antibiotic-resistant ptsI phosphotransferase [AMR Gene Family]

Accession ARO:3004250
DefinitionPtsI family phosphotransferases are involved in cyclic AMP synthesis, which regulates glpT expression. Mutations in PtsI family genes can negatively affect expression of UhpT, which is needed for fosfomycin import.
Drug Classphosphonic acid antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_drug_class phosphonic acid antibiotic [Drug Class]
1 ontology terms | Show

Takahata S, et al. 2010. Int J Antimicrob Agents 35(4): 333-337. Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli. (PMID 20071153)