smegmatis 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7925 with a2266g UPDATED 7926 with a2267g UPDATED 7925 with a2266g UPDATED 7926 with a2267g " 2811 UPDATE Mycobacterium avium 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7913 with a2272c UPDATED 7914 with a2274g UPDATED 7915 with a2274t UPDATED 7913 with a2272c UPDATED 7914 with a2274g UPDATED 7915 with a2274t " 2813 UPDATE Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8173 with a2266c UPDATED 8174 with a2266g UPDATED 8172 with a2266t UPDATED 8173 with a2266c UPDATED 8174 with a2266g UPDATED 8172 with a2266t " 2814 UPDATE Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to azithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7923 with a2268c UPDATED 7923 with a2268c " 2815 UPDATE Mycobacterium kansasii 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8171 with a2265t UPDATED 8171 with a2265t " 2793 UPDATE Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7817 with g1628g UPDATED 7818 with g1627a UPDATED 7817 with g1628g UPDATED 7818 with g1627a " 2802 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; telithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7847 with g2057a UPDATED 7848 with a2058g UPDATED 7845 with t754a UPDATED 7849 with a2058t UPDATED 7850 with c2611t UPDATED 7847 with g2057a UPDATED 7848 with a2058g UPDATED 7845 with t754a UPDATED 7849 with a2058t UPDATED 7850 with c2611t " 2810 UPDATE Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7910 with a2271g UPDATED 7911 with a2272g UPDATED 7912 with a2272c UPDATED 8349 with a2058c UPDATED 8350 with a2058g UPDATED 8351 with a2058t UPDATED 8352 with a2059c UPDATED 8353 with a2059g UPDATED 7910 with a2271g UPDATED 7911 with a2272g UPDATED 7912 with a2272c UPDATED 8349 with a2058c UPDATED 8350 with a2058g UPDATED 8351 with a2058t UPDATED 8352 with a2059c UPDATED 8353 with a2059g " 2817 UPDATE Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; spiramycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8175 with a2125g UPDATED 8176 with a2126g UPDATED 8177 with c2641a UPDATED 8178 with c2641g UPDATED 8175 with a2125g UPDATED 8176 with a2126g UPDATED 8177 with c2641a UPDATED 8178 with c2641g " 2819 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics; linezolid; oxazolidinone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7932 with g2032a UPDATED 7934 with g2032c UPDATED 7933 with g2032t UPDATED 7935 with g2447t UPDATED 7932 with g2032a UPDATED 7934 with g2032c UPDATED 7933 with g2032t UPDATED 7935 with g2447t " 2820 UPDATE Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; azithromycin; josamycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7939 with a2663c UPDATED 8725 with c196a UPDATED 9884 with a2107c UPDATED 9885 with a2107g UPDATED 9886 with a2109g UPDATED 9887 with t2663c UPDATED 7939 with a2663c UPDATED 8725 with c196a UPDATED 9884 with a2107c UPDATED 9885 with a2107g UPDATED 9886 with a2109g UPDATED 9887 with t2663c " 3412 UPDATE OXA-126 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2824 UPDATE Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7945 with a2063g UPDATED 7946 with a2064g UPDATED 7945 with a2063g UPDATED 7946 with a2064g " 2825 UPDATE Halobacterium halobium 23S rRNA mutation conferring resistance to chloramphenicol 23S rRNA with mutation conferring resistance to phenicol antibiotics; chloramphenicol; phenicol antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7947 with a2088c UPDATED 7948 with c2471t UPDATED 7947 with a2088c UPDATED 7948 with c2471t " 2826 UPDATE Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; 23S rRNA with mutation conferring resistance to streptogramins antibiotics; tylosin; pristinamycin IA; virginiamycin M1; josamycin; macrolide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7949 with a2129c UPDATED 7949 with a2129c " 2827 UPDATE Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid aminosalicylate resistant dihydrofolate reductase; para-aminosalicylic acid; salicylic acid antibiotic; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A SNP in the promoter region of a gene which alters transcription of that gene, encoded as [wild-type][-][position][mutation], for example t-11c. Var represents any possible substitution. This is a pilot parameter in need of further documentation. UPDATED 8013 with g-11a " 2828 UPDATE mecD methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2834 UPDATE Mycobacterium tuberculosis iniB with mutation conferring resistance to ethambutol Ethambutol resistant iniB; ethambutol; polyamine antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A SNP in the promoter region of a gene which alters transcription of that gene, encoded as [wild-type][-][position][mutation], for example t-11c. Var represents any possible substitution. This is a pilot parameter in need of further documentation. UPDATED 8201 with c-89t " 2836 UPDATE Bla2 subclass B1 Bacillus anthracis Bla beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2839 UPDATE GOB-18 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2840 UPDATE NPS-1 NPS beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2841 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to chloramphenicol 23S rRNA with mutation conferring resistance to phenicol antibiotics; chloramphenicol; phenicol antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8226 with g2057a UPDATED 8226 with g2057a " 3621 UPDATE LAP-2 LAP beta-lactamase; cefepime; cefuroxime; amoxicillin; piperacillin; benzylpenicillin; cefalotin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2844 UPDATE Rhodobacter sphaeroides ampC beta-lactamase ampC-type beta-lactamase; benzylpenicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2822 UPDATE Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; telithromycin; clarithromycin; tylosin; spiramycin; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7942 with g2087a UPDATED 7943 with a2578t UPDATED 7942 with g2087a UPDATED 7943 with a2578t " 2843 UPDATE Escherichia coli ampC beta-lactamase ampC-type beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 2377 UPDATE Escherichia coli PtsI with mutation conferring resistance to fosfomycin antibiotic-resistant ptsI phosphotransferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2850 UPDATE Salmonella enterica gyrA with mutation conferring resistance to triclosan triclosan resistant gyrA; triclosan; disinfecting agents and antiseptics; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2900 UPDATE EBR-2 EBR beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2851 UPDATE Escherichia coli gyrA with mutation conferring resistance to triclosan triclosan resistant gyrA; triclosan; disinfecting agents and antiseptics; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2874 UPDATE ACI-1 ACI beta-lactamase; ceftazidime; amoxicillin; cefotaxime; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 2876 UPDATE OXA-436 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2877 UPDATE OXA-535 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3413 UPDATE OXA-127 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3435 UPDATE OXA-268 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2886 UPDATE Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; ampicillin; cefaclor; cefotaxime; cefditoren; cefdinir; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3436 UPDATE OXA-269 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2889 UPDATE TRU-1 TRU beta-lactamase; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 237 UPDATE Chryseobacterium meningosepticum BlaB BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3465 UPDATE OXA-303 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3494 UPDATE OXA-409 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3520 UPDATE OXA-451 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3524 UPDATE OXA-457 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3551 UPDATE ARL-3 ARL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3567 UPDATE CBP-1 CBP beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3601 UPDATE GOB-15 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3701 UPDATE Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfisoxazole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3415 UPDATE OXA-151 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3437 UPDATE OXA-270 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3466 UPDATE OXA-304 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3495 UPDATE OXA-411 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3521 UPDATE OXA-452 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3525 UPDATE OXA-458 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3552 UPDATE ARL-4 ARL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3568 UPDATE CGA-1 CGA beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3602 UPDATE GOB-16 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; model_sequences; ARO_category "UPDATED accession with AAW82618.1 UPDATED sequence with MRNFAILFFLLITFSWKAQVVKEPENTNEEWSRSYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGLAGSLPMIKENIKKLGFNYKDIKILLLTQAHYDHTGALKDLQTETGAKFYADSADADVLKTGGKSDYEMGKYGATFKAIKPDILLKDQDKIKLGNTTLTLLHHPGHTKGSCSFIFETKDENRNYKVLIANMPSVIVDRKFSEIKDYPNIQADYAYTFKAMKKLDFDLWVASHASQFDLHTKHKEGDPYNPQVFMDKANYFAFLNSLETDYLEKIKNDSQKK UPDATED accession with AY899331.1 UPDATED fmin with 0 UPDATED fmax with 873 UPDATED strand with + UPDATED sequence with ATGAGAAACTTTGCAATTTTATTTTTTTTACTGATCACTTTCAGCTGGAAAGCACAGGTTGTTAAAGAACCGGAAAATACAAATGAAGAATGGTCCCGATCATATGAGCCATTCAGAATTGCGGGTAACTTATACTATGTAGGAACTTACGATCTGGCTTCTTATTTAATAGTTACCGATAAAGGAAATATTCTCATTAATACAGGATTGGCTGGTTCTCTTCCTATGATAAAAGAGAATATTAAAAAACTGGGATTCAATTATAAAGACATTAAAATTCTGCTTTTAACCCAGGCGCATTATGATCATACAGGTGCATTAAAAGATTTGCAAACAGAAACAGGTGCGAAATTTTATGCAGACAGTGCTGATGCTGATGTATTGAAAACGGGCGGTAAATCCGATTATGAAATGGGGAAATACGGGGCAACCTTTAAGGCGATTAAGCCTGATATCCTGTTGAAAGATCAGGATAAAATAAAACTGGGGAATACAACCTTAACTTTACTTCATCATCCGGGGCACACAAAAGGTTCATGCAGTTTTATATTTGAAACAAAGGATGAAAACAGAAATTATAAAGTGCTGATAGCCAATATGCCATCGGTTATAGTTGACCGTAAGTTTTCCGAAATAAAAGATTACCCTAATATTCAGGCCGATTATGCTTATACATTTAAAGCCATGAAAAAACTGGATTTTGATCTTTGGGTCGCTTCACATGCAAGTCAGTTTGATTTACATACAAAACATAAAGAGGGAGACCCTTATAACCCACAGGTATTTATGGATAAGGCCAATTATTTTGCATTCCTCAATAGCCTGGAAACAGATTATCTGGAAAAAATTAAAAACGACTCACAAAAGAAATAA UPDATED partial with 0 UPDATED NCBI_taxonomy_cvterm_id with 36960 UPDATED NCBI_taxonomy_name with Elizabethkingia meningoseptica UPDATED NCBI_taxonomy_id with 238 DELETED 5800 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3416 UPDATE OXA-152 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3438 UPDATE OXA-271 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3467 UPDATE OXA-305 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3496 UPDATE OXA-412 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3526 UPDATE OXA-459 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3553 UPDATE ARL-5 ARL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3603 UPDATE GOB-2 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3620 UPDATE LAP-1 LAP beta-lactamase; cefepime; cefuroxime; amoxicillin; piperacillin; benzylpenicillin; cefalotin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3417 UPDATE OXA-153 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3439 UPDATE OXA-272 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3468 UPDATE OXA-306 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3497 UPDATE OXA-413 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3527 UPDATE OXA-460 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3554 UPDATE ARL-6 ARL Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3564 UPDATE BPU-1 BPU Beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3604 UPDATE GOB-3 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3418 UPDATE OXA-154 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3440 UPDATE OXA-273 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3498 UPDATE OXA-414 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3528 UPDATE OXA-461 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3555 UPDATE AST-1 AST Beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3605 UPDATE GOB-4 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3419 UPDATE OXA-155 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3441 UPDATE OXA-275 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3470 UPDATE OXA-308 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3499 UPDATE OXA-416 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3529 UPDATE OXA-464 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3606 UPDATE GOB-5 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3420 UPDATE OXA-156 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3442 UPDATE OXA-276 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3471 UPDATE OXA-336 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3503 UPDATE OXA-430 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3500 UPDATE OXA-417 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3530 UPDATE OXA-465 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3607 UPDATE GOB-6 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3579 UPDATE CMY-135 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3652 UPDATE CMY-136 CMY beta-lactamase; cefuroxime; cefotaxime; ceftolozane; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Ceftolozane is a fifth-generation cephalosporin antibiotic developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics. DELETED 35962 " 3626 UPDATE LEN-37 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3636 UPDATE LEN-34 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3994 UPDATE TEM-231 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3580 UPDATE DES-1 DES beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2909 UPDATE OXA-664 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2910 UPDATE OXA-665 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3421 UPDATE OXA-157 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2912 UPDATE OXA-274 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2913 UPDATE OXA-286 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3443 UPDATE OXA-277 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3472 UPDATE OXA-337 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2960 UPDATE OXA-663 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3501 UPDATE OXA-427 OXA beta-lactamase; OXA-427-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3531 UPDATE OXA-466 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3422 UPDATE OXA-158 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3654 UPDATE Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin Zoliflodacin resistant gyrB; Zoliflodacin; zoliflodacin-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3444 UPDATE OXA-279 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3473 UPDATE OXA-339 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3502 UPDATE OXA-429 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3532 UPDATE OXA-470 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3574 UPDATE CKO-1 CKO beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3608 UPDATE GOB-7 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3618 UPDATE IMP-49 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3623 UPDATE LEN-25 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3627 UPDATE SHV-4 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3628 UPDATE Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; cefixime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3633 UPDATE OXA-724 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3656 UPDATE Burkholderia dolosa gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3657 UPDATE NDM-15 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3423 UPDATE OXA-185 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3445 UPDATE OXA-280 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3474 UPDATE OXA-340 