| Accession | ARO:3000008 |
| Synonym(s) | penam |
| Definition | Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 150 ontology terms | Show + CAM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PNGM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics [AMR Gene Family] confers_resistance_to_drug_class + methicillin resistant PBP2 [AMR Gene Family] confers_resistance_to_drug_class + Acinetobacter baumannii AbuO confers_resistance_to_drug_class + VCC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + NDM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MexCD-OprJ confers_resistance_to_drug_class + BlaZ beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + R39 beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BlaB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + JOHN beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CGB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CAU beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + subclass B3 LRA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + Rm3 family beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A LRA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A Bacillus anthracis Bla beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + subclass B1 Bacillus anthracis Bla beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class C LRA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ampC-type beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + blaF family beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + EXO beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + RCP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + KHM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + NPS beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FEZ beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class D LRA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + GOB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + THIN-B beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + AIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SMB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MexAB-OprM confers_resistance_to_drug_class + MexXY-OprM confers_resistance_to_drug_class + AcrEF-TolC confers_resistance_to_drug_class + MdsABC confers_resistance_to_drug_class + SmeABC confers_resistance_to_drug_class + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] confers_resistance_to_drug_class + Outer Membrane Porin (Opr) [AMR Gene Family] confers_resistance_to_drug_class + IMP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + GIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BlaA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + subclass B1 Bacillus cereus Bc beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LCR beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CARB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ROB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + GES beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + KPC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + TEM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + AER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SHV beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LEN beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BEL beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXY beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OKP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ACC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ACT beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MOX beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OCH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + VIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SHW beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + TRU beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ACI beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ARL Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + AST Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FONA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FRI beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BRO Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BPU Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BCL Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BES Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CBP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CGA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CKO beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CME beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ERP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FAR beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FPH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FTU beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + DES beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SCO beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LMB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + YRC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + blaS [AMR Gene Family] confers_resistance_to_drug_class + EBR beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LAP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PRC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A Mycobacterium abscessus beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A Mycobacterium tuberculosis bla beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + KBL beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PJM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SSA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + WUS beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LAQ beta lactamase [AMR Gene Family] confers_resistance_to_drug_class + CAE beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PSZ beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + AMZ beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-1-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-10-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-114-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-12-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-134-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-143-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-184-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-198-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-2-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-211-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-213-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-214-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-22-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-229-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-23-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-24-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-266-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-274-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-286-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-294-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-364-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-372-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-42-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-427-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-46-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-48-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-493-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-5-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-50-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-51-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-548-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-55-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-58-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-60-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-61-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-62-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-63-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-679-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-727-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXA-9-like beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BOR beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + GMA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + HBL beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + HER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PEN-A beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PEN-B beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + RSD1 [AMR Gene Family] confers_resistance_to_drug_class + SED beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + penicillin with extended spectrum + beta-lactamase sensitive penicillin + beta-lactamase resistant penicillin |
| Publications | Tipper DJ. 1985. Pharmacol Ther 27(1): 1-35. Mode of action of beta-lactam antibiotics. (PMID 3889939) |
| Curator | Description | Most Recent Edit |
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