Accession | ARO:3000113 |
Definition | Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. |
Drug Class | streptogramin antibiotic, streptogramin A antibiotic, pleuromutilin antibiotic |
Resistance Mechanism | antibiotic target protection |
Classification | 7 ontology terms | Show |
Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class streptogramin A antibiotic [Drug Class] + confers_resistance_to_drug_class pleuromutilin antibiotic [Drug Class] + ABC-F ATP-binding cassette ribosomal protection protein |
Sub-Term(s) | 7 ontology terms | Show |
Publications | Chesneau O, et al. 2005. Antimicrob Agents Chemother 49(3): 973-980. Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci. (PMID 15728891) Kadlec K, et al. 2010. J. Antimicrob. Chemother. 65(12):2692-3 Small plasmids carrying vga(A) or vga(C) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-resistant Staphylococcus aureus ST398 from swine. (PMID 20876620) Schwendener S, et al. 2011. Antimicrob Agents Chemother 55(10): 4900-4904. New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene. (PMID 21768510) |