subclass B3 (metallo-) beta-lactamase

Accession ARO:3000571
DefinitionMetallo-beta-lactamases of subclass B3 are similar to B1 in that they have activity against penicillins, cephalosporins and carbapenems; however, the are only active with two Zn(II) ions in the active site.
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
16 ontology terms | Show
+ PNGM beta-lactamase [AMR Gene Family]
+ FEZ beta-lactamase [AMR Gene Family]
+ GOB beta-lactamase [AMR Gene Family]
+ THIN-B beta-lactamase [AMR Gene Family]
+ L1 family beta-lactamase [AMR Gene Family]
+ AIM beta-lactamase [AMR Gene Family]
+ SMB beta-lactamase [AMR Gene Family]
+ CAU beta-lactamase [AMR Gene Family]
+ BJP beta-lactamase [AMR Gene Family]
+ subclass B3 PEDO beta-lactamase [AMR Gene Family]
+ CPS beta-lactamase [AMR Gene Family]
+ ESP beta-lactamase [AMR Gene Family]
+ MSI beta-lactamase [AMR Gene Family]
+ SPG beta-lacatamase [AMR Gene Family]
+ Rm3 family beta-lactamase [AMR Gene Family]
+ subclass B3 LRA beta-lactamase [AMR Gene Family]
Publications

Lienard BM, et al. 2008. Org Biomol Chem 6(13): 2282-2294. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. (PMID 18563261)