antibiotic resistant Rv2535c

Accession ARO:3007690
DefinitionRv2535c or pepQ encodes a putative Xaa-Pro aminopeptidase and is a new genetic determinant of low-level bedaquiline and clofazimine cross-resistance in Mycobacterium tuberculosis when mutated.
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show
+ bedaquiline resistant Rv2535c [AMR Gene Family]

Almeida D, et al. 2016. Antimicrob Agents Chemother 60(8):4590-9 Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis. (PMID 27185800)