antibiotic sensitive signal peptidase I

Accession ARO:3000717
DefinitionSignal peptidase I is a bacterial signal peptidase that cleaves signal peptides from translated proteins. These signal peptides direct proteins to their destination, and then must be cleaved in order to function.
Classification1 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic target
+ targeted_by_antibiotic arylomycin [Antibiotic]

Smith PA, et al. 2011. Antimicrob Agents Chemother 55(3): 1130-1134. In vitro activities of arylomycin natural-product antibiotics against Staphylococcus epidermidis and other coagulase-negative staphylococci. (PMID 21189343)

Kulanthaivel P, et al. 2004. J Biol Chem 279(35): 36250-36258. Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I. (PMID 15173160)

Kreil G. 1981. Annu Rev Biochem 50: 317-348. Transfer of proteins across membranes. (PMID 7023361)