UDP-glucuronic acid decarboxylase [AMR Gene Family]

Accession ARO:3007567
DefinitionUDP-glucuronic acid decarboxylase catalyzes the decarboxylation of UDP-glucuronic acid. Accumulation of UDP-glucuronic acid mediates resistance to 5-flucytosine.
Drug Classpyrimidine antifungal drug
Resistance Mechanismresistance by absence
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class pyrimidine antifungal drug [Drug Class]
+ gene conferring resistance via absence
1 ontology terms | Show

Billmyre RB, et al. 2020. Nat Commun 11(1):127 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus. (PMID 31913284)

Chang YC, et al. 2021. Nat Commun 12(1):3418 Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci. (PMID 34103502)