Model_id Action ARO_name ARO_category Changes To Summary 2252 ADD LpxD Acinetobacter mutant Lpx gene conferring resistance to colistin; colistin A; colistin B; peptide antibiotic; antibiotic target alteration; N/A N/A 2313 ADD Enterococcus faecalis YvlB with mutation conferring daptomycin resistance daptomycin resistant YvlB; daptomycin; peptide antibiotic; antibiotic target alteration; N/A N/A 2312 ADD Enterococcus faecalis drmA with mutation conferring daptomycin resistance daptomycin resistant drmA; daptomycin; peptide antibiotic; antibiotic target alteration; N/A N/A 2302 ADD Enterococcus faecalis gdpD with mutation conferring daptomycin resistance daptomycin resistant gdpD; daptomycin; peptide antibiotic; antibiotic target alteration; N/A N/A 3717 ADD Mycobacterium tuberculosis Rv1667 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv1667; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3734 ADD Mycobacterium tuberculosis nat mutations conferring resistance to isoniazid isoniazid resistant nat; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; N/A N/A 3708 ADD Mycobacterium tuberculosis whib7 mutations confer resistance to kanamycin Kanamycin resistant whib7; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; N/A N/A 3736 ADD Mycobacterium tuberculosis Rv0565c mutation conferring resistance to ethionamide Ethionamide resistant Rv0565c; ethionamide; thioamide antibiotic; antibiotic target alteration; N/A N/A 3744 ADD Mycobacterium tuberculosis ald mutations confer resistance to cycloserine cycloserine resistant ald; cycloserine; cycloserine-like antibiotic; antibiotic target alteration; N/A N/A 2269 ADD Escherichia coli nfsB with mutation conferring resistance to nitrofurantoin Antibiotic resistant nfsB; nitrofurantoin; nitrofuran antibiotic; antibiotic target alteration; N/A N/A 2304 ADD Staphylococcus aureus agrA with mutation conferring resistance to daptomycin daptomycin resistant agrA; daptomycin; peptide antibiotic; antibiotic target alteration; N/A N/A 3714 ADD Mycobacterium tuberculosis gpsI with mutations conferring resistance to pyrazinamide pyrazinamide resistant gpsI; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; N/A N/A 3749 ADD Neisseria gonorrhoeae mtrC with mutation conferring resistance to azithromycin resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 3895 ADD Mycobacterium tuberculosis ethA mutations conferring resistance to perchlozone perchlozone resistant ethA; perchlozone; thiosemicarbazone antibiotic; antibiotic target alteration; N/A N/A 3710 ADD Mycobacterium tuberculosis Rv1258c mutations confer resistance to streptomycin streptomycin resistant Rv1258c; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; N/A N/A 6024 ADD Mycobacterium tuberculosis iniA mutations conferring resistance to isoniazid isoniazid resistant iniA; isoniazid; isoniazid-like antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; N/A N/A 7519 ADD CMH-28 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7518 ADD CMH-27 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7850 ADD OXA-1011 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 7517 ADD CMH-26 CMH beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 7567 ADD CTX-M-260 CTX-M beta-lactamase; cephalosporin; antibiotic inactivation; N/A N/A 5925 ADD Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftazidime; aztreonam; ceftaroline; monobactam; cephalosporin; penicillin beta-lactam; antibiotic target alteration; N/A N/A 8524 ADD OXY-1-7 OXY beta-lactamase; monobactam; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 154 UPDATE mgrA ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; methicillin; ciprofloxacin; acriflavine; tetracycline; daptomycin; moxifloxacin; cefotaxime; norfloxacin; sparfloxacin; moenomycin A1; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; moenomycin antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000687 UPDATED category_aro_cvterm_id with 37031 UPDATED category_aro_name with moenomycin antibiotic UPDATED category_aro_description with Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis. UPDATED category_aro_class_name with Drug Class " 209 UPDATE AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein aminoglycoside bifunctional resistance protein; astromicin; amikacin; sisomicin; kanamycin A; tobramycin; gentamicin; aminoglycoside antibiotic; antibiotic inactivation; model_name "UPDATED model_name with AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein " 440 UPDATE MexA efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 36005 " 276 UPDATE tetR major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2710 with H64Y UPDATED 2711 with N82H UPDATED 2712 with T103I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 442 UPDATE OpmD resistance-nodulation-cell division (RND) antibiotic efflux pump; acriflavine; norfloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35968 " 632 UPDATE basR pmr phosphoethanolamine transferase; polymyxin B; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 4374 with L157Q UPDATED 4375 with L71R UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 986 UPDATE baeS resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin; aminoglycoside antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 13134 with D89V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1118 UPDATE OXA-2 OXA beta-lactamase; OXA-2-like beta-lactamase; oxacillin; ceftazidime; amoxicillin; ampicillin; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "DELETED 35990 " 1027 UPDATE tet(H) major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_description "UPDATED ARO_description with TetH is a tetracycline efflux protein expressed in Gram-negative bacteria (Actinobacillus, Acinetobacter, Gallibacterium, Histophilus, Mannheimia, Moraxella, Pasteurella, and Psychrobacter). Its gene is linked to the resistance genes sul2, and strA, which confer resistance to sulfamethoxazole and streptomycin, respectively. " 1041 UPDATE MexS resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 7573 with V104A UPDATED 7574 with F253L UPDATED 7575 with D44E UPDATED 7576 with S60F UPDATED 7577 with F185L UPDATED 7578 with V73A UPDATED 7579 with L270Q UPDATED 7580 with C245G UPDATED 7581 with A166P UPDATED 7582 with S60P UPDATED 7583 with L263Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1344 UPDATE MexH resistance-nodulation-cell division (RND) antibiotic efflux pump; acriflavine; norfloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35968 " 1337 UPDATE baeR resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin; aminoglycoside antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 13135 with S104N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1608 UPDATE MexT resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 7570 with G258D UPDATED 7571 with Y138D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1607 UPDATE Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 4483 with S575T UPDATED 4484 with N609D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1925 UPDATE MexB efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 36005 " 1966 UPDATE lmrA ATP-binding cassette (ABC) antibiotic efflux pump; lincomycin; puromycin; lincosamide antibiotic; nucleoside antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2887 with Q52P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 29 UPDATE Escherichia coli folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfadiazine; sulfadimidine; sulfadoxine; sulfamethoxazole; sulfisoxazole; sulfacetamide; mafenide; sulfasalazine; sulfamethizole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED 2281 with P64S UPDATED 2282 with P64A UPDATED 2283 with P64H UPDATED 2114 with P64R UPDATED 2115 with P64L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2033 UPDATE mtrR major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; palmitic acid; oleic acid; linoleic acid; macrolide antibiotic; antibacterial free fatty acids; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 8942 with G45D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 90 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 2054 with H481N UPDATED 2055 with A473T UPDATED 2057 with L466S UPDATED 2083 with A477T UPDATED 2862 with Q468K UPDATED 2056 with Q465R UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 111 UPDATE Escherichia coli gyrB conferring resistance to aminocoumarin aminocoumarin resistant gyrB; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED 2156 with R136L UPDATED 2158 with R136H UPDATED 2159 with R136S UPDATED 2160 with R136G UPDATED 2161 with R136I UPDATED 2162 with R136E UPDATED 2157 with R136C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 335 UPDATE Staphylococcus aureus parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2827 with P587S UPDATED 2829 with D434N UPDATED 2828 with D434H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 462 UPDATE Staphylococcus aureus pgsA mutations conferring resistance to daptomycin daptomycin resistant pgsA; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 2214 with S177F UPDATED 2215 with K66R UPDATED 2229 with V59N UPDATED 2213 with A64V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41344 " 489 UPDATE Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin antibiotic resistant gidB; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 15748 with M1Var UPDATED 15750 with M1Var UPDATED 15751 with M1Var UPDATED 15759 with M1Var UPDATED 15768 with M1Var UPDATED 15775 with M1Var UPDATED 15779 with M1Var UPDATED 15782 with M1Var UPDATED 15786 with M1Var UPDATED 15794 with M1Var UPDATED 15802 with M1Var UPDATED 15806 with M1Var UPDATED 15821 with M1Var UPDATED 15830 with M1Var UPDATED 15831 with M1Var UPDATED 15836 with M1Var UPDATED 15837 with M1Var UPDATED 15856 with M1Var UPDATED 15857 with M1Var UPDATED 15863 with M1Var UPDATED 15877 with M1Var UPDATED 15889 with M1Var UPDATED 15907 with M1Var UPDATED 15920 with M1Var UPDATED 15928 with M1Var UPDATED 15953 with M1Var UPDATED 15958 with M1Var UPDATED 15978 with M1Var UPDATED 15984 with M1Var UPDATED 15989 with M1Var UPDATED 15999 with M1Var UPDATED 16001 with M1Var UPDATED 16008 with M1Var UPDATED 16017 with M1Var UPDATED 15756 with A200E UPDATED 15824 with A134E UPDATED 15854 with V105E UPDATED 15897 with P84L UPDATED 15922 with G73A UPDATED 15925 with G73E UPDATED 15933 with S70N UPDATED 15942 with D67H UPDATED 15967 with H48Q UPDATED 3677 with M1Var UPDATED 2663 with W45C UPDATED 2664 with R47Q UPDATED 2665 with I55S UPDATED 2666 with D67H UPDATED 2667 with S70R UPDATED 2668 with G71V UPDATED 2670 with Q127P UPDATED 2671 with A134E UPDATED 2672 with A138E UPDATED 2673 with W148R UPDATED 2674 with A183E UPDATED 2676 with A200E UPDATED 3235 with P75S UPDATED 3670 with A183T UPDATED 3672 with W45S UPDATED 3673 with P84L UPDATED 3675 with H48Y UPDATED 3676 with G30R UPDATED 3679 with G117E UPDATED 3681 with L79F UPDATED 3682 with L49F UPDATED 3683 with G164C UPDATED 3688 with P84C UPDATED 3689 with V188M UPDATED 8863 with V124G UPDATED 8864 with E92A UPDATED 8865 with V139A UPDATED 8866 with G37V UPDATED 9962 with L79S UPDATED 13201 with N51T UPDATED 2675 with V188G UPDATED 9840 with L79S UPDATED 9842 with E92D UPDATED 9841 with E92D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 2666 UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. DELETED 41345 " 196 UPDATE Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol ethambutol resistant embB; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED 13302 with D328Y UPDATED 13303 with D354A UPDATED 13340 with G406A UPDATED 13341 with G406D UPDATED 13342 with G406S UPDATED 13392 with M306I UPDATED 13394 with M306V UPDATED 13411 with Q497K UPDATED 13412 with Q497R UPDATED 13626 with N1033K UPDATED 13680 with M306Var UPDATED 15432 with M306L UPDATED 15433 with M306V UPDATED 15434 with M306I UPDATED 15435 with Y319S UPDATED 15437 with Y319C UPDATED 15438 with D328Y UPDATED 15444 with D354A UPDATED 15450 with G406S UPDATED 15451 with G406C UPDATED 15452 with G406D UPDATED 15453 with G406A UPDATED 15458 with Q497R UPDATED 15459 with Q497K UPDATED 9465 with Y334H UPDATED 9469 with L402V UPDATED 9471 with G406C UPDATED 9474 with A454T UPDATED 9476 with Q497R UPDATED 9481 with S22C UPDATED 9482 with N296H UPDATED 9486 with Y319S UPDATED 9487 with Y319C UPDATED 9488 with D328Y UPDATED 9489 with F330S UPDATED 9484 with M306V UPDATED 9466 with S347I UPDATED 9467 with D354A UPDATED 9470 with G406S UPDATED 9473 with G406A UPDATED 9485 with M306I UPDATED 9472 with G406D UPDATED 9475 with Q497K UPDATED 9477 with D1024N UPDATED 9483 with M306L UPDATED 2238 with D328Y UPDATED 2239 with D328G UPDATED 2240 with F330V UPDATED 2242 with G406A UPDATED 2243 with L413P UPDATED 2296 with S297A UPDATED 2297 with D299E UPDATED 2298 with M306L UPDATED 2299 with M306V UPDATED 2300 with M306I UPDATED 2301 with M306T UPDATED 2345 with D311H UPDATED 2413 with L239P UPDATED 2414 with D240H UPDATED 2426 with Y334H UPDATED 2440 with E368A UPDATED 2446 with P375A UPDATED 2450 with E378A UPDATED 2453 with S380R UPDATED 2460 with P397Q UPDATED 2470 with G406S UPDATED 2471 with G406C UPDATED 2472 with G406D UPDATED 2478 with P446H UPDATED 2482 with R460C UPDATED 2485 with I465D UPDATED 2486 with R469P UPDATED 2487 with R471P UPDATED 2488 with Q497R UPDATED 2489 with Q497K UPDATED 2490 with G745D UPDATED 2491 with D959A UPDATED 2493 with D1024N UPDATED 3589 with R507G UPDATED 3593 with Y319C UPDATED 3594 with Y333C UPDATED 3595 with Y319N UPDATED 2464 with N399H UPDATED 2492 with M1000R UPDATED 3588 with E504Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 15433 DELETED 3596 DELETED 40330 " 366 UPDATE Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol ethambutol resistant iniA; ethambutol; polyamine antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 3334 with G308R UPDATED 3856 with P3A UPDATED 3857 with R537H UPDATED 3333 with S501W UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 505 UPDATE Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol Ethambutol resistant iniC; ethambutol; polyamine antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_type with insertion mutation from peptide sequence UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to the reference sequence, one or more amino acids are inserted. These represent in-frame insertions which do not result in frameshift variants and where the insertion is not a duplication of a sequence immediately N-terminal (5'), and are denoted with wildtype flanking residues. Format is given by [wildtype AA position]_[wildtype AA position]ins[AA sequence], e.g. K464_D465insE or P46_A47insYS. UPDATED param_type_id with 41344 UPDATED 18563 with T78_R79insT UPDATED 18562 with R97_G98insA UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 3530 with S501W UPDATED 2346 with P248A UPDATED 3352 with W83G UPDATED 18563 with W83G UPDATED 18562 with W83G DELETED param_type DELETED 41345 " 597 UPDATE Klebsiella pneumoniae ramR mutants resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2110 with K5E UPDATED 2112 with T162I UPDATED 2113 with A19V UPDATED 2134 with A16D UPDATED 2135 with I88N UPDATED 2863 with G96D UPDATED 2111 with T43M UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 627 UPDATE Escherichia coli rpoB mutants conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. UPDATED 9917 with T43M UPDATED 2024 with Q513L UPDATED 2025 with Q513P UPDATED 2026 with H526Y UPDATED 2027 with R529C UPDATED 2028 with R529S UPDATED 2029 with S531F UPDATED 2030 with L533P UPDATED 2031 with T563P UPDATED 2032 with P564L UPDATED 2033 with V146F UPDATED 2034 with R687H DELETED param_type " 756 UPDATE Enterococcus faecium liaR mutant conferring daptomycin resistance daptomycin resistant liaR; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 22 with W73C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 794 UPDATE Staphylococcus aureus rpoC conferring resistance to daptomycin daptomycin-resistant beta prime subunit of RNA polymerase (rpoC); daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 2071 with Q961K UPDATED 2070 with F632S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 851 UPDATE Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide Pyrazinamide resistant pncA; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_type with synonymous substitution for alternative promoter UPDATED param_description with A synonymous or silent substitution in the coding DNA sequence of one gene which influences the promoter region of another gene. These substitutions do not change the amino acid sequence of a protein but may still influence the phenotype, including decreased susceptibility to antimicrobial compounds. UPDATED param_type_id with 48039 UPDATED 13939 with F50F UPDATED 13954 with G150G UPDATED 13957 with G16G UPDATED 14011 with N118N UPDATED 14021 with P62P UPDATED 14035 with Q122Q UPDATED 14042 with S164S UPDATED 14057 with T114T UPDATED 14062 with T142T UPDATED 14066 with T177T UPDATED 14071 with V125V UPDATED 14086 with V183V UPDATED 14101 with Y41Y UPDATED 14104 with A171A UPDATED 14112 with A38A UPDATED 13975 with H71H UPDATED 14121 with A79A UPDATED 14154 with D56D UPDATED 14169 with E107E UPDATED 14116 with A46A UPDATED 13943 with F94F UPDATED 14000 with L19L UPDATED 14099 with Y34Y UPDATED 14115 with A3A UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13253 with -11a>g UPDATED 13854 with -12t>c UPDATED 13855 with -7t>c UPDATED 15398 with -7t>c UPDATED 15399 with -11a>g UPDATED 15400 with -11a>t UPDATED 15401 with -11a>c UPDATED 15402 with -12t>c UPDATED 9702 with -11a>g UPDATED 9701 with -11a>c UPDATED 13254 with A134V UPDATED 13261 with A146E UPDATED 13263 with A146V UPDATED 13264 with A161P UPDATED 13266 with A171T UPDATED 13269 with A3E UPDATED 13271 with A46E UPDATED 13272 with A46V UPDATED 13278 with C138R UPDATED 13253 with C138R UPDATED 13280 with C138Y UPDATED 13283 with C14R UPDATED 13285 with C14Y UPDATED 13290 with C72R UPDATED 13292 with C72W UPDATED 13295 with D12A UPDATED 13296 with D12E UPDATED 13297 with D12N UPDATED 13299 with D136N UPDATED 13300 with D136Y UPDATED 13307 with D49G UPDATED 13308 with D49N UPDATED 13309 with D49V UPDATED 13310 with D63G UPDATED 13311 with D63H UPDATED 13314 with D8G UPDATED 13315 with D8H UPDATED 13316 with D8N UPDATED 13317 with D8Y UPDATED 13323 with E174G UPDATED 13325 with F58L UPDATED 13326 with F58S UPDATED 13335 with G17D UPDATED 13338 with G23V UPDATED 13346 with G78D UPDATED 13350 with G97S UPDATED 13351 with H137P UPDATED 13352 with H137R UPDATED 13357 with H51Q UPDATED 13358 with H51R UPDATED 13360 with H57D UPDATED 13361 with H57Q UPDATED 13362 with H57R UPDATED 13363 with H71R UPDATED 13364 with H82R UPDATED 13365 with I133T UPDATED 13368 with I5T UPDATED 13369 with I6T UPDATED 13373 with K96E UPDATED 13375 with K96N UPDATED 13376 with K96Q UPDATED 13377 with L116R UPDATED 13378 with L151S UPDATED 13379 with L172P UPDATED 13382 with L19P UPDATED 13383 with L27P UPDATED 13386 with L4S UPDATED 13387 with L4W UPDATED 13388 with L85P UPDATED 13390 with M175V UPDATED 13402 with P54L UPDATED 13403 with P54T UPDATED 13407 with Q10P UPDATED 13408 with Q10R UPDATED 13409 with Q141P UPDATED 13414 with S104C UPDATED 13422 with S66P UPDATED 13423 with S67P UPDATED 13427 with T135P UPDATED 13428 with T142K UPDATED 13429 with T142M UPDATED 13430 with T160P UPDATED 13432 with T47A UPDATED 13434 with T76I UPDATED 13435 with T76P UPDATED 13437 with V125D UPDATED 13438 with V128G UPDATED 13439 with V139A UPDATED 13440 with V139G UPDATED 13441 with V139L UPDATED 13442 with V139M UPDATED 13443 with V155G UPDATED 13444 with V180F UPDATED 13445 with V180G UPDATED 13450 with V7D UPDATED 13451 with V7F UPDATED 13452 with V7G UPDATED 13453 with W119R UPDATED 13455 with W68C UPDATED 13456 with W68G UPDATED 13457 with W68L UPDATED 13458 with W68R UPDATED 13461 with Y103H UPDATED 13462 with Y34D UPDATED 13463 with Y41H UPDATED 13796 with G78C UPDATED 13797 with G97R UPDATED 13799 with K48E UPDATED 13800 with L159V UPDATED 13803 with A171E UPDATED 13804 with P54Q UPDATED 13807 with D12G UPDATED 13812 with S32I UPDATED 13813 with F94L UPDATED 13814 with F94S UPDATED 13816 with G108R UPDATED 13817 with G132A UPDATED 13818 with G132D UPDATED 13819 with G162D UPDATED 13821 with G24D UPDATED 13822 with G97C UPDATED 13823 with G97D UPDATED 13826 with H57P UPDATED 13827 with H57Y UPDATED 13828 with H71D UPDATED 13829 with H71Q UPDATED 13830 with H71Y UPDATED 13833 with K96R UPDATED 13834 with K96T UPDATED 13836 with L120P UPDATED 13837 with L159P UPDATED 13841 with M175I UPDATED 13842 with M175T UPDATED 13844 with V21G UPDATED 13845 with P54S UPDATED 13846 with P62L UPDATED 13847 with P62Q UPDATED 13849 with V7L UPDATED 13852 with S104R UPDATED 13853 with S59P UPDATED 13855 with S59P UPDATED 13858 with T135N UPDATED 13859 with T142A UPDATED 13861 with T168P UPDATED 13867 with V125G UPDATED 13939 with V125G UPDATED 13954 with V125G UPDATED 13934 with F106S UPDATED 13935 with F106Y UPDATED 13936 with F13I UPDATED 13937 with F13V UPDATED 13938 with F13Y UPDATED 13957 with F13Y UPDATED 13940 with F58I UPDATED 13941 with F81S UPDATED 13942 with F94C UPDATED 13945 with G101E UPDATED 13946 with G105D UPDATED 13947 with G105R UPDATED 13948 with G105V UPDATED 13949 with G108E UPDATED 13950 with G124S UPDATED 13951 with G132C UPDATED 13952 with G132R UPDATED 13953 with G132V UPDATED 13955 with G162A UPDATED 13956 with G162V UPDATED 13958 with G16R UPDATED 13960 with G17C UPDATED 13961 with G24V UPDATED 13962 with G55C UPDATED 13963 with G75V UPDATED 13854 with G75V UPDATED 13965 with H137D UPDATED 13966 with H42N UPDATED 13968 with H43P UPDATED 13969 with H43Q UPDATED 13970 with H51D UPDATED 13971 with H51L UPDATED 13972 with H51N UPDATED 13973 with H57L UPDATED 13974 with H57N UPDATED 14011 with H57N UPDATED 13976 with H71L UPDATED 13977 with H71N UPDATED 13978 with H82L UPDATED 13979 with I133F UPDATED 13980 with I133N UPDATED 13981 with I31F UPDATED 13983 with I31T