restructuring of bacterial cell wall conferring antibiotic resistance

Accession ARO:3000213
Synonym(s)molecular bypass conferring antibiotic resistance
DefinitionPeptidoglycan precursors ending in D-Ala-D-Lac or D-Ala-D-Ser instead of D-Ala-D-Ala conferring high level glycopeptide resistance.
Resistance Mechanismantibiotic target alteration
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ antibiotic target alteration [Resistance Mechanism]
2 ontology terms | Show

Bugg TD, et al. 1991. Biochemistry 30(43): 10408-10415. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. (PMID 1931965)

Marshall CG, et al. 1997. Proc Natl Acad Sci U S A 94(12): 6480-6483. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. (PMID 9177243)