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3533 UPDATE OXA-471 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3575 UPDATE CME-1 CME beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3577 UPDATE CMY-132 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3609 UPDATE GOB-8 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3619 UPDATE IMP-52 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3624 UPDATE LEN-35 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3660 UPDATE NDM-19 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2785 UPDATE Klebsiella pneumoniae OmpK37 General Bacterial Porin with reduced permeability to beta-lactams; cefoxitin; cefotaxime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3634 UPDATE LEN-30 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3651 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to capreomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; capreomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13259 with a1401g UPDATED 13334 with g1484t UPDATED 14212 with c1402t UPDATED 14742 with a1401g UPDATED 14746 with c1402t UPDATED 14757 with g1484t UPDATED 9445 with a1401g UPDATED 9446 with g1484t UPDATED 9447 with a514c UPDATED 9279 with a1401g UPDATED 13259 with a1401g UPDATED 13334 with g1484t UPDATED 14212 with c1402t UPDATED 14742 with a1401g UPDATED 14746 with c1402t UPDATED 14757 with g1484t UPDATED 9445 with a1401g UPDATED 9446 with g1484t UPDATED 9447 with a514c UPDATED 9279 with a1401g DELETED 42998 " 3653 UPDATE SCO-1 SCO beta-lactamase; cefepime; ceftazidime; cefuroxime; amoxicillin; piperacillin; cefotaxime; cefalotin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 3995 UPDATE TEM-232 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3629 UPDATE Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 3329 UPDATE Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin fluoroquinolone resistant parC; moxifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3646 UPDATE Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 9376 with ggataaaaagtcttttt:dela UPDATED 9377 with ggataaaaagtcttttt:instt UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9355 with c2600t UPDATED 9356 with a2145g UPDATED 9357 with c2597t UPDATED 9358 with a2045g UPDATED 10522 with a2059g UPDATED 10523 with c2611t UPDATED 9355 with c2600t UPDATED 9356 with a2145g UPDATED 9357 with c2597t UPDATED 9358 with a2045g UPDATED 10522 with a2059g UPDATED 10523 with c2611t " 3649 UPDATE Neisseria gonorrhoeae mtrR with mutation conferring resistance resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9876 with -nt-ggataaaaagtcttttt:a UPDATED 9877 with +nt-ggataaaaagtcttttt:tt " 3631 UPDATE Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3014 UPDATE IMP-55 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3015 UPDATE IMP-56 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3424 UPDATE OXA-234 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3446 UPDATE OXA-281 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3475 UPDATE OXA-341 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3504 UPDATE OXA-431 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3534 UPDATE OXA-472 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3578 UPDATE CMY-133 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3024 UPDATE KPC-24 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3610 UPDATE GOB-9 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3625 UPDATE LEN-36 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3635 UPDATE LEN-32 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3659 UPDATE NDM-18 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3425 UPDATE OXA-252 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3447 UPDATE OXA-282 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3476 UPDATE OXA-342 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3505 UPDATE OXA-432 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3535 UPDATE OXA-473 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3426 UPDATE OXA-259 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3448 UPDATE OXA-283 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3477 UPDATE OXA-343 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3506 UPDATE OXA-433 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3536 UPDATE OXA-474 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3637 UPDATE LEN-38 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3427 UPDATE OXA-260 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3449 UPDATE OXA-284 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3478 UPDATE OXA-344 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3507 UPDATE OXA-437 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3537 UPDATE OXA-475 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3581 UPDATE DHA-9 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 3638 UPDATE LEN-39 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3662 UPDATE NDM-21 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3252 UPDATE Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8567 with a2074c UPDATED 8568 with a2075g UPDATED 8567 with a2074c UPDATED 8568 with a2075g " 4129 UPDATE ACT-34 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3996 UPDATE TEM-233 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3254 UPDATE NDM-11 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3639 UPDATE LEN-40 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3267 UPDATE Clostridioides difficile murG with mutation conferring resistance to vancomycin murG transferase; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3266 UPDATE CAM-1 CAM beta-lactamase; cefoxitin; ceftazidime; meropenem; imipenem; doripenem; cefotaxime; ceftolozane; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Ceftolozane is a fifth-generation cephalosporin antibiotic developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3272 UPDATE PNGM-1 PNGM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3281 UPDATE Acinetobacter baumannii AbuO resistance-nodulation-cell division (RND) antibiotic efflux pump; amikacin; tigecycline; streptomycin; carbenicillin; ceftriaxone; meropenem; benzalkonium chloride; chlorhexidine; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3990 UPDATE TEM-227 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4130 UPDATE ACT-39 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3298 UPDATE Klebsiella pneumoniae KpnG major facilitator superfamily (MFS) antibiotic efflux pump; erythromycin; gentamicin C; ciprofloxacin; spectinomycin; streptomycin; tobramycin; ceftazidime; ertapenem; piperacillin; azithromycin; imipenem; polymyxin B; polymyxin B1; polymyxin B2; polymyxin B3; polymyxin B4; norfloxacin; ticarcillin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3299 UPDATE Klebsiella pneumoniae KpnH major facilitator superfamily (MFS) antibiotic efflux pump; erythromycin; gentamicin C; ciprofloxacin; spectinomycin; streptomycin; tobramycin; ceftazidime; ertapenem; piperacillin; azithromycin; imipenem; polymyxin B; polymyxin B1; polymyxin B2; polymyxin B3; polymyxin B4; norfloxacin; ticarcillin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3450 UPDATE OXA-285 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3479 UPDATE OXA-345 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3508 UPDATE OXA-438 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3538 UPDATE OXA-476 OXA beta-lactamase; OXA-63-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3582 UPDATE ERP-1 ERP beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3663 UPDATE NDM-22 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3751 UPDATE TEM-181 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3758 UPDATE VMB-1 VMB beta-lactamase; ceftriaxone; amoxicillin; meropenem; imipenem; ampicillin; cefotaxime; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3760 UPDATE CMY-150 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3761 UPDATE LMB-1 LMB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3762 UPDATE IMP-68 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3766 UPDATE FRI-4 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3767 UPDATE FRI-5 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3768 UPDATE FRI-6 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3769 UPDATE FRI-7 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3770 UPDATE FRI-8 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3771 UPDATE FRI-9 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3772 UPDATE FLC-1 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3779 UPDATE Yrc-1 YRC beta-lactamase; cefoxitin; ceftazidime; cefuroxime; amoxicillin; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; model_name; ARO_name; CARD_short_name; ARO_description; ARO_category "UPDATED model_name with YRC-1 UPDATED ARO_name with YRC-1 UPDATED CARD_short_name with YRC-1 UPDATED ARO_description with YRC-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase. UPDATED category_aro_name with YRC beta-lactamase UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3783 UPDATE YajC resistance-nodulation-cell division (RND) antibiotic efflux pump; vancomycin; tigecycline; tetracycline; linezolid; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; oxazolidinone antibiotic; glycopeptide antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3790 UPDATE MecC-type methicillin resistance repressor MecI methicillin resistant PBP2; methicillin; penicillin beta-lactam; antibiotic target replacement; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3809 UPDATE ROB-3 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3800 UPDATE OXA-837 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3805 UPDATE ParS resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr); erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; imipenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3806 UPDATE ParR resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr); erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; imipenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3810 UPDATE ROB-4 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3811 UPDATE ROB-5 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3812 UPDATE ROB-6 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3813 UPDATE ROB-7 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3815 UPDATE ROB-8 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3816 UPDATE ROB-10 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3817 UPDATE Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics; tiamulin; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3818 UPDATE Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; tiamulin; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9965 with g2061a UPDATED 9966 with g2061t UPDATED 9967 with a2451t UPDATED 9968 with c2452t UPDATED 9969 with t2500a UPDATED 9970 with t2504g UPDATED 9965 with g2061a UPDATED 9966 with g2061t UPDATED 9967 with a2451t UPDATED 9968 with c2452t UPDATED 9969 with t2500a UPDATED 9970 with t2504g " 3814 UPDATE ROB-2 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3826 UPDATE OXA-899 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3827 UPDATE OXA-898 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3829 UPDATE mecC-type BlaZ BlaZ beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35971 " 3834 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide prothionamide resistant katG; prothionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 10039 with -nt1384:a DELETED 43012 " 3836 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid isoniazid resistant ethA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 10075 with R279Ter UPDATED 10090 with E420Ter UPDATED 10107 with W289Ter UPDATED 10105 with -nt385:a UPDATED 10106 with -nt1339:c UPDATED 10108 with -nt455:c UPDATED 10109 with -nt697:t UPDATED 10116 with -nt43:g UPDATED 10089 with -nt822:g UPDATED 10098 with -nt751:a UPDATED 10099 with -nt884:t UPDATED 10100 with -nt1043:t UPDATED 10101 with -nt1133:c UPDATED 10119 with -nt34:g UPDATED 10091 with +nt213:a UPDATED 10094 with +nt755:g UPDATED 10095 with +nt756:g UPDATED 10097 with +nt757:c UPDATED 10103 with +nt11:a UPDATED 10104 with +nt797:g UPDATED 10112 with +nt1247:a UPDATED 10114 with +nt673:g UPDATED 10092 with +nt342:a UPDATED 10093 with +nt672:g UPDATED 10118 with +nt1219:a DELETED 43012 " 3837 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide prothionamide resistant ethA; prothionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 10135 with R279Ter UPDATED 10150 with E420Ter UPDATED 10167 with W289Ter UPDATED 10148 with -nt822:g UPDATED 10158 with -nt751:a UPDATED 10159 with -nt884:t UPDATED 10160 with -nt1043:t UPDATED 10161 with -nt1133:c UPDATED 10168 with -nt455:c UPDATED 10169 with -nt697:t UPDATED 10176 with -nt1043:t UPDATED 10177 with -nt34:g UPDATED 10181 with -nt1033:a UPDATED 10165 with -nt385:a UPDATED 10166 with -nt1339:c UPDATED 10151 with +nt213:a UPDATED 10152 with +nt342:a UPDATED 10153 with +nt672:g UPDATED 10154 with +nt755:c UPDATED 10155 with +nt756:c UPDATED 10156 with +nt757:c UPDATED 10163 with +nt11:a UPDATED 10164 with +nt797:g UPDATED 10172 with +nt1247:a UPDATED 10174 with +nt673:g UPDATED 10179 with +nt1219:a UPDATED 10180 with +nt1336:c DELETED 43012 " 3838 UPDATE Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide prothionamide resistant mshA; prothionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3839 UPDATE blaS1 blaS; cefoxitin; carbenicillin; oxacillin; ceftriaxone; piperacillin; ampicillin; mezlocillin; cefixime; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3856 UPDATE OXA-846 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3857 UPDATE NDM-29 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3862 UPDATE OXA-906 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3864 UPDATE OXA-850 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3991 UPDATE TEM-228 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3883 UPDATE OXA-668 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3884 UPDATE OXA-818 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3885 UPDATE OXA-812 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3890 UPDATE CMY-134 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3891 UPDATE CMY-143 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3892 UPDATE CMY-107 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3893 UPDATE CMY-158 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3894 UPDATE CMY-173 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3896 UPDATE CMY-147 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3897 UPDATE CMY-146 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3898 UPDATE CMY-156 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3899 UPDATE CMY-160 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3900 UPDATE CMY-162 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3901 UPDATE CMY-140 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3902 UPDATE CMY-164 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3903 UPDATE CMY-161 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3904 UPDATE CMY-165 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3905 UPDATE CMY-166 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3906 UPDATE CMY-149 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3907 UPDATE CMY-139 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3908 UPDATE CMY-148 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3909 UPDATE CMY-163 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3910 UPDATE CMY-154 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3911 UPDATE CMY-142 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3912 UPDATE CMY-141 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3913 UPDATE CMY-124 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3914 