bicarbonate [Adjuvant]

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Accession ARO:3007319
DefinitionBicarbonate is an ion capable of increasing bacterial membrane permeability by altering the proton motive force. This enhances the entry of antibiotics.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show

Farha MA, et al. 2018. ACS Infect Dis 4(3):382-390 Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force. (PMID 29264917)

Farha MA, et al. 2020. ACS Infect Dis 6(10):2709-2718 Overcoming Acquired and Native Macrolide Resistance with Bicarbonate. (PMID 32898415)