antibiotic resistant kasA [AMR Gene Family]

Accession ARO:3003462
DefinitionkasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids.
Drug Classisoniazid-like antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ derives_from antibiotic sensitive kasA
+ confers_resistance_to_drug_class isoniazid-like antibiotic [Drug Class]
1 ontology terms | Show

Lee AS, et al. 1999. Antimicrob Agents Chemother 43(8): 2087-2089. Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore. (PMID 10428945)