antibiotic resistant Mycobacterium tuberculosis nitroreductase [AMR Gene Family]

Accession ARO:3007656
DefinitionInactivation of the F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents plays a role in antibiotic resistance.
Drug Classnitroimidazole antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_drug_class nitroimidazole antibiotic [Drug Class]
1 ontology terms | Show

Mansjö M, et al. 2022. Antimicrob Agents Chemother 66(12):e0102622 The ddn Trp20Stop Mutation and Its Association with Lineage 4.5 and Resistance to Delamanid and Pretomanid in Mycobacterium tuberculosis. (PMID 36409105)