pyrazinamide resistant rpsA [AMR Gene Family]

Accession ARO:3004722
Synonym(s)Ribosomal protein S1
DefinitionThe 30S ribosomal protein S1 of Mycobacterium tuberculosis is required for mRNA translation initiation, playing a particular role in trans-translation. Mutations to rpsA prevent pyrazinoic acid, the active form of pyrazinamide catalyzed by pncA, from targeting RpsA to inhibit translation.
Drug Classpyrazine antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_drug_class pyrazine antibiotic [Drug Class]
1 ontology terms | Show

Khan MT, et al. . J. Biol. Regul. Homeost. Agents 32(3):705-709 Pyrazinamide-resistant mycobacterium tuberculosis isolates from Khyber Pakhtunkhwa and rpsA mutations. (PMID 29921403)

Shi W, et al. 2011. Science 333(6049):1630-2 Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. (PMID 21835980)