hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase

Accession ARO:3000203
DefinitionMechanism of enzymatic degradation common to Ambler Class B beta-lactamases. One or two zinc atoms are used to orient a hydroxide nucleophile for attack of the beta-lactam ring. In contrast to serine beta-lactamases, no acyl-enzyme intermediate is formed.
Resistance Mechanismantibiotic inactivation
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show

De Pascale G and Wright GD. 2010. Chembiochem 11(10): 1325-1334. Antibiotic resistance by enzyme inactivation: from mechanisms to solutions. (PMID 20564281)