UPDATE CMY-125 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3915 UPDATE CMY-145 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3916 UPDATE CMY-122 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3917 UPDATE CMY-157 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3918 UPDATE CMY-171 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3919 UPDATE CMY-155 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3920 UPDATE CMY-96 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3922 UPDATE SHV-205 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3923 UPDATE SHV-222 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3924 UPDATE SHV-198 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3925 UPDATE SHV-195 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3926 UPDATE SHV-201 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3927 UPDATE SHV-212 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3928 UPDATE SHV-204 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3929 UPDATE SHV-197 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3930 UPDATE SHV-216 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3931 UPDATE CMY-121 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3932 UPDATE CMY-152 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3933 UPDATE CMY-97 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3934 UPDATE CMY-151 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3935 UPDATE CMY-128 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3936 UPDATE CMY-129 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3992 UPDATE TEM-229 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3993 UPDATE TEM-230 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3937 UPDATE CMY-127 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3938 UPDATE CMY-89 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3939 UPDATE CMY-153 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3940 UPDATE CMY-130 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4131 UPDATE ACT-40 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3941 UPDATE CMY-144 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3942 UPDATE CMY-138 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 3944 UPDATE OXA-544 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3945 UPDATE SHV-194 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3946 UPDATE SHV-220 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3947 UPDATE SHV-210 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3948 UPDATE SHV-208 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3949 UPDATE SHV-206 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3950 UPDATE SHV-226 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3951 UPDATE SHV-196 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3952 UPDATE SHV-211 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3953 UPDATE SHV-219 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3954 UPDATE SHV-199 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3955 UPDATE SHV-227 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3956 UPDATE SHV-223 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3957 UPDATE SHV-214 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3958 UPDATE SHV-207 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3959 UPDATE SHV-1b-b SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3960 UPDATE SHV-218 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3961 UPDATE SHV-193 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3962 UPDATE SHV-224 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3963 UPDATE SHV-225 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3964 UPDATE SHV-209 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3965 UPDATE SHV-215 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3969 UPDATE SHV-228 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3970 UPDATE SHV-200 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3971 UPDATE SHV-203 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3972 UPDATE SHV-217 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3973 UPDATE SHV-213 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3974 UPDATE SHV-221 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3975 UPDATE SHV-202 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3976 UPDATE TEM-5 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3977 UPDATE TEM-9 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3978 UPDATE TEM-31 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3979 UPDATE TEM-32 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3980 UPDATE TEM-35 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3981 UPDATE TEM-36 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3982 UPDATE TEM-37 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3983 UPDATE TEM-39 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3985 UPDATE TEM-210 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3986 UPDATE TEM-212 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3987 UPDATE TEM-224 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3988 UPDATE TEM-225 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3989 UPDATE TEM-226 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3997 UPDATE TEM-234 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3998 UPDATE TEM-235 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 3999 UPDATE TEM-236 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4000 UPDATE TEM-237 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4001 UPDATE TEM-238 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4002 UPDATE TEM-240 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4003 UPDATE TEM-241 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4004 UPDATE TEM-242 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4005 UPDATE TEM-243 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4046 UPDATE OXA-540 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4047 UPDATE OXA-779 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4048 UPDATE OXA-838 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4049 UPDATE OXA-539 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4050 UPDATE OXA-543 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4051 UPDATE OXA-681 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4052 UPDATE OXA-737 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4053 UPDATE OXA-541 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4054 UPDATE OXA-835 OXA beta-lactamase; OXA-46-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4055 UPDATE OXA-926 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4104 UPDATE KPC-39 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4056 UPDATE OXA-570 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4057 UPDATE OXA-573 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4058 UPDATE OXA-571 OXA beta-lactamase; OXA-60-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4059 UPDATE OXA-672 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4060 UPDATE OXA-671 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4061 UPDATE OXA-673 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4062 UPDATE OXA-931 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4063 UPDATE OXA-930 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4064 UPDATE OXA-895 OXA beta-lactamase; OXA-229-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4065 UPDATE OXA-641 OXA beta-lactamase; OXA-372-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4067 UPDATE OXA-496 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4068 UPDATE OXA-915 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4070 UPDATE OXA-648 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4071 UPDATE OXA-646 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4072 UPDATE OXA-649 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4073 UPDATE OXA-897 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4074 UPDATE OXA-653 OXA beta-lactamase; OXA-24-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4075 UPDATE OXA-499 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4076 UPDATE OXA-825 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4088 UPDATE KPC-23 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4089 UPDATE KPC-25 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4090 UPDATE KPC-26 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4091 UPDATE KPC-18 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4092 UPDATE KPC-27 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4093 UPDATE KPC-29 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4094 UPDATE KPC-28 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4095 UPDATE KPC-31 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4096 UPDATE KPC-32 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4097 UPDATE KPC-30 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4098 UPDATE KPC-33 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4099 UPDATE KPC-34 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4100 UPDATE KPC-35 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4101 UPDATE KPC-36 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4102 UPDATE KPC-37 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4103 UPDATE KPC-38 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4105 UPDATE KPC-40 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4106 UPDATE KPC-41 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4107 UPDATE KPC-42 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4108 UPDATE KPC-43 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4109 UPDATE KPC-45 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4110 UPDATE KPC-46 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4111 UPDATE KPC-49 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4112 UPDATE KPC-50 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4113 UPDATE KPC-51 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4114 UPDATE KPC-52 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4115 UPDATE KPC-54 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4116 UPDATE KPC-55 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4117 UPDATE KPC-56 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4118 UPDATE KPC-57 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4123 UPDATE ACC-1a ACC beta-lactamase; cefepime; ceftazidime; piperacillin; aztreonam; cefotaxime; cefotetan; flomoxef; moxalactam; cefpirome; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4124 UPDATE ACC-1b ACC beta-lactamase; cefepime; ceftazidime; piperacillin; aztreonam; cefotaxime; cefotetan; flomoxef; moxalactam; cefpirome; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4125 UPDATE ACC-1c ACC beta-lactamase; cefepime; ceftazidime; piperacillin; aztreonam; cefotaxime; cefotetan; flomoxef; moxalactam; cefpirome; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4126 UPDATE ACC-1d ACC beta-lactamase; cefepime; ceftazidime; piperacillin; aztreonam; cefotaxime; cefotetan; flomoxef; moxalactam; cefpirome; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4127 UPDATE ACC-7 ACC beta-lactamase; ceftazidime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4128 UPDATE ACC-8 ACC beta-lactamase; ceftazidime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4136 UPDATE ACT-45 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4137 UPDATE ACT-46 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4138 UPDATE ACT-47 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4139 UPDATE ACT-48 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4140 UPDATE ACT-49 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4141 UPDATE ACT-50 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4142 UPDATE ACT-51 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4143 UPDATE ACT-52 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4144 UPDATE ACT-53 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4145 UPDATE ACT-54 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4146 UPDATE ACT-55 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4147 UPDATE ACT-56 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4148 UPDATE ACT-57 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4149 UPDATE ACT-58 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4150 UPDATE ACT-59 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4151 UPDATE ACT-60 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4152 UPDATE ACT-61 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4153 UPDATE ACT-62 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4154 UPDATE ACT-63 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4155 UPDATE ACT-64 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4156 UPDATE ACT-65 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4157 UPDATE ACT-66 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4158 UPDATE ACT-67 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4159 UPDATE ACT-68 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4160 UPDATE ACT-69 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4161 UPDATE ACT-70 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4162 UPDATE ACT-72 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4163 UPDATE ACT-73 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4164 UPDATE ACT-74 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4165 UPDATE ACT-75 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4166 UPDATE ACT-76 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4167 UPDATE ACT-77 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4168 UPDATE ACT-78 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4169 UPDATE ACT-79 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4170 UPDATE ACT-80 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4171 UPDATE ACT-81 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4172 UPDATE ACT-82 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4173 UPDATE ACT-83 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4174 UPDATE ACT-84 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4175 UPDATE ACT-87 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4368 UPDATE BEL-4 BEL beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4370 UPDATE BlaB-1 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4371 UPDATE BlaB-10 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4372 UPDATE BlaB-11 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4373 UPDATE BlaB-12 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4374 UPDATE BlaB-13 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4375 UPDATE BlaB-14 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4376 UPDATE BlaB-15 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4377 UPDATE BlaB-16 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4378 UPDATE BlaB-17 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4379 UPDATE BlaB-18 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4380 UPDATE BlaB-19 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4381 UPDATE BlaB-2 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4382 UPDATE BlaB-20 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4383 UPDATE BlaB-22 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4384 UPDATE BlaB-23 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4385 UPDATE BlaB-24 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4386 UPDATE BlaB-25 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4387 UPDATE BlaB-26 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4388 UPDATE BlaB-27 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4389 UPDATE BlaB-28 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4390 UPDATE BlaB-29 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4391 UPDATE BlaB-3 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4392 UPDATE BlaB-30 