| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009185 |
| Definition | Azoxystrobin (brand name Amistar, Syngenta) is widely used as a very broad spectrum fungicide in agriculture, particularly in wheat farming. It is an inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, and binds very tightly to the Qo site of Complex III of the mitochondrial electron transport chain, thereby ultimately preventing the generation of ATP. |
| SMILES | CO/C=C(\C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)/C(=O)OC |
| CAS | 131860-33-8 |
| CHEBI | 40909 |
| ChEMBL | CHEMBL230001 |
| PubChem | 3034285 |
| Drug Class | strobilurin fungicide |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + strobilurin fungicide [Drug Class] |
| Sub-Term(s) | 6 ontology terms | Show + Colletotrichum gloeosporioides cytochrome b protein with mutations conferring resistance to azoxystrobin confers_resistance_to_antibiotic + Colletotrichum siamense cytochrome b protein with mutations associated with resistance to azoxystrobin confers_resistance_to_antibiotic + Colletotrichum graminicola cytochrome b protein with mutations associated with resistance to azoxystrobin confers_resistance_to_antibiotic + Colletotrichum siamense beta-tubulin with mutations conferring resistance to azoxystrobin confers_resistance_to_antibiotic + Aspergillus fumigatus beta-tubulin with mutations conferring resistance to azoxystrobin confers_resistance_to_antibiotic + Aspergillus fumigatus Cyp51A with mutations conferring resistance to azoxystrobin confers_resistance_to_antibiotic |
| Publications | Wiggins TE, et al. 1994. Biochem Soc Trans 22(1):68S Mode of action of the new methoxyacrylate antifungal agent ICIA5504. (PMID 8206299) Cabras P, et al. 1998. J AOAC Int 81(6):1185-9 Gas chromatographic determination of azoxystrobin, fluazinam, kresoxim-methyl, mepanipyrim, and tetraconazole in grapes, must, and wine. (PMID 9850581) |
| Curator | Description | Most Recent Edit |
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