SPR741 [Adjuvant]

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Accession ARO:3007312
DefinitionSPR741 is an experimental cationic peptide used to increase permeability of the outer membrane of Gram-negative bacteria. It is currently in clinical trials in combination with a variety of antibiotics.
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Zurawski DV, et al. 2017. Antimicrob Agents Chemother 61(12): SPR741, an Antibiotic Adjuvant, Potentiates the In Vitro and In Vivo Activity of Rifampin against Clinically Relevant Extensively Drug-Resistant Acinetobacter baumannii. (PMID 28947471)