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4393 UPDATE BlaB-31 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4394 UPDATE BlaB-32 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4395 UPDATE BlaB-33 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4396 UPDATE BlaB-34 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4397 UPDATE BlaB-35 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4398 UPDATE BlaB-36 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4399 UPDATE BlaB-38 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4400 UPDATE BlaB-39 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4401 UPDATE BlaB-5 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4402 UPDATE BlaB-6 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4403 UPDATE BlaB-7 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4404 UPDATE BlaB-8 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4405 UPDATE BlaB-9 BlaB beta-lactamase; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4409 UPDATE CARB-11 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4410 UPDATE CARB-24 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4411 UPDATE CARB-25 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4412 UPDATE CARB-26 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4413 UPDATE CARB-27 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4414 UPDATE CARB-28 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4415 UPDATE CARB-29 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4416 UPDATE CARB-30 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4417 UPDATE CARB-31 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4418 UPDATE CARB-32 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4419 UPDATE CARB-33 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4420 UPDATE CARB-34 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4421 UPDATE CARB-35 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4422 UPDATE CARB-36 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4423 UPDATE CARB-38 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4424 UPDATE CARB-40 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4425 UPDATE CARB-41 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4426 UPDATE CARB-42 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4427 UPDATE CARB-43 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4428 UPDATE CARB-44 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4429 UPDATE CARB-45 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4430 UPDATE CARB-46 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4431 UPDATE CARB-47 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4432 UPDATE CARB-48 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4433 UPDATE CARB-49 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4434 UPDATE CARB-50 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4435 UPDATE CARB-51 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4436 UPDATE CARB-52 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4437 UPDATE CARB-53 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4438 UPDATE CARB-54 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4439 UPDATE CARB-55 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4463 UPDATE CME-2 CME beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4469 UPDATE CMY-106 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4470 UPDATE CMY-109 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4471 UPDATE CMY-131 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4472 UPDATE CMY-137 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4473 UPDATE CMY-159 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4474 UPDATE CMY-167 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4475 UPDATE CMY-168 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4476 UPDATE CMY-169 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4477 UPDATE CMY-170 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4478 UPDATE CMY-174 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4479 UPDATE CMY-8b CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 4576 UPDATE DHA-23 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4577 UPDATE DHA-24 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4578 UPDATE DHA-25 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4579 UPDATE DHA-26 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4580 UPDATE DHA-27 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4581 UPDATE DHA-28 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4582 UPDATE DHA-29 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4583 UPDATE DHA-4 DHA beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4586 UPDATE EBR-3 EBR beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4587 UPDATE EBR-4 EBR beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4602 UPDATE FOX-12 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4603 UPDATE FOX-13 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4604 UPDATE FOX-14 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4605 UPDATE FOX-15 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4606 UPDATE FOX-16 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4607 UPDATE FOX-17 FOX beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 35962 " 4608 UPDATE FRI-10 FRI beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4609 UPDATE GES-25 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4610 UPDATE GES-27 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4611 UPDATE GES-28 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4612 UPDATE GES-29 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4613 UPDATE GES-30 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4614 UPDATE GES-31 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4615 UPDATE GES-32 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4616 UPDATE GES-33 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4617 UPDATE GES-34 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4618 UPDATE GES-35 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4619 UPDATE GES-36 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4620 UPDATE GES-37 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4621 UPDATE GES-38 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4622 UPDATE GES-39 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4623 UPDATE GES-40 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4624 UPDATE GES-41 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4625 UPDATE GES-42 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4626 UPDATE GES-43 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4627 UPDATE GES-44 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4628 UPDATE GES-45 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4629 UPDATE GES-46 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4632 UPDATE GOB-19 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4633 UPDATE GOB-20 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4634 UPDATE GOB-21 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4635 UPDATE GOB-22 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4636 UPDATE GOB-23 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4637 UPDATE GOB-24 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4638 UPDATE GOB-25 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4639 UPDATE GOB-26 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4640 UPDATE GOB-27 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4641 UPDATE GOB-28 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4642 UPDATE GOB-29 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4643 UPDATE GOB-30 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4644 UPDATE GOB-31 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4645 UPDATE GOB-32 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4646 UPDATE GOB-33 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4647 UPDATE GOB-34 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4648 UPDATE GOB-35 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4649 UPDATE GOB-36 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4650 UPDATE GOB-37 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4651 UPDATE GOB-38 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4652 UPDATE GOB-39 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4653 UPDATE GOB-40 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4654 UPDATE GOB-41 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4655 UPDATE GOB-42 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4656 UPDATE GOB-43 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4657 UPDATE GOB-44 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4658 UPDATE GOB-45 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4659 UPDATE GOB-46 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4660 UPDATE GOB-48 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4661 UPDATE GOB-49 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4662 UPDATE GOB-50 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4663 UPDATE GOB-51 GOB beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4679 UPDATE IMP-17 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4680 UPDATE IMP-23 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4681 UPDATE IMP-39 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4682 UPDATE IMP-46 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4683 UPDATE IMP-53 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4684 UPDATE IMP-54 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4685 UPDATE IMP-58 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4686 UPDATE IMP-59 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4687 UPDATE IMP-60 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4688 UPDATE IMP-61 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4689 UPDATE IMP-62 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4690 UPDATE IMP-63 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4691 UPDATE IMP-64 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4692 UPDATE IMP-65 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4693 UPDATE IMP-66 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4694 UPDATE IMP-67 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4695 UPDATE IMP-69 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4696 UPDATE IMP-70 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4697 UPDATE IMP-71 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4698 UPDATE IMP-73 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4699 UPDATE IMP-74 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4700 UPDATE IMP-75 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4701 UPDATE IMP-76 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4702 UPDATE IMP-77 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4703 UPDATE IMP-78 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4704 UPDATE IMP-79 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4705 UPDATE IMP-80 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4706 UPDATE IMP-81 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4707 UPDATE IMP-82 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4708 UPDATE IMP-83 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4709 UPDATE IMP-84 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4710 UPDATE IMP-85 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4711 UPDATE IMP-88 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4712 UPDATE IMP-89 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4719 UPDATE KPC-21 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4720 UPDATE KPC-44 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4721 UPDATE KPC-58 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4722 UPDATE KPC-59 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4723 UPDATE KPC-60 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4724 UPDATE KPC-61 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4725 UPDATE KPC-62 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4726 UPDATE KPC-63 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4727 UPDATE KPC-64 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4728 UPDATE KPC-65 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4729 UPDATE KPC-66 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4730 UPDATE KPC-71 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4731 UPDATE KPC-72 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4732 UPDATE KPC-73 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4733 UPDATE KPC-74 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4734 UPDATE KPC-75 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4735 UPDATE KPC-76 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4736 UPDATE KPC-77 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4737 UPDATE KPC-78 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4738 UPDATE KPC-79 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4739 UPDATE KPC-80 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4740 UPDATE KPC-81 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4741 UPDATE KPC-82 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4743 UPDATE LEN-27 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4744 UPDATE LEN-28 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4745 UPDATE LEN-31 LEN beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 4771 UPDATE MOX-10 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4772 UPDATE MOX-11 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4773 UPDATE MOX-12 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4774 UPDATE MOX-13 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4775 UPDATE MOX-14 MOX beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4778 UPDATE NDM-26 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4779 UPDATE NDM-30 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4780 UPDATE NDM-31 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 4782 UPDATE OKP-A-17 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4783 UPDATE OKP-B-16 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4784 UPDATE OKP-B-21 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4785 UPDATE OKP-B-22 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4786 UPDATE OKP-B-23 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4787 UPDATE OKP-B-24 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4788 UPDATE OKP-B-34 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4789 UPDATE OKP-B-36 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4790 UPDATE OKP-B-40 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4791 UPDATE OKP-B-41 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4792 UPDATE OKP-B-45 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4793 UPDATE OKP-C-1 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4794 UPDATE OKP-D-1 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4802 UPDATE OXA-114b OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4803 UPDATE OXA-114c OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4804 UPDATE OXA-114d OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4805 UPDATE OXA-114e OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4806 UPDATE OXA-114f OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4807 UPDATE OXA-114g OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4808 UPDATE OXA-114h OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4809 UPDATE OXA-114i OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4810 UPDATE OXA-114j OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4811 UPDATE OXA-114k OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4812 UPDATE OXA-114l OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4813 UPDATE OXA-114m OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4814 UPDATE OXA-114n OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4815 UPDATE OXA-114p OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4816 UPDATE OXA-114q OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4817 UPDATE OXA-114r OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4818 UPDATE OXA-114s OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4819 UPDATE OXA-114t OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4820 UPDATE OXA-114u OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4821 UPDATE OXA-114v OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4822 UPDATE OXA-114w OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4823 UPDATE OXA-114x OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4824 UPDATE OXA-159 OXA beta-lactamase; OXA-62-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4825 UPDATE OXA-193 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4826 UPDATE OXA-307 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4827 UPDATE OXA-395 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4828 UPDATE OXA-396 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4829 UPDATE OXA-489 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4830 UPDATE OXA-491 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4831 UPDATE OXA-493 OXA beta-lactamase; OXA-493-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4832 UPDATE OXA-494 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4833 UPDATE OXA-497 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4834 UPDATE OXA-498 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4835 UPDATE OXA-500 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4836 UPDATE OXA-501 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4837 UPDATE OXA-502 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4838 UPDATE OXA-503 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4839 UPDATE OXA-504 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4840 UPDATE OXA-505 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4841 UPDATE OXA-506 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4842 UPDATE OXA-507 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4843 UPDATE OXA-508 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4844 UPDATE OXA-509 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4845 UPDATE OXA-510 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4846 UPDATE OXA-511 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4847 UPDATE OXA-512 OXA beta-lactamase; OXA-58-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4848 UPDATE OXA-513 OXA beta-lactamase; OXA-364-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4849 UPDATE OXA-514 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4850 UPDATE OXA-515 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4851 UPDATE OXA-516 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4852 UPDATE OXA-517 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4853 UPDATE OXA-518 OXA beta-lactamase; OXA-493-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4854 UPDATE OXA-519 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4855 UPDATE OXA-520 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4856 UPDATE OXA-521 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4857 UPDATE OXA-522 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4858 UPDATE OXA-523 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4859 UPDATE OXA-524 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4860 UPDATE OXA-525 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4861 UPDATE OXA-526 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4862 UPDATE OXA-527 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4863 UPDATE OXA-528 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4864 UPDATE OXA-529 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4865 UPDATE OXA-530 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4866 UPDATE OXA-531 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4867 UPDATE OXA-532 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4868 UPDATE OXA-533 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4869 UPDATE OXA-534 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4870 UPDATE OXA-536 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4871 UPDATE OXA-537 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4872 UPDATE OXA-538 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4873 UPDATE OXA-542 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4874 UPDATE OXA-545 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4875 UPDATE OXA-546 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4876 UPDATE OXA-547 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4877 UPDATE OXA-548 OXA beta-lactamase; OXA-548-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4878 UPDATE OXA-549 OXA beta-lactamase; OXA-548-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4879 UPDATE OXA-550 OXA beta-lactamase; OXA-548-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4880 UPDATE OXA-551 OXA beta-lactamase; OXA-548-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4881 UPDATE OXA-552 OXA beta-lactamase; OXA-548-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4882 UPDATE OXA-553 OXA beta-lactamase; OXA-548-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4883 UPDATE OXA-554 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4884 UPDATE OXA-555 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4885 UPDATE OXA-556 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4886 UPDATE OXA-557 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4887 UPDATE OXA-558 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4888 UPDATE OXA-559 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4889 UPDATE OXA-560 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4890 UPDATE OXA-561 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4891 UPDATE OXA-562 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4892 UPDATE OXA-563 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4893 UPDATE OXA-564 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4894 UPDATE OXA-565 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4895 UPDATE OXA-566 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4896 UPDATE OXA-567 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4897 UPDATE OXA-568 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4898 UPDATE OXA-569 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4899 UPDATE OXA-572 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4900 UPDATE OXA-574 OXA beta-lactamase; OXA-22-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4901 UPDATE OXA-575 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4902 UPDATE OXA-576 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4903 UPDATE OXA-577 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4904 UPDATE OXA-578 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4905 UPDATE OXA-579 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4906 UPDATE OXA-580 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4907 UPDATE OXA-581 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4908 UPDATE OXA-582 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4909 UPDATE OXA-583 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4910 UPDATE OXA-584 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4911 UPDATE OXA-585 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4912 UPDATE OXA-586 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4913 UPDATE OXA-587 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4914 UPDATE OXA-588 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4915 UPDATE OXA-589 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4916 UPDATE OXA-590 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4917 UPDATE OXA-591 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4918 UPDATE OXA-592 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4919 UPDATE OXA-593 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4920 UPDATE OXA-594 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4921 UPDATE OXA-595 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4922 UPDATE OXA-596 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4923 UPDATE OXA-597 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4924 UPDATE OXA-598 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4925 UPDATE OXA-599 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4926 UPDATE OXA-600 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4927 UPDATE OXA-601 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4928 UPDATE OXA-602 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4929 UPDATE OXA-603 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4930 UPDATE OXA-604 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4931 UPDATE OXA-605 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4932 UPDATE OXA-606 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4933 UPDATE OXA-607 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4934 UPDATE OXA-608 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4935 UPDATE OXA-609 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4936 UPDATE OXA-610 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4937 UPDATE OXA-611 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4938 UPDATE OXA-612 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4939 UPDATE OXA-613 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4940 UPDATE OXA-614 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4941 UPDATE OXA-615 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4942 UPDATE OXA-616 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4943 UPDATE OXA-617 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4944 UPDATE OXA-618 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4945 UPDATE OXA-619 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4946 UPDATE OXA-620 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4947 UPDATE OXA-621 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4948 UPDATE OXA-622 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4949 UPDATE OXA-623 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4950 UPDATE OXA-624 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4951 UPDATE OXA-625 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4952 UPDATE OXA-626 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4953 UPDATE OXA-627 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4954 UPDATE OXA-628 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4955 UPDATE OXA-629 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4956 UPDATE OXA-630 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4957 UPDATE OXA-631 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4958 UPDATE OXA-632 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4959 UPDATE OXA-633 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4960 UPDATE OXA-634 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4961 UPDATE OXA-635 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4962 UPDATE OXA-636 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4963 UPDATE OXA-637 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4964 UPDATE OXA-638 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4965 UPDATE OXA-639 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4966 UPDATE OXA-640 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4967 UPDATE OXA-642 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4968 UPDATE OXA-643 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4969 UPDATE OXA-644 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4970 UPDATE OXA-645 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4971 UPDATE OXA-650 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4972 UPDATE OXA-651 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4973 UPDATE OXA-652 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4974 UPDATE OXA-654 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4975 UPDATE OXA-655 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4976 UPDATE OXA-656 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4977 UPDATE OXA-657 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4978 UPDATE OXA-658 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4979 UPDATE OXA-659 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4980 UPDATE OXA-660 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4981 UPDATE OXA-661 OXA beta-lactamase; OXA-266-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4982 UPDATE OXA-662 OXA beta-lactamase; OXA-211-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4983 UPDATE OXA-666 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4984 UPDATE OXA-667 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4985 UPDATE OXA-669 OXA beta-lactamase; OXA-274-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4986 UPDATE OXA-670 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4987 UPDATE OXA-674 OXA beta-lactamase; OXA-286-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4988 UPDATE OXA-675 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4989 UPDATE OXA-676 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4990 UPDATE OXA-677 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4991 UPDATE OXA-678 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4992 UPDATE OXA-679 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4993 UPDATE OXA-680 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4994 UPDATE OXA-682 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4995 UPDATE OXA-683 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4996 UPDATE OXA-684 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4997 UPDATE OXA-685 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4998 UPDATE OXA-686 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4999 UPDATE OXA-687 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5000 UPDATE OXA-688 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5001 UPDATE OXA-689 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5002 UPDATE OXA-690 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5003 UPDATE OXA-691 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5004 UPDATE OXA-692 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5005 UPDATE OXA-693 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5006 UPDATE OXA-694 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5007 UPDATE OXA-695 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5008 UPDATE OXA-696 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5009 UPDATE OXA-697 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5010 UPDATE OXA-698 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5011 UPDATE OXA-699 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5012 UPDATE OXA-700 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5013 UPDATE OXA-701 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5014 UPDATE OXA-702 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5015 UPDATE OXA-703 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5016 UPDATE OXA-704 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5017 UPDATE OXA-705 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5018 UPDATE OXA-706 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5019 UPDATE OXA-707 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5020 UPDATE OXA-708 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5021 UPDATE OXA-709 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5022 UPDATE OXA-710 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5023 UPDATE OXA-711 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5024 UPDATE OXA-712 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5025 UPDATE OXA-713 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5026 UPDATE OXA-714 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5027 UPDATE OXA-715 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5028 