Community Acquired Respiratory Distress Syndrome toxin

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Accession VIRO:0000140
DefinitionCARDS toxin (Community Acquired Respiratory Distress Syndrome toxin) is a ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae. CARDS toxin binds to human surfactant protein A and annexin A2 on airway epithelial cells and is internalized, leading to disruption of monolayer integrity and cell death.
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Parent Term(s)1 ontology terms | Show

Kannan TR and Baseman JB. 2006. Proc Natl Acad Sci U S A 103(17): 6724-6729. ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens. (PMID 16617115)

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