UPDATED 13984 with I52T UPDATED 13985 with I5F UPDATED 13986 with I5M UPDATED 13987 with I5N UPDATED 13988 with I6F UPDATED 13989 with I6M UPDATED 13991 with K48T UPDATED 13993 with L116Q UPDATED 13994 with L117Q UPDATED 13995 with L120Q UPDATED 13997 with L156P UPDATED 13998 with L156R UPDATED 13999 with L159Q UPDATED 14001 with L19Q UPDATED 14002 with L27Q UPDATED 14003 with L35P UPDATED 14005 with L4F UPDATED 14006 with L4V UPDATED 14007 with L85Q UPDATED 14008 with M175K UPDATED 14009 with M1L UPDATED 14010 with N112S UPDATED 14021 with N112S UPDATED 14012 with A134P UPDATED 14013 with N118Y UPDATED 14014 with N11T UPDATED 14015 with N149I UPDATED 14017 with P115A UPDATED 14018 with P115R UPDATED 14019 with P54R UPDATED 14020 with P62A UPDATED 14035 with P62A UPDATED 14022 with A143D UPDATED 14023 with P62R UPDATED 14024 with P69L UPDATED 14025 with P69Q UPDATED 14026 with P70A UPDATED 14027 with P70S UPDATED 14028 with P77S UPDATED 14030 with Q10E UPDATED 14031 with Q10H UPDATED 14034 with Q122K UPDATED 14042 with Q122K UPDATED 14036 with R123S UPDATED 14037 with R140P UPDATED 14038 with R154M UPDATED 14039 with R176P UPDATED 14040 with R29C UPDATED 14041 with A146S UPDATED 14057 with A146S UPDATED 14043 with S164T UPDATED 14044 with S179N UPDATED 14046 with S186F UPDATED 14047 with S18L UPDATED 14048 with S18T UPDATED 14050 with S59F UPDATED 14051 with S65F UPDATED 14055 with S88T UPDATED 14056 with T114A UPDATED 14062 with T114A UPDATED 14058 with T135I UPDATED 14059 with T135S UPDATED 14060 with A152V UPDATED 14061 with T142R UPDATED 14066 with T142R UPDATED 14063 with T153N UPDATED 14064 with T160K UPDATED 14065 with T160R UPDATED 14071 with T160R UPDATED 14068 with T76S UPDATED 14069 with V109L UPDATED 14070 with V125A UPDATED 14086 with V125A UPDATED 14072 with V128A UPDATED 14073 with V128D UPDATED 14074 with V130E UPDATED 14075 with V131D UPDATED 14076 with V131F UPDATED 14077 with V131I UPDATED 14078 with A165D UPDATED 14079 with V139E UPDATED 14080 with V147A UPDATED 14081 with V155E UPDATED 14083 with V163E UPDATED 14084 with V180D UPDATED 14085 with V183D UPDATED 14101 with V183D UPDATED 14087 with V21A UPDATED 14088 with A170S UPDATED 14089 with V21E UPDATED 14090 with V44D UPDATED 14091 with V7A UPDATED 14092 with V93E UPDATED 14093 with V93L UPDATED 14095 with W119G UPDATED 14096 with W119L UPDATED 14097 with A170V UPDATED 14104 with A170V UPDATED 14112 with A170V UPDATED 14105 with A26V UPDATED 14106 with A28S UPDATED 14107 with A30P UPDATED 14108 with A30S UPDATED 14109 with A30V UPDATED 14110 with A36D UPDATED 14111 with A36S UPDATED 14113 with A38G UPDATED 14114 with A38S UPDATED 13975 with A38S UPDATED 14121 with M1Var UPDATED 14120 with A46P UPDATED 14154 with A46P UPDATED 14122 with A79P UPDATED 14124 with A89V UPDATED 14127 with C138F UPDATED 14128 with C138G UPDATED 14130 with C14W UPDATED 14131 with C184R UPDATED 14133 with C72F UPDATED 14134 with C72Y UPDATED 14140 with D110E UPDATED 14142 with D110H UPDATED 14144 with D129E UPDATED 14145 with D12H UPDATED 14146 with D12Y UPDATED 14147 with D136V UPDATED 14148 with D145E UPDATED 14149 with D158G UPDATED 14150 with D166V UPDATED 14151 with D49E UPDATED 14152 with D49H UPDATED 14153 with D49Y UPDATED 14169 with D49Y UPDATED 14157 with D63E UPDATED 14159 with D80H UPDATED 14160 with D86V UPDATED 14161 with D8A UPDATED 14168 with D8V UPDATED 14172 with E127D UPDATED 14176 with E173G UPDATED 14177 with E174K UPDATED 14094 with E174K UPDATED 14098 with E174K UPDATED 14100 with E174K UPDATED 14102 with E174K UPDATED 14103 with E174K UPDATED 14126 with E174K UPDATED 14129 with E174K UPDATED 14132 with E174K UPDATED 14170 with E174K UPDATED 14171 with E174K UPDATED 14173 with E174K UPDATED 14174 with E174K UPDATED 14178 with E174K UPDATED 14116 with E174K UPDATED 13415 with E174K UPDATED 13460 with E174K UPDATED 13808 with E174K UPDATED 13850 with E174K UPDATED 13932 with E174K UPDATED 13933 with E174K UPDATED 13944 with E174K UPDATED 13990 with E174K UPDATED 13992 with E174K UPDATED 13996 with E174K UPDATED 14004 with E174K UPDATED 14029 with E174K UPDATED 14033 with E174K UPDATED 14052 with E174K UPDATED 14053 with E174K UPDATED 14054 with E174K UPDATED 13279 with C138S UPDATED 13298 with D136H UPDATED 13313 with D8E UPDATED 13329 with G132S UPDATED 13359 with H51Y UPDATED 13374 with K96M UPDATED 13389 with L85R UPDATED 13404 with P62S UPDATED 13416 with S164P UPDATED 13433 with T47S UPDATED 13794 with F81V UPDATED 13810 with S104G UPDATED 13825 with T114P UPDATED 13835 with L116P UPDATED 13851 with R123P UPDATED 13866 with V125F UPDATED 13959 with G16V UPDATED 13964 with G78V UPDATED 13967 with H42Q UPDATED 13982 with I31N UPDATED 14016 with N149Y UPDATED 14032 with Q10L UPDATED 14049 with S32N UPDATED 14067 with T22I UPDATED 14082 with V155M UPDATED 14125 with A92E UPDATED 14143 with D110N UPDATED 14158 with D63Y UPDATED 14179 with E181K UPDATED 14175 with E181K UPDATED 13327 with E181K UPDATED 14045 with E181K UPDATED 13943 with Q10P UPDATED 14000 with Q10P UPDATED 14099 with Q10P UPDATED 14115 with Q10P UPDATED 15094 with M1Var UPDATED 15097 with E174K UPDATED 15108 with E174K UPDATED 15109 with E174K UPDATED 15120 with E174K UPDATED 15143 with E174K UPDATED 15150 with E174K UPDATED 15187 with E174K UPDATED 15192 with E174K UPDATED 15201 with E174K UPDATED 15204 with E174K UPDATED 15213 with E174K UPDATED 15221 with E174K UPDATED 15223 with E174K UPDATED 15236 with E174K UPDATED 15244 with E174K UPDATED 15273 with E174K UPDATED 15277 with E174K UPDATED 15279 with E174K UPDATED 15281 with E174K UPDATED 15345 with E174K UPDATED 15350 with E174K UPDATED 15352 with E174K UPDATED 15370 with E174K UPDATED 15095 with L182S UPDATED 15096 with L182W UPDATED 15098 with V180G UPDATED 15101 with V180A UPDATED 15102 with V180F UPDATED 15103 with T177P UPDATED 15104 with M175T UPDATED 15105 with M175I UPDATED 15106 with M175R UPDATED 15107 with M175V UPDATED 15111 with L172P UPDATED 15112 with A171P UPDATED 15114 with A171E UPDATED 15117 with T168P UPDATED 15119 with S164P UPDATED 15121 with V163A UPDATED 15122 with G162D UPDATED 15126 with T160P UPDATED 15127 with T160K UPDATED 15129 with L159V UPDATED 15130 with L159R UPDATED 15131 with L159P UPDATED 15134 with V155G UPDATED 15135 with V155A UPDATED 15136 with V155M UPDATED 15137 with R154G UPDATED 15138 with R154M UPDATED 15139 with L151S UPDATED 15140 with A146T UPDATED 15141 with A146V UPDATED 15142 with A146E UPDATED 15144 with A143G UPDATED 15145 with T142A UPDATED 15146 with T142K UPDATED 15147 with T142P UPDATED 15148 with T142M UPDATED 15149 with Q141P UPDATED 15151 with R140P UPDATED 15152 with V139L UPDATED 15153 with V139G UPDATED 15154 with V139A UPDATED 15155 with V139M UPDATED 15156 with C138R UPDATED 15158 with H137P UPDATED 15161 with D136V UPDATED 15162 with D136G UPDATED 15166 with T135P UPDATED 15167 with T135N UPDATED 15168 with A134V UPDATED 15171 with I133T UPDATED 15174 with G132A UPDATED 15175 with G132D UPDATED 15176 with G132S UPDATED 15177 with G132C UPDATED 15178 with V131G UPDATED 15179 with V131F UPDATED 15180 with V130G UPDATED 15181 with V130M UPDATED 15182 with D129N UPDATED 15183 with V128G UPDATED 15184 with V125F UPDATED 15185 with V125G UPDATED 15188 with R121P UPDATED 15189 with L120R UPDATED 15190 with L120P UPDATED 15191 with L120Q UPDATED 15193 with W119L UPDATED 15194 with W119R UPDATED 15195 with W119G UPDATED 15196 with W119C UPDATED 15197 with L116R UPDATED 15198 with L116P UPDATED 15199 with T114P UPDATED 15202 with G108R UPDATED 15203 with G108E UPDATED 15205 with F106S UPDATED 15206 with F106L UPDATED 15207 with G105V UPDATED 15208 with G105D UPDATED 15209 with S104G UPDATED 15210 with S104I UPDATED 15211 with S104R UPDATED 15212 with Y103C UPDATED 15215 with Y103H UPDATED 15216 with Y103D UPDATED 15217 with A102T UPDATED 15220 with A102P UPDATED 15222 with T100P UPDATED 15224 with G97R UPDATED 15225 with G97S UPDATED 15226 with G97D UPDATED 15227 with G97V UPDATED 15228 with G97C UPDATED 15229 with K96Q UPDATED 15230 with K96E UPDATED 15231 with K96R UPDATED 15232 with K96T UPDATED 15233 with K96N UPDATED 15235 with Y95D UPDATED 15237 with F94L UPDATED 15238 with F94S UPDATED 15239 with F94C UPDATED 15241 with V93L UPDATED 15242 with V93A UPDATED 15245 with I90S UPDATED 15246 with I90N UPDATED 15247 with I90T UPDATED 15249 with L85R UPDATED 15250 with L85P UPDATED 15251 with H82R UPDATED 15253 with G78S UPDATED 15254 with G78D UPDATED 15255 with G78V UPDATED 15257 with T76I UPDATED 15258 with T76P UPDATED 15259 with C72R UPDATED 15261 with C72Y UPDATED 15263 with H71P UPDATED 15264 with H71R UPDATED 15266 with H71Y UPDATED 15269 with P69L UPDATED 15270 with W68C UPDATED 15271 with W68L UPDATED 15272 with W68G UPDATED 15275 with W68R UPDATED 15276 with S67P UPDATED 15278 with S66P UPDATED 15282 with Y64D UPDATED 15283 with D63A UPDATED 15285 with D63G UPDATED 15286 with P62R UPDATED 15288 with P62S UPDATED 15289 with P62T UPDATED 15290 with P62L UPDATED 15291 with T61P UPDATED 15293 with S59P UPDATED 15294 with F58C UPDATED 15295 with F58S UPDATED 15296 with F58L UPDATED 15298 with H57Q UPDATED 15300 with H57R UPDATED 15301 with H57L UPDATED 15302 with H57Y UPDATED 15303 with H57D UPDATED 15304 with P54R UPDATED 15305 with P54L UPDATED 15306 with P54Q UPDATED 15307 with P54S UPDATED 15308 with P54T UPDATED 15309 with H51R UPDATED 15310 with H51D UPDATED 15311 with H51P UPDATED 15312 with H51Y UPDATED 15313 with H51Q UPDATED 15315 with D49G UPDATED 15316 with D49N UPDATED 15317 with D49A UPDATED 15318 with D49E UPDATED 15319 with K48T UPDATED 15320 with K48E UPDATED 15321 with T47P UPDATED 15322 with T47A UPDATED 15324 with A46E UPDATED 15325 with A46V UPDATED 15327 with V44G UPDATED 15328 with H43P UPDATED 15330 with L35P UPDATED 15332 with Y34S UPDATED 15334 with Y34D UPDATED 15336 with I31S UPDATED 15337 with I31T UPDATED 15339 with L27P UPDATED 15341 with G24D UPDATED 15343 with V21G UPDATED 15344 with L19P UPDATED 15348 with G17D UPDATED 15353 with C14W UPDATED 15356 with C14R UPDATED 15357 with F13L UPDATED 15358 with F13S UPDATED 15359 with F13I UPDATED 15361 with D12G UPDATED 15362 with D12E UPDATED 15363 with D12A UPDATED 15364 with D12N UPDATED 15366 with Q10H UPDATED 15367 with Q10R UPDATED 15368 with Q10P UPDATED 15372 with V9G UPDATED 15374 with D8E UPDATED 15375 with D8H UPDATED 15376 with D8G UPDATED 15377 with D8N UPDATED 15378 with D8A UPDATED 15379 with D8Y UPDATED 15380 with V7G UPDATED 15381 with V7A UPDATED 15382 with V7F UPDATED 15383 with V7L UPDATED 15386 with I6T UPDATED 15388 with I5S UPDATED 15389 with L4S UPDATED 15390 with L4W UPDATED 15391 with A3E UPDATED 15329 with A3E UPDATED 15333 with A3E UPDATED 16053 with H71D UPDATED 15398 with H71D UPDATED 15399 with H71D UPDATED 15401 with H71D UPDATED 15402 with H71D UPDATED 15400 with C138W UPDATED 3433 with E174K UPDATED 3436 with E174K UPDATED 4160 with E174K UPDATED 4230 with E174K UPDATED 4238 with E174K UPDATED 4243 with E174K UPDATED 4309 with E174K UPDATED 9933 with E174K UPDATED 2572 with I5S UPDATED 2573 with V7G UPDATED 2575 with Q10R UPDATED 2582 with A26G UPDATED 2584 with Y41H UPDATED 2598 with P69R UPDATED 2602 with C72R UPDATED 2605 with L85P UPDATED 2608 with K96N UPDATED 2614 with N118T UPDATED 2618 with G132S UPDATED 2621 with H137P UPDATED 2623 with C138Y UPDATED 2625 with V139L UPDATED 2629 with T142K UPDATED 2630 with T142M UPDATED 3424 with D12E UPDATED 3425 with T47A UPDATED 3427 with P54T UPDATED 3434 with G17D UPDATED 3435 with Y34S UPDATED 4158 with D8Y UPDATED 4159 with Q10K UPDATED 4162 with T47S UPDATED 4164 with S66P UPDATED 4165 with K96E UPDATED 4166 with A102T UPDATED 4167 with A102V UPDATED 4169 with L116R UPDATED 4170 with V125D UPDATED 4172 with I133T UPDATED 4173 with Q141P UPDATED 4174 with R154G UPDATED 4175 with T160P UPDATED 4176 with A161P UPDATED 4177 with D12A UPDATED 4178 with D12N UPDATED 4179 with H51Q UPDATED 4192 with H57D UPDATED 4193 with W68L UPDATED 4195 with V139A UPDATED 4196 with R121P UPDATED 4199 with H137R UPDATED 4201 with W119R UPDATED 4202 with F94P UPDATED 4204 with T76P UPDATED 4205 with L19P UPDATED 4207 with S104C UPDATED 4209 with M1S UPDATED 4210 with L4W UPDATED 4211 with V7D UPDATED 4214 with V9G UPDATED 4215 with V9G UPDATED 4217 with C14R UPDATED 4218 with C14Y UPDATED 4219 with G23V UPDATED 4220 with G23V UPDATED 4221 with V45G UPDATED 4222 with A46E UPDATED 4223 with D49A UPDATED 4224 with F58L UPDATED 4226 with S67P UPDATED 4228 with W68G UPDATED 4229 with W68S UPDATED 4232 with T76I UPDATED 4233 with G78D UPDATED 4234 with L85R UPDATED 4235 with K96Q UPDATED 4236 with Y103H UPDATED 4237 with Y103S UPDATED 4239 with T135P UPDATED 4240 with D136N UPDATED 4241 with D136Y UPDATED 4242 with V139M UPDATED 4245 with A146T UPDATED 4246 with V155G UPDATED 4247 with L159R UPDATED 4248 with L172P UPDATED 4249 with V180F UPDATED 4272 with L172A UPDATED 4274 with A171T UPDATED 4280 with H51Y UPDATED 4276 with P62H UPDATED 4281 with A171V UPDATED 4282 with D136H UPDATED 4283 with A3E UPDATED 4284 with L27P UPDATED 4286 with P54L UPDATED 4291 with M175V UPDATED 4293 with A46V UPDATED 4294 with D53A UPDATED 4296 with H71E UPDATED 4297 with H82R UPDATED 4298 with G97S UPDATED 4299 with A134V UPDATED 4300 with C138S UPDATED 4301 with T168N UPDATED 4307 with T47P UPDATED 8569 with W68C UPDATED 9923 with L182S UPDATED 9924 with E174G UPDATED 9926 with A161G UPDATED 9927 with V157G UPDATED 9930 with T100P UPDATED 9931 with R140G UPDATED 9934 with K96M UPDATED 9935 with S164P UPDATED 9937 with H57Q UPDATED 9938 with H57Q UPDATED 9939 with G17S UPDATED 9940 with V9A UPDATED 13039 with D63H UPDATED 13178 with R140S UPDATED 13179 with D8G UPDATED 13180 with R154W UPDATED 13181 with Y64D UPDATED 4168 with E181K UPDATED 2576 with Q10P UPDATED 4163 with D49V UPDATED 4180 with A171P UPDATED 4208 with I90S UPDATED 4212 with V7F UPDATED 4227 with W68R UPDATED 4287 with C72W UPDATED 9932 with C138W UPDATED 9678 with H71D UPDATED 9680 with H71D UPDATED 9646 with Y34D UPDATED 9647 with L4S UPDATED 9648 with D49N UPDATED 9649 with D49G UPDATED 9650 with I5T UPDATED 9651 with H51R UPDATED 9652 with P54L UPDATED 9653 with H57D UPDATED 9656 with F58S UPDATED 9657 with I6T UPDATED 9658 with P62S UPDATED 9659 with D63G UPDATED 9660 with S67P UPDATED 9661 with W68R UPDATED 9662 with W68G UPDATED 9663 with P69R UPDATED 9664 with V7G UPDATED 9666 with T76P UPDATED 9667 with D8N UPDATED 9668 with D8H UPDATED 9669 with H82R UPDATED 9670 with D8E UPDATED 9671 with L85R UPDATED 9673 with T100P UPDATED 9674 with Q10P UPDATED 9675 with Q10R UPDATED 9683 with Q10R UPDATED 9679 with L116R UPDATED 9687 with L116R UPDATED 9681 with D12A UPDATED 9684 with I133T UPDATED 9685 with T135P UPDATED 9686 with D136Y UPDATED 9688 with C14R UPDATED 9689 with C138R UPDATED 9690 with V139G UPDATED 9692 with A146E UPDATED 9693 with A146V UPDATED 9694 with L151S UPDATED 9696 with M175V UPDATED 9697 with V180F UPDATED 9698 with V180A UPDATED 9699 with V180G UPDATED 9700 with L182S UPDATED 9676 with L182S UPDATED 9677 with L182S UPDATED 9695 with L182S UPDATED 9702 with L182S UPDATED 9655 with H57R UPDATED 9672 with G97S UPDATED 9691 with Q141P UPDATED 9665 with H71R UPDATED 9682 with V128G UPDATED 9701 with L182S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 13939 DELETED 13939 UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. DELETED 8095 DELETED 41343 " 984 UPDATE Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2121 with D90G UPDATED 2122 with D95N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1088 UPDATE Staphylococcus aureus rpoB mutants conferring resistance to daptomycin daptomycin-resistant beta-subunit of RNA polymerase (rpoB); daptomycin; peptide antibiotic; rifamycin antibiotic; antibiotic target alteration; model_param "UPDATED 2047 with I953S UPDATED 2048 with A1085V UPDATED 2049 with A621E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1108 UPDATE Enterococcus faecium liaS mutant conferring daptomycin resistance daptomycin resistant liaS; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2203 with E192G UPDATED 2252 with H264Q UPDATED 39 with A180T UPDATED 44 with T120A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1166 UPDATE Staphylococcus aureus gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2117 with S84L UPDATED 2118 with S85P UPDATED 2119 with E88K UPDATED 2120 with E88A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1175 UPDATE Enterococcus faecium cls conferring resistance to daptomycin daptomycin resistant cls; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 2072 with H215R UPDATED 2075 with K59T UPDATED 3574 with N13I UPDATED 3578 with N13T UPDATED 3584 with A20D UPDATED 3585 with R267H UPDATED 3586 with D27N UPDATED 12948 with G177T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41344 " 1176 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid isoniazid resistant katG; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 13301 with D142G UPDATED 13337 with G182R UPDATED 13417 with S315I UPDATED 13419 with S315T UPDATED 13454 with W191R UPDATED 13459 with W90R UPDATED 13709 with A109V UPDATED 13717 with A614E UPDATED 13729 with G125D UPDATED 13732 with G297V UPDATED 13737 with L141F UPDATED 13738 with L159P UPDATED 13743 with L704S UPDATED 13757 with R104Q UPDATED 13760 with S481L UPDATED 13762 with S700P UPDATED 13765 with T180K UPDATED 13780 with W191G UPDATED 13781 with W300C UPDATED 13782 with W328L UPDATED 13783 with W328L UPDATED 13784 with S315Var UPDATED 13418 with S315N UPDATED 13748 with P232R UPDATED 13778 with V633A UPDATED 14855 with V1Var UPDATED 14858 with S315Var UPDATED 14872 with S315Var UPDATED 14873 with S315Var UPDATED 14874 with S315Var UPDATED 14885 with S315Var UPDATED 14889 with S315Var UPDATED 14903 with S315Var UPDATED 14914 with S315Var UPDATED 14923 with S315Var UPDATED 14929 with S315Var UPDATED 14930 with S315Var UPDATED 14934 with S315Var UPDATED 14945 with S315Var UPDATED 14946 with S315Var UPDATED 14962 with S315Var UPDATED 14977 with S315Var UPDATED 15008 with S315Var UPDATED 15009 with S315Var UPDATED 15020 with S315Var UPDATED 15023 with S315Var UPDATED 15027 with S315Var UPDATED 15033 with S315Var UPDATED 15036 with S315Var UPDATED 15062 with S315Var UPDATED 15068 with S315Var UPDATED 15082 with S315Var UPDATED 15083 with S315Var UPDATED 15086 with S315Var UPDATED 15087 with S315Var UPDATED 14956 with W328L UPDATED 14965 with S315T UPDATED 14966 with S315R UPDATED 14968 with S315I UPDATED 14969 with S315N UPDATED 3763 with S315Var UPDATED 8241 with S315Var UPDATED 2284 with S315T UPDATED 3236 with P131R UPDATED 3238 with W91R UPDATED 3239 with R463L UPDATED 3241 with R128Q UPDATED 3242 with P131Q UPDATED 3243 with V68G UPDATED 3245 with S315N UPDATED 3246 with M126I UPDATED 3247 with S315I UPDATED 3693 with D194Y UPDATED 3696 with D63E UPDATED 3697 with R104L UPDATED 3698 with W107R UPDATED 3699 with H108E UPDATED 3700 with H108Q UPDATED 3701 with N138D UPDATED 3702 with N138S UPDATED 3703 with Y229F UPDATED 3704 with W300G UPDATED 3705 with T262R UPDATED 3706 with T275P UPDATED 3708 with Y337C UPDATED 3709 with A350S UPDATED 3710 with S315G UPDATED 3711 with S315R UPDATED 3712 with L587M UPDATED 3713 with G629S UPDATED 3714 with D735N UPDATED 3723 with Q127E UPDATED 3724 with P232S UPDATED 3725 with N133T UPDATED 3726 with S383P UPDATED 3727 with H97R UPDATED 3728 with R489S UPDATED 3729 with M420T UPDATED 3730 with D387H UPDATED 3731 with G123E UPDATED 3732 with G299S UPDATED 3734 with M176T UPDATED 3735 with R632C UPDATED 3740 with Y64S UPDATED 3741 with Y95C UPDATED 3742 with P131T UPDATED 3743 with A139P UPDATED 3744 with D142G UPDATED 3745 with A162V UPDATED 3746 with G269D UPDATED 3747 with T306P UPDATED 3748 with R385W UPDATED 3749 with D387G UPDATED 3751 with Q439P UPDATED 3752 with F483L UPDATED 3753 with A541D UPDATED 3754 with G32D UPDATED 3755 with V47E UPDATED 3756 with D194G UPDATED 3757 with A256T UPDATED 3759 with T667P UPDATED 3760 with M624V UPDATED 3762 with I335T UPDATED 3764 with Q127P UPDATED 3766 with Q352E UPDATED 3767 with Y98C UPDATED 3769 with G269R UPDATED 3777 with S17T UPDATED 3786 with A93T UPDATED 3794 with A110V UPDATED 3795 with A139V UPDATED 3797 with H276M UPDATED 3798 with Q295H UPDATED 3802 with S17N UPDATED 3803 with G19D UPDATED 3804 with Q224E UPDATED 3805 with A243S UPDATED 3806 with A550D UPDATED 3807 with P2S UPDATED 3808 with S140N UPDATED 3810 with G279D UPDATED 3811 with G285D UPDATED 3812 with G316D UPDATED 3813 with S457I UPDATED 3814 with G593D UPDATED 8239 with S303L UPDATED 8240 with S303C UPDATED 8242 with D311N UPDATED 8243 with D311S UPDATED 8244 with L427I UPDATED 8246 with L430V UPDATED 8247 with T435R UPDATED 8248 with L436G UPDATED 8249 with Q471Y UPDATED 8250 with Q471H UPDATED 8252 with L472Q UPDATED 8253 with L472I UPDATED 8254 with V473D UPDATED 8255 with V473I UPDATED 8256 with V473K UPDATED 8257 with V473R UPDATED 8258 with V473M UPDATED 8259 with V473S UPDATED 8260 with V473F UPDATED 8261 with V473W UPDATED 8262 with V473Y UPDATED 8263 with V473G UPDATED 8264 with V473N UPDATED 3715 with W107F UPDATED 3716 with M255C UPDATED 3717 with M255I UPDATED 3718 with M255Y UPDATED 3719 with T275V UPDATED 3720 with W321F UPDATED 3721 with W328F UPDATED 3722 with R418L UPDATED 10001 with A312P UPDATED 10002 with N660D UPDATED 10003 with L147P UPDATED 10010 with N508D UPDATED 10012 with G125S UPDATED 10014 with Q461P UPDATED 10015 with E607A UPDATED 10017 with G111S UPDATED 10018 with G33V UPDATED 12300 with P365R UPDATED 12838 with P365R UPDATED 12874 with P365R UPDATED 12875 with P365R UPDATED 12876 with P365R UPDATED 12877 with P365R UPDATED 12878 with P365R UPDATED 12879 with P365R UPDATED 12880 with P365R UPDATED 12881 with P365R UPDATED 13045 with Q439H UPDATED 13046 with Y413C UPDATED 13047 with G169S UPDATED 13048 with T677P UPDATED 13049 with D189G UPDATED 13050 with D419Y UPDATED 13051 with R484H UPDATED 13053 with F183L UPDATED 13054 with W161C UPDATED 13055 with A312E UPDATED 13056 with R78P UPDATED 13057 