|Synonym(s)||GBS β-h/c Streptococcus beta-haemolysin|
|Definition||Coded by gene CylE. Beta-haemolysin from Streptococcus agalactiae is a pore-forming toxin that induces apoptosis of host cells, promotes cellular invasion, impairs cardiac function, promotes liver failure, induces host inflammatory responses that contribute to neurological sequelae and triggers iNOS and cytokine release.|
|Classification||4 ontology terms | Show|
|Parent Term(s)||2 ontology terms | Show|
Nizet V, et al. 2002. Trends Microbiol. 10(12):575-80 Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. (PMID 12564994)
Rajagopal L. 2009. Future Microbiol 4(2): 201-221. Understanding the regulation of Group B Streptococcal virulence factors. (PMID 19257847)
Private model - RGI is not currently using this model.