isoprenoid synthesis enzyme targeted by antibiotic

Accession ARO:3000715
DefinitionEnzymes in this pathway generate important precursors for macromolecules. While eukaryotes and prokaryotes both synthesize isoprenoids, many bacteria and notably mycobacteria use an alternative pathway that is targeted by antibiotics.
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Parent Term(s)1 ontology terms | Show
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Dhiman RK, et al. 2005. J Bacteriol 187(24): 8395-8402. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. (PMID 16321944)

Singh N, et al. 2007. Curr Pharm Des 13(11): 1161-1177. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme. (PMID 17430177)