Accession ARO:3000503
DefinitionAcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classfluoroquinolone antibiotic, cephalosporin, penam, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
6 ontology terms | Show
+ AcrE part_of
+ AcrF part_of
+ TolC part_of
+ AcrS regulates
+ H-NS regulates
+ AcrEF-TolC confers resistance to ciprofloxacin

Lau SY and Zgurskaya HI. 2005. J Bacteriol 187(22): 7815-7825. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. (PMID 16267305)

Zheng J, et al. 2008. J Antimicrob Chemother 63(1): 95-102. Effect of transcriptional activators RamA and SoxS on expression of multidrug efflux pumps AcrAB and AcrEF in fluoroquinolone-resistant Salmonella Typhimurium. (PMID 18984645)

Klein JR, et al. 1991. Mol Gen Genet 230(1-2): 230-240. Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. (PMID 1720861)

George AM. 1996. FEMS Microbiol Lett 139(1): 1-10. Multidrug resistance in enteric and other gram-negative bacteria. (PMID 8647368)

Nishino K, et al. 2003. Antimicrob Agents Chemother 47(9): 3030-3033. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams. (PMID 12937021)