| Accession | ARO:3003128 |
| CARD Short Name | OXA-436 |
| Definition | An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017. |
| AMR Gene Family | OXA beta-lactamase, OXA-48-like beta-lactamase |
| Drug Class | penam, carbapenem |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter freundiiwgs, Enterobacter asburiaewgs |
| Resistomes with Sequence Variants | Citrobacter freundiiwgs, Enterobacter asburiaewgs, Shewanella putrefaciensg |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + penam [Drug Class] + beta-lactamase + class D beta-lactamase + oxacillin [Antibiotic] + OXA beta-lactamase [AMR Gene Family] + carbapenem [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + OXA-48-like beta-lactamase [AMR Gene Family] |
| Publications | Samuelsen Ø, et al. 2017. Antimicrob. Agents Chemother. : Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark. (PMID 29061750) |
Prevalence of OXA-436 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 0% | 0.39% | 0% |
| Enterobacter asburiae | 0% | 0% | 1.19% | 0% |
| Shewanella putrefaciens | 11.11% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500
Type of Antibiotic Resistance: Acquired