Antibiotic resistant iniA

Accession ARO:3003446
DefinitioniniA, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell.
Resistance Mechanismantibiotic efflux, antibiotic target alteration
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
1 ontology terms | Show
+ Ethambutol resistant iniA [AMR Gene Family]

Colangeli R, et al. 2005. Mol Microbiol 55(6): 1829-1840. The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. (PMID 15752203)