PBT2 [Adjuvant]

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Accession ARO:3007144
DefinitionPBT2 is a former Alzheimer's and Huntington's disease candidate drug that has since been shown to increase susceptibility to colistin, polymyxin B, and tetracycline in N. gonorrhoeae. It is thought to inactivate lipooligosaccharide phosphoethanolamine transferase A, resulting in alteration of cell membrane charge.
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Parent Term(s)1 ontology terms | Show

Jen FE, et al. 2021. J Antimicrob Chemother 76(11):2850-2853 A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides. (PMID 34450628)