antibiotic-resistant cya adenylate cyclase [AMR Gene Family]

Accession ARO:3004251
DefinitionAdenylate cyclases encoded by cya genes, which are involved in the synthesis cyclic AMP which regulates the fosfomycin transporter glpT. Mutations in cya genes can confer resistance to fosfomycin.
Drug Classphosphonic acid antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_drug_class phosphonic acid antibiotic [Drug Class]
1 ontology terms | Show

Sakamoto Y, et al. 2003. Biosci. Biotechnol. Biochem. 67(9):2030-3 Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli. (PMID 14519998)