antibiotic resistant inhA

Accession ARO:3003417
Synonym(s)enoyl-acyl carrier reductase
DefinitioninhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. It is inhibited by isoniazid. Mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis.
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show

Banerjee A, et al. 1994. Science 263(5144): 227-230. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. (PMID 8284673)