Salmonella typhi cytolethal distending toxin

Accession VIRO:0000141
DefinitionSalmonella typhi cytolethal distending toxin differs from classic cytolethal distending toxins in which the genes encoding CdtA and CdtC are absent. Normally CdtA and CdtC mediate target cell binding and membrane translocation of CdtB, which then induces DNA damage through its nuclease. CdtB from S. typhi is produced with the pertussis-like toxins PltA and PltB only inside the host cell.
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Haghjoo E, et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101(13):4614-9 Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. (PMID 15070766)

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