antibiotic resistant ethA

Accession ARO:3003456
Synonym(s)FAD-containing monooxygenase
DefinitionMonooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. It is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species.
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
4 ontology terms | Show
+ ethionamide resistant ethA [AMR Gene Family]
+ isoniazid resistant ethA [AMR Gene Family]
+ prothionamide resistant ethA [AMR Gene Family]
+ perchlozone resistant ethA [AMR Gene Family]

Baulard AR, et al. 2000. J Biol Chem 275(36): 28326-28331. Activation of the pro-drug ethionamide is regulated in mycobacteria. (PMID 10869356)