| Accession | ARO:3007088 |
| Synonym(s) | POL7080 |
| Definition | A peptidomimetic antibiotic with specific, potent action against members of the Pseudomonas genus. Murepavadin disrupts lipopolysaccharide biosynthesis by binding to lypopolysaccharide transport protein D. |
| SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCCN)NC(=O)[C@H](CCN)NC1=O |
| PubChem | 91824766 |
| ChEMBL | CHEMBL3946483 |
| Drug Class | protegrin-1-like antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + protegrin-1-like antibiotic [Drug Class] |
| Publications | Srinivas N, et al. 2010. Science 327(5968):1010-3 Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa. (PMID 20167788) Díez-Aguilar M, et al. 2021. J Antimicrob Chemother 76(4):984-992 Murepavadin antimicrobial activity against and resistance development in cystic fibrosis Pseudomonas aeruginosa isolates. (PMID 33367642) |
| Curator | Description | Most Recent Edit |
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