Resistance in Mycobacterium tuberculosis is almost exclusively SNVs. Unlike other organisms, culture and antibiotic susceptibility testing for TB is very challenging. The TB community instead developed a likelihood framework, based on statistical association of SNVs with observed phenotypic resistance across a large number of sequenced genomes, organized as mutation catalogs. It is important to note that each catalog may recycle data from earlier catalogs. These data have also been incorporated into CARD, the Antibiotic Resistance Ontology (ARO), and CARD's Resistance Gene Identifier (RGI) software. Curator Acknowledgements: Brian Alcock, Monica Warner, Karyn Mukiri, Sidrah Shaikh, Nilasha Mohan.
PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).
| Gene | Mutation | Mutation type | PubMed | ReSeqTB | CRyPTIC | WHO |
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