with D189N UPDATED 13058 with D675Y UPDATED 13059 with E233G UPDATED 13060 with G124S UPDATED 13061 with A122D UPDATED 13062 with R385P UPDATED 13063 with Q88P UPDATED 13064 with G182R UPDATED 13065 with L132R UPDATED 13066 with M257V UPDATED 13067 with T271I UPDATED 13068 with T326P UPDATED 13069 with W90R UPDATED 13071 with A109T UPDATED 3694 with V633A UPDATED 10019 with V633A UPDATED 3240 with L101P UPDATED 3707 with W328G UPDATED 3733 with D419H UPDATED 3737 with D542H UPDATED 3750 with T394M UPDATED 3768 with A379T UPDATED 8251 with L472K UPDATED 10016 with H417Q UPDATED 13052 with N655D UPDATED 9552 with R463L UPDATED 9554 with T667P UPDATED 9555 with W191R UPDATED 9556 with S315N UPDATED 9558 with S315R UPDATED 9560 with I317V UPDATED 9557 with S315T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14956 UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. DELETED 41343 " 1197 UPDATE Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin antibiotic-resistant rpsL; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13370 with K43R UPDATED 13371 with K88Q UPDATED 13372 with K88R UPDATED 14616 with K43R UPDATED 14620 with K88R UPDATED 14621 with K88Q UPDATED 14622 with K88M UPDATED 9844 with K43R UPDATED 9845 with K88R UPDATED 2045 with K88Q UPDATED 2651 with T40I UPDATED 2653 with K43R UPDATED 2661 with K88R UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14616 " 1301 UPDATE Staphylococcus aureus cls conferring resistance to daptomycin daptomycin resistant cls; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3440 with T33N UPDATED 622 with A23V UPDATED 687 with L52F UPDATED 653 with F60S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1320 UPDATE Klebsiella mutant PhoP conferring antibiotic resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED 2871 with D191Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1339 UPDATE Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol ethambutol resistant embR; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED 2369 with Q379R UPDATED 2350 with C110Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1354 UPDATE Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol ethambutol resistant embA; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13480 with -12c>t UPDATED 13482 with -16c>g UPDATED 13483 with -16c>t UPDATED 13482 with C110Y UPDATED 13483 with C110Y UPDATED 13480 with A462V UPDATED 2395 with D4N UPDATED 2396 with A201T UPDATED 2397 with G321S UPDATED 2398 with G350D UPDATED 2400 with D833A UPDATED 2401 with P913S UPDATED 3583 with G5S UPDATED 2399 with A462V DELETED param_type " 1360 UPDATE Bartonella bacilliformis gyrB conferring resistance to aminocoumarin aminocoumarin resistant gyrB; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED 3428 with G124S UPDATED 3429 with R184Q UPDATED 3430 with T214A UPDATED 3431 with T214I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1574 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid isoniazid resistant inhA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 13366 with I194T UPDATED 13367 with I21T UPDATED 13425 with S94A UPDATED 14807 with S94A UPDATED 9548 with S94A UPDATED 9549 with T162S UPDATED 9550 with I194T UPDATED 2220 with I21V UPDATED 2221 with I21T UPDATED 2222 with I47T UPDATED 2223 with V78A UPDATED 2224 with S94A UPDATED 2288 with I95P UPDATED 2289 with I194T UPDATED 2709 with I16T UPDATED 10055 with G141E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14807 " 1822 UPDATE Staphylococcus aureus gyrB conferring resistance to aminocoumarin aminocoumarin resistant gyrB; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED 2142 with S128L UPDATED 2143 with R144S UPDATED 2144 with R144I UPDATED 2145 with I56S UPDATED 2146 with I102S UPDATED 2147 with T173A UPDATED 3442 with G85S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1849 UPDATE Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides Antibiotic resistant tlyA; streptomycin; capreomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. UPDATED 3828 with G85S UPDATED 3829 with G85S UPDATED 3835 with G85S UPDATED 3908 with G85S UPDATED 2189 with L150P UPDATED 2188 with A91E UPDATED 2257 with R14W UPDATED 2259 with P183L UPDATED 3831 with A67E UPDATED 3832 with K69E UPDATED 3833 with V128E UPDATED 3836 with F185L UPDATED 3840 with E238K UPDATED 3401 with L118P UPDATED 2235 with N236K UPDATED 9448 with G85S DELETED param_type DELETED 41343 " 1935 UPDATE Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 13275 with A90V UPDATED 13318 with D94A UPDATED 13319 with D94G UPDATED 13320 with D94H UPDATED 13321 with D94N UPDATED 13322 with D94Y UPDATED 13347 with G88A UPDATED 13349 with G88C UPDATED 13424 with S91P UPDATED 14269 with G88C UPDATED 14271 with G88A UPDATED 14272 with D89N UPDATED 14274 with A90V UPDATED 14276 with S91P UPDATED 14278 with D94N UPDATED 14281 with D94H UPDATED 14282 with D94Y UPDATED 14283 with D94A UPDATED 14284 with D94G UPDATED 9603 with D94N UPDATED 9605 with D94G UPDATED 9609 with G88C UPDATED 9612 with D94H UPDATED 9622 with D94A UPDATED 9625 with D89N UPDATED 9626 with A90V UPDATED 9627 with S91P UPDATED 2091 with D94G UPDATED 2093 with D94A UPDATED 2094 with D89N UPDATED 2095 with D89G UPDATED 2096 with G88C UPDATED 2180 with S91P UPDATED 2181 with D94N UPDATED 2216 with D94Y UPDATED 2217 with D94V UPDATED 2502 with G88A UPDATED 2503 with A90V UPDATED 2504 with A90G UPDATED 3611 with A90G UPDATED 3841 with A74S UPDATED 3843 with A74S UPDATED 3844 with T80A UPDATED 3849 with P102H UPDATED 4589 with D94T UPDATED 2092 with D89V UPDATED 3842 with D89V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14269 " 1943 UPDATE Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid antibiotic resistant kasA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 2567 with R121K UPDATED 2568 with G387D UPDATED 2569 with F413L UPDATED 3771 with G269S UPDATED 3772 with G312S UPDATED 3791 with D66N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2068 UPDATE Escherichia coli 16S rRNA mutation conferring resistance to edeine 16s rRNA with mutation conferring resistance to peptide antibiotics; edeine A; edeine B; edeine D; edeine F; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3073 with a1499g UPDATED 4842 with t1506a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2070 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13256 with a1401g UPDATED 13331 with g1484t UPDATED 14741 with a1401g UPDATED 14745 with c1402t UPDATED 14756 with g1484t UPDATED 9439 with a1401g UPDATED 9440 with g1484t UPDATED 9442 with a514c UPDATED 12973 with a1401g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14741 " 2076 UPDATE Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12974 with c1198t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2137 UPDATE Escherichia coli EF-Tu mutants conferring resistance to kirromycin elfamycin resistant EF-Tu; kirromycin; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 2947 with Q125K UPDATED 3302 with G317D UPDATED 3303 with Q125R UPDATED 3306 with Y161D UPDATED 3307 with Y161N UPDATED 3308 with L121Q UPDATED 3310 with A376S UPDATED 3311 with Q125E UPDATED 3312 with E379K UPDATED 3410 with Q330H UPDATED 3411 with A376T UPDATED 3313 with Y161C UPDATED 3305 with A376V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2158 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin elfamycin resistant EF-Tu; pulvomycin; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 2934 with T335A UPDATED 2965 with R334C UPDATED 3019 with R234F UPDATED 3020 with R234S UPDATED 3030 with R231C UPDATED 3044 with R231V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2078 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12951 with a1408g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2124 UPDATE Clostridioides difficile EF-Tu mutants conferring resistance to elfamycin elfamycin resistant EF-Tu; LFF571; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 3422 with G261E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1545 UPDATE Escherichia coli gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2050 with S83I UPDATED 2051 with D87N UPDATED 2052 with D87G UPDATED 2053 with D87H UPDATED 2084 with D87Y UPDATED 3318 with S83W UPDATED 3326 with S83L UPDATED 3327 with D87V UPDATED 3328 with D87V UPDATED 3404 with A67S UPDATED 3405 with A84P UPDATED 3397 with Q106H UPDATED 3398 with G81C UPDATED 3329 with G81C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1005 UPDATE Escherichia coli soxR with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; nalidixic acid; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2230 with R20H UPDATED 2233 with G121D UPDATED 3895 with R90G UPDATED 3896 with S31A UPDATED 3897 with R71S UPDATED 7541 with R71S UPDATED 12870 with R71S UPDATED 18555 with R71S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18555 with S128del DELETED 3893 UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. " 1055 UPDATE Escherichia coli parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2226 with D476N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2066 UPDATE Escherichia coli soxS with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; enrofloxacin; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic; model_param "UPDATED 3562 with A12S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1989 UPDATE Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2128 with Y114F UPDATED 2185 with M109I UPDATED 2867 with V165I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1721 UPDATE Mycobacterium leprae folP with mutation conferring resistance to dapsone dapsone resistant dihydropteroate synthase folP; dapsone; sulfone antibiotic; antibiotic target alteration; model_param "UPDATED 2140 with T53A UPDATED 2175 with T53I UPDATED 2200 with P55R UPDATED 2201 with P55L UPDATED 2202 with P55S UPDATED 3292 with T53P UPDATED 3293 with T53N UPDATED 3294 with P55T UPDATED 3295 with P55A UPDATED 3296 with P55H UPDATED 3407 with V48G UPDATED 3408 with V48A UPDATED 3409 with V48F UPDATED 3406 with R54G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 100 UPDATE Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide ethionamide resistant ethA; ethionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED 15477 with M1Var UPDATED 15480 with M1Var UPDATED 15482 with M1Var UPDATED 15485 with M1Var UPDATED 15489 with M1Var UPDATED 15492 with M1Var UPDATED 15494 with M1Var UPDATED 15497 with M1Var UPDATED 15499 with M1Var UPDATED 15504 with M1Var UPDATED 15511 with M1Var UPDATED 15515 with M1Var UPDATED 15517 with M1Var UPDATED 15522 with M1Var UPDATED 15531 with M1Var UPDATED 15533 with M1Var UPDATED 15534 with M1Var UPDATED 15537 with M1Var UPDATED 15546 with M1Var UPDATED 15554 with M1Var UPDATED 15557 with M1Var UPDATED 15558 with M1Var UPDATED 15559 with M1Var UPDATED 15561 with M1Var UPDATED 15565 with M1Var UPDATED 15566 with M1Var UPDATED 15570 with M1Var UPDATED 15571 with M1Var UPDATED 15579 with M1Var UPDATED 15581 with M1Var UPDATED 15583 with M1Var UPDATED 15587 with M1Var UPDATED 15589 with M1Var UPDATED 15593 with M1Var UPDATED 15644 with M1Var UPDATED 15645 with M1Var UPDATED 15646 with M1Var UPDATED 15647 with M1Var UPDATED 15659 with M1Var UPDATED 15661 with M1Var UPDATED 15663 with M1Var UPDATED 15666 with M1Var UPDATED 15668 with M1Var UPDATED 15670 with M1Var UPDATED 15672 with M1Var UPDATED 15674 with M1Var UPDATED 15677 with M1Var UPDATED 15682 with M1Var UPDATED 15683 with M1Var UPDATED 15685 with M1Var UPDATED 15691 with M1Var UPDATED 15704 with M1Var UPDATED 15718 with M1Var UPDATED 15720 with M1Var UPDATED 15725 with M1Var UPDATED 15503 with C403Y UPDATED 15516 with S390F UPDATED 15526 with N379D UPDATED 15544 with A341V UPDATED 15611 with R207G UPDATED 15617 with V202G UPDATED 15673 with T88I UPDATED 15696 with S57Y UPDATED 15715 with L35R UPDATED 15594 with L35R UPDATED 15599 with L35R UPDATED 15602 with L35R UPDATED 15603 with L35R UPDATED 15608 with L35R UPDATED 15613 with L35R UPDATED 15618 with L35R UPDATED 15639 with L35R UPDATED 15640 with L35R UPDATED 15743 with L35R UPDATED 9504 with T342K UPDATED 9505 with N379D UPDATED 9510 with H281P UPDATED 9506 with H281P UPDATED 9508 with Y84D UPDATED 9507 with E223K UPDATED 2496 with I338S UPDATED 2497 with G385D UPDATED 2498 with T392A UPDATED 2499 with G413D UPDATED 2500 with R463S UPDATED 4143 with G43C UPDATED 4144 with P51L UPDATED 4145 with D58A UPDATED 4149 with T342K UPDATED 4150 with A381P UPDATED 4151 with T186K UPDATED 8346 with Y84D UPDATED 8312 with Y84D UPDATED 2494 with G43S UPDATED 2495 with E223K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 9505 UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 15743 with -7t>c UPDATED 8312 with -11t>c UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. DELETED 41343 " 1323 UPDATE Salmonella serovars parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2227 with V461G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1671 UPDATE Salmonella serovars soxS with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic; model_param "UPDATED 2234 with E52K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 953 UPDATE Enterococcus faecalis liaF mutant conferring daptomycin resistance daptomycin resistant liaF; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18553 with R177del DELETED 3861 UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to the reference sequence, one or more amino acids are inserted. These represent in-frame insertions which do not result in frameshift variants and where the insertion is not a duplication of a sequence immediately N-terminal (5'), and are denoted with wildtype flanking residues. Format is given by [wildtype AA position]_[wildtype AA position]ins[AA sequence], e.g. K464_D465insE or P46_A47insYS. UPDATED 18554 with R177_T178insI DELETED 3868 UPDATED 3862 with T194I UPDATED 18554 with T194I UPDATED 18553 with T194I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1135 UPDATE Staphylococcus aureus parE conferring resistance to aminocoumarin aminocoumarin resistant parE; novobiocin; clorobiocin; coumermycin A1; aminocoumarin antibiotic; antibiotic target alteration; model_param "UPDATED 2193 with R136G UPDATED 4410 with G78S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 570 UPDATE Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfadiazine; sulfadimidine; sulfadoxine; sulfamethoxazole; sulfisoxazole; sulfacetamide; mafenide; sulfasalazine; sulfamethizole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED 2116 with F25I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 431 UPDATE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_name; model_param "UPDATED model_name with Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline UPDATED 2102 with Y137H UPDATED 2103 with R94S UPDATED 2104 with L78M UPDATED 2105 with V45E UPDATED 2106 with R73C UPDATED 2107 with R73S UPDATED 2108 with R77C UPDATED 2109 with G103S UPDATED 2130 with I49S UPDATED 2131 with A70T UPDATED 2132 with R77L UPDATED 2852 with R94H UPDATED 7640 with S3N UPDATED 8206 with R58L UPDATED 3898 with R58L UPDATED 2133 with V96E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. " 2116 UPDATE Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12981 with c1194g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2147 UPDATE Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa elfamycin resistant EF-Tu; enacyloxin IIa; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 3566 with A375T UPDATED 3567 with G316D UPDATED 3568 with Q124K UPDATED 3569 with Q329H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2131 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13273 with a514c UPDATED 13288 with c517t UPDATED 14665 with a514c UPDATED 14668 with c517t UPDATED 14687 with g878a UPDATED 9846 with a1401g UPDATED 9848 with a514c UPDATED 9849 with c517t UPDATED 2911 with a1401g UPDATED 2949 with g427c UPDATED 3052 with a514c UPDATED 3054 with a906g UPDATED 4801 with c517t UPDATED 4802 with c513t UPDATED 4804 with c492t UPDATED 4805 with a514t UPDATED 7820 with c516t UPDATED 12595 with g878a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14665 " 821 UPDATE Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin rifamycin-resistant arabinosyltransferase; rifampin; rifamycin antibiotic; antibiotic target alteration; model_param "UPDATED 2649 with Y319D UPDATED 2650 with Y333H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1001 UPDATE Staphylococcus aureus mprF with mutation conferring resistance to daptomycin daptomycin resistant mprF; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 2206 with S295L UPDATED 2207 with G61V UPDATED 2208 with S337L UPDATED 2210 with P314L UPDATED 2211 with T345I UPDATED 2212 with T345A UPDATED 3609 with I420N UPDATED 3613 with T345K UPDATED 3614 with T472K UPDATED 3615 with M347R UPDATED 3616 with L341S UPDATED 3617 with V351E UPDATED 2209 with L826F UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1203 UPDATE Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid antibiotic resistant ndh; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 9583 with R268H UPDATED 2310 with V18A UPDATED 2402 with R13C UPDATED 3641 with A300P UPDATED 3642 with R268H UPDATED 3643 with T110A UPDATED 3644 with G313R UPDATED 3646 with L50V UPDATED 10057 with G339A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 3642 DELETED 41345 " 1395 UPDATE Neisseria gonorrhoeae porin PIB (por) General Bacterial Porin with reduced permeability to beta-lactams; tetracycline; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; reduced permeability to antibiotic; model_param "UPDATED 3288 with G339A UPDATED 3289 with G339A UPDATED 60 with G120K UPDATED 61 with G120D UPDATED 64 with A121D DELETED param_type " 1432 UPDATE Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol ethambutol resistant embC; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED 9492 with V987G UPDATED 2261 with T270I UPDATED 2263 with Q491R UPDATED 2264 with L502P UPDATED 2371 with A247P UPDATED 2372 with L251R UPDATED 2373 with A254G UPDATED 2375 with H285Y UPDATED 2376 with V287F UPDATED 2377 with G288W UPDATED 2378 with G288V UPDATED 2379 with Y296H UPDATED 2380 with Y296S UPDATED 2381 with I297L UPDATED 2382 with I297T UPDATED 2383 with M300R UPDATED 2385 with V303G UPDATED 2386 with A307T UPDATED 2387 with G308D UPDATED 2388 with Y309N UPDATED 2389 with M310K UPDATED 2390 with G325S UPDATED 2391 with W326R UPDATED 2392 with Y327N UPDATED 2393 with N394D UPDATED 2394 with V981L UPDATED 3612 with R738Q UPDATED 4128 with R738Q UPDATED 4130 with R738Q UPDATED 4135 with R738Q UPDATED 4138 with R738Q UPDATED 4139 with R738Q UPDATED 2262 with P398S UPDATED 2384 with R302G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 4129 " 1710 UPDATE Mycobacterium leprae gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2165 with D464N UPDATED 2169 with N502D UPDATED 2172 with E504V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2069 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 3060 with a1408g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2073 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; G418; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4812 with t1406a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2074 UPDATE Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12949 with c1066t UPDATED 4810 with c1192t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2109 UPDATE Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 14218 with A504V UPDATED 14237 with S447F UPDATED 14240 with D461H UPDATED 14241 with D461N UPDATED 14243 with N499D UPDATED 14245 with N499T UPDATED 14249 with E501V UPDATED 14250 with E501D UPDATED 14252 with A504V UPDATED 9616 with E501D UPDATED 9630 with N499T UPDATED 3460 with V301L UPDATED 3463 with V301L UPDATED 3464 with V301L UPDATED 3505 with T500P UPDATED 3506 with T500P UPDATED 3513 with E501V UPDATED 3504 with T500N UPDATED 3508 with N499K UPDATED 3512 with N499K UPDATED 3507 with E501D UPDATED 3845 with N499D UPDATED 3462 with N499D UPDATED 3461 with D461H UPDATED 9615 with V457L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED 3460 with V301L UPDATED 3504 with T500N UPDATED 3505 with T500P UPDATED 3508 with N499K DELETED 14252 UPDATED 3460 with V301L UPDATED 3845 with N499D UPDATED 3461 with D461H UPDATED 3462 with N499D UPDATED 3504 with T500N UPDATED 3505 with T500P UPDATED 3507 with E501D UPDATED 3508 with N499K UPDATED 3513 with E501V DELETED 40438 " 2077 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12950 with a1389g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 212 UPDATE Staphylococcus aureus parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3982 with S80F UPDATED 3984 with E84G UPDATED 3983 with S80Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 535 UPDATE Morganella morganii gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2164 with S464Y UPDATED 3448 with S463A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 36 UPDATE Mycobacterium leprae gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2127 with A91T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1696 UPDATE Salmonella serovars gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 2174 with E466D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1441 UPDATE Klebsiella aerogenes Omp36 General Bacterial Porin with reduced permeability to beta-lactams; cefepime; imipenem; cefpirome; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; model_param "UPDATED 2085 with G133D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2085 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2925 with g1068a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2097 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; paromomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2995 with a1408g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2113 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4827 with