bicyclomycin [Drug Class]

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Accession ARO:0000055
Synonym(s)Bicozamycinum Bicozamycin Bicozamicina Bacteron Bicozamycine Aizumycin Bacfeed
DefinitionBicyclomycin represents a unique class of antibiotics, discovered in 1972. It is obtained by the fermentation of Streptomyces sapporonensis. In the crystalline form bicyclomycin is observed to be rhombic or monoclinic, depending on the solvent used. This antibiotic kills bacteria by inhibiting the Rho transcription terminator factor, halting ribonucleic acid (RNA) synthesis.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
3 ontology terms | Show
+ rho transcription terminator factor targeted_by_antibiotic
+ bcr-1 confers_resistance_to_antibiotic
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
Publications

Park HG, et al. 1995. Arch Biochem Biophys 323(2): 447-454. Bicyclomycin and dihydrobicyclomycin inhibition kinetics of Escherichia coli rho-dependent transcription termination factor ATPase activity. (PMID 7487110)

Kohn H and Widger W. 2005. Curr Drug Targets Infect Disord 5(3): 273-295. The molecular basis for the mode of action of bicyclomycin. (PMID 16181146)