formicamycin O [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3007587
DefinitionFormicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates.
SMILESCOc1cc2c(c(-c3c(O)cc(OC)c(Cl)c3C)c1)C(=O)[C@@]1(O)C(=O)c3c(O)cc(O)cc3C(C)(C)[C@H]1C2
PubChem156020171
ChEBI226636
ChEMBLCHEMBL4648236
Drug Classpolyketide with antibiotic activity
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Devine R, et al. 2021. Cell Chem Biol 28(4):515-523.e5 Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds. (PMID 33440167)

Curator Acknowledgements
Curator Description Most Recent Edit