UPDATE OXA-716 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5029 UPDATE OXA-717 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5030 UPDATE OXA-718 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5031 UPDATE OXA-719 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5032 UPDATE OXA-720 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5033 UPDATE OXA-721 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5034 UPDATE OXA-722 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5035 UPDATE OXA-723 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5036 UPDATE OXA-726 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5037 UPDATE OXA-727 OXA beta-lactamase; OXA-727-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5038 UPDATE OXA-728 OXA beta-lactamase; OXA-727-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5039 UPDATE OXA-729 OXA beta-lactamase; OXA-55-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5040 UPDATE OXA-730 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5041 UPDATE OXA-731 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5042 UPDATE OXA-732 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5043 UPDATE OXA-733 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5044 UPDATE OXA-734 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5045 UPDATE OXA-735 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5046 UPDATE OXA-736 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5047 UPDATE OXA-738 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5048 UPDATE OXA-739 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5049 UPDATE OXA-740 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5050 UPDATE OXA-741 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5051 UPDATE OXA-742 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5052 UPDATE OXA-743 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5053 UPDATE OXA-744 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5054 UPDATE OXA-745 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5055 UPDATE OXA-746 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5056 UPDATE OXA-747 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5057 UPDATE OXA-748 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5058 UPDATE OXA-749 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5059 UPDATE OXA-750 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5060 UPDATE OXA-751 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5061 UPDATE OXA-752 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5062 UPDATE OXA-753 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5063 UPDATE OXA-754 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5064 UPDATE OXA-755 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5065 UPDATE OXA-756 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5066 UPDATE OXA-757 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5067 UPDATE OXA-758 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5068 UPDATE OXA-759 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5069 UPDATE OXA-760 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5070 UPDATE OXA-761 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5071 UPDATE OXA-762 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5072 UPDATE OXA-763 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5073 UPDATE OXA-764 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5074 UPDATE OXA-765 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5075 UPDATE OXA-766 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5076 UPDATE OXA-767 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5077 UPDATE OXA-768 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5078 UPDATE OXA-769 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5079 UPDATE OXA-770 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5080 UPDATE OXA-771 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5081 UPDATE OXA-772 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5082 UPDATE OXA-773 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5083 UPDATE OXA-774 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5084 UPDATE OXA-775 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5085 UPDATE OXA-776 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5086 UPDATE OXA-777 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5087 UPDATE OXA-778 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5088 UPDATE OXA-780 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5089 UPDATE OXA-781 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5090 UPDATE OXA-782 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5091 UPDATE OXA-783 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5092 UPDATE OXA-784 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5093 UPDATE OXA-785 OXA beta-lactamase; OXA-184-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5094 UPDATE OXA-786 OXA beta-lactamase; OXA-61-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5095 UPDATE OXA-787 OXA beta-lactamase; OXA-364-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5096 UPDATE OXA-788 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5097 UPDATE OXA-789 OXA beta-lactamase; OXA-364-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5098 UPDATE OXA-793 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5099 UPDATE OXA-794 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5100 UPDATE OXA-795 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5101 UPDATE OXA-796 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5102 UPDATE OXA-797 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5103 UPDATE OXA-798 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5104 UPDATE OXA-799 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5105 UPDATE OXA-800 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5106 UPDATE OXA-801 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5107 UPDATE OXA-802 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5108 UPDATE OXA-803 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5109 UPDATE OXA-804 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5110 UPDATE OXA-805 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5111 UPDATE OXA-806 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5112 UPDATE OXA-807 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5113 UPDATE OXA-808 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5114 UPDATE OXA-809 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5115 UPDATE OXA-810 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5116 UPDATE OXA-811 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5117 UPDATE OXA-813 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5118 UPDATE OXA-814 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5119 UPDATE OXA-815 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5120 UPDATE OXA-816 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5121 UPDATE OXA-817 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5122 UPDATE OXA-819 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5123 UPDATE OXA-820 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5124 UPDATE OXA-821 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5125 UPDATE OXA-822 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5126 UPDATE OXA-823 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5127 UPDATE OXA-824 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5128 UPDATE OXA-826 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5129 UPDATE OXA-827 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5130 UPDATE OXA-828 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5131 UPDATE OXA-829 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5132 UPDATE OXA-830 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5133 UPDATE OXA-831 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5134 UPDATE OXA-832 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5135 UPDATE OXA-833 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5136 UPDATE OXA-834 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5137 UPDATE OXA-836 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5138 UPDATE OXA-839 OXA beta-lactamase; OXA-114-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5139 UPDATE OXA-840 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5140 UPDATE OXA-841 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5141 UPDATE OXA-842 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5142 UPDATE OXA-843 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5143 UPDATE OXA-844 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5144 UPDATE OXA-845 OXA beta-lactamase; OXA-214-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5145 UPDATE OXA-847 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5146 UPDATE OXA-848 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5147 UPDATE OXA-849 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5148 UPDATE OXA-851 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5149 UPDATE OXA-852 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5150 UPDATE OXA-853 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5151 UPDATE OXA-854 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5152 UPDATE OXA-855 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5153 UPDATE OXA-856 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5154 UPDATE OXA-857 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5155 UPDATE OXA-858 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5156 UPDATE OXA-859 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5157 UPDATE OXA-860 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5158 UPDATE OXA-861 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5159 UPDATE OXA-862 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5160 UPDATE OXA-863 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5161 UPDATE OXA-864 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5162 UPDATE OXA-865 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5163 UPDATE OXA-866 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5164 UPDATE OXA-867 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5165 UPDATE OXA-868 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5166 UPDATE OXA-869 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5167 UPDATE OXA-870 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5168 UPDATE OXA-871 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5169 UPDATE OXA-872 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5170 UPDATE OXA-873 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5171 UPDATE OXA-874 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5172 UPDATE OXA-875 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5173 UPDATE OXA-876 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5174 UPDATE OXA-877 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5175 UPDATE OXA-878 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5176 UPDATE OXA-879 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5177 UPDATE OXA-880 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5178 UPDATE OXA-881 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5179 UPDATE OXA-882 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5180 UPDATE OXA-883 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5181 UPDATE OXA-884 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5182 UPDATE OXA-885 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5183 UPDATE OXA-886 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5184 UPDATE OXA-887 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5185 UPDATE OXA-888 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5186 UPDATE OXA-889 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5187 UPDATE OXA-890 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5188 UPDATE OXA-891 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5189 UPDATE OXA-892 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5190 UPDATE OXA-893 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5191 UPDATE OXA-894 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5192 UPDATE OXA-896 OXA beta-lactamase; OXA-9-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5193 UPDATE OXA-900 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5194 UPDATE OXA-901 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5195 UPDATE OXA-902 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5196 UPDATE OXA-903 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5197 UPDATE OXA-904 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5198 UPDATE OXA-905 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5199 UPDATE OXA-907 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5200 UPDATE OXA-908 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5201 UPDATE OXA-909 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5202 UPDATE OXA-910 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5203 UPDATE OXA-911 OXA beta-lactamase; OXA-23-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5204 UPDATE OXA-912 OXA beta-lactamase; OXA-12-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5205 UPDATE OXA-913 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5206 UPDATE OXA-914 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5207 UPDATE OXA-916 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5208 UPDATE OXA-917 OXA beta-lactamase; OXA-427-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5209 UPDATE OXA-918 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5210 UPDATE OXA-919 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5211 UPDATE OXA-920 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5212 UPDATE OXA-921 OXA beta-lactamase; OXA-1-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5213 UPDATE OXA-922 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5214 UPDATE OXA-923 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5215 UPDATE OXA-924 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5216 UPDATE OXA-925 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5217 UPDATE OXA-927 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5218 UPDATE OXA-928 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5219 UPDATE OXA-929 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5220 UPDATE OXA-932 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5221 UPDATE OXA-935 OXA beta-lactamase; OXA-10-like beta-lactamase; oxacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5222 UPDATE OXA-937 OXA beta-lactamase; OXA-50-like beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5223 UPDATE OXA-938 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5224 UPDATE OXA-939 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5225 UPDATE OXA-940 OXA beta-lactamase; OXA-51-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5226 UPDATE OXA-941 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5227 UPDATE OXA-942 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5228 UPDATE OXA-943 OXA beta-lactamase; OXA-213-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5229 UPDATE OXA-945 OXA beta-lactamase; OXA-143-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5230 UPDATE OXA-946 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5231 UPDATE OXA-947 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5232 UPDATE OXA-948 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5233 UPDATE OXA-949 OXA beta-lactamase; OXA-679-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5234 UPDATE OXY-2-11 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5235 UPDATE OXY-2-12 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5236 UPDATE OXY-2-13 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5237 UPDATE OXY-2-14 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5238 UPDATE OXY-2-15 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5613 UPDATE PER-10 