antibiotic resistant pncA

Accession ARO:3004267
DefinitionPoint mutations in pncA prevent the enzyme from activating antibiotics, such as pyrazinamide.
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show
+ Pyrazinamide resistant pncA [AMR Gene Family]

Scorpio A, et al. 1997. Antimicrob Agents Chemother 41(3): 540-543. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. (PMID 9055989)