formicamycin E [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3007585
DefinitionFormicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates.
SMILESCOc1cc(OC)c(-c2cc(OC)c(Cl)c3c2C(=O)[C@@]2(O)C(=O)c4c(O)cc(O)c(Cl)c4C(C)(C)[C@H]2C3)c(C)c1Cl
PubChem146684585
ChEBI219460
ChEMBLCHEMBL4647076
Drug Classpolyketide with antibiotic activity
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Devine R, et al. 2021. Cell Chem Biol 28(4):515-523.e5 Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds. (PMID 33440167)

Curator Acknowledgements
Curator Description Most Recent Edit