class B (metallo-) beta-lactamase

Accession ARO:3000004
Synonym(s)Molecular Class B beta-lactamase
DefinitionAmbler Class B beta-lactamases are the metallo-beta-lactamases. These enzymes possess one or two zinc ions in the active site, which are used to orient a hydroxide nucleophile to attack the carbonyl on a beta-lactam ring. There are currently no inhibitors in late-stage development for these relatively new beta-lactamases.
Resistance Mechanismantibiotic inactivation
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
6 ontology terms | Show

Hall BG, et al. 2003. J Mol Evol 57(3): 249-254. The metallo-beta-lactamases fall into two distinct phylogenetic groups. (PMID 14629034)

Garau G, et al. 2004. Antimicrob Agents Chemother 48(7): 2347-2349. Update of the standard numbering scheme for class B beta-lactamases. (PMID 15215079)