t1406a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2129 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2910 with c1192a UPDATED 2919 with g1064a UPDATED 2959 with g1064c UPDATED 3070 with c1192g UPDATED 4815 with g1064t UPDATED 4816 with c1192t UPDATED 4817 with c1066t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1894 UPDATE Salmonella enterica ramR mutants resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2136 with R46P UPDATED 2137 with M84I UPDATED 2138 with Y59H UPDATED 2139 with T18P UPDATED 2155 with G25A UPDATED 2864 with E160D UPDATED 3899 with T50P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2133 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 12983 with a1401g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2152 UPDATE Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2897 with g1065c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2176 UPDATE glycopeptide resistance gene cluster VanN glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4681 with g1065c " 2177 UPDATE glycopeptide resistance gene cluster VanA glycopeptide resistance gene cluster; vancomycin; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4671 with g1065c " 2178 UPDATE glycopeptide resistance gene cluster VanO glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4682 with g1065c " 2179 UPDATE glycopeptide resistance gene cluster VanE glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4679 with g1065c " 2180 UPDATE glycopeptide resistance gene cluster VanL glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4680 with g1065c " 2181 UPDATE glycopeptide resistance gene cluster VanF glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4676 with g1065c " 2182 UPDATE glycopeptide resistance gene cluster VanD glycopeptide resistance gene cluster; vancomycin; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4674 with g1065c " 2183 UPDATE glycopeptide resistance gene cluster VanB glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4672 with g1065c " 2184 UPDATE glycopeptide resistance gene cluster VanC glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4673 with g1065c " 2185 UPDATE glycopeptide resistance gene cluster VanM glycopeptide resistance gene cluster; vancomycin; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4677 with g1065c " 2186 UPDATE glycopeptide resistance gene cluster VanG glycopeptide resistance gene cluster; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4678 with g1065c " 2196 UPDATE Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; ofloxacin; sparfloxacin; pefloxacin; sitafloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3315 with g1065c UPDATED 3316 with g1065c UPDATED 3143 with T83I UPDATED 3144 with H80R UPDATED 3145 with D87N UPDATED 3317 with D87N DELETED param_type " 2075 UPDATE Salmonella enterica soxR with mutation conferring antibiotic resistance ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 3900 with R20H UPDATED 3901 with G121D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2093 UPDATE Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 3027 with c1193g UPDATED 4808 with c1193t UPDATED 2932 with g1194c UPDATED 3010 with a1192g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2143 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12986 with a1401g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2132 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13258 with a1401g UPDATED 14743 with a1401g UPDATED 14747 with c1402t UPDATED 14758 with g1484t UPDATED 9599 with a1401g UPDATED 9600 with a514c UPDATED 9601 with c517t UPDATED 2923 with c1402a UPDATED 3014 with a1401g UPDATED 4800 with g1484t UPDATED 4799 with c1402t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14743 " 2127 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13021 with a1402g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2154 UPDATE Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2975 with a1184g UPDATED 4806 with c1185t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2122 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12982 with a1355g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2128 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2958 with a1375g UPDATED 4796 with c1376t UPDATED 4797 with g1458t UPDATED 4798 with t1373a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2111 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 12980 with a1355g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2084 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4795 with c1376t UPDATED 3036 with a1375g UPDATED 4793 with g1458t UPDATED 4794 with t1373a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2105 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2896 with a1375g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2155 UPDATE Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED 2931 with g1032c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2100 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2981 with a1355g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2091 UPDATE Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 3008 with a1355g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2090 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4786 with t1373a UPDATED 4787 with g1458t UPDATED 4788 with c1376t UPDATED 3075 with a1375g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2126 UPDATE Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; tobramycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 3049 with a1375g UPDATED 4790 with c1376t UPDATED 4791 with g1458t UPDATED 4792 with t1373a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2198 UPDATE Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones fluoroquinolone resistant parE; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3149 with M437I UPDATED 3150 with A473V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2136 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2904 with a1408g UPDATED 4813 with t1406a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2140 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2966 with a523c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2146 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4825 with c528t UPDATED 4826 with g527t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2157 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; gentamicin C; gentamicin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 3018 with a1408g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1450 UPDATE Escherichia coli parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3972 with S80I UPDATED 3973 with E84G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2083 UPDATE Mycoplasma hominis parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 9862 with S91I UPDATED 9864 with K149R UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2096 UPDATE Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kasugamycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2941 with g926c UPDATED 2951 with a1519c UPDATED 2979 with a794g UPDATED 2998 with a1519g UPDATED 3050 with g926a UPDATED 4822 with a794t UPDATED 4823 with a1519t UPDATED 4824 with g926t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2145 UPDATE Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED 3061 with g1058c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2102 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; hygromycin B; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 7842 with t1348c UPDATED 7843 with c1439t UPDATED 7844 with t1441c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2149 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; hygromycin B; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4831 with t1389c UPDATED 4832 with c1480t UPDATED 4830 with t1482c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2106 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2929 with a1391g UPDATED 4838 with t1389a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2088 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 2948 with a503c UPDATED 3056 with g504c UPDATED 4828 with c502t UPDATED 4829 with c506t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2141 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; neomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4840 with t1389a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2099 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 3029 with a1391g UPDATED 4837 with t1389a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2142 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 12984 with g1475a UPDATED 12985 with g1475t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2205 UPDATE MexJ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; macrolide antibiotic; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 37250 " 2206 UPDATE MexK resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; macrolide antibiotic; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 37250 " 2249 UPDATE LpxA Acinetobacter mutant Lpx gene conferring resistance to colistin; colistin A; colistin B; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3337 with Q72K UPDATED 3335 with H159D UPDATED 3336 with G68D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41343 " 2251 UPDATE LpxC Acinetobacter mutant Lpx gene conferring resistance to colistin; colistin A; colistin B; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3342 with P30L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41343 " 2257 UPDATE Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A elfamycin resistant EF-Tu; GE2270A; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 3418 with G261S UPDATED 3419 with V278A UPDATED 3420 with G279A UPDATED 3421 with V295C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2224 UPDATE Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem Outer Membrane Porin (Opr); imipenem; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; model_param "UPDATED 3176 with Q142X UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2276 UPDATE Staphylococcus aureus ileS with mutation conferring resistance to mupirocin antibiotic-resistant isoleucyl-tRNA synthetase (ileS); mupirocin; mupirocin-like antibiotic; antibiotic target alteration; model_param "UPDATED 3605 with V588F UPDATED 3606 with V631F UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2284 UPDATE Escherichia coli murA with mutation conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED 3623 with D369N UPDATED 3624 with L370I UPDATED 3627 with C115D UPDATED 3628 with C115E UPDATED 3639 with C115S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2290 UPDATE Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED 13249 with D117C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3312 UPDATE Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; moxifloxacin; azithromycin; macrolide antibiotic; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 8730 with a2071c UPDATED 8732 with a2071t UPDATED 8733 with a2072g UPDATED 8731 with a2071g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 651 UPDATE Staphylococcus aureus mprF defensin resistant mprF; defensin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 8269 with T345A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2268 UPDATE eatAv Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; pleuromutilin; pleuromutilin antibiotic; antibiotic target protection; model_param "UPDATED 3466 with T450I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2285 UPDATE Staphylococcus aureus murA with mutation conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 3638 with T450I UPDATED 3630 with V65L UPDATED 3631 with G257D UPDATED 3632 with D278E UPDATED 3633 with E291D UPDATED 3634 with Q362R UPDATED 3635 with T396N DELETED param_type " 2286 UPDATE Borreliella burgdorferi murA with mutation conferring resistance to fosfomycin antibiotic-resistant murA transferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED 3640 with D116C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2288 UPDATE Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid antibiotic resistant ndh; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 3664 with R202W UPDATED 3665 with L239P UPDATED 3666 with V329A UPDATED 3667 with D366G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41345 " 2310 UPDATE Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin elfamycin resistant EF-Tu; kirromycin; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 8300 with A379T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2294 UPDATE Campylobacter jejuni gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3817 with T86I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2314 UPDATE Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 9881 with G79C UPDATED 9882 with S81L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2305 UPDATE Enterococcus faecalis gshF with mutation conferring daptomycin resistance daptomycin resistant gshF; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3891 with E554K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2301 UPDATE Enterococcus faecalis YybT with mutation conferring daptomycin resistance daptomycin resistant YybT; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3878 with I440S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2306 UPDATE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; ceftazidime; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_name; model_param "UPDATED model_name with Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime UPDATED 3903 with R45C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2295 UPDATE Enterococcus faecium liaF mutant conferring daptomycin resistance daptomycin resistant liaF; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 3859 with I144T UPDATED 3860 with L39F UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2296 UPDATE Enterococcus faecalis liaS mutant conferring daptomycin resistance daptomycin resistant liaS; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 3865 with A180T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2297 UPDATE Enterococcus faecalis liaR mutant conferring daptomycin resistance daptomycin resistant liaR; daptomycin; peptide antibiotic; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 3870 with D191N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2293 UPDATE Bacillus subtilis pgsA with mutation conferring resistance to daptomycin daptomycin resistant pgsA; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3815 with A64V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2299 UPDATE Staphylococcus aureus walK with mutation conferring resistance to daptomycin daptomycin resistant walK; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3875 with L10F UPDATED 3887 with S221P UPDATED 3888 with R263C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2315 UPDATE Acinetobacter baumannii parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 9872 with S84L UPDATED 9873 with V104I UPDATED 9874 with D105E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1670 UPDATE nalC protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED 4363 with S209R UPDATED 4364 with R97G UPDATED 4366 with A186T UPDATED 7533 with G71E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 36005 " 2373 UPDATE Escherichia coli UhpT with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED 4358 with E350Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 383 UPDATE Pseudomonas mutant PhoQ conferring resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED 4370 with K123Q UPDATED 4371 with V260G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2374 UPDATE Escherichia coli uhpA with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_name; model_param "UPDATED model_name with Escherichia coli uhpA with mutation conferring resistance to fosfomycin UPDATED 4362 with G97D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2379 UPDATE Escherichia coli cyaA with mutation conferring resistance to fosfomycin antibiotic-resistant cya adenylate cyclase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_name; model_param "UPDATED model_name with Escherichia coli cyaA with mutation conferring resistance to fosfomycin UPDATED 4382 with S352T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 660 UPDATE Streptococcus pneumoniae parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 9866 with S82F UPDATED 9867 with D86H UPDATED 9865 with S82Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2104 UPDATE Ureaplasma urealyticum parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3974 with S83L UPDATED 3975 with S83W UPDATED 3976 with S84P UPDATED 4636 with E87Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2401 UPDATE Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4438 with S84Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2402 UPDATE Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4440 with S84F UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2403 UPDATE Salmonella enterica gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4443 with S97P UPDATED 4444 with S83F UPDATED 4445 with D87N UPDATED 4446 with D87Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2406 UPDATE rpsJ tetracycline-resistant ribosomal protection protein; tetracycline; tetracycline antibiotic; antibiotic target protection; model_param "UPDATED 4458 with V57L UPDATED 4457 with V57M UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2407 UPDATE Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4461 with G80N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2410 UPDATE Salmonella enterica parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4487 with W106G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2411 UPDATE Shigella flexneri gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; nalidixic acid; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4489 with N57K UPDATED 4490 with H80P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2412 UPDATE Shigella flexneri parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; nalidixic acid; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4492 with A85T UPDATED 4493 with D111H UPDATED 4494 with S129P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2409 UPDATE Neisseria meningititis PBP2 conferring resistance to beta-lactam Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; cefixime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 4464 with G482S UPDATED 4466 with F504L UPDATED 4467 with A510V UPDATED 4468 with I312M UPDATED 4469 with V316T UPDATED 4470 with N512Y UPDATED 4471 with G545S UPDATED 4472 with A501P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2416 UPDATE abcA ATP-binding cassette (ABC) antibiotic efflux pump; methicillin; daptomycin; cefotaxime; moenomycin A1; cephalosporin; penicillin beta-lactam; peptide antibiotic; moenomycin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "UPDATED category_aro_accession with 3000687 UPDATED category_aro_cvterm_id with 37031 UPDATED category_aro_name with moenomycin antibiotic UPDATED category_aro_description with Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis. UPDATED category_aro_class_name with Drug Class " 1035 UPDATE Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 4481 with E475G UPDATED 4482 with T488A UPDATED 4480 with T445A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2394 UPDATE Staphylococcus aureus menA with mutation conferring resistance to lysocin lysocin resistant menA; Lysocin E; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 4430 with G33D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2380 UPDATE Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin antibiotic-resistant GlpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 4391 with G33D UPDATED 4385 with W137R UPDATED 4386 with F3I UPDATED 4387 with L27F UPDATED 4388 with A100V UPDATED 4389 with V213I UPDATED 4390 with G352D DELETED param_type DELETED 41343 " 2462 UPDATE Cutibacterium acnes gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4555 with S101L UPDATED 4556 with D105G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2381 UPDATE Staphylococcus aureus UhpT with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 4399 with D105G UPDATED 4400 with D105G UPDATED 4396 with G358V UPDATED 4397 with G112E UPDATED 4398 with W425R DELETED param_type DELETED 41343 " 3353 UPDATE Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; clindamycin; macrolide antibiotic; lincosamide antibiotic; antibiotic target alteration; model_param "UPDATED 8802 with c656t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1600 UPDATE Pseudomonas mutant PhoP conferring resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED 4367 with R117L UPDATED 4368 with A110V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2436 UPDATE D-Ala-D-Ala ligase Van ligase; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param; model_sequences; CARD_short_name "UPDATED 4524 with E13G UPDATED 4525 with G99R UPDATED 4526 with V241D UPDATED 4527 with D295G UPDATED 4528 with P313L UPDATED 18559 with P313L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18559 with D244_V245del DELETED 4529 DELETED 41345 UPDATED accession with AAB17902.2 UPDATED sequence with MKITLLYGGRSAEHEVSILSAFSVLNAIYYNYYQVQLVFITKEGQWVKGPLLTEKPASKDVLHLSWDPSGQTEEGFTGKVINPGEIKEEGAIVFPVLHGPNGEDGTIQGFLETLNMPYVGAGVLTSACAMDKIMTKYILQAAGVPQVPYVPVLKNQWKENPKKVFDQCEGSLLYPMFVKPANMGSSVGITKAENREELQNALATAYQYDSRAIVEQGIEAREIEVAVLGNEDVRTTLPGEVVKDVAFYDYEAKYINNKIEMQIPAEVPEEVYQKAQEYAKLAYTMLGGSGLSRCDFFLTNKNELFLNELNSMPGFTEFSMYPLLWENMGLKYGDLIEELIQLGMNRYHQRQSFFEKNE UPDATED accession with U39790.2 UPDATED fmin with 42 UPDATED fmax with 1119 UPDATED strand with + UPDATED sequence with