Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime

Accession ARO:3004078
DefinitionAcrR is the repressor of the AcrAB operon, where a mutation in AcrR allows AcrAB-TolC to confer resistance to ciprofloxacin, tetracycline, and ceftazidime.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, cephalosporin, penam, aminoglycoside antibiotic, glycylcycline, diaminopyrimidine antibiotic, monobactam, aminocoumarin antibiotic, carbapenem, rifamycin antibiotic, triclosan, fluoroquinolone antibiotic, antibacterial free fatty acids, acridine dye, macrolide antibiotic, phenicol antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification32 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ AcrAB-TolC
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic cefalotin [Antibiotic]
Publications

Webber MA, et al. 2005. Antimicrob. Agents Chemother. 49(10):4390-2 Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates. (PMID 16189130)

Resistomes

Prevalence of Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: E. coli AcrAB-TolC with AcrR mutation conferring resistance to cirpofloxacin

Model Description: AcrR is the repressor of the AcrAB operon, where a mutation in AcrR allows AcrAB-TolC to confer resistance to ciprofloxacin.

tolCacrBEscherichia coli acrR with mutation conferring multidrug antibiotic resistanceEscherichia coli acrA