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5614 UPDATE PER-11 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5615 UPDATE PER-12 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5616 UPDATE PER-13 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5617 UPDATE PER-14 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5618 UPDATE PER-15 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5619 UPDATE PER-16 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5620 UPDATE PER-8 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5621 UPDATE PER-9 PER beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5652 UPDATE SHV-115 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5653 UPDATE SHV-116 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5654 UPDATE SHV-132 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5655 UPDATE SHV-146 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5656 UPDATE SHV-171 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5657 UPDATE SHV-190 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5658 UPDATE SHV-191 SHV beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5659 UPDATE SIM-2 SIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5668 UPDATE TEM-98 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5669 UPDATE TEM-99 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5689 UPDATE VHH-1 VHH beta-lactamase; ampicillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5690 UPDATE VHW-1 VHW beta-lactamase; ampicillin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5691 UPDATE VIM-40 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5692 UPDATE VIM-41 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5693 UPDATE VIM-44 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5694 UPDATE VIM-45 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5695 UPDATE VIM-46 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5696 UPDATE VIM-47 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5697 UPDATE VIM-48 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5698 UPDATE VIM-49 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5699 UPDATE VIM-50 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5700 UPDATE VIM-51 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5701 UPDATE VIM-52 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5702 UPDATE VIM-53 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5703 UPDATE VIM-54 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5704 UPDATE VIM-55 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5705 UPDATE VIM-56 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5706 UPDATE VIM-57 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5707 UPDATE VIM-58 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5708 UPDATE VIM-59 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5709 UPDATE VIM-60 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5710 UPDATE VIM-61 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5711 UPDATE VIM-62 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5712 UPDATE VIM-63 VIM beta-lactamase; cefepime; ceftazidime; ertapenem; meropenem; imipenem; ampicillin; cefotaxime; faropenem; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5713 UPDATE VIM-64 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5714 UPDATE VIM-65 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5715 UPDATE VIM-66 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5716 UPDATE VIM-67 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5717 UPDATE VIM-68 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5718 UPDATE VIM-69 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5719 UPDATE VIM-70 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5720 UPDATE VIM-71 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5721 UPDATE VIM-72 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5722 UPDATE VIM-73 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5727 UPDATE mdeA major facilitator superfamily (MFS) antibiotic efflux pump; ciprofloxacin; acriflavine; kanamycin A; tetracycline; oxacillin; ampicillin; nalidixic acid; fluoroquinolone antibiotic; aminoglycoside antibiotic; penicillin beta-lactam; tetracycline antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5736 UPDATE NDM-33 NDM beta-lactamase; ciprofloxacin; ceftazidime; fluoroquinolone antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2823 UPDATE Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 8308 with g2057a UPDATED 8308 with g2057a " 332 UPDATE R39 R39 beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 826 UPDATE TolC ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; gentamicin C; tigecycline; ciprofloxacin; spectinomycin; streptomycin; tetracycline; tobramycin; oxacillin; ceftazidime; ertapenem; piperacillin; novobiocin; azithromycin; rifampin; imipenem; chloramphenicol; polymyxin B; polymyxin B1; polymyxin B2; polymyxin B3; polymyxin B4; ampicillin; nalidixic acid; norfloxacin; cefalotin; triclosan; ticarcillin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 1812 UPDATE KHM-1 KHM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 3 UPDATE Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics General Bacterial Porin with reduced permeability to beta-lactams; cefepime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2148 UPDATE Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2086 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 2900 with a964g UPDATED 12977 with a1055g UPDATED 12979 with g1053a UPDATED 12978 with c1054t UPDATED 2900 with a964g UPDATED 12977 with a1055g UPDATED 12979 with g1053a UPDATED 12978 with c1054t " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; ofloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 3453 UPDATE OXA-289 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2223 UPDATE MexZ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2254 UPDATE Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid antibiotic resistant fusA; fusidic acid; fusidane antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2256 UPDATE Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid antibiotic resistant fusE; fusidic acid; fusidane antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2272 UPDATE Enterococcus faecalis cls with mutation conferring resistance to daptomycin daptomycin resistant cls; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2080 UPDATE Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4818 with c1192t UPDATED 4818 with c1192t " 2300 UPDATE Acinetobacter baumannii ampC beta-lactamase ampC-type beta-lactamase; cefepime; piperacillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3330 UPDATE Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones fluoroquinolone resistant gyrA; moxifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2375 UPDATE Rm3 Rm3 family beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2405 UPDATE Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; sitafloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2482 UPDATE Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 4749 with a474c UPDATED 4751 with a858c UPDATED 4752 with a859g UPDATED 4753 with a1123g UPDATED 4754 with a1123c UPDATED 4755 with g1125a UPDATED 4750 with c856t UPDATED 4748 with t14g UPDATED 4749 with a474c UPDATED 4751 with a858c UPDATED 4752 with a859g UPDATED 4753 with a1123g UPDATED 4754 with a1123c UPDATED 4755 with g1125a UPDATED 4750 with c856t UPDATED 4748 with t14g " 3403 UPDATE Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide pyrazinamide resistant rpsA; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_type with frameshift mutation UPDATED param_description with A frameshift mutation, caused by a nucleotide insertion or deletion that does not equal 3 bases, encoded as [wild-type][position]fs, for example S531fs. Termination can also be denoted as: Ter[position]fs. UPDATED param_type_id with 40494 UPDATED 9722 with Ter482fs UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 9719 with A381V UPDATED 9720 with A412V UPDATED 9721 with A440T UPDATED 9719 with A381V UPDATED 9720 with A412V UPDATED 9721 with A440T DELETED 42998 " 2287 UPDATE Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid antibiotic resistant ndh; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 1745 UPDATE KPC-2 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2666 UPDATE Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan antibiotic resistant fabI; triclosan; disinfecting agents and antiseptics; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2683 UPDATE MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 2681 UPDATE Escherichia coli fabG mutations conferring resistance to triclosan antibiotic resistant fabG; triclosan; disinfecting agents and antiseptics; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 2694 UPDATE MexCD-OprJ with type A NfxB mutation resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5943 UPDATE TEM-247 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2818 UPDATE Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; spiramycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 7931 with a2305g UPDATED 7931 with a2305g " 3268 UPDATE Clostridioides difficile gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; ciprofloxacin; levofloxacin; moxifloxacin; gemifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5751 UPDATE OXA-290 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5752 UPDATE Helicobacter pylori gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; levofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A set of nucleotide or amino acid substitutions in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[SNP 1],[SNP 2],etc+[cvterm_id gene 2],[SNP 1],[SNP 2],etc. For example: 39879,A90V,M94V+40052,D472H. A nucleotide substitution resulting in a change from an amino acid codon to a stop codon is encoded as [wild type amino acid][position][Ter], for example Q42Ter. " 5753 UPDATE Helicobacter pylori gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; levofloxacin; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A set of nucleotide or amino acid substitutions in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[SNP 1],[SNP 2],etc+[cvterm_id gene 2],[SNP 1],[SNP 2],etc. For example: 39879,A90V,M94V+40052,D472H. A nucleotide substitution resulting in a change from an amino acid codon to a stop codon is encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5756 UPDATE Helicobacter pylori pbp3 conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5757 UPDATE Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5758 UPDATE Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 12510 with L610Ter UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5759 UPDATE Helicobacter pylori frxA mutation conferring resistance to metronidazole Antibiotic resistant Helicobacter pylori nitroreductase; metronidazole; nitroimidazole antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 12437 with R86Ter UPDATED 12455 with L39Ter UPDATED 12462 with K105Ter UPDATED 12463 with M149Ter UPDATED 12464 with A192Ter UPDATED 12461 with E199Ter UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A set of nucleotide or amino acid substitutions in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[SNP 1],[SNP 2],etc+[cvterm_id gene 2],[SNP 1],[SNP 2],etc. For example: 39879,A90V,M94V+40052,D472H. A nucleotide substitution resulting in a change from an amino acid codon to a stop codon is encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 12440 with 45615,N73Ter+45620,R3T UPDATED 12450 with 45615,M21V,A80T,Q119Ter+45620,A70V UPDATED 12460 with 45615,L717F,Q113Ter+45620,L39Ter UPDATED param_description with A set of nonsense mutations in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[wild-type][position][Ter]+[cvterm_id gene 2],[wild-type][position][Ter], etc. For example: 45615,Q11Ter+45620,Q5Ter. UPDATED 12443 with 45615,Q11Ter+45620,Q5Ter " 5761 UPDATE VAM-1 VAM beta-lactamase; tetracycline; ceftriaxone; ampicillin; cefotaxime; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 4069 UPDATE OXA-647 OXA beta-lactamase; OXA-134-like beta-lactamase; oxacillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5750 UPDATE Helicobacter pylori rpoB mutation conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); levofloxacin; rifampin; fluoroquinolone antibiotic; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5763 UPDATE Neisseria gonorrhoeae rpld 50S rRNA with mutation conferring resistance to macrolide antibiotics; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5767 UPDATE Bacillus subtilis rpoB mutants conferring resistance to rifampin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5769 UPDATE PRC-1 PRC beta-lactamase; cefazolin; ceftriaxone; amoxicillin; benzylpenicillin; ampicillin; cefotaxime; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5770 UPDATE KPC-90 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5771 UPDATE KPC-83 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5775 UPDATE BcIII class A Bacillus cereus Bc beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "DELETED 40360 " 5776 UPDATE KPC-93 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5795 UPDATE ROB-11 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5796 UPDATE ROB-12 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3808 UPDATE ROB-13 ROB beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5799 UPDATE MAB class A Mycobacterium abscessus beta-lactamase; ceftazidime; cefuroxime; amoxicillin; cefalotin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5800 UPDATE blaC class A Mycobacterium tuberculosis bla beta-lactamase; cefoxitin; amoxicillin; cefalotin; temocillin; ticarcillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5801 UPDATE Mycobacterium tuberculosis Rv1258c mutations confer resistance to ethambutol and capreomycin multidrug resistant Rv1258c; ethambutol; capreomycin; aminoglycoside antibiotic; polyamine antibiotic; isoniazid-like antibiotic; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5802 UPDATE Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin multidrug resistant Rv1258c; streptomycin; isoniazid; pyrazinamide; aminoglycoside antibiotic; polyamine antibiotic; isoniazid-like antibiotic; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5755 UPDATE Helicobacter pylori rdxA mutation conferring resistance to metronidazole Antibiotic resistant Helicobacter pylori nitroreductase; metronidazole; nitroimidazole antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 12411 with Q50Ter UPDATED 12412 with Q5Ter UPDATED 12438 with N73Ter UPDATED 12482 with A50Ter UPDATED 13116 with D59Ter UPDATED param_description with A set of nucleotide or amino acid substitutions in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[SNP 1],[SNP 2],etc+[cvterm_id gene 2],[SNP 1],[SNP 2],etc. For example: 39879,A90V,M94V+40052,D472H. A nucleotide substitution resulting in a change from an amino acid codon to a stop codon is encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED 12441 with 45615,N73Ter+45620,R3T UPDATED 12449 with 45615,M21V,A80T,Q119Ter+45620,A70V UPDATED param_description with A set of nonsense mutations in different genes that are all required to confer resistance to an antibiotic drug or drug class, encoded as: [cvterm_id gene 1],[wild-type][position][Ter]+[cvterm_id gene 2],[wild-type][position][Ter], etc. For example: 45615,Q11Ter+45620,Q5Ter. UPDATED 12442 with 45615,Q11Ter+45620,Q5Ter " 2092 UPDATE Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; acriflavine; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5811 UPDATE KPC-123 KPC beta-lactamase; cefepime; ceftazidime; cefotaxime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 3658 UPDATE NDM-16a NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5815 UPDATE NDM-16b NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5818 UPDATE KBL-1 KBL