TTGAAGATTACTTTACTATATGGCGGACGCAGCGCAGAGCATGAAGTTTCCATTCTTTCCGCATTTTCAGTTTTAAATGCCATTTATTATAATTATTACCAAGTTCAACTCGTATTTATTACAAAAGAAGGACAATGGGTCAAAGGTCCATTACTAACAGAAAAACCTGCTAGCAAAGATGTCTTGCATCTTTCATGGGACCCAAGTGGACAGACAGAGGAAGGCTTTACAGGAAAAGTGATCAATCCGGGAGAAATCAAAGAAGAAGGAGCCATCGTTTTTCCAGTTTTACACGGGCCAAACGGGGAAGATGGAACGATCCAAGGCTTCTTAGAGACATTGAATATGCCTTATGTCGGCGCAGGCGTATTGACCAGTGCATGTGCCATGGATAAAATCATGACCAAGTATATTTTACAAGCTGCTGGTGTGCCGCAAGTTCCTTATGTACCAGTACTTAAGAATCAATGGAAAGAAAATCCTAAAAAAGTATTTGATCAATGTGAAGGTTCTTTGCTTTATCCGATGTTTGTCAAACCTGCGAATATGGGTTCTAGTGTCGGCATTACAAAGGCAGAAAACCGAGAAGAGCTGCAAAATGCTTTAGCAACAGCCTATCAGTATGATTCTCGAGCAATCGTTGAACAAGGAATTGAAGCGCGCGAAATCGAAGTTGCTGTATTAGGAAATGAAGATGTTCGGACGACTTTGCCTGGCGAAGTCGTAAAAGACGTAGCATTCTATGATTATGAAGCCAAATATATCAATAATAAAATCGAAATGCAGATTCCAGCCGAAGTGCCGGAAGAAGTTTATCAAAAAGCGCAAGAGTACGCGAAGTTAGCTTACACGATGTTAGGTGGAAGCGGATTGAGCCGGTGCGATTTCTTTTTGACAAATAAAAATGAATTATTCCTGAATGAATTAAACTCTATGCCAGGATTTACGGAGTTCAGTATGTACCCACTCTTATGGGAAAATATGGGCTTGAAATACGGTGATTTGATTGAAGAACTGATTCAATTAGGAATGAATCGATACCATCAGCGTCAATCTTTTTTTGAAAAAAATGAATAA UPDATED partial with 0 UPDATED NCBI_taxonomy_cvterm_id with 36779 UPDATED NCBI_taxonomy_name with Enterococcus faecium UPDATED NCBI_taxonomy_id with 1352 DELETED 3769 UPDATED CARD_short_name with ddl " 3269 UPDATE Clostridioides difficile rpoB with mutation conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 8677 with R505K UPDATED 8678 with H502N UPDATED 8679 with S488P UPDATED 8680 with S498T UPDATED 8827 with H502L UPDATED 8828 with H502Y UPDATED 8829 with H502Y UPDATED 8830 with D492N UPDATED 8831 with D492V UPDATED 8832 with S550F UPDATED 8833 with S550Y UPDATED 8840 with Q1073R UPDATED 8842 with P496S UPDATED 8848 with S488T UPDATED 8826 with S488T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2144 UPDATE Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol ethambutol resistant embB; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED 2950 with T610K UPDATED 2969 with Q998R UPDATED 2917 with F1012S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2476 UPDATE Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin 16S rRNA with mutation conferring resistance to pactamycin; pactamycin; pactamycin-like antibiotic; antibiotic target alteration; model_param "UPDATED 7809 with a633g UPDATED 7811 with c735t UPDATED 7810 with c734t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2478 UPDATE Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED 4758 with a965g UPDATED 4759 with a967c UPDATED 4761 with a967c UPDATED 12459 with a926g UPDATED 12458 with a928c UPDATED 4760 with a928c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 12556 " 3716 UPDATE Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv0191; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 9723 with V179A UPDATED 9724 with A213T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3726 UPDATE Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid isoniazid resistant inbR; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 12576 with R9H UPDATED 12578 with L17Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2812 UPDATE Mycobacteroides chelonae 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7916 with a2272c UPDATED 7917 with a2272g UPDATED 7918 with a2273c UPDATED 7919 with a2273g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3380 UPDATE Clostridioides difficile rpoC with mutation conferring resistance to vancomycin vancomycin-resistant beta prime subunit of RNA polymerase (rpoC); vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 8841 with D244Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2550 UPDATE Clostridioides difficile gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; ofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4650 with A384D UPDATED 8663 with C245T UPDATED 8664 with D71V UPDATED 8665 with T82I UPDATED 8666 with T82V UPDATED 8667 with A118T UPDATED 8689 with T83I UPDATED 8808 with D71G UPDATED 8809 with T82A UPDATED 8810 with D81N UPDATED 8811 with R90K UPDATED 8812 with D103N UPDATED 8839 with L345I UPDATED 8843 with A118S UPDATED 8844 with A92E UPDATED 8845 with A92E UPDATED 8847 with P116A UPDATED 8813 with Q123K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2551 UPDATE glycopeptide resistance gene cluster VanI glycopeptide resistance gene cluster; vancomycin; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 4683 with Q123K " 3727 UPDATE Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid isoniazid resistant mshA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 9563 with A187V UPDATED 10059 with F355S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2098 UPDATE Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin 16s rRNA with mutation conferring resistance to peptide antibiotics; viomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 2985 with g1475a UPDATED 4844 with g1475t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3718 UPDATE Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv2731; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 9731 with P82T UPDATED 9732 with F89L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3729 UPDATE Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid isoniazid resistant mshC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 9566 with A403G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 320 UPDATE Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 4473 with I371T UPDATED 4474 with R384G UPDATED 4475 with N514H UPDATED 4477 with N605T UPDATED 4478 with M400T UPDATED 4479 with M339F UPDATED 4476 with L546V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3720 UPDATE Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide pyrazinamide resistant Rv3169; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 9733 with L546V UPDATED 9734 with N56S UPDATED 9737 with A194P UPDATED 9736 with A190G UPDATED 9735 with W171R DELETED param_type " 1474 UPDATE MexR protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_name; model_param; ARO_category "UPDATED model_name with MexR UPDATED 2760 with I72N UPDATED 2761 with L75P UPDATED 2762 with L75R UPDATED 2763 with R83C UPDATED 2825 with R91C UPDATED 2826 with R91H UPDATED 2888 with L45P UPDATED 2889 with I46N UPDATED 2890 with L57R UPDATED 6704 with L57P UPDATED 7614 with N53D UPDATED 7615 with H107P UPDATED 2891 with T69I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 36005 " 2705 UPDATE MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7584 with A190G " 1213 UPDATE nalD protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param; ARO_category "UPDATED 6750 with S32N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41345 DELETED 36005 " 2688 UPDATE ArmR protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; ARO_category "DELETED 36005 " 2689 UPDATE Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid 23S rRNA with mutation conferring resistance to linezolid antibiotics; linezolid; macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; oxazolidinone antibiotic; glycopeptide antibiotic; phenicol antibiotic; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED 7941 with g2604t UPDATED 7940 with c2579t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2691 UPDATE Type A NfxB resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 7548 with R42G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2693 UPDATE Type B NfxB resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 7549 with H87R UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2707 UPDATE MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin resistance-nodulation-cell division (RND) antibiotic efflux pump; trimethoprim; chloramphenicol; norfloxacin; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7585 with H87R " 2267 UPDATE Escherichia coli nfsA mutations conferring resistance to nitrofurantoin antibiotic resistant nfsA; nitrofurantoin; nitrofuran antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 8193 with H87R UPDATED 8194 with H87R UPDATED 3467 with R15C UPDATED 3469 with R203L UPDATED 3470 with R203C UPDATED 3471 with G131D UPDATED 3472 with S33R UPDATED 8195 with R133S UPDATED 8192 with R133S DELETED param_type DELETED 41343 " 2108 UPDATE Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A elfamycin resistant EF-Tu; GE2270A; elfamycin antibiotic; antibiotic target alteration; model_param "UPDATED 3055 with G258A UPDATED 4119 with G275A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 624 UPDATE Mycobacterium leprae rpoB mutations conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 2040 with V472I UPDATED 2041 with S456L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1305 UPDATE OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; azithromycin; chloramphenicol; thiamphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35977 " 2695 UPDATE MexCD-OprJ with type B NfxB mutation resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; gentamicin C; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7552 with S456L " 2712 UPDATE MexXY-OprA resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; tetracycline; tobramycin; meropenem; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7589 with S456L " 2724 UPDATE MuxABC-OpmB resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; novobiocin; aztreonam; kitasamycin; rokitamycin; macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7597 with S456L " 3731 UPDATE Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid isoniazid resistant mymA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 9575 with S456L UPDATED 9569 with M371I UPDATED 9574 with A205T DELETED param_type " 2729 UPDATE MexJK-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; macrolide antibiotic; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7606 with A205T " 2731 UPDATE MexJK-OpmH resistance-nodulation-cell division (RND) antibiotic efflux pump; triclosan; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7607 with A205T " 2732 UPDATE MexVW-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; acriflavine; tetracycline; chloramphenicol; macrolide antibiotic; fluoroquinolone antibiotic; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7705 with A205T " 2733 UPDATE TriABC-OpmH resistance-nodulation-cell division (RND) antibiotic efflux pump; triclosan; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7609 with A205T " 2745 UPDATE AcrAB-TolC resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7768 with A205T " 2748 UPDATE oqxAB resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; nitrofurantoin; trimethoprim; fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7704 with A205T " 2760 UPDATE MexGHI-OpmD resistance-nodulation-cell division (RND) antibiotic efflux pump; acriflavine; tetracycline; norfloxacin; fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7742 with A205T " 2761 UPDATE MexPQ-OpmE resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; acriflavine; tetracycline; imipenem; trimethoprim; chloramphenicol; thiamphenicol; kitasamycin; rokitamycin; macrolide antibiotic; carbapenem; tetracycline antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7743 with A205T " 2762 UPDATE MexMN-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; chloramphenicol; thiamphenicol; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7744 with A205T " 2763 UPDATE MdtABC-TolC resistance-nodulation-cell division (RND) antibiotic efflux pump; novobiocin; aminocoumarin antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7745 with A205T " 2765 UPDATE EmrAB-TolC major facilitator superfamily (MFS) antibiotic efflux pump; nalidixic acid; fluoroquinolone antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7747 with A205T " 2766 UPDATE EmrKY-TolC major facilitator superfamily (MFS) antibiotic efflux pump; tetracycline; tetracycline antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7748 with A205T " 2768 UPDATE MdtEF-TolC resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cloxacillin; oxacillin; norfloxacin; macrolide antibiotic; fluoroquinolone antibiotic; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7750 with A205T " 2769 UPDATE MdtNOP major facilitator superfamily (MFS) antibiotic efflux pump; acriflavine; puromycin; nucleoside antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7752 with A205T " 2775 UPDATE Pseudomonas aeruginosa soxR ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; ARO_category "DELETED 35963 " 2747 UPDATE AcrEF-TolC confers resistance to ciprofloxacin resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7771 with A205T " 2805 UPDATE Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; pleuromutilin; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED 7889 with a2072g UPDATED 7890 with a2073g UPDATED 7892 with g2461a UPDATED 7891 with g2075t UPDATED 7895 with g2461t UPDATED 7897 with a2586t UPDATED 7896 with t2518g UPDATED 7894 with c2069a UPDATED 7893 with a2517t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2791 UPDATE Streptococcus mitis CdsA with mutation conferring daptomycin resistance daptomycin resistant CdsA; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 7791 with D222N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2833 UPDATE Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin 23S rRNA with mutation conferring resistance to macrolide antibiotics; tylosin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8198 with a2058g UPDATED 8199 with a2058t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2792 UPDATE Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7794 with a2330t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2794 UPDATE Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7905 with a2146c UPDATED 7908 with a2147g UPDATED 7909 with a2147c UPDATED 7907 with a2146t UPDATED 12515 with a1410g UPDATED 12516 with a2167g UPDATED 12517 with c1707t UPDATED 12518 with c2922t UPDATED 12519 with c2922t UPDATED 12597 with a2144g UPDATED 13112 with a2142g UPDATED 7906 with a2146g UPDATED 12514 with a2143g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2798 UPDATE AxyZ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; cefepime; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 7819 with V29G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2806 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin 23S rRNA with mutation conferring resistance to lincosamide antibiotics; clindamycin; lincosamide antibiotic; antibiotic target alteration; model_param "UPDATED 7898 with g2032a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2807 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7899 with g2032t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2808 UPDATE Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7900 with g2281a UPDATED 7901 with g2294a UPDATED 7902 with g2295a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2803 UPDATE Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid aminosalicylate resistant thymidylate synthase; para-aminosalicylic acid; salicylic acid antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 7856 with g2295a UPDATED 7859 with g2295a UPDATED 7861 with g2295a UPDATED 7851 with W101R UPDATED 7852 with H75N UPDATED 7853 with T22A UPDATED 7854 with T202A UPDATED 7855 with Y36C UPDATED 7857 with V77F UPDATED 7858 with W83C UPDATED 7860 with G91R UPDATED 7862 with S105P UPDATED 7863 with R126Q UPDATED 7864 with F152V UPDATED 7865 with C161T UPDATED 7866 with H207R UPDATED 7868 with P224L UPDATED 7869 with R235P DELETED 7867 DELETED 7867 DELETED param_type DELETED 41343 " 2804 UPDATE Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid aminosalicylate resistant dihydrofolate synthase; para-aminosalicylic acid; salicylic acid antibiotic; antibiotic target alteration; model_param "UPDATED 7874 with E40Q UPDATED 7875 with E40G UPDATED 7873 with T20P UPDATED 7876 with I43T UPDATED 7877 with I43S UPDATED 7878 with I43A UPDATED 7879 with R49P UPDATED 7880 with R49W UPDATED 7881 with L56V UPDATED 7882 with R91W UPDATED 7883 with S150G UPDATED 7884 with S150C UPDATED 7885 with E153A UPDATED 7886 with E153G UPDATED 7887 with A420V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2816 UPDATE Mycolicibacterium smegmatis 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7925 with a2266g UPDATED 7926 with a2267g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2811 UPDATE Mycobacterium avium 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7914 with a2274g UPDATED 7915 with a2274t UPDATED 7913 with a2272c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2813 UPDATE Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8173 with a2266c UPDATED 8174 with a2266g UPDATED 8172 with a2266t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2814 UPDATE Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to azithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7923 with a2268c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2815 UPDATE Mycobacterium kansasii 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8171 with a2265t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2793 UPDATE Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED param_type with synonymous substitution for alternative promoter UPDATED param_description with A synonymous or silent substitution in the coding DNA sequence of one gene which influences the promoter region of another gene. These substitutions do not change the amino acid sequence of a protein but may still influence the phenotype, including decreased susceptibility to antimicrobial compounds. UPDATED param_type_id with 48039 UPDATED 7817 with g1628g UPDATED 7818 with g1627a UPDATED 7817 with g1627a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 7817 DELETED 7817 " 2802 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; telithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7848 with a2058g UPDATED 7845 with t754a UPDATED 7850 with c2611t UPDATED 7847 with g2057a UPDATED 7849 with a2058t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2810 UPDATE Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7910 with a2271g UPDATED 7911 with a2272g UPDATED 7912 with a2272c UPDATED 8349 with a2058c UPDATED 8350 with a2058g UPDATED 8351 with a2058t UPDATED 8353 with a2059g UPDATED 8352 with a2059c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2817 UPDATE Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; spiramycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8175 with a2125g UPDATED 8177 with c2641a UPDATED 8178 with c2641g UPDATED 8176 with a2126g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2819 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics; linezolid; oxazolidinone antibiotic; antibiotic target alteration; model_param "UPDATED 7932 with g2032a UPDATED 7934 with g2032c UPDATED 7935 with g2447t UPDATED 7933 with g2032t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2820 UPDATE Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; azithromycin; josamycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8725 with c196a UPDATED 9884 with a2107c UPDATED 9885 with a2107g UPDATED 9886 with a2109g UPDATED 9887 with t2663c UPDATED 7939 with a2663c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2824 UPDATE Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7945 with a2063g UPDATED 7946 with a2064g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2825 UPDATE Halobacterium halobium 23S rRNA mutation conferring resistance to chloramphenicol 23S rRNA with mutation conferring resistance to phenicol antibiotics; chloramphenicol; phenicol antibiotic; antibiotic target alteration; model_param "UPDATED 7947 with a2088c UPDATED 7948 with c2471t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2826 UPDATE Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; 23S rRNA with mutation conferring resistance to streptogramins antibiotics; tylosin; pristinamycin IA; virginiamycin M1; josamycin; macrolide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic; antibiotic target alteration; model_param "UPDATED 7949 with a2129c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2827 UPDATE Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid aminosalicylate resistant dihydrofolate reductase; para-aminosalicylic acid; salicylic acid antibiotic; antibiotic target replacement; model_param "UPDATED 8013 with a2129c UPDATED 7951 with G8R DELETED param_type UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 8013 with -11g>a " 2704 UPDATE MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim resistance-nodulation-cell division (RND) antibiotic efflux pump; ciprofloxacin; trimethoprim; chloramphenicol; fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7572 with G8R " 2834 UPDATE Mycobacterium tuberculosis iniB with mutation conferring resistance to ethambutol Ethambutol resistant iniB; ethambutol; polyamine antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 8201 with G8R UPDATED 8200 with A47T DELETED param_type UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 8201 with -89c>t " 2835 UPDATE PatA-PatB ATP-binding cassette (ABC) antibiotic efflux pump; ciprofloxacin; norfloxacin; fluoroquinolone antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 8203 with A47T " 2841 UPDATE Escherichia coli 23S rRNA with mutation conferring resistance to chloramphenicol 23S rRNA with mutation conferring resistance to phenicol antibiotics; chloramphenicol; phenicol antibiotic; antibiotic target alteration; model_param "UPDATED 8226 with g2057a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2822 UPDATE Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; telithromycin; clarithromycin; tylosin; spiramycin; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7942 with g2087a UPDATED 7943 with a2578t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2377 UPDATE Escherichia coli PtsI with mutation conferring resistance to fosfomycin antibiotic-resistant ptsI phosphotransferase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; model_param "UPDATED 4379 with V25I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2850 UPDATE Salmonella enterica gyrA