Accession ARO:3000503
DefinitionAcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, acridine dye, penam, macrolide antibiotic, antibacterial free fatty acids, phenicol antibiotic, carbapenem, fluoroquinolone antibiotic, glycylcycline, aminoglycoside antibiotic, monobactam, triclosan, cephalosporin, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification23 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class penam [Drug Class]
6 ontology terms | Show
+ AcrE part_of
+ AcrF part_of
+ TolC part_of
+ AcrS regulates
+ H-NS regulates
+ AcrEF-TolC confers resistance to ciprofloxacin

Lau SY and Zgurskaya HI. 2005. J Bacteriol 187(22): 7815-7825. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. (PMID 16267305)

Zheng J, et al. 2008. J Antimicrob Chemother 63(1): 95-102. Effect of transcriptional activators RamA and SoxS on expression of multidrug efflux pumps AcrAB and AcrEF in fluoroquinolone-resistant Salmonella Typhimurium. (PMID 18984645)

Klein JR, et al. 1991. Mol Gen Genet 230(1-2): 230-240. Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. (PMID 1720861)

George AM. 1996. FEMS Microbiol Lett 139(1): 1-10. Multidrug resistance in enteric and other gram-negative bacteria. (PMID 8647368)

Nishino K, et al. 2003. Antimicrob Agents Chemother 47(9): 3030-3033. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams. (PMID 12937021)