beta-lactamase; amoxicillin; piperacillin; benzylpenicillin; ampicillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5816 UPDATE Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5822 UPDATE NDM-34 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5823 UPDATE NDM-35 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5824 UPDATE NDM-36 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5825 UPDATE NDM-37 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5826 UPDATE NDM-38 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5827 UPDATE NDM-39 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5828 UPDATE NDM-40 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5829 UPDATE NDM-41 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5830 UPDATE NDM-42 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5831 UPDATE NDM-43 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5901 UPDATE PJM-1 PJM beta-lactamase; cefoxitin; imipenem; ampicillin; cefotaxime; cefalotin; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; model_sequences; ARO_category "UPDATED accession with WP_213603971.1 UPDATED sequence with MTLRSTLLSALVALALPSAALASDATTAKACADDAGWNDPATPLKVYGNTWYVGTCGISALLVTSDEGHILVDAATPQAGPQILANIRALGFKPEDVRAIVFSHEHFDHAGSLAELQQATGAPVYARAPAVATLKRGASDRSDPQHEVLDPFAPVQQVVVLDDDGVVRVGPLALQVVSTPGHTPGGTSWTWRSCEGDDCRQMVYADSLTAISDDVYRYSDDAAHPGYVAAFRETLARVAALECDILVTPHPSASQLWSRIGPRADRPLVDTSACRTYAQTATQRLDKRLADEASKPPVPAP UPDATED accession with NG_080789.1 UPDATED fmin with 100 UPDATED fmax with 1006 UPDATED strand with + UPDATED sequence with ATGACGCTCCGCTCCACCCTGCTTTCCGCTCTGGTCGCGCTCGCGCTTCCCTCCGCCGCGCTCGCTTCCGACGCGACCACGGCCAAAGCCTGCGCCGACGATGCCGGCTGGAACGATCCCGCCACGCCGCTGAAGGTCTACGGCAACACCTGGTACGTCGGCACGTGCGGCATCAGCGCCTTGCTGGTGACCTCCGATGAAGGCCACATCCTGGTCGACGCCGCCACGCCGCAGGCCGGCCCGCAGATCCTCGCCAATATCCGCGCCCTCGGCTTCAAGCCGGAGGATGTGCGTGCCATCGTGTTCTCGCACGAGCACTTCGACCATGCCGGCAGCCTGGCCGAGTTGCAGCAGGCCACGGGCGCGCCTGTGTATGCGCGTGCGCCTGCCGTTGCCACGCTCAAGCGCGGCGCCAGCGATCGCAGCGATCCGCAGCATGAGGTACTCGATCCGTTCGCGCCGGTCCAGCAGGTGGTCGTACTCGACGACGACGGCGTGGTGCGTGTCGGTCCGCTCGCCCTGCAGGTCGTTTCCACGCCGGGACACACGCCCGGCGGCACCAGCTGGACCTGGCGCTCGTGCGAGGGCGACGACTGCCGGCAGATGGTCTACGCCGACAGCCTGACCGCGATCTCCGACGACGTGTACCGCTACAGCGACGATGCGGCGCACCCTGGTTACGTGGCGGCATTCCGCGAGACGCTGGCGCGGGTCGCGGCACTCGAGTGCGACATCCTGGTGACGCCACATCCGTCGGCCAGCCAACTCTGGTCCCGCATCGGTCCTCGCGCCGACCGCCCGCTGGTCGACACCAGCGCCTGCCGCACCTATGCACAGACCGCGACGCAGCGGCTGGACAAGCGGCTCGCGGACGAAGCGTCGAAGCCCCCCGTGCCTGCGCCTTGA UPDATED partial with 0 UPDATED NCBI_taxonomy_cvterm_id with 46123 UPDATED NCBI_taxonomy_name with Pseudoxanthomonas japonensis UPDATED NCBI_taxonomy_id with 69284 DELETED 8595 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5902 UPDATE KPC-87 KPC beta-lactamase; meropenem; imipenem; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5903 UPDATE KPC-86 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5904 UPDATE KPC-95 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5906 UPDATE KPC-94 KPC beta-lactamase; ceftazidime; meropenem; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5923 UPDATE Klebsiella pneumoniae lamB with mutations conferring resistance to ceftazidime-avibactam Sugar Porin (SP); ceftazidime; fluoroquinolone antibiotic; cephalosporin; tetracycline antibiotic; reduced permeability to antibiotic; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5924 UPDATE Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftazidime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5972 UPDATE Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13255 with a1401g UPDATED 13330 with g1484t UPDATED 13072 with a1401g UPDATED 13074 with g1484t UPDATED 13075 with c462t UPDATED 13076 with a514c UPDATED 13077 with c1402t UPDATED 13255 with a1401g UPDATED 13330 with g1484t UPDATED 13072 with a1401g UPDATED 13074 with g1484t UPDATED 13075 with c462t UPDATED 13076 with a514c UPDATED 13077 with c1402t " 5974 UPDATE Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13257 with a1401g UPDATED 13078 with a1401g UPDATED 13080 with g1484t UPDATED 13081 with c462t UPDATED 13082 with a514c UPDATED 13083 with c1402t UPDATED 13257 with a1401g UPDATED 13078 with a1401g UPDATED 13080 with g1484t UPDATED 13081 with c462t UPDATED 13082 with a514c UPDATED 13083 with c1402t " 6038 UPDATE VIM-77 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6040 UPDATE VIM-79 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6042 UPDATE VIM-81 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5965 UPDATE Shigella flexneri acrA resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5930 UPDATE KPC-96 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5931 UPDATE EBR-5 EBR beta-lactamase; ceftazidime; cefuroxime; piperacillin; ampicillin; cefalotin; ceftiofur; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic predominantly used in veterinary medicine. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5932 UPDATE LAQ-1 LAQ beta lactamase; cefoxitin; cefazolin; cefepime; benzylpenicillin; ampicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5933 UPDATE WUS-1 WUS beta-lactamase; carbenicillin; imipenem; ampicillin; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5934 UPDATE SSA SSA beta-lactamase; cefoxitin; ceftazidime; amoxicillin; ampicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5935 UPDATE NDM-44 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5936 UPDATE NDM-45 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5937 UPDATE KPC-100 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5938 UPDATE NDM-46 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5939 UPDATE NDM-47 NDM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5941 UPDATE KPC-97 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5942 UPDATE KPC-98 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5940 UPDATE TEM-246 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5944 UPDATE TEM-244 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5945 UPDATE KPC-99 KPC beta-lactamase; ceftazidime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5946 UPDATE TEM-245 TEM beta-lactamase; ceftazidime; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 5950 UPDATE IMP-96 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5951 UPDATE IMP-92 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5952 UPDATE IMP-93 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5953 UPDATE IMP-94 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5954 UPDATE IMP-95 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5956 UPDATE Mycobacterium avium gyrA with mutation conferring resistance to Fluoroquinolone fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; moxifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_name; model_param; ARO_name "UPDATED model_name with Mycobacterium avium gyrA with mutation conferring resistance to fluoroquinolone UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED ARO_name with Mycobacterium avium gyrA with mutation conferring resistance to fluoroquinolone " 5949 UPDATE IMP-91 IMP beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5960 UPDATE Mycobacterium abscessus atpE with mutation conferring resistance to bedaquiline antibiotic resistant ATP synthase; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5961 UPDATE Pseudomonas aeruginosa ampR with mutation conferring resistance to aztreonam PDC beta-lactamase; ampR transcriptional regulator with mutation conferring resistance to monobactam antibiotics; aztreonam; monobactam; carbapenem; cephalosporin; antibiotic target alteration; antibiotic inactivation; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5969 UPDATE Bacillus subtilis rpsE mutations conferring resistance to spectinomycin spectinomycin resistant rpsE; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5970 UPDATE Streptococcus pyogenes PBP2x conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; ampicillin; cefotaxime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param; ARO_category "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5976 UPDATE Erysipelothrix rhusiopathiae gyrA with mutation conferring resistance to enrofloxacin fluoroquinolone resistant gyrA; enrofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 5977 UPDATE OXA-1038 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; meropenem; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5978 UPDATE OXA-1039 OXA beta-lactamase; OXA-48-like beta-lactamase; oxacillin; meropenem; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5979 UPDATE FRI-11 FRI beta-lactamase; ertapenem; meropenem; imipenem; carbapenem; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5980 UPDATE KPC-125 KPC beta-lactamase; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5981 UPDATE CAE-1 CAE beta-lactamase; cefazolin; ceftriaxone; cefuroxime; piperacillin; ampicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 5986 UPDATE PSZ-1 PSZ beta-lactamase; cefoxitin; cefazolin; amoxicillin; benzylpenicillin; ampicillin; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 5987 UPDATE CDA-1 clavulanic acid; CDA beta-lactamase; cefoxitin; cefalotin; ticarcillin; cephaloridine; ticarcillin-clavulanic acid; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 3000008 UPDATED category_aro_cvterm_id with 36017 UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 6037 UPDATE VIM-76 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6039 UPDATE VIM-78 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6041 UPDATE VIM-80 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6043 UPDATE VIM-82 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6044 UPDATE VIM-83 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6045 UPDATE VIM-84 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6006 UPDATE OXA-481 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6007 UPDATE TEM-103 TEM beta-lactamase; amoxicillin; ampicillin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 6008 UPDATE TEM-61 TEM beta-lactamase; ceftazidime; aztreonam; ampicillin; cefotaxime; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 6009 UPDATE OKP-B-14 OKP beta-lactamase; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6010 UPDATE OXA-105 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6004 UPDATE Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline bedaquiline resistant Rv0678; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; model_param; ARO_category "UPDATED param_type with nonsense mutation UPDATED param_description with A nucleotide substitution resulting in a change from an amino acid codon to a stop codon, encoded as [wild type amino acid][position][Ter], for example Q42Ter. UPDATED param_type_id with 40394 UPDATED 14494 with W42Ter UPDATED 14559 with Y92Ter UPDATED 14583 with E113Ter UPDATED 14585 with Q115Ter UPDATED 14594 with R132Ter UPDATED 14595 with R134Ter UPDATED 14598 with E138Ter UPDATED 14604 with Y145Ter UPDATED 14608 with E147Ter UPDATED 14611 with R156Ter UPDATED 14615 with Y157Ter UPDATED 14470 with Q22Ter UPDATED 14487 with R38Ter UPDATED 14517 with S53Ter UPDATED 14545 with Q76Ter UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 14477 with L32S UPDATED 14485 with A36V UPDATED 14495 with C46R UPDATED 14530 with I67S UPDATED 14535 with N70D UPDATED 14588 with L117R UPDATED 14591 with G121R UPDATED 14606 with M146T UPDATED 14477 with L32S UPDATED 14485 with A36V UPDATED 14495 with C46R UPDATED 14530 with I67S UPDATED 14535 with N70D UPDATED 14588 with L117R UPDATED 14591 with G121R UPDATED 14606 with M146T UPDATED category_aro_description with Loss-of-function mutations in the Mycobacterium Rv0678 gene associated with bedaquiline resistance. " 6012 UPDATE Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline bedaquiline resistant Rv2535c; clofazimine; bedaquiline; fluoroquinolone antibiotic; diarylquinoline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 6013 UPDATE AMZ-1 AMZ beta-lactamase; cefoxitin; amoxicillin; benzylpenicillin; ampicillin; cefalotin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6014 UPDATE CMY-185 CMY beta-lactamase; cephalosporin; antibiotic inactivation; ARO_category "UPDATED category_aro_accession with 0000032 UPDATED category_aro_cvterm_id with 35951 UPDATED category_aro_name with cephalosporin UPDATED category_aro_description with Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. UPDATED category_aro_class_name with Drug Class DELETED 35962 " 6015 UPDATE Salmonella gallinarum folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfamethoxazole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 6016 UPDATE Salmonella isangi gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 6017 UPDATE Salmonella isangi gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 6011 UPDATE MdtQ Outer Membrane Porin (Opr); monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6019 UPDATE Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. UPDATED 13171 with a2100g UPDATED 13172 with a2101g UPDATED 13171 with a2100g UPDATED 13172 with a2101g " 6022 UPDATE Vibrio vulnificus rpoB mutants conferring resistance to rifampin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 6023 UPDATE OXA-410 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 355 UPDATE TEM-1 TEM beta-lactamase; cefazolin; amoxicillin; ampicillin; cefalotin; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_description with Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 40360 " 2404 UPDATE Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; sitafloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A nucleotide or amino acid substitution that confers elevated resistance to antibiotic(s) relative to wild type with format [wild-type][position][mutation], e.g. R184Q. Var represents any possible substitution. " 6027 UPDATE CARB-56 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6028 UPDATE VIM-74 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6036 UPDATE VIM-75 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6046 UPDATE VIM-85 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6047 UPDATE VIM-86 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6048 UPDATE VIM-87 VIM beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. DELETED 35962 " 6049 UPDATE GES-47 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6050 UPDATE GES-48 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6051 UPDATE GES-49 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6052 UPDATE GES-50 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6053 UPDATE GES-51 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6054 UPDATE GES-52 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6055 UPDATE GES-53 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6056 UPDATE GES-54 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6057 UPDATE GES-55 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6058 UPDATE GES-56 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6059 UPDATE GES-57 GES beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6060 UPDATE CARB-57 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 6061 UPDATE CARB-58 CARB beta-lactamase; penicillin beta-lactam; antibiotic inactivation; ARO_category "UPDATED category_aro_name with penicillin beta-lactam UPDATED category_aro_description with Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. " 2845 DELETE Laribacter hongkongensis ampC beta-lactamase ampC-type beta-lactamase; cephalosporin; penam; antibiotic inactivation; N/A N/A 2888 DELETE HERA-1 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A 3614 DELETE HERA-5 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A 3611 DELETE HERA-2 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A 3613 DELETE HERA-4 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A 3612 DELETE HERA-3 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A 3615 DELETE HERA-6 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A 3616 DELETE HERA-8 HERA beta-lactamase; penam; antibiotic inactivation; N/A N/A