Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline

Accession ARO:3004079
DefinitionThe Escherichia coli AcrAB-TolC with MarR mutation (Y137H) conferring resistance to ciprofloxacin and tetracycline.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, rifamycin antibiotic, glycylcycline, acridine dye, fluoroquinolone antibiotic, aminocoumarin antibiotic, penam, carbapenem, monobactam, macrolide antibiotic, diaminopyrimidine antibiotic, antibacterial free fatty acids, triclosan, aminoglycoside antibiotic, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification32 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ AcrAB-TolC
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic cefalotin [Antibiotic]
Publications

Webber MA, et al. 2001. Antimicrob. Agents Chemother. 45(5):1550-2 Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli. (PMID 11302826)

Resistomes

Prevalence of Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline

Model Description: The Escherichia coli AcrAB-TolC with MarR mutation (Y137H) conferring resistance to ciprofloxacin and tetracycline.

Escherichia coli marR mutant conferring antibiotic resistancetolCacrBEscherichia coli acrA