determinant of aminocoumarin resistance

Accession ARO:3000477
DefinitionPoint mutations to DNA topoisomerase enzymes clinically shown to confer resistance to aminocoumarins. In some cases, expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can also confer aminocoumarin resistance.
Drug Classaminocoumarin antibiotic
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ determinant of antibiotic resistance
+ confers_resistance_to_drug_class aminocoumarin antibiotic [Drug Class]
5 ontology terms | Show
+ aminocoumarin resistant gyrB [AMR Gene Family]
+ aminocoumarin resistant parY [AMR Gene Family]
+ aminocoumarin resistant parE [AMR Gene Family]
+ aminocoumarin resistant alaS [AMR Gene Family]
+ aminocoumarin resistant cysB [AMR Gene Family]

Schmutz E, et al. 2004. Microbiology 150(PT 3): 641-647. Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. (PMID 14993313)

Schmutz E, et al. 2003. Antimicrob Agents Chemother 47(3): 869-877. Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (PMID 12604514)

Li SM and Heide L. 2006. Planta Med 72(12): 1093-1099. The biosynthetic gene clusters of aminocoumarin antibiotics. (PMID 16868863)