Accession | ARO:3000128 |
Definition | A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. |
Drug Class | aminoglycoside antibiotic |
Resistance Mechanism | antibiotic inactivation |
Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + phosphorylation of antibiotic conferring resistance + antibiotic molecule |
Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + aminoglycoside phosphotransferase (APH) |
Sub-Term(s) | 6 ontology terms | Show |