EC-8

Accession ARO:3006881
CARD Short NameEC-8
DefinitionEC-8 is a EC beta-lactamase.
AMR Gene FamilyEC beta-lactamase
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsEscherichia colig+wgs, Escherichia fergusoniig+wgs, Escherichia marmotaeg+wgs, Shigella boydiiwgs, Shigella sonneiwgs
Classification13 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ EC beta-lactamase [AMR Gene Family]
Resistomes

Prevalence of EC-8 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Escherichia coli6.65%0%6.35%0%
Escherichia fergusonii98.36%0%51.09%0%
Escherichia marmotae81.82%0%64.58%0%
Shigella boydii0%0%5.56%0%
Shigella sonnei0%0%0.95%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 725


>gb|WP_063860454.1|+|EC-8 [Escherichia coli]
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLG
GDAIARGEIKLSDPATKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDDVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDITEKTLQQGIQL
AQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVTAAWQILNALQ


>gb|NG_049086.1|+|101-1234|EC-8 [Escherichia coli]
ATGTTCAAAACGACGCTCTGCGCCTTATTAATTACCGCCTCTTGCTCCACATTTGCCGCCCCTCAACAAATCAACGATATTGTGCATCGC
ACAATTACCCCGCTTATAGAGCAACAAAAGATCCCCGGTATGGCGGTGGCGGTAATTTATCAGGGTAAACCTTATTACTTTACCTGGGGC
TATGCGGACATCGCCAAAAAGCAGCCCGTCACACAGCAAACGTTGTTTGAGTTAGGTTCGGTCAGCAAAACATTTACGGGCGTGCTTGGT
GGCGACGCTATTGCACGAGGGGAAATCAAGTTAAGCGATCCCGCGACAAAATACTGGCCTGAACTTACCGCTAAACAATGGAATGGGATC
ACACTATTACATCTTGCGACCTACACCGCTGGCGGCCTGCCATTGCAGGTGCCGGATGACGTTAAATCCTCAAGCGACTTGCTGCGCTTC
TATCAAAACTGGCAGCCTGCATGGGCTCCAGGAACACAACGTCTGTATGCCAACTCCAGTATCGGTTTGTTCGGCGCACTGGCTGTGAAG
CCGTCTGGTTTGAGTTTTGAGCAGGCGATGCAAACTCGTGTCTTCCAGCCACTCAAACTCAACCATACGTGGATTAATGTACCGCCCGCA
GAAGAAAAGAATTACGCCTGGGGATATCGCGAAGGTAAGGCAGTGCATGTTTCGCCAGGGGCGTTAGATGCTGAAGCTTATGGTGTGAAG
TCGACCATTGAAGATATGGCCCGCTGGGTGCAAAGCAATTTAAAACCCCTTGATATCACTGAGAAAACGCTTCAACAAGGGATACAACTG
GCACAATCTCGCTACTGGCAAACCGGCGATATGTATCAGGGCCTGGGCTGGGAAATGCTGGACTGGCCGGTAAATCCTGACAGCATCATT
AACGGCAGTGACAATAAAATTGCACTGGCAGCACGCCCCGTAAAAGCGATTACGCCCCCAACTCCTGCAGTGCGCGCATCATGGGTACAT
AAAACAGGGGCGACCGGCGGATTTGGTAGCTATGTCGCGTTTATTCCAGAAAAAGAGCTGGGTATCGTGATGCTGGCTAACAAAAACTAT
CCCAATCCAGCGAGAGTCACTGCCGCCTGGCAGATTCTCAACGCTCTACAGTAA