Accession VIRO:0000154
Synonym(s)Zona occludens toxin
DefinitionZona occludens toxin (Zot) from Vibrio cholerae is a toxin that has the ability to increase mucosal permeability by reversible loosening of the intestinal tight junctions (zonula occludens), rather than an irreversible opening as seen with Clostridioides difficile toxin A
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show

Marinaro M, et al. 2003. Infect. Immun. 71(4):1897-902 Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. (PMID 12654806)

Lee A, et al. 2003. FEBS Lett. 555(3):638-42 The intestinal zonula occludens toxin (ZOT) receptor recognises non-native ZOT conformers and localises to the intercellular contacts. (PMID 14675787)

Fasano A, et al. 1995. J. Clin. Invest. 96(2):710-20 Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. (PMID 7635964)

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