Alcock et al. CARD 2020: Antibiotic Resistome Surveillance with the Comprehensive Antibiotic Resistance Database. Nucleic Acids Research, in press.
Guitor et al. Capturing the Resistome: A robust and reliable targeted capture method for detecting antibiotic resistance determinants. Antimicrobial Agents and Chemotherapy, in press.
Faltyn et al. 2019. Evolution and nomenclature of the trimethoprim resistant dihydrofolate (dfr) reductases. Preprints, 2019050137.
Tsang et al. 2019. Pathogen taxonomy updates at the Comprehensive Antibiotic Resistance Database: Implications for molecular epidemiology. Preprints, 2019070222.
Jia et al. 2017. CARD 2017: expansion and model-centric curation of the Comprehensive Antibiotic Resistance Database. Nucleic Acids Research, 45, D566-573.
McArthur et al. 2013. The Comprehensive Antibiotic Resistance Database. Antimicrobial Agents and Chemotherapy, 57, 3348-57.
1. About the CARD, ARO, and RGI
The Comprehensive Antibiotic Resistance Database ("CARD") provides data, models, and algorithms relating to the molecular basis of antimicrobial resistance. The CARD provides curated reference sequences and SNPs organized via the Antibiotic Resistance Ontology ("ARO"). These data can be browsed on the website or downloaded in a number of formats. These data are additionally associated with detection models, in the form of curated homology cut-offs and SNP maps, for prediction of resistome from molecular sequences. These models can be downloaded or can be used for analysis of genome sequences using the Resistance Gene Identifier ("RGI"), either online or as a stand-alone tool.
The CARD was designed and developed by the laboratories of Drs. Gerry Wright and Andrew G. McArthur of McMaster University's Department of Biochemistry & Biomedical Sciences (Hamilton, Ontario, Canada) with the help of a global team of collaborators. It is built entirely using open source software and tools. This research has been supported by funds from the Canadian Foundation for Innovation, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Medical Research Council (UK), and Ontario Research Fund, as well as a Cisco Research Chair in Bioinformatics supported by Cisco Systems Canada, Inc. (Dr. McArthur), Canada Research Chair (Dr. Wright), and Killam Research Fellowship (Dr. Wright).
CARD: Expert-curated collection of molecular sequences and mutations underlying AMR, organized by the Antibiotic Resistance Ontology. RGI: Prediction of complete resistome from genomic and metagenomic data. Resistomes & Variants: Pre-compiled resistomes, allelic variants, and AMR gene prevalence data for priority pathogens. Annotation Services: Have the CARD team annotate your genomic data. Hosting Services: Host your own genome sequence collections on the CARD website, private & password-secure, with annotation constantly updated by RGI. Bait Capture: Hybridization bait enrichment of AMR alleles for your metagenomic sequencing projects.
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