with mutation conferring resistance to triclosan triclosan resistant gyrA; triclosan; disinfecting agents and antiseptics; antibiotic target alteration; model_param "UPDATED 8272 with S83F UPDATED 8273 with D87G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2851 UPDATE Escherichia coli gyrA with mutation conferring resistance to triclosan triclosan resistant gyrA; triclosan; disinfecting agents and antiseptics; antibiotic target alteration; model_param "UPDATED 8275 with S83F UPDATED 8276 with D87G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2886 UPDATE Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; ampicillin; cefaclor; cefotaxime; cefditoren; cefdinir; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 8321 with D350N UPDATED 8322 with S357N UPDATED 8323 with S385T UPDATED 8324 with L389F UPDATED 8325 with V562L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3707 UPDATE Mycobacterium tuberculosis eis mutations confer resistance to kanamycin kanamycin resistant eis; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13284 with -14c>t UPDATED 13328 with -10g>a UPDATED 15412 with -10g>a UPDATED 15413 with -12c>t UPDATED 15414 with -14c>t UPDATED 15415 with -37g>t UPDATED 13328 with V562L UPDATED 13284 with V562L UPDATED 15412 with V562L UPDATED 15413 with V562L UPDATED 15414 with V562L UPDATED 15415 with V562L UPDATED 9594 with V163I DELETED 13016 DELETED 13016 DELETED param_type " 3701 UPDATE Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfisoxazole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED 9878 with R228S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3702 UPDATE Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide inhA with mutations with conferring resistance to ethionamide; ethionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED 14806 with S94A UPDATED 9515 with I194T UPDATED 9517 with I21T UPDATED 9516 with I21V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3703 UPDATE Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid isoniazid resistant nudC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 9587 with S287N UPDATED 9588 with P239R UPDATED 9590 with P239R UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. " 3706 UPDATE Mycobacterium tuberculosis ponA1 mutations confer resistance to rifabutin rifamycin resistant ponA1; rifampin; rifabutin; rifamycin antibiotic; antibiotic target alteration; model_name; model_param; ARO_name "UPDATED model_name with Mycobacterium tuberculosis ponA1 mutations conferring resistance to rifabutin UPDATED param_type with duplication of peptide sequence UPDATED param_description with A duplication is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, a copy of one or more amino acids is inserted directly C-terminal of the original copy of that sequence. UPDATED param_type_id with 48031 UPDATED 9738 with P627_P629dup UPDATED 9758 with V624_P626dup UPDATED 9759 with P627dup UPDATED 9760 with P626_P628dup UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to the reference sequence, one or more amino acids are inserted. These represent in-frame insertions which do not result in frameshift variants and where the insertion is not a duplication of a sequence immediately N-terminal (5'), and are denoted with wildtype flanking residues. Format is given by [wildtype AA position]_[wildtype AA position]ins[AA sequence], e.g. K464_D465insE or P46_A47insYS. UPDATED 18566 with P630_P631insPPW DELETED 9738 UPDATED 9739 with G363D UPDATED 9749 with T658A UPDATED 9758 with A516T UPDATED 9759 with A516T UPDATED 9760 with A516T UPDATED 18566 with A516T UPDATED 9740 with Q365H UPDATED 9755 with A516T UPDATED 9753 with I41M UPDATED 9738 with A516T UPDATED 18561 with A516T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18561 with P631del DELETED 9762 UPDATED ARO_name with Mycobacterium tuberculosis ponA1 mutations conferring resistance to rifabutin " 2907 UPDATE vmlR Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; lincomycin; virginiamycin M1; tiamulin; virginiamycin S2; retapamulin; iboxamycin; hygromycin A; A201A; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic; antibiotic without defined classification; nucleoside antibiotic; pleuromutilin antibiotic; antibiotic target protection; ARO_category "UPDATED category_aro_accession with 3000003 UPDATED category_aro_cvterm_id with 36012 UPDATED category_aro_name with antibiotic without defined classification UPDATED category_aro_description with These compounds are antibiotics of unique structure or origin, without a defined classification. UPDATED category_aro_class_name with Drug Class " 3654 UPDATE Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin Zoliflodacin resistant gyrB; Zoliflodacin; zoliflodacin-like antibiotic; antibiotic target alteration; model_param "UPDATED 12582 with K450N UPDATED 12583 with K450T UPDATED 12584 with D429N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3628 UPDATE Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; cefixime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 9277 with A501P UPDATED 9289 with A501V UPDATED 9292 with A311V UPDATED 9290 with A501T UPDATED 9294 with V316P UPDATED 9296 with T483S UPDATED 9350 with F504L UPDATED 9361 with G542S UPDATED 9352 with A510V UPDATED 9362 with P551S UPDATED 9353 with A516G UPDATED 9363 with P551L UPDATED 10520 with N513Y UPDATED 10521 with G545S UPDATED 18564 with G545S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to the reference sequence, one or more amino acids are inserted. These represent in-frame insertions which do not result in frameshift variants and where the insertion is not a duplication of a sequence immediately N-terminal (5'), and are denoted with wildtype flanking residues. Format is given by [wildtype AA position]_[wildtype AA position]ins[AA sequence], e.g. K464_D465insE or P46_A47insYS. UPDATED 18564 with R345_D346insD DELETED 9378 " 3656 UPDATE Burkholderia dolosa gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 9429 with G81D UPDATED 9430 with T83I UPDATED 9431 with D87H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3735 UPDATE Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid isoniazid resistant sigI; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param; model_sequences "UPDATED 9592 with K270Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED accession with NP_215705.1 UPDATED sequence with MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLRAPVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQHRVVTRAFIEACSNGDLDTLLEVLDPGVAGEIDARKGVVVVGADRVGPTILRHWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLDPLRAELGGG UPDATED accession with NC_000962.3 UPDATED fmin with 1332091 UPDATED fmax with 1332964 UPDATED strand with + UPDATED sequence with ATGTCGCAACACGACCCGGTAAGTGCGGCCTGGCGGGCGCATCGGGCCTACCTGGTGGACCTCGCGTTTCGTATGGTAGGTGACATCGGCGTGGCCGAAGACATGGTGCAAGAGGCATTTTCCCGCTTGCTGCGGGCTCCGGTCGGCGACATCGACGACGAGCGTGGCTGGCTGATCGTGGTCACCAGCCGGCTGTGCCTGGATCACATCAAGTCGGCGTCGACACGCCGGGAGCGCCCGCAGGACATCGCCGCATGGCACGACGGTGACGCCAGCGTGTCATCGGTTGACCCGGCTGACCGGGTGACTCTCGACGACGAGGTCCGGCTGGCTTTGCTGATCATGCTCGAGCGCCTCGGCCCCGCGGAGCGGGTGGTGTTCGTGCTGCACGAGATCTTTGGGCTGCCCTACCAGCAAATCGCCACGACGATTGGCAGCCAGGCCTCCACATGCCGGCAGCTGGCTCATCGGGCCCGTCGCAAGATCAACGAATCGCGCATTGCGGCCAGCGTGGAGCCAGCCCAGCATCGCGTCGTCACCAGAGCTTTCATCGAAGCCTGCTCCAACGGAGACCTGGACACCCTGCTCGAGGTGCTGGATCCGGGTGTCGCCGGCGAGATCGACGCCCGCAAAGGCGTTGTCGTCGTGGGCGCGGATCGGGTTGGCCCGACCATCCTGCGCCACTGGAGTCACCCCGCCACCGTCCTGGTAGCCCAGCCGGTGTGCGGTCAACCGGCGGTGCTGGCCTTTGTCAACCGAGCGCTTGCCGGCGTGTTGGCCCTGTCGATCGAGGCCGGCAAGATCACAAAAATCCATGTCTTAGTGCAGCCTTCAACATTGGACCCGTTACGGGCCGAACTCGGCGGCGGTTAG UPDATED partial with 0 UPDATED NCBI_taxonomy_cvterm_id with 39507 UPDATED NCBI_taxonomy_name with Mycobacterium tuberculosis H37Rv UPDATED NCBI_taxonomy_id with 83332 DELETED 8785 " 3651 UPDATE Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to capreomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; capreomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13259 with a1401g UPDATED 13334 with g1484t UPDATED 14212 with c1402t UPDATED 14742 with a1401g UPDATED 14746 with c1402t UPDATED 14757 with g1484t UPDATED 9445 with a1401g UPDATED 9446 with g1484t UPDATED 9447 with a514c UPDATED 9279 with a1401g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 14742 " 3629 UPDATE Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 9243 with L421P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3329 UPDATE Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin fluoroquinolone resistant parC; moxifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 8771 with G81C UPDATED 8772 with D82N UPDATED 8773 with S83R UPDATED 8774 with S83I UPDATED 8775 with D87N UPDATED 8776 with D87H UPDATED 8777 with D87Y UPDATED 8778 with D87G UPDATED 8779 with V103I UPDATED 8784 with P62S UPDATED 8785 with A67S UPDATED 8786 with A66T UPDATED 8787 with S83N UPDATED 8788 with A119V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3646 UPDATE Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 9356 with a2145g UPDATED 9355 with c2600t UPDATED 9358 with a2045g UPDATED 9357 with c2597t UPDATED 10522 with a2059g UPDATED 10523 with c2611t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 43161 " 3649 UPDATE Neisseria gonorrhoeae mtrR with mutation conferring resistance resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; azithromycin; macrolide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 9273 with A39T UPDATED 9274 with G45D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 43161 " 3631 UPDATE Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftriaxone; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 9247 with E666K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3709 UPDATE Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin streptomycin resistant whib7; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13186 with -116a>g UPDATED 13186 with E666K DELETED param_type " 3742 UPDATE Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine cycloserine resistant ddlA; cycloserine; cycloserine-like antibiotic; antibiotic target alteration; model_param "UPDATED 13184 with T365A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3746 UPDATE Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin rifampicin resistant rpoC; rifampin; rifabutin; rifamycin antibiotic; antibiotic target alteration; model_param "UPDATED param_type with synonymous substitution for alternative promoter UPDATED param_description with A synonymous or silent substitution in the coding DNA sequence of one gene which influences the promoter region of another gene. These substitutions do not change the amino acid sequence of a protein but may still influence the phenotype, including decreased susceptibility to antimicrobial compounds. UPDATED param_type_id with 48039 UPDATED 9820 with Y61Y UPDATED 9744 with V483G UPDATED 9800 with N416S UPDATED 9801 with V431M UPDATED 9802 with G433S UPDATED 9803 with P434L UPDATED 9804 with K445R UPDATED 9805 with F452S UPDATED 9806 with V483A UPDATED 9808 with W484G UPDATED 9809 with D485Y UPDATED 9810 with I491V UPDATED 9811 with I491T UPDATED 9812 with L507V UPDATED 9813 with L516P UPDATED 9815 with Q523E UPDATED 9816 with H525Q UPDATED 9817 with L527V UPDATED 9823 with N698S UPDATED 9824 with A734V UPDATED 9825 with E750Q UPDATED 9827 with P1040A UPDATED 9828 with P1040S UPDATED 9829 with P1040R UPDATED 9830 with P1040L UPDATED 9832 with Q1110H UPDATED 9833 with E1113G UPDATED 9834 with Q1125H UPDATED 9835 with T1230I UPDATED 9837 with V1252L UPDATED 9839 with G332S UPDATED 9820 with G332S UPDATED 9814 with V517L UPDATED 9836 with V1252M UPDATED 9831 with E1092D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 9820 DELETED 9820 " 3747 UPDATE Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin rifampicin resistant rpoA; rifampin; rifamycin antibiotic; antibiotic target alteration; model_param "UPDATED 9769 with V183A UPDATED 9770 with V183G UPDATED 9771 with T187A UPDATED 9773 with G31S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3712 UPDATE Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide antibiotic resistant polyketide synthase genes; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 9707 with A957P UPDATED 9708 with N1899S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3738 UPDATE Mycobacterium tuberculosis mshC mutations conferring resistance to ethionamide ethionamide resistant mshC; ethionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED 9518 with A403G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3713 UPDATE Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide antibiotic resistant polyketide synthase genes; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 9709 with A437P UPDATED 9711 with A1248T UPDATED 9715 with V1522A UPDATED 9710 with P563H UPDATED 9713 with M127I UPDATED 9717 with E1823A UPDATED 9718 with V295M UPDATED 9714 with I1508L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3723 UPDATE Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid Isoniazid resistant ahpC; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13291 with -72c>t UPDATED 13343 with -48g>a UPDATED 13687 with -57c>t UPDATED 13291 with V295M UPDATED 13343 with V295M UPDATED 13687 with G48A UPDATED 9526 with V295M UPDATED 13006 with C52T UPDATED 13007 with C72T UPDATED 13008 with C81T UPDATED 13009 with G48A DELETED param_type " 3724 UPDATE Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid isoniazid resistant fabG1; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_type with synonymous substitution for alternative promoter UPDATED param_description with A synonymous or silent substitution in the coding DNA sequence of one gene which influences the promoter region of another gene. These substitutions do not change the amino acid sequence of a protein but may still influence the phenotype, including decreased susceptibility to antimicrobial compounds. UPDATED param_type_id with 48039 UPDATED 13700 with L203L UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13192 with -15c>t UPDATED 13194 with -17t>g UPDATED 13196 with -8c>t UPDATED 13195 with -8t>a UPDATED 13398 with -15c>t UPDATED 13399 with -17g>t UPDATED 13400 with -8t>c UPDATED 14181 with -15c>Var UPDATED 14182 with -8t>Var UPDATED 14180 with -16a>Var UPDATED 14765 with -17g>t UPDATED 14767 with -15c>t UPDATED 14769 with -16a>g UPDATED 14771 with -8t>c UPDATED 14773 with -8t>g UPDATED 14775 with -8t>a UPDATED 13398 with G48A UPDATED 13400 with G48A UPDATED 13700 with G48A UPDATED 14182 with G48A UPDATED 14180 with G48A UPDATED 14181 with G48A UPDATED 13399 with G48A UPDATED 14765 with G48A UPDATED 14769 with G48A UPDATED 14771 with G48A UPDATED 14773 with G48A UPDATED 14775 with G48A UPDATED 14767 with G48A UPDATED 13192 with G48A UPDATED 13194 with G48A UPDATED 13196 with G48A UPDATED 13195 with G48A DELETED param_type " 3740 UPDATE Mycobacterium tuberculosis ubiA mutations confer resistance to ethambutol ethambutol resistant ubiA; ethambutol; polyamine antibiotic; antibiotic target alteration; model_param "UPDATED 9500 with S173A UPDATED 9502 with A237V UPDATED 9503 with R240C UPDATED 9501 with W175C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3252 UPDATE Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8568 with a2075g UPDATED 8567 with a2074c UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3267 UPDATE Clostridioides difficile murG with mutation conferring resistance to vancomycin murG transferase; vancomycin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 8659 with P108L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3715 UPDATE Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide pyrazinamide resistant mas; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 9639 with P398R UPDATED 9640 with P495R UPDATED 9645 with S213C UPDATED 9642 with L98M UPDATED 9644 with T2005P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3725 UPDATE Mycobacterium tuberculosis furA mutations confer resistance to isoniazid isoniazid resistant furA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED param_type_id with 41339 UPDATED 18571 with -26c>g UPDATED 12570 with A14V UPDATED 18571 with A14V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3817 UPDATE Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics; tiamulin; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED 9963 with R144C UPDATED 9964 with R144H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3818 UPDATE Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics; tiamulin; pleuromutilin antibiotic; antibiotic target alteration; model_param "UPDATED 9966 with g2061t UPDATED 9967 with a2451t UPDATED 9969 with t2500a UPDATED 9965 with g2061a UPDATED 9968 with c2452t UPDATED 9970 with t2504g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3834 UPDATE Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide prothionamide resistant katG; prothionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED 10022 with A312P UPDATED 10023 with N660D UPDATED 10024 with S315T UPDATED 10025 with S315N UPDATED 10026 with A264V UPDATED 10027 with L147P UPDATED 10032 with D142G UPDATED 10034 with M126I UPDATED 10035 with W91R UPDATED 10036 with S315G UPDATED 10037 with G490S UPDATED 10043 with N508D UPDATED 10045 with G125S UPDATED 10046 with Q127P UPDATED 10048 with Q461P UPDATED 10049 with E607A UPDATED 10050 with H417Q UPDATED 10051 with G111S UPDATED 10052 with G33V UPDATED 12882 with G33V UPDATED 12883 with G33V UPDATED 12885 with G33V UPDATED 12886 with G33V UPDATED 12887 with G33V UPDATED 12888 with G33V UPDATED 12889 with G33V UPDATED 12890 with G33V UPDATED 10040 with A110V UPDATED 12884 with A110V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 41343 " 3836 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid isoniazid resistant ethA; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 10075 with A110V UPDATED 10090 with A110V UPDATED 10107 with A110V UPDATED 10062 with P28S UPDATED 10063 with L35R UPDATED 10065 with D56Y UPDATED 10066 with D58G UPDATED 10067 with W69C UPDATED 10068 with H102P UPDATED 10070 with Y141N UPDATED 10071 with T186P UPDATED 10072 with T189R UPDATED 10073 with Q246P UPDATED 10076 with S329P UPDATED 10078 with A341V UPDATED 10079 with N345K UPDATED 10081 with A352E UPDATED 10083 with C403Y UPDATED 10084 with F480S UPDATED 10096 with L267V UPDATED 10111 with V179F UPDATED 10113 with A395D UPDATED 10117 with Q254P UPDATED 12891 with Q254P UPDATED 12892 with Q254P UPDATED 12893 with Q254P UPDATED 12894 with Q254P UPDATED 12895 with Q254P UPDATED 12896 with Q254P UPDATED 10064 with G42D UPDATED 10082 with M372R DELETED param_type DELETED 41343 " 3837 UPDATE Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide prothionamide resistant ethA; prothionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 10135 with M372R UPDATED 10167 with M372R UPDATED 10124 with P28S UPDATED 10125 with L35R UPDATED 10126 with G42D UPDATED 10128 with D58G UPDATED 10129 with W69C UPDATED 10130 with H102P UPDATED 10131 with Y141N UPDATED 10132 with T186P UPDATED 10133 with T189R UPDATED 10136 with S329P UPDATED 10138 with A341V UPDATED 10139 with N345K UPDATED 10141 with A352E UPDATED 10142 with M372R UPDATED 10143 with C403Y UPDATED 10157 with L267V UPDATED 10171 with V179F UPDATED 10173 with A395D UPDATED 10175 with Q246P UPDATED 10178 with Q254P UPDATED 12908 with Q254P UPDATED 12909 with Q254P UPDATED 12911 with Q254P UPDATED 12912 with Q254P UPDATED 12913 with Q254P UPDATED 10150 with Q254P UPDATED 10127 with D56Y UPDATED 10144 with F480S UPDATED 12910 with F480S DELETED param_type DELETED 41343 " 3838 UPDATE Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide prothionamide resistant mshA; prothionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED 10182 with F355S UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2823 UPDATE Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; clarithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 8308 with g2057a UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 995 UPDATE MexG efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 36005 " 1647 UPDATE MexI resistance-nodulation-cell division (RND) antibiotic efflux pump; acriflavine; norfloxacin; fluoroquinolone antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; ARO_category "DELETED 35968 " 3 UPDATE Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics General Bacterial Porin with reduced permeability to beta-lactams; cefepime; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; reduced permeability to antibiotic; model_param "UPDATED 2253 with G141D UPDATED 2254 with G141E UPDATED 2255 with R154A UPDATED 2256 with R154D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2148 UPDATE Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; enoxacin; ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; lomefloxacin; nalidixic acid; norfloxacin; ofloxacin; trovafloxacin; grepafloxacin; sparfloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3048 with P462S UPDATED 4638 with E502Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2086 UPDATE Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline 16S rRNA with mutation conferring resistance to tetracycline derivatives; tetracycline; tetracycline antibiotic; antibiotic target alteration; model_param "UPDATED 2900 with a964g UPDATED 12977 with a1055g UPDATED 12979 with g1053a UPDATED 12978 with c1054t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2215 UPDATE Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; ofloxacin; pefloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 3986 with S80L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2223 UPDATE MexZ resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; arbekacin; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; model_param "UPDATED 3168 with G195E UPDATED 3173 with V44A UPDATED 3174 with G46S UPDATED 3175 with Q10Z UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2254 