| Accession | VIRO:0000298 |
| Synonym(s) | Sags |
| Definition | A classification of toxins that are primarily produced by Staphylococcus aureus and Streptococcus pyogenes. The toxin acts to crosslink major histocompatibility complex (MHC) class II antigens and T‐cell receptors (TCR) as a method of targeting the immunological adaptive response. The effect of these toxins results in stimulation of a large number of T-cells amounting to a phenomenon known as a cytokine storm. This is known as the toxic shock syndrome (TSS). |
| Classification | 5 ontology terms | Show + process or component of pathogenesis biology or chemistry + biological effect of virulence + virulence factor + host cell damaging + toxin [Virulence Factor] |
| Parent Term(s) | 1 ontology terms | Show + exotoxin |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Fraser JD, et al. 2008. Immunol. Rev. 225:226-43 The bacterial superantigen and superantigen-like proteins. (PMID 18837785) |
| Curator | Description | Most Recent Edit |
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