| Accession | ARO:3007778 |
| Definition | Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
| SMILES | C[C@@H]1c2nc(N)[nH]c2[C@@]2(O)C[C@]1(C)c1cc(-c3cnc(-c4c[nH]c5cc(Br)ccc45)c(=O)[nH]3)[nH]c1C2=O |
| PubChem | 459934 |
| Drug Class | bis-indole alkaloid with antibiotic activity |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + bis-indole alkaloid with antibiotic activity [Drug Class] |
| Publications | Yamazaki K, et al. 2024. Org Lett 26(3):670-675 Total Synthesis of Dragmacidins G and H. (PMID 38206835) Wright AE, et al. 2017. Mar Drugs 15(1): Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites. (PMID 28085024) |
| Curator | Description | Most Recent Edit |
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