| Accession | ARO:3002835 |
| Synonym(s) | linA |
| CARD Short Name | lnuA |
| Definition | lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes. |
| AMR Gene Family | lincosamide nucleotidyltransferase (LNU) |
| Drug Class | lincosamide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Clostridium botulinumwgs, Enterococcus faecaliswgs, Enterococcus faeciumwgs, Enterococcus hiraewgs, Escherichia coliwgs, Helicobacter pyloriwgs, Lactobacillus crispatuswgs, Lactobacillus johnsoniig+wgs, Lactococcus garvieaep+wgs, Listeria innocuap+wgs, Listeria monocytogeneswgs, Macrococcus canisp+wgs, Staphylococcus arlettaep+wgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitiswgs, Staphylococcus epidermidisp+wgs, Staphylococcus equorump+wgs, Staphylococcus haemolyticuswgs, Staphylococcus hominiswgs, Staphylococcus pasteuriwgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus simulansp+wgs, Staphylococcus warnerip+wgs, Streptococcus pneumoniaewgs, Streptococcus suiswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + nucleotidylation of antibiotic conferring resistance + lincosamide antibiotic [Drug Class] + antibiotic inactivation enzyme |
| Parent Term(s) | 3 ontology terms | Show + lincosamide nucleotidyltransferase (LNU) [AMR Gene Family] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic pirlimycin [Antibiotic] |
| Publications | Luthje P, et al. 2007. J Antimicrob Chemother 59(4): 600-606. Identification and characterization of nine novel types of small staphylococcal plasmids carrying the lincosamide nucleotidyltransferase gene lnu(A). (PMID 17329268) |
Prevalence of lnuA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Clostridium botulinum | 0% | 0% | 0.27% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.16% | 0% |
| Enterococcus faecium | 0% | 0% | 0.14% | 0% |
| Enterococcus hirae | 0% | 0% | 0.46% | 0% |
| Escherichia coli | 0% | 0% | 0.06% | 0% |
| Helicobacter pylori | 0% | 0% | 0.05% | 0% |
| Lactobacillus crispatus | 0% | 0% | 3.72% | 0% |
| Lactobacillus johnsonii | 33.33% | 0% | 17.24% | 0% |
| Lactococcus garvieae | 0% | 4.17% | 2.22% | 0% |
| Listeria innocua | 0% | 5.26% | 0.75% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.05% | 0% |
| Macrococcus canis | 0% | 6.25% | 12.5% | 0% |
| Staphylococcus arlettae | 0% | 8.33% | 10% | 0% |
| Staphylococcus aureus | 0.09% | 0.74% | 1.12% | 0% |
| Staphylococcus capitis | 0% | 0% | 3.16% | 0% |
| Staphylococcus epidermidis | 0% | 0.86% | 3.51% | 0% |
| Staphylococcus equorum | 0% | 10.81% | 16.07% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 5.27% | 0% |
| Staphylococcus hominis | 0% | 0% | 8.78% | 0% |
| Staphylococcus pasteuri | 0% | 0% | 7.69% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 1.03% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 12.59% | 0% |
| Staphylococcus simulans | 0% | 23.53% | 3.39% | 0% |
| Staphylococcus warneri | 0% | 7.5% | 6.56% | 0% |
| Streptococcus pneumoniae | 0% | 0% | 0.03% | 0% |
| Streptococcus suis | 0% | 0% | 0.1% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300