UPDATE Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid antibiotic resistant fusA; fusidic acid; fusidane antibiotic; antibiotic target alteration; model_param "DELETED 3376 UPDATED 3355 with G192S UPDATED 3356 with H457Y UPDATED 3357 with L461K UPDATED 3358 with L461K UPDATED 3367 with H457Q UPDATED 3368 with M453I UPDATED 3369 with P404L UPDATED 3370 with A376V UPDATED 3371 with F441Y UPDATED 3372 with V90A UPDATED 3373 with V90I UPDATED 3374 with V90I UPDATED 3375 with V90I UPDATED 3377 with L461S UPDATED 3379 with L461F UPDATED 3360 with T436I UPDATED 3361 with G452S UPDATED 3362 with L456F UPDATED 3364 with R464C UPDATED 3366 with P406L UPDATED 3380 with F88L UPDATED 3381 with Q115L UPDATED 3382 with P404Q UPDATED 3383 with V407F UPDATED 3384 with D434N UPDATED 3385 with G451V UPDATED 3386 with G452C UPDATED 3387 with G452V UPDATED 3388 with G452V UPDATED 3389 with R464H UPDATED 3390 with R464S UPDATED 3391 with R464L UPDATED 10274 with H457N UPDATED 10275 with H457L UPDATED 3365 with H457L DELETED param_type " 2256 UPDATE Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid antibiotic resistant fusE; fusidic acid; fusidane antibiotic; antibiotic target alteration; model_param "UPDATED 3414 with Q140L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2272 UPDATE Enterococcus faecalis cls with mutation conferring resistance to daptomycin daptomycin resistant cls; daptomycin; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 3603 with H215R UPDATED 3582 with R267H UPDATED 3581 with R218Q UPDATED 18556 with R218Q UPDATED 18557 with R218Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18556 with N74_Q76del UPDATED 18557 with K61del DELETED 3850 DELETED 41344 " 2080 UPDATE Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4818 with c1192t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3330 UPDATE Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones fluoroquinolone resistant gyrA; moxifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 8782 with M95I UPDATED 8789 with G93C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2405 UPDATE Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones fluoroquinolone resistant parC; ciprofloxacin; sitafloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4454 with S87R UPDATED 4455 with E91G UPDATED 13183 with S87N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2482 UPDATE Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; streptomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 4751 with a858c UPDATED 4752 with a859g UPDATED 4753 with a1123g UPDATED 4754 with a1123c UPDATED 4755 with g1125a UPDATED 4750 with c856t UPDATED 4749 with a474c UPDATED 4748 with t14g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3403 UPDATE Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide pyrazinamide resistant rpsA; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. UPDATED 9722 with t14g UPDATED 9719 with A381V UPDATED 9720 with A412V UPDATED 9721 with A440T UPDATED 8872 with D342N UPDATED 8873 with D343N UPDATED 8874 with A344P UPDATED 8877 with S324F UPDATED 8878 with E325K UPDATED 8879 with G341R UPDATED 8880 with D123A UPDATED 8875 with I351F UPDATED 18560 with I351F DELETED param_type UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18560 with A438del DELETED 8881 " 2287 UPDATE Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid antibiotic resistant ndh; isoniazid; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 3649 with I17T UPDATED 3650 with T29P UPDATED 3651 with H46P UPDATED 3652 with G84D UPDATED 3653 with L100P UPDATED 3654 with A115T UPDATED 3655 with Y122N UPDATED 3656 with R145C UPDATED 3657 with F170S UPDATED 3658 with A187P UPDATED 3659 with V246A UPDATED 3660 with V272E UPDATED 3661 with V300G UPDATED 3663 with Y361H UPDATED 3662 with Q335H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2666 UPDATE Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan antibiotic resistant fabI; triclosan; disinfecting agents and antiseptics; isoniazid-like antibiotic; antibiotic target alteration; model_param "UPDATED 7383 with G93A UPDATED 7384 with G93S UPDATED 7385 with G93V UPDATED 7386 with M159T UPDATED 7387 with F203L UPDATED 7388 with F203C UPDATED 7389 with F203A UPDATED 7390 with F203V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2681 UPDATE Escherichia coli fabG mutations conferring resistance to triclosan antibiotic resistant fabG; triclosan; disinfecting agents and antiseptics; antibiotic target alteration; model_param "UPDATED 7530 with Y151V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2694 UPDATE MexCD-OprJ with type A NfxB mutation resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; novobiocin; trimethoprim; chloramphenicol; ofloxacin; macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7551 with Y151V " 2746 UPDATE AcrAD-TolC resistance-nodulation-cell division (RND) antibiotic efflux pump; neomycin; amikacin; kanamycin A; tobramycin; gentamicin; aminoglycoside antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 7770 with Y151V " 2818 UPDATE Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics 23S rRNA with mutation conferring resistance to macrolide antibiotics; spiramycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 7931 with a2305g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3705 UPDATE Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide pyrazinamide resistant clpC1; pyrazinamide; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 9636 with G258V UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 3739 UPDATE Mycobacterium tuberculosis fabG1 mutation conferring resistance to ethionamide ethionamide resistant fabG1; ethionamide; thioamide antibiotic; antibiotic target alteration; model_param "UPDATED param_type with synonymous substitution for alternative promoter UPDATED param_description with A synonymous or silent substitution in the coding DNA sequence of one gene which influences the promoter region of another gene. These substitutions do not change the amino acid sequence of a protein but may still influence the phenotype, including decreased susceptibility to antimicrobial compounds. UPDATED param_type_id with 48039 UPDATED 14217 with L203L UPDATED param_type with nucleotide substitution in promoter region UPDATED param_description with A nucleotide sequence change where, compared to a reference sequence, one nucleotide is replaced by one other nucleotide in the promoter region of a gene. These substitutions are indicated as upstream of the reference sequence transcription initiation site. Format is given by [-][position][wildtype][>][mutation], e.g. -11t>c or -15g>Var where Var represents any possible substitution. UPDATED 13198 with -15c>t UPDATED 13200 with -8t>a UPDATED 13397 with -15c>t UPDATED 14764 with -17g>t UPDATED 14766 with -15c>t UPDATED 14768 with -16a>g UPDATED 14770 with -8t>c UPDATED 14772 with -8t>g UPDATED 14774 with -8t>a UPDATED 13397 with G258V UPDATED 14217 with G258V UPDATED 14766 with G258V UPDATED 14768 with G258V UPDATED 14770 with G258V UPDATED 14772 with G258V UPDATED 14774 with G258V UPDATED 14764 with G258V UPDATED 13198 with G258V UPDATED 13200 with G258V DELETED param_type " 3268 UPDATE Clostridioides difficile gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; ciprofloxacin; levofloxacin; moxifloxacin; gemifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 8669 with D426N UPDATED 8670 with R447L UPDATED 8671 with E466V UPDATED 8672 with S416A UPDATED 8673 with D426V UPDATED 8675 with E466K UPDATED 8814 with R377G UPDATED 8815 with R389P UPDATED 8816 with E399K UPDATED 8818 with V423F UPDATED 8819 with R457T UPDATED 8820 with D465Y UPDATED 8834 with S366A UPDATED 8835 with S366V UPDATED 8836 with S464T UPDATED 8837 with I139R UPDATED 8838 with V130I UPDATED 8846 with K444F UPDATED 8674 with R447K UPDATED 8817 with D409N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5752 UPDATE Helicobacter pylori gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; levofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 12352 with T87I UPDATED 12353 with A88P UPDATED 12354 with D91H UPDATED 12358 with D99V UPDATED 12362 with V172I UPDATED 12365 with D34N UPDATED 12367 with D34N UPDATED 12368 with D34N UPDATED 12369 with G85C UPDATED 12541 with N87K UPDATED 12542 with N87Y UPDATED 12544 with D91G UPDATED 12545 with D91N UPDATED 12546 with D91Y UPDATED 12898 with D91Y UPDATED 12899 with D91Y UPDATED 12900 with D91Y UPDATED 12903 with D91Y UPDATED 12906 with D91Y UPDATED 12907 with D91Y UPDATED 13165 with D87G UPDATED 12364 with D87G UPDATED 12543 with N87I UPDATED 12901 with N87I UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 12902 DELETED 40438 " 5753 UPDATE Helicobacter pylori gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; levofloxacin; norfloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 12373 with N87I UPDATED 12374 with N87I UPDATED 12375 with N87I UPDATED 12377 with N87I UPDATED 12378 with E463K UPDATED 12379 with E463K UPDATED 12380 with E463K UPDATED 12381 with E463K UPDATED 12382 with E463K UPDATED 13239 with E463K UPDATED 12376 with E463K DELETED param_type " 5756 UPDATE Helicobacter pylori pbp3 conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 12384 with A499V UPDATED 12387 with D2N UPDATED 12388 with A50S UPDATED 12389 with F490Y UPDATED 12390 with A541T UPDATED 12385 with E536K UPDATED 12987 with V374L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5757 UPDATE Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 12413 with A296V UPDATED 12414 with S494H UPDATED 12415 with A541M UPDATED 12416 with E572G UPDATED 12417 with I259T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5758 UPDATE Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED param_type with insertion mutation from peptide sequence UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to the reference sequence, one or more amino acids are inserted. These represent in-frame insertions which do not result in frameshift variants and where the insertion is not a duplication of a sequence immediately N-terminal (5'), and are denoted with wildtype flanking residues. Format is given by [wildtype AA position]_[wildtype AA position]ins[AA sequence], e.g. K464_D465insE or P46_A47insYS. UPDATED param_type_id with 41344 UPDATED 18538 with K464_D465insE UPDATED 18539 with K464_D465insN UPDATED 18542 with G595_V596insA UPDATED 18541 with G595_V596insS UPDATED 18540 with G595_V596insG UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 12510 with I259T UPDATED 12418 with T556S UPDATED 12419 with N562Y UPDATED 12420 with T593A UPDATED 12421 with S414R UPDATED 12422 with G595S UPDATED 12426 with S405N UPDATED 12427 with A474T UPDATED 12428 with T558S UPDATED 12429 with N562H UPDATED 12430 with S402G UPDATED 12432 with N107R UPDATED 12433 with A201V UPDATED 12434 with V250I UPDATED 12435 with S543T UPDATED 12511 with V374L UPDATED 12512 with S414N UPDATED 12513 with I450V UPDATED 12552 with T593S UPDATED 12553 with T593G UPDATED 12554 with T593K UPDATED 13113 with R649K UPDATED 13114 with R656P UPDATED 13115 with R656H UPDATED 12425 with F366L UPDATED 18538 with F366L UPDATED 18539 with F366L UPDATED 18542 with F366L UPDATED 18541 with F366L UPDATED 18540 with F366L DELETED param_type DELETED 41340 " 5759 UPDATE Helicobacter pylori frxA mutation conferring resistance to metronidazole Antibiotic resistant Helicobacter pylori nitroreductase; metronidazole; nitroimidazole antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 12437 with F366L UPDATED 12455 with F366L UPDATED 12462 with F366L UPDATED 12463 with F366L UPDATED 12464 with F366L UPDATED 12439 with R3T UPDATED 12451 with P41L UPDATED 12452 with A15V UPDATED 12468 with A16T UPDATED 12469 with A32V UPDATED 12470 with A85V UPDATED 12471 with I44F UPDATED 12472 with I117M UPDATED 12473 with M126F UPDATED 12474 with S43A UPDATED 12475 with V7I UPDATED 12476 with Y62D UPDATED 12501 with A48G UPDATED 12502 with G441A UPDATED 12503 with C13A UPDATED 12507 with A70G UPDATED 12508 with K97E UPDATED 12509 with V9I UPDATED 12461 with V9I UPDATED 12445 with V9I DELETED param_type UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. DELETED 40590 " 5761 UPDATE VAM-1 VAM beta-lactamase; ceftriaxone; ampicillin; cefotaxime; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; ARO_category "DELETED 35968 " 5750 UPDATE Helicobacter pylori rpoB mutation conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); levofloxacin; rifampin; fluoroquinolone antibiotic; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 12306 with L525P UPDATED 12307 with Q527K UPDATED 12308 with Q527R UPDATED 12309 with D530V UPDATED 12310 with S545L UPDATED 12311 with I586N UPDATED 12313 with D530G UPDATED 12314 with D530I UPDATED 12315 with D530Y UPDATED 12316 with D530L UPDATED 12317 with D530F UPDATED 12318 with H540Y UPDATED 12319 with H540N UPDATED 12320 with L525I UPDATED 12321 with D530N UPDATED 12322 with D530E UPDATED 12323 with I2619V UPDATED 12325 with T2537A UPDATED 12326 with F2538L UPDATED 12327 with I837V UPDATED 12331 with A2414T UPDATED 12332 with K2068R UPDATED 12336 with V149F UPDATED 12337 with V149Q UPDATED 12338 with V149K UPDATED 12339 with V149E UPDATED 12340 with V149D UPDATED 12341 with V149W UPDATED 12342 with R701H UPDATED 12383 with A2414V UPDATED 12897 with A2414V UPDATED 12312 with I586L UPDATED 12324 with V2592L UPDATED 12333 with Q2079K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5763 UPDATE Neisseria gonorrhoeae rpld 50S rRNA with mutation conferring resistance to macrolide antibiotics; azithromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 12558 with G70D UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5767 UPDATE Bacillus subtilis rpoB mutants conferring resistance to rifampin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 12589 with S487L UPDATED 12590 with A478N UPDATED 12591 with Q469K UPDATED 12592 with Q469R UPDATED 12593 with H482Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5801 UPDATE Mycobacterium tuberculosis Rv1258c mutations confer resistance to ethambutol and capreomycin multidrug resistant Rv1258c; ethambutol; capreomycin; aminoglycoside antibiotic; polyamine antibiotic; isoniazid-like antibiotic; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 12644 with T297P UPDATED 12645 with I328T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5802 UPDATE Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin multidrug resistant Rv1258c; streptomycin; isoniazid; pyrazinamide; aminoglycoside antibiotic; polyamine antibiotic; isoniazid-like antibiotic; pyrazine antibiotic; antibiotic target alteration; model_param "UPDATED 12648 with S292L UPDATED 12649 with V219A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5755 UPDATE Helicobacter pylori rdxA mutation conferring resistance to metronidazole Antibiotic resistant Helicobacter pylori nitroreductase; metronidazole; nitroimidazole antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 12411 with V219A UPDATED 12412 with V219A UPDATED 12438 with V219A UPDATED 12482 with V219A UPDATED 13116 with V219A UPDATED 12386 with R16C UPDATED 12392 with R16H UPDATED 12393 with C19Y UPDATED 12394 with T31E UPDATED 12395 with R90K UPDATED 12396 with H97T UPDATED 12397 with S108A UPDATED 12398 with A118T UPDATED 12399 with A118S UPDATED 12400 with G189C UPDATED 12402 with P106S UPDATED 12404 with A68E UPDATED 12405 with A67V UPDATED 12408 with A1G UPDATED 12436 with A1G UPDATED 12444 with C148Y UPDATED 12446 with G189S UPDATED 12479 with G189S UPDATED 12480 with G189S UPDATED 12481 with G189S UPDATED 12483 with G189S UPDATED 12484 with G189S UPDATED 12496 with G47A UPDATED 12497 with T184G UPDATED 12498 with G60A UPDATED 12499 with C273T UPDATED 12500 with C49T UPDATED 12504 with D59N UPDATED 12505 with L210V UPDATED 12506 with H97Y UPDATED 12478 with H97Y UPDATED 13117 with D59S UPDATED 12401 with K64N UPDATED 12485 with K64N DELETED param_type UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. DELETED 40438 " 5809 UPDATE glycopeptide resistance gene cluster vanP glycopeptide resistance gene cluster; vancomycin; teicoplanin; glycopeptide antibiotic; antibiotic target alteration; model_param "UPDATED 12653 with K64N " 2092 UPDATE Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; acriflavine; tetracycline; rifampin; chloramphenicol; ampicillin; norfloxacin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; model_param "UPDATED 2992 with R45C UPDATED 7538 with R45C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. DELETED 41343 " 5816 UPDATE Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin ATP-binding cassette (ABC) antibiotic efflux pump; pmr phosphoethanolamine transferase; transmembrane protein conferring colistin resistance; erythromycin; polymyxin B; colistin A; colistin B; macrolide antibiotic; peptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; resistance by absence; model_param "UPDATED 12717 with V24G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5923 UPDATE Klebsiella pneumoniae lamB with mutations conferring resistance to ceftazidime-avibactam Sugar Porin (SP); ceftazidime; fluoroquinolone antibiotic; cephalosporin; tetracycline antibiotic; reduced permeability to antibiotic; model_param "UPDATED 12832 with R374L UPDATED 12833 with R374S UPDATED 12834 with R134P UPDATED 12835 with R33H UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5924 UPDATE Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; ceftazidime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 12836 with L367Q UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5972 UPDATE Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; kanamycin A; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13255 with a1401g UPDATED 13330 with g1484t UPDATED 13074 with g1484t UPDATED 13075 with c462t UPDATED 13076 with a514c UPDATED 13077 with c1402t UPDATED 13072 with a1401g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 13074 " 5974 UPDATE Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics; amikacin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13257 with a1401g UPDATED 13078 with a1401g UPDATED 13080 with g1484t UPDATED 13082 with a514c UPDATED 13083 with c1402t UPDATED 13081 with c462t UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. DELETED 13078 " 5929 UPDATE almEFG polymyxin resistance operon; colistin A; colistin B; peptide antibiotic; antibiotic target alteration; model_param "UPDATED 12842 with c462t " 5960 UPDATE Mycobacterium abscessus atpE with mutation conferring resistance to bedaquiline antibiotic resistant ATP synthase; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; model_param "UPDATED 12938 with A64P UPDATED 12937 with D29A UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5961 UPDATE Pseudomonas aeruginosa ampR with mutation conferring resistance to aztreonam PDC beta-lactamase; ampR transcriptional regulator with mutation conferring resistance to monobactam antibiotics; aztreonam; monobactam; carbapenem; cephalosporin; antibiotic target alteration; antibiotic inactivation; model_param "UPDATED 12939 with D135N UPDATED 12940 with D135G UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5969 UPDATE Bacillus subtilis rpsE mutations conferring resistance to spectinomycin spectinomycin resistant rpsE; spectinomycin; aminoglycoside antibiotic; antibiotic target alteration; model_param "UPDATED 13022 with C85G UPDATED 13023 with A77T UPDATED 13025 with G64C UPDATED 13026 with G83C UPDATED 13027 with G83A UPDATED 13028 with C88G UPDATED 13029 with G83T UPDATED 13030 with G73T UPDATED 13031 with A67G UPDATED 13024 with A67G UPDATED 13032 with G89C UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5970 UPDATE Streptococcus pyogenes PBP2x conferring resistance to beta-lactam antibiotics Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics; amoxicillin; ampicillin; cefotaxime; cephalosporin; penicillin beta-lactam; antibiotic target alteration; model_param "UPDATED 13036 with T553K UPDATED 13037 with P601L UPDATED 13038 with M593T UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5976 UPDATE Erysipelothrix rhusiopathiae gyrA with mutation conferring resistance to enrofloxacin fluoroquinolone resistant gyrA; enrofloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 13087 with T86I UPDATED 13088 with T86K UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5984 UPDATE Clostridium sporogenes cplR Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins; clindamycin; retapamulin; iboxamycin; hygromycin A; lincosamide antibiotic; antibiotic without defined classification; pleuromutilin antibiotic; antibiotic target protection; ARO_category "UPDATED category_aro_accession with 3000003 UPDATED category_aro_cvterm_id with 36012 UPDATED category_aro_name with antibiotic without defined classification UPDATED category_aro_description with These compounds are antibiotics of unique structure or origin, without a defined classification. UPDATED category_aro_class_name with Drug Class " 6065 UPDATE VRA-F ATP-binding cassette (ABC) antibiotic efflux pump; vancomycin; glycopeptide antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; model_param "UPDATED 13250 with K84E UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 6000 UPDATE Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics antibiotic resistant Mycobacterium tuberculosis nitroreductase; delamanid; pretomanid; nitroimidazole antibiotic; antibiotic target alteration; model_param "UPDATED 15418 with M1Var UPDATED 15419 with M1Var UPDATED 15423 with M1Var UPDATED 15424 with M1Var UPDATED 15420 with L49P UPDATED 13131 with M1Var UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. " 6004 UPDATE Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline bedaquiline resistant Rv0678; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 14494 with L49P UPDATED 14559 with L49P UPDATED 14583 with L49P UPDATED 14585 with L49P UPDATED 14594 with L49P