| Accession | ARO:3003918 |
| CARD Short Name | apmA |
| Definition | Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA. |
| AMR Gene Family | AAC(2') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Staphylococcus aureuswgs |
| Resistomes with Sequence Variants | Enterococcus faecalisp+wgs, Enterococcus faeciumwgs, Staphylococcus aureuswgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Fessler AT, et al. 2011. Antimicrob. Agents Chemother. 55(1):373-5 Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. (PMID 20876371) Bordeleau E, et al. 2021. mBio 12(1): ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin. (PMID 33563840) Bordeleau E, et al. 2023. Nat Chem Biol : Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. (PMID 37973888) |
Prevalence of apmA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus faecalis | 0% | 0.25% | 0.04% | 0% |
| Enterococcus faecium | 0% | 0% | 0.1% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.15% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500