GOB beta-lactamase [AMR Gene Family]

Accession ARO:3004212
DefinitionThe GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems.
Drug Classcarbapenem, penam, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ subclass B3 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
49 ontology terms | Show

Morán-Barrio J, et al. 2016. Antimicrob. Agents Chemother. 60(10):6013-22 Crystal Structure of the Metallo-β-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site. (PMID 27458232)

Morán-Barrio J, et al. 2007. J. Biol. Chem. 282(25):18286-93 The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site. (PMID 17403673)

Bellais S, et al. 2000. Antimicrob Agents Chemother 44(7): 1878-1886. Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum. (PMID 10858348)