UPDATED 14595 with L49P UPDATED 14598 with L49P UPDATED 14604 with L49P UPDATED 14608 with L49P UPDATED 14611 with L49P UPDATED 14615 with L49P UPDATED 14470 with L49P UPDATED 14487 with L49P UPDATED 14477 with L32S UPDATED 14485 with A36V UPDATED 14495 with C46R UPDATED 14530 with I67S UPDATED 14535 with N70D UPDATED 14588 with L117R UPDATED 14591 with G121R UPDATED 14606 with M146T UPDATED 14517 with M146T UPDATED 14545 with M146T UPDATED 13141 with T33A DELETED param_type " 6012 UPDATE Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline bedaquiline resistant Rv2535c; clofazimine; bedaquiline; fluoroquinolone antibiotic; diarylquinoline antibiotic; antibiotic target alteration; model_param "UPDATED 13152 with L44P UPDATED 13154 with L44P UPDATED 13202 with L44P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED param_description with A frameshift is a sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, translation shifts to another reading frame as caused by nucleotide insertions and deletions. In ARO, these are annotated at the protein level with the first changed most N-terminal wildtype amino acid position. Format is given as [wildtype AA][position]fs, e.g. S531fs where S531 is a frameshifted coordinate beginning with codon 531. Termination may also be denoted as: Ter[position]fs. " 6015 UPDATE Salmonella gallinarum folP with mutation conferring resistance to sulfonamides sulfonamide resistant dihydropteroate synthase folP; sulfamethoxazole; sulfonamide antibiotic; antibiotic target alteration; model_param "UPDATED 13158 with R171P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 6016 UPDATE Salmonella isangi gyrA conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 13161 with S83F UPDATED 13160 with D87N UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 6017 UPDATE Salmonella isangi gyrB conferring resistance to fluoroquinolones fluoroquinolone resistant gyrB; ciprofloxacin; nalidixic acid; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 13162 with S464F UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 6019 UPDATE Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin 23S rRNA with mutation conferring resistance to macrolide antibiotics; erythromycin; macrolide antibiotic; antibiotic target alteration; model_param "UPDATED 13171 with a2100g UPDATED 13172 with a2101g UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 6022 UPDATE Vibrio vulnificus rpoB mutants conferring resistance to rifampin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 13175 with S522L UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 2404 UPDATE Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones fluoroquinolone resistant gyrA; ciprofloxacin; sitafloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 4449 with S91F UPDATED 4450 with D95G UPDATED 4451 with D95N UPDATED 13182 with D95Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 6070 UPDATE Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to clofazimine clofazimine resistant Rv0678; clofazimine; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 14546 with D95Y UPDATED 14584 with D95Y UPDATED 14586 with D95Y UPDATED 14599 with D95Y UPDATED 14605 with D95Y UPDATED 14612 with D95Y UPDATED 14471 with D95Y UPDATED 14478 with L32S UPDATED 14486 with A36V UPDATED 14488 with A36V UPDATED 14496 with C46R UPDATED 14531 with I67S UPDATED 14536 with N70D UPDATED 14589 with L117R UPDATED 14592 with G121R UPDATED 14607 with M146T DELETED param_type " 6071 UPDATE Mycobacterium tuberculosis atpE with mutation conferring resistance to bedaquiline antibiotic resistant ATP synthase; bedaquiline; diarylquinoline antibiotic; antibiotic target alteration; model_param "UPDATED 14624 with D28G UPDATED 14625 with D28A UPDATED 14626 with D28V UPDATED 14627 with E61D UPDATED 14628 with A63P UPDATED 14629 with I66M UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 8079 UPDATE OXA-1251 OXA beta-lactamase; oxacillin; penicillin beta-lactam; antibiotic inactivation; model_sequences "UPDATED accession with XBP46887.1 UPDATED sequence with MTVRLVSRALGAALFASALTLPARADVLCTLVADAADGRILFQQGTRQDCTQRYTPASTFKLPIALMGADAGILQGPHQPVWNYQPAYPDWGGEAWRQPTDPARWIKYSVVWYSQLTARALGQERFQRYTSAFGYGNADVSGEPGKHNGTDGAWIISSLRISPFEQVDFLRKFVNRQLPVKAAAYDLAENLFEVGEADGWRLYGKTGTGSPGSHGVYTPANAYGWFVGWARKDDRQLVFARLLQDEGATQPNAGLRARDGLMRDWAAMVTAPRK UPDATED accession with PP850002.1 UPDATED fmin with 0 UPDATED fmax with 825 UPDATED strand with + UPDATED sequence with ATGACAGTTCGACTCGTTTCGCGCGCCCTGGGCGCAGCCCTCTTTGCGTCCGCCCTGACCCTGCCCGCCCGGGCGGACGTCCTGTGCACCCTGGTGGCCGACGCCGCCGACGGCCGCATCCTGTTCCAGCAGGGCACGCGGCAGGACTGCACGCAGCGCTACACCCCCGCCTCGACCTTCAAGCTGCCCATCGCCCTGATGGGCGCGGATGCCGGCATCCTGCAGGGCCCGCACCAGCCCGTCTGGAACTACCAGCCCGCTTATCCCGACTGGGGCGGCGAGGCCTGGCGCCAGCCCACCGATCCGGCTCGCTGGATCAAGTATTCGGTGGTCTGGTACTCGCAGTTGACCGCCAGGGCGCTGGGGCAGGAGCGCTTCCAGCGCTACACCTCCGCGTTCGGTTATGGCAACGCGGACGTCTCGGGTGAACCCGGCAAGCACAACGGCACCGATGGCGCGTGGATCATCTCCTCGCTGCGCATTTCGCCGTTTGAGCAGGTGGACTTCCTGCGCAAGTTCGTCAACCGGCAACTGCCCGTCAAGGCGGCTGCCTATGACCTGGCCGAGAACCTGTTCGAGGTCGGCGAAGCCGACGGCTGGCGCCTGTACGGCAAGACCGGAACCGGCTCGCCCGGCAGCCACGGTGTCTACACGCCGGCCAACGCCTATGGCTGGTTCGTCGGCTGGGCGCGCAAGGACGACCGCCAACTGGTGTTTGCCCGCCTGCTGCAGGACGAGGGGGCGACCCAGCCCAATGCCGGCCTGCGCGCCCGCGACGGCCTGATGCGCGACTGGGCCGCCATGGTCACGGCGCCCCGCAAATAG UPDATED partial with 0 UPDATED NCBI_taxonomy_cvterm_id with 39091 UPDATED NCBI_taxonomy_name with Achromobacter ruhlandii UPDATED NCBI_taxonomy_id with 72557 DELETED 10906 " 1237 UPDATE Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin rifamycin-resistant beta-subunit of RNA polymerase (rpoB); rifampin; rifaximin; rifabutin; rifapentine; rifamycin antibiotic; antibiotic target alteration; antibiotic target replacement; model_param "UPDATED 13304 with D435G UPDATED 13305 with D435V UPDATED 13306 with D435Y UPDATED 13353 with H445D UPDATED 13354 with H445L UPDATED 13355 with H445R UPDATED 13356 with H445Y UPDATED 13384 with L430P UPDATED 13385 with L452P UPDATED 13395 with M434I UPDATED 13410 with Q432P UPDATED 13420 with S450L UPDATED 13421 with S450W UPDATED 13887 with G981D UPDATED 13915 with T676P UPDATED 13920 with V170F UPDATED 13922 with V359A UPDATED 14117 with D435A UPDATED 14118 with D435F UPDATED 14119 with D435N UPDATED 14123 with D545E UPDATED 14135 with H445C UPDATED 14136 with H445F UPDATED 14137 with H445G UPDATED 14138 with H445N UPDATED 14139 with H445P UPDATED 14141 with I491F UPDATED 14155 with Q432K UPDATED 14156 with Q432L UPDATED 14162 with S431T UPDATED 14163 with S441L UPDATED 14164 with S441Q UPDATED 14165 with S450F UPDATED 14166 with S450Q UPDATED 14167 with S450Y UPDATED 14198 with L440Var UPDATED 14200 with G442Var UPDATED 14201 with L443Var UPDATED 14202 with T444Var UPDATED 14203 with H445Var UPDATED 14204 with K446Var UPDATED 14205 with R447Var UPDATED 14206 with R448Var UPDATED 14207 with L449Var UPDATED 14208 with S450Var UPDATED 14209 with A451Var UPDATED 14210 with L452Var UPDATED 14184 with G426Var UPDATED 14185 with T427Var UPDATED 14186 with S428Var UPDATED 14187 with Q429Var UPDATED 14188 with L430Var UPDATED 14189 with S431Var UPDATED 14190 with Q432Var UPDATED 14191 with F433Var UPDATED 14192 with M434Var UPDATED 14193 with D435Var UPDATED 14194 with Q436Var UPDATED 14195 with N437Var UPDATED 14196 with N438Var UPDATED 14197 with P439Var UPDATED 14199 with S441Var UPDATED 14183 with F425Var UPDATED 16044 with T444Var UPDATED 16045 with H445Var UPDATED 16046 with K446Var UPDATED 16047 with R447Var UPDATED 16048 with R448Var UPDATED 16049 with L449Var UPDATED 16050 with S450Var UPDATED 16051 with A451Var UPDATED 16052 with L452Var UPDATED 16028 with S428Var UPDATED 16029 with Q429Var UPDATED 16030 with L430Var UPDATED 16031 with S431Var UPDATED 16032 with Q432Var UPDATED 16033 with F433Var UPDATED 16034 with M434Var UPDATED 16035 with D435Var UPDATED 16036 with Q436Var UPDATED 16037 with N437Var UPDATED 16038 with N438Var UPDATED 16039 with P439Var UPDATED 16040 with L440Var UPDATED 16041 with S441Var UPDATED 16042 with G442Var UPDATED 16043 with L443Var UPDATED 14327 with V170F UPDATED 14333 with G426S UPDATED 14334 with T427P UPDATED 14335 with T427S UPDATED 14336 with T427A UPDATED 14337 with T427G UPDATED 14338 with T427N UPDATED 14339 with T427I UPDATED 14340 with S428G UPDATED 14341 with S428R UPDATED 14342 with S428T UPDATED 14343 with S428I UPDATED 14344 with Q429L UPDATED 14345 with Q429P UPDATED 14346 with Q429H UPDATED 14347 with L430R UPDATED 14348 with L430P UPDATED 14349 with S431G UPDATED 14350 with S431T UPDATED 14351 with S431R UPDATED 14352 with S431N UPDATED 14353 with Q432L UPDATED 14354 with Q432E UPDATED 14355 with Q432N UPDATED 14356 with Q432K UPDATED 14357 with Q432P UPDATED 14358 with Q432H UPDATED 14359 with M434L UPDATED 14360 with M434R UPDATED 14361 with M434V UPDATED 14362 with M434T UPDATED 14363 with D435G UPDATED 14364 with D435Y UPDATED 14365 with M434I UPDATED 14366 with Q436N UPDATED 14367 with N437Y UPDATED 14368 with D435A UPDATED 14369 with D435N UPDATED 14370 with D435F UPDATED 14371 with D435H UPDATED 14372 with D435L UPDATED 14373 with D435V UPDATED 14374 with D435E UPDATED 14375 with Q436R UPDATED 14376 with Q436P UPDATED 14377 with N437H UPDATED 14378 with N437D UPDATED 14379 with N437S UPDATED 14380 with N437I UPDATED 14381 with N438H UPDATED 14382 with P439S UPDATED 14383 with P439L UPDATED 14384 with P439A UPDATED 14385 with S441A UPDATED 14386 with S441L UPDATED 14387 with S441V UPDATED 14388 with S441Q UPDATED 14389 with S441M UPDATED 14390 with S441K UPDATED 14391 with G442E UPDATED 14392 with S441W UPDATED 14393 with L443S UPDATED 14394 with T444P UPDATED 14395 with L443W UPDATED 14396 with L443F UPDATED 14397 with T444S UPDATED 14398 with T444I UPDATED 14399 with H445Y UPDATED 14400 with H445S UPDATED 14401 with K446Q UPDATED 14402 with H445P UPDATED 14403 with H445N UPDATED 14404 with H445F UPDATED 14405 with H445L UPDATED 14406 with H445R UPDATED 14407 with H445C UPDATED 14408 with H445G UPDATED 14409 with H445T UPDATED 14410 with H445D UPDATED 14411 with H445Q UPDATED 14412 with K446R UPDATED 14413 with K446E UPDATED 14414 with K446T UPDATED 14415 with R448L UPDATED 14416 with R448K UPDATED 14417 with R448Q UPDATED 14418 with L449M UPDATED 14419 with S450F UPDATED 14420 with S450A UPDATED 14421 with S450L UPDATED 14422 with S450G UPDATED 14423 with S450Q UPDATED 14424 with A451G UPDATED 14425 with S450V UPDATED 14426 with S450M UPDATED 14427 with S450C UPDATED 14428 with S450Y UPDATED 14429 with S450W UPDATED 14430 with A451V UPDATED 14431 with L452V UPDATED 14432 with L452M UPDATED 14433 with L452P UPDATED 14435 with I491F UPDATED 4074 with L452Var UPDATED 3254 with L457R UPDATED 3265 with M434I UPDATED 3268 with I491F UPDATED 3264 with D435Y UPDATED 3253 with L452R UPDATED 3261 with H445S UPDATED 3267 with L430P UPDATED 3256 with D435V UPDATED 3277 with H445D UPDATED 3266 with M434V UPDATED 3257 with L452P UPDATED 3262 with K446Q UPDATED 3280 with S450W UPDATED 3263 with D435T UPDATED 3276 with H445C UPDATED 3278 with H445R UPDATED 3275 with H445Y UPDATED 3269 with S441L UPDATED 3994 with A286V UPDATED 4005 with D435G UPDATED 4004 with D435N UPDATED 4001 with E423A UPDATED 3995 with L440P UPDATED 4000 with Q409H UPDATED 4003 with Q432K UPDATED 4002 with Q432L UPDATED 3998 with Q432P UPDATED 3997 with S441W UPDATED 3993 with V170F UPDATED 4035 with S431R UPDATED 4023 with S431T UPDATED 4033 with R447H UPDATED 4106 with L457P UPDATED 4031 with S441Q UPDATED 4032 with K446N UPDATED 4024 with S450C UPDATED 4078 with L430M UPDATED 4107 with L464M UPDATED 4043 with T427A UPDATED 4044 with T427H UPDATED 4052 with H445F UPDATED 4109 with L490V UPDATED 4049 with N438K UPDATED 4042 with T427P UPDATED 4082 with N437H UPDATED 4055 with S450F UPDATED 4077 with T427S UPDATED 4083 with N437I UPDATED 4022 with L430R UPDATED 4038 with F505L UPDATED 4061 with F505L UPDATED 4037 with H445G UPDATED 4105 with H445G UPDATED 4058 with H445G UPDATED 4059 with H445G UPDATED 4015 with R447P UPDATED 4019 with R448Q UPDATED 4080 with D435K UPDATED 4110 with R552C UPDATED 4111 with E592D UPDATED 4041 with G426D UPDATED 4048 with D435H UPDATED 4051 with G442A UPDATED 4025 with H445E UPDATED 4020 with H445N UPDATED 4028 with L430V UPDATED 4036 with L440M UPDATED 4108 with L440M UPDATED 4067 with L440M UPDATED 4065 with L440M UPDATED 4066 with L440M UPDATED 4060 with L440M UPDATED 4075 with H445P UPDATED 4057 with H445P UPDATED 4012 with S428Q UPDATED 4014 with L443S UPDATED 4011 with S428R UPDATED 4068 with S428R UPDATED 4030 with N437T UPDATED 4053 with H445Q UPDATED 4046 with Q432D UPDATED 4047 with Q432E UPDATED 4016 with H445T UPDATED 4073 with Q432R UPDATED 4076 with Q436H UPDATED 4013 with Q436L UPDATED 4039 with S493L UPDATED 8229 with T427N UPDATED 8237 with P439T UPDATED 8230 with S431N UPDATED 13237 with S431N UPDATED 3274 with S441Q UPDATED 3259 with S450G UPDATED 4008 with S450L UPDATED 4040 with G426S UPDATED 4007 with H445L UPDATED 4021 with S431I UPDATED 4062 with S431I UPDATED 18573 with S431I UPDATED 18574 with S431I UPDATED 18575 with S431I UPDATED 18576 with S431I UPDATED 18577 with S431I UPDATED 18578 with S431I UPDATED 18579 with S431I UPDATED 18581 with S431I UPDATED 18582 with S431I UPDATED 9742 with S450L UPDATED 9743 with H445Y UPDATED 9775 with H445D UPDATED 9779 with Q432P UPDATED 9780 with M434I UPDATED 9782 with D435G UPDATED 9783 with D435V UPDATED 9787 with S450W UPDATED 9788 with P45L UPDATED 9790 with I480V UPDATED 9791 with F503S UPDATED 9792 with L731P UPDATED 9793 with R827H UPDATED 9794 with H835R UPDATED 9795 with G836S UPDATED 9796 with Q975H UPDATED 9785 with H445R UPDATED 9797 with I1106T UPDATED 9776 with H445L UPDATED 9786 with P45S UPDATED 9778 with L430P UPDATED 9781 with D435Y UPDATED 9789 with L452P UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. UPDATED 3253 with L452R UPDATED 3254 with L457R UPDATED 3263 with D435T UPDATED 3994 with A286V UPDATED 3995 with L440P UPDATED 4000 with Q409H UPDATED 4001 with E423A UPDATED 4012 with S428Q UPDATED 4013 with Q436L UPDATED 4015 with R447P UPDATED 4025 with H445E UPDATED 4028 with L430V UPDATED 4030 with N437T UPDATED 4032 with K446N UPDATED 4033 with R447H UPDATED 4036 with L440M UPDATED 4039 with S493L UPDATED 4041 with G426D UPDATED 4044 with T427H UPDATED 4046 with Q432D UPDATED 4049 with N438K UPDATED 4051 with G442A UPDATED 4073 with Q432R UPDATED 4076 with Q436H UPDATED 4078 with L430M UPDATED 4080 with D435K UPDATED 4106 with L457P UPDATED 4107 with L464M UPDATED 4109 with L490V UPDATED 4110 with R552C UPDATED 4111 with E592D UPDATED 8237 with P439T UPDATED 4021 with S431I DELETED 14202 UPDATED 3253 with L452R UPDATED 3254 with L457R UPDATED 3256 with D435V UPDATED 3257 with L452P UPDATED 3261 with H445S UPDATED 3262 with K446Q UPDATED 3263 with D435T UPDATED 3264 with D435Y UPDATED 3265 with M434I UPDATED 3266 with M434V UPDATED 3267 with L430P UPDATED 3268 with I491F UPDATED 3269 with S441L UPDATED 3275 with H445Y UPDATED 3276 with H445C UPDATED 3277 with H445D UPDATED 3278 with H445R UPDATED 3280 with S450W UPDATED 3993 with V170F UPDATED 3994 with A286V UPDATED 3995 with L440P UPDATED 3997 with S441W UPDATED 3998 with Q432P UPDATED 4000 with Q409H UPDATED 4001 with E423A UPDATED 4002 with Q432L UPDATED 4003 with Q432K UPDATED 4004 with D435N UPDATED 4005 with D435G UPDATED 4011 with S428R UPDATED 4012 with S428Q UPDATED 4013 with Q436L UPDATED 4014 with L443S UPDATED 4015 with R447P UPDATED 4016 with H445T UPDATED 4019 with R448Q UPDATED 4020 with H445N UPDATED 4022 with L430R UPDATED 4023 with S431T UPDATED 4024 with S450C UPDATED 4025 with H445E UPDATED 4028 with L430V UPDATED 4030 with N437T UPDATED 4031 with S441Q UPDATED 4032 with K446N UPDATED 4033 with R447H UPDATED 4035 with S431R UPDATED 4036 with L440M UPDATED 4037 with H445G UPDATED 4039 with S493L UPDATED 4041 with G426D UPDATED 4042 with T427P UPDATED 4043 with T427A UPDATED 4044 with T427H UPDATED 4046 with Q432D UPDATED 4047 with Q432E UPDATED 4048 with D435H UPDATED 4049 with N438K UPDATED 4051 with G442A UPDATED 4052 with H445F UPDATED 4053 with H445Q UPDATED 4055 with S450F UPDATED 4073 with Q432R UPDATED 4075 with H445P UPDATED 4076 with Q436H UPDATED 4077 with T427S UPDATED 4078 with L430M UPDATED 4080 with D435K UPDATED 4082 with N437H UPDATED 4083 with N437I UPDATED 4106 with L457P UPDATED 4107 with L464M UPDATED 4109 with L490V UPDATED 4110 with R552C UPDATED 4111 with E592D UPDATED 8229 with T427N UPDATED 8230 with S431N UPDATED 8237 with P439T UPDATED 3259 with S450G UPDATED 3274 with S441Q UPDATED 4007 with H445L UPDATED 4021 with S431I UPDATED 4040 with G426S DELETED 3251 UPDATED param_description with A sequence change where, compared to a reference sequence, one codon is replaced by a termination codon through a nucleotide substitution. These are described as a substitution of the wildtype codon to a termination codon. Format is given as [wild type AA][position][Ter], for example Q42Ter where Q42 is a wildtype amino acid replaced by a premature termination codon. UPDATED 18573 with Q432Ter UPDATED 4074 with S441Ter DELETED 4045 UPDATED param_description with A peptide sequence change between the translation initiation (start) and termination (stop) codon where, compared to a reference sequence, one or more amino acids are deleted and therefore are not present. These represent in-frame deletions which do not result in frameshift variants and may include multiple amino acids. Format is given by [wildtype AA][position]del for a single peptide deletion or [wildtype AA][position]_[wildtype AA][position]del for a deleted peptide range, e.g. K527del or Q517_N518del. UPDATED 18574 with Q432del UPDATED 18575 with F433del UPDATED 18576 with M434del UPDATED 18577 with D435del UPDATED 18578 with N437del UPDATED 18579 with H445del UPDATED 18581 with P439del UPDATED 18582 with Q436del DELETED 4026 UPDATED 4057 with S450L,S540A UPDATED 4058 with H445S,M434V UPDATED 4059 with H445S,P454H UPDATED 4060 with H445Y,E460G UPDATED 4061 with D435Y,L430R UPDATED 4065 with S450L,F433V UPDATED 4066 with S450L,H445C UPDATED 4067 with L430R,D435V UPDATED 4068 with L430P,M434I UPDATED 4105 with H445P,K446Q UPDATED 4108 with E481G,P483L UPDATED 13237 with H445D,S450L UPDATED 4062 with D435E,S441L DELETED 4103 DELETED 41344 " 6069 UPDATE Mycobacterium tuberculosis fgd1 with mutation conferring resistance to delamanid delamanid-resistant fgd1; delamanid; nitroimidazole antibiotic; antibiotic target alteration; model_param "UPDATED 14322 with V1Var UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 5956 UPDATE Mycobacterium avium gyrA with mutation conferring resistance to fluoroquinolone fluoroquinolone resistant gyrA; ciprofloxacin; levofloxacin; moxifloxacin; fluoroquinolone antibiotic; antibiotic target alteration; model_param "UPDATED 12925 with D95G UPDATED 12926 with D95Y UPDATED param_description with A sequence change where, compared to a reference sequence, one amino acid is replaced by one other amino acid that is associated with elevated resistance to antibiotic(s) relative to wild type. Format is given as [wild-type][position][mutation], e.g. R184Q or R447Var where Var represents any possible substitution. " 1155 DELETE ACT-9 ACT beta-lactamase; carbapenem; cephalosporin; penicillin beta-lactam; antibiotic inactivation; N/A N/A 2202 DELETE AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein aminoglycoside bifunctional resistance protein; astromicin; amikacin; sisomicin; kanamycin A; tobramycin; gentamicin; aminoglycoside antibiotic; antibiotic inactivation; N/A N/A 2372 DELETE Escherichia coli GlpT with mutation conferring resistance to fosfomycin antibiotic-resistant GlpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; N/A N/A 2376 DELETE Escherichia coli uhpA with mutation conferring resistance to fosfomycin antibiotic-resistant UhpT; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; N/A N/A 2378 DELETE Escherichia coli cyaA with mutation conferring resistance to fosfomycin antibiotic-resistant cya adenylate cyclase; fosfomycin; phosphonic acid antibiotic; antibiotic target alteration; N/A N/A 2713 DELETE MexXY-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 2682 DELETE MexAB-OprM with NalC mutations conferring resistance to aztreonam resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 2680 DELETE MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 2686 DELETE MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 2679 DELETE MexAB-OprM with MexR mutations confers resistance to multiple antibiotics resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 2711 DELETE MexXY-OprM resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin; macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A 2743 DELETE Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; ceftazidime; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; N/A N/A 2744 DELETE Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline resistance-nodulation-cell division (RND) antibiotic efflux pump; tigecycline; ciprofloxacin; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan; fluoroquinolone antibiotic; cephalosporin; glycylcycline; penicillin beta-lactam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic target alteration; antibiotic efflux; N/A N/A 2219 DELETE MexL resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; tetracycline; triclosan; macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics; efflux pump complex or subunit conferring antibiotic resistance; protein(s) and two-component regulatory system modulating antibiotic efflux; antibiotic efflux; N/A N/A 2683 DELETE MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics resistance-nodulation-cell division (RND) antibiotic efflux pump; erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole; macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; penicillin beta-lactam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; efflux pump complex or subunit conferring antibiotic resistance; antibiotic efflux; N/A N/A