metformin [Adjuvant]

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Accession ARO:3007318
DefinitionMetformin is a first-line medication for type 2 diabetes. It has been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics, such as tetracyclines, beta-lactams, and rifampicin. Metformin is also able to inhibit antibiotic efflux pumps such as AcrAB-TolC and MdtK.
Classification4 ontology terms | Show
Parent Term(s)3 ontology terms | Show

Masadeh MM, et al. 2021. Clin Pharmacol 13:83-90 Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria. (PMID 34007223)

Liu Y, et al. 2020. Adv Sci (Weinh) 7(12):1902227 Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria. (PMID 32596101)