| Accession | ARO:3004212 |
| Definition | The GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems. |
| Drug Class | carbapenem, penam, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactamase + beta-lactam antibiotic + cephem + class B (metallo-) beta-lactamase |
| Parent Term(s) | 4 ontology terms | Show + subclass B3 (metallo-) beta-lactamase + confers_resistance_to_drug_class carbapenem [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] |
| Sub-Term(s) | 49 ontology terms | Show + GOB-1 + GOB-18 + GOB-10 + GOB-11 + GOB-12 + GOB-13 + GOB-14 + GOB-15 + GOB-16 + GOB-2 + GOB-3 + GOB-4 + GOB-5 + GOB-6 + GOB-7 + GOB-8 + GOB-9 + GOB-19 + GOB-20 + GOB-21 + GOB-22 + GOB-23 + GOB-24 + GOB-25 + GOB-26 + GOB-27 + GOB-28 + GOB-29 + GOB-30 + GOB-31 + GOB-32 + GOB-33 + GOB-34 + GOB-35 + GOB-36 + GOB-37 + GOB-38 + GOB-39 + GOB-40 + GOB-41 + GOB-42 + GOB-43 + GOB-44 + GOB-45 + GOB-46 + GOB-48 + GOB-49 + GOB-50 + GOB-51 |
| Publications | Morán-Barrio J, et al. 2016. Antimicrob. Agents Chemother. 60(10):6013-22 Crystal Structure of the Metallo-β-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site. (PMID 27458232) Morán-Barrio J, et al. 2007. J. Biol. Chem. 282(25):18286-93 The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site. (PMID 17403673) Bellais S, et al. 2000. Antimicrob Agents Chemother 44(7): 1878-1886. Